IRF2BP2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IRF2BP2
Entrez Gene ID	359948
Full Name	interferon regulatory factor 2 binding protein 2
Synonyms	CVID14
General protein information	Preferred Names interferon regulatory factor 2 binding protein 2 Names interferon regulatory factor 2-binding protein 2 IRF-2-binding protein 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q42.3
Summary	This gene encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
Disorder MIM:	615332
Disorder Html:	?Immunodeficiency, common variable, 14, 617765 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001077397.1	NP_001070865.1	interferon regulatory factor 2-binding protein 2 isoform B
NM_182972.2	NP_892017.2	interferon regulatory factor 2-binding protein 2 isoform A

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	IRF2BP2	XP_005618905.1
Bos taurus (cattle)	IRF2BP2	XP_002698856.2
Mus musculus (house mouse)	Irf2bp2	NP_001158070.1
	LOC718705	XP_002808312.1
Rattus norvegicus (Norway rat)	Irf2bp2	XP_003751945.1
Homo sapiens (human)	IRF2BP2	NP_892017.2
Danio rerio (zebrafish)	irf2bp2b	NP_999917.1
Xenopus tropicalis (tropical clawed frog)	irf2bp2	NP_001001988.1
Pan troglodytes (chimpanzee)	IRF2BP2	XP_525097.2
Danio rerio (zebrafish)	irf2bp2a	NP_956275.1

Gene Ontology
Bibliography

Related articles in PubMed

The cryptic IRF2BP2-RARA fusion transforms hematopoietic stem/progenitor cells and induces retinoid-sensitive acute promyelocytic leukemia.
Jovanovic JV, Chill?n MC, Vincent-Fabert C, Dillon R, Voisset E, Guti?rrez NC, Sanz RG, Lopez AA, Morgan YG, Lok J, Solomon E, Duprez E, D?az MG, Grimwade D
Leukemia31(3)747-751(2017 Mar)

Mutation in IRF2BP2 is responsible for a familial form of common variable immunodeficiency disorder.
Keller MD, Pandey R, Li D, Glessner J, Tian L, Henrickson SE, Chinn IK, Monaco-Shawver L, Heimall J, Hou C, Otieno FG, Jyonouchi S, Calabrese L, van Montfrans J, Orange JS, Hakonarson H
The Journal of allergy and clinical immunology138(2)544-550.e4(2016 Aug)

Control of developmentally primed erythroid genes by combinatorial co-repressor actions.
Stadhouders R, Cico A, Stephen T, Thongjuea S, Kolovos P, Baymaz HI, Yu X, Demmers J, Bezstarosti K, Maas A, Barroca V, Kockx C, Ozgur Z, van Ijcken W, Arcangeli ML, Andrieu-Soler C, Lenhard B, Grosveld F, Soler E
Nature communications68893(2015 Nov)

IRF2BP2 Reduces Macrophage Inflammation and Susceptibility to Atherosclerosis.
Chen HH, Keyhanian K, Zhou X, Vilmundarson RO, Almontashiri NA, Cruz SA, Pandey NR, Lerma Yap N, Ho T, Stewart CA, Huang H, Hari A, Geoffrion M, McPherson R, Rayner KJ, Stewart AF
Circulation research117(8)671-83(2015 Sep)

Discovery and refinement of loci associated with lipid levels.
Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang HY, Demirkan A, Den Hertog HM, Do R, Donnelly LA, Ehret GB, Esko T, Feitosa MF, Ferreira T, Fischer K, Fontanillas P, Fraser RM, Freitag DF, Gurdasani D, Heikkil? K, Hypp?nen E, Isaacs A, Jackson AU, Johansson ?, Johnson T, Kaakinen M, Kettunen J, Kleber ME, Li X, Luan J, Lyytik?inen LP, Magnusson PKE, Mangino M, Mihailov E, Montasser ME, M?ller-Nurasyid M, Nolte IM, O'Connell JR, Palmer CD, Perola M, Petersen AK, Sanna S, Saxena R, Service SK, Shah S, Shungin D, Sidore C, Song C, Strawbridge RJ, Surakka I, Tanaka T, Teslovich TM, Thorleifsson G, Van den Herik EG, Voight BF, Volcik KA, Waite LL, Wong A, Wu Y, Zhang W, Absher D, Asiki G, Barroso I, Been LF, Bolton JL, Bonnycastle LL, Brambilla P, Burnett MS, Cesana G, Dimitriou M, Doney ASF, D?ring A, Elliott P, Epstein SE, Ingi Eyjolfsson G, Gigante B, Goodarzi MO, Grallert H, Gravito ML, Groves CJ, Hallmans G, Hartikainen AL, Hayward C, Hernandez D, Hicks AA, Holm H, Hung YJ, Illig T, Jones MR, Kaleebu P, Kastelein JJP, Khaw KT, Kim E, Klopp N, Komulainen P, Kumari M, Langenberg C, Lehtim?ki T, Lin SY, Lindstr?m J, Loos RJF, Mach F, McArdle WL, Meisinger C, Mitchell BD, M?ller G, Nagaraja R, Narisu N, Nieminen TVM, Nsubuga RN, Olafsson I, Ong KK, Palotie A, Papamarkou T, Pomilla C, Pouta A, Rader DJ, Reilly MP, Ridker PM, Rivadeneira F, Rudan I, Ruokonen A, Samani N, Scharnagl H, Seeley J, Silander K, Stan??kov? A, Stirrups K, Swift AJ, Tiret L, Uitterlinden AG, van Pelt LJ, Vedantam S, Wainwright N, Wijmenga C, Wild SH, Willemsen G, Wilsgaard T, Wilson JF, Young EH, Zhao JH, Adair LS, Arveiler D, Assimes TL, Bandinelli S, Bennett F, Bochud M, Boehm BO, Boomsma DI, Borecki IB, Bornstein SR, Bovet P, Burnier M, Campbell H, Chakravarti A, Chambers JC, Chen YI, Collins FS, Cooper RS, Danesh J, Dedoussis G, de Faire U, Feranil AB, Ferri?res J, Ferrucci L, Freimer NB, Gieger C, Groop LC, Gudnason V, Gyllensten U, Hamsten A, Harris TB, Hingorani A, Hirschhorn JN, Hofman A, Hovingh GK, Hsiung CA, Humphries SE, Hunt SC, Hveem K, Iribarren C, J?rvelin MR, Jula A, K?h?nen M, Kaprio J, Kes?niemi A, Kivimaki M, Kooner JS, Koudstaal PJ, Krauss RM, Kuh D, Kuusisto J, Kyvik KO, Laakso M, Lakka TA, Lind L, Lindgren CM, Martin NG, M?rz W, McCarthy MI, McKenzie CA, Meneton P, Metspalu A, Moilanen L, Morris AD, Munroe PB, Nj?lstad I, Pedersen NL, Power C, Pramstaller PP, Price JF, Psaty BM, Quertermous T, Rauramaa R, Saleheen D, Salomaa V, Sanghera DK, Saramies J, Schwarz PEH, Sheu WH, Shuldiner AR, Siegbahn A, Spector TD, Stefansson K, Strachan DP, Tayo BO, Tremoli E, Tuomilehto J, Uusitupa M, van Duijn CM, Vollenweider P, Wallentin L, Wareham NJ, Whitfield JB, Wolffenbuttel BHR, Ordovas JM, Boerwinkle E, Palmer CNA, Thorsteinsdottir U, Chasman DI, Rotter JI, Franks PW, Ripatti S, Cupples LA, Sandhu MS, Rich SS, Boehnke M, Deloukas P, Kathiresan S, Mohlke KL, Ingelsson E, Abecasis GR,
Nature genetics45(11)1274-1283(2013 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A novel IRFBP2 mutation was identified in a family with autosomal dominant CVID. Transduction experiments suggest that the mutant protein has an effect on B-cell differentiation and is likely a monogenic cause of the family's CVID phenotype.
Title: Mutation in IRF2BP2 is responsible for a familial form of common variable immunodeficiency disorder.

ETO2 and IRF2BP2 interacting with the NCOR1/SMRT co-repressor complex, suppresses the expression of erythroid genes until erythroid differentiation.
Title: Control of developmentally primed erythroid genes by combinatorial co-repressor actions.

A deletion variant that lowers IRF2BP2 expression predisposes to coronary artery disease in humans.
Title: IRF2BP2 Reduces Macrophage Inflammation and Susceptibility to Atherosclerosis.

analysis of an IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma
Title: Whole-transcriptome sequencing identifies novel IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma.

Nuclear localization of IRF2BP2 depends on phosphorylation near a conserved NLS. Changes in phosphorylation status likely control nucleocytoplasmic localization of IRF2BP2 during muscle differentiation.
Title: Identification of a phosphorylation-dependent nuclear localization motif in interferon regulatory factor 2 binding protein 2.

The following IRF2BP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IRF2BP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu24879	NM_182972.2 Latest version!	Homo sapiens interferon regulatory factor 2 binding protein 2 (IRF2BP2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$244.50-$342.30 $489.00
OHu24794	NM_001077397.1 Latest version!	Homo sapiens interferon regulatory factor 2 binding protein 2 (IRF2BP2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$335.30 $479.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IRF2BP2 ( NM_182972.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_892017.2 Homo sapiens interferon regulatory factor 2 binding protein 2 (IRF2BP2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu24879
Clone ID Related Accession (Same CDS sequence)	NM_182972.2
Accession Version	NM_182972.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1764bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Homo sapiens(human)
Product	interferon regulatory factor 2-binding protein 2 isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY278023.1, BE408503.1, CD640986.1 and BC020516.1. On Oct 26, 2006 this sequence version replaced NM_182972.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY278023.1, SRR1660807.124427.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145544, SAMEA2147920 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCGCGG CGGTGGCGGT GGCGGCCGCG TCCCGGCGGC AGTCGTGCTA CCTGTGTGAC 
CTGCCCCGCA TGCCCTGGGC CATGATCTGG GACTTCACCG AACCCGTCTG CCGCGGCTGC 
GTCAACTACG AGGGCGCCGA CCGCGTCGAG TTCGTCATCG AGACGGCGCG GCAGCTCAAG 
CGGGCGCACG GCTGCTTCCC GGAGGGTCGC TCCCCACCCG GCGCCGCGGC CTCGGCCGCC 
GCCAAGCCGC CGCCGCTCTC CGCCAAGGAC ATCCTTTTGC AGCAGCAGCA GCAGCTTGGC 
CACGGCGGCC CCGAGGCGGC CCCGCGCGCG CCGCAGGCCT TGGAGCGCTA CCCGTTGGCG 
GCCGCGGCCG AGAGGCCCCC GCGCCTCGGC TCTGACTTCG GCAGCAGCCG CCCGGCAGCG 
AGCCTGGCCC AGCCGCCGAC GCCGCAGCCG CCGCCCGTGA ACGGCATCCT GGTGCCCAAC 
GGCTTCTCCA AGCTAGAGGA GCCGCCCGAG CTGAATCGCC AGAGCCCGAA CCCGCGGCGC 
GGCCACGCGG TGCCGCCCAC CCTGGTGCCG CTCATGAACG GCTCGGCCAC GCCGCTGCCC 
ACCGCGCTCG GCCTCGGCGG CCGCGCTGCC GCCTCCTTAG CCGCGGTGTC CGGAACCGCG 
GCCGCCAGCC TGGGCTCCGC GCAGCCCACC GATCTGGGCG CCCACAAGCG GCCGGCATCC 
GTGTCGAGCA GCGCTGCCGT GGAGCACGAG CAGCGTGAGG CGGCAGCCAA GGAGAAACAA 
CCGCCGCCGC CTGCGCACCG GGGCCCGGCC GACAGCCTGT CCACCGCGGC CGGGGCCGCC 
GAGCTGAGCG CGGAAGGTGC GGGCAAGAGC CGCGGGTCTG GAGAGCAGGA CTGGGTCAAC 
AGGCCCAAGA CCGTGCGCGA CACGCTGCTG GCGCTGCACC AGCACGGCCA CTCGGGGCCC 
TTCGAGAGCA AGTTTAAGAA GGAGCCGGCC CTGACTGCAG GCAGGTTGTT GGGTTTCGAG 
GCCAACGGGG CCAACGGGTC TAAAGCAGTT GCAAGAACAG CAAGGAAAAG GAAGCCCTCT 
CCAGAACCAG AAGGTGAAGT CGGGCCCCCT AAGATCAACG GAGAGGCCCA GCCGTGGCTG 
TCCACATCCA CAGAGGGGCT CAAGATCCCC ATGACTCCTA CATCCTCTTT TGTGTCTCCG 
CCACCACCCA CTGCCTCACC TCATTCCAAC CGGACCACAC CGCCTGAAGC GGCCCAGAAT 
GGCCAGTCCC CCATGGCAGC CCTGATCTTA GTAGCAGACA ATGCAGGGGG CAGTCATGCC 
TCAAAAGATG CCAACCAGGT TCACTCCACT ACCAGGAGGA ATAGCAACAG TCCGCCCTCT 
CCGTCCTCTA TGAACCAAAG AAGGCTGGGC CCCAGAGAGG TGGGGGGCCA GGGAGCAGGC 
AACACAGGAG GACTGGAGCC AGTGCACCCT GCCAGCCTCC CGGACTCCTC TCTGGCAACC 
AGTGCCCCGC TGTGCTGCAC CCTCTGCCAC GAGCGGCTGG AGGACACCCA TTTTGTGCAG 
TGCCCGTCCG TCCCTTCGCA CAAGTTCTGC TTCCCTTGCT CCAGACAAAG CATCAAACAG 
CAGGGAGCTA GTGGAGAGGT CTATTGTCCC AGTGGGGAAA AATGCCCTCT TGTGGGCTCC 
AATGTCCCCT GGGCCTTTAT GCAAGGGGAA ATTGCAACCA TCCTTGCTGG AGATGTGAAA 
GTGAAAAAAG AGAGAGACTC GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_892017.2
CDS	32..1795
Translation	MAAAVAVAAASRRQSCYLCDLPRMPWAMIWDFTEPVCRGCVNYEGADRVEFVIETARQLKRAHGCFPEGRSPPGAAASAAAKPPPLSAKDILLQQQQQLGHGGPEAAPRAPQALERYPLAAAAERPPRLGSDFGSSRPAASLAQPPTPQPPPVNGILVPNGFSKLEEPPELNRQSPNPRRGHAVPPTLVPLMNGSATPLPTALGLGGRAAASLAAVSGTAAASLGSAQPTDLGAHKRPASVSSSAAVEHEQREAAAKEKQPPPPAHRGPADSLSTAAGAAELSAEGAGKSRGSGEQDWVNRPKTVRDTLLALHQHGHSGPFESKFKKEPALTAGRLLGFEANGANGSKAVARTARKRKPSPEPEGEVGPPKINGEAQPWLSTSTEGLKIPMTPTSSFVSPPPPTASPHSNRTTPPEAAQNGQSPMAALILVADNAGGSHASKDANQVHSTTRRNSNSPPSPSSMNQRRLGPREVGGQGAGNTGGLEPVHPASLPDSSLATSAPLCCTLCHERLEDTHFVQCPSVPSHKFCFPCSRQSIKQQGASGEVYCPSGEKCPLVGSNVPWAFMQGEIATILAGDVKVKKERDS

Target ORF information:

RefSeq Version	NM_182972.2
Organism	Homo sapiens(human)
Definition	Homo sapiens interferon regulatory factor 2 binding protein 2 (IRF2BP2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_182972.2

ORF Insert Sequence:

ATGGCCGCGG CGGTGGCGGT GGCGGCCGCG TCCCGGCGGC AGTCGTGCTA CCTGTGTGAC 
CTGCCCCGCA TGCCCTGGGC CATGATCTGG GACTTCACCG AACCCGTCTG CCGCGGCTGC 
GTCAACTACG AGGGCGCCGA CCGCGTCGAG TTCGTCATCG AGACGGCGCG GCAGCTCAAG 
CGGGCGCACG GCTGCTTCCC GGAGGGTCGC TCCCCACCCG GCGCCGCGGC CTCGGCCGCC 
GCCAAGCCGC CGCCGCTCTC CGCCAAGGAC ATCCTTTTGC AGCAGCAGCA GCAGCTTGGC 
CACGGCGGCC CCGAGGCGGC CCCGCGCGCG CCGCAGGCCT TGGAGCGCTA CCCGTTGGCG 
GCCGCGGCCG AGAGGCCCCC GCGCCTCGGC TCTGACTTCG GCAGCAGCCG CCCGGCAGCG 
AGCCTGGCCC AGCCGCCGAC GCCGCAGCCG CCGCCCGTGA ACGGCATCCT GGTGCCCAAC 
GGCTTCTCCA AGCTAGAGGA GCCGCCCGAG CTGAATCGCC AGAGCCCGAA CCCGCGGCGC 
GGCCACGCGG TGCCGCCCAC CCTGGTGCCG CTCATGAACG GCTCGGCCAC GCCGCTGCCC 
ACCGCGCTCG GCCTCGGCGG CCGCGCTGCC GCCTCCTTAG CCGCGGTGTC CGGAACCGCG 
GCCGCCAGCC TGGGCTCCGC GCAGCCCACC GATCTGGGCG CCCACAAGCG GCCGGCATCC 
GTGTCGAGCA GCGCTGCCGT GGAGCACGAG CAGCGTGAGG CGGCAGCCAA GGAGAAACAA 
CCGCCGCCGC CTGCGCACCG GGGCCCGGCC GACAGCCTGT CCACCGCGGC CGGGGCCGCC 
GAGCTGAGCG CGGAAGGTGC GGGCAAGAGC CGCGGGTCTG GAGAGCAGGA CTGGGTCAAC 
AGGCCCAAGA CCGTGCGCGA CACGCTGCTG GCGCTGCACC AGCACGGCCA CTCGGGGCCC 
TTCGAGAGCA AGTTTAAGAA GGAGCCGGCC CTGACTGCAG GCAGGTTGTT GGGTTTCGAG 
GCCAACGGGG CCAACGGGTC TAAAGCAGTT GCAAGAACAG CAAGGAAAAG GAAGCCCTCT 
CCAGAACCAG AAGGTGAAGT CGGGCCCCCT AAGATCAACG GAGAGGCCCA GCCGTGGCTG 
TCCACATCCA CAGAGGGGCT CAAGATCCCC ATGACTCCTA CATCCTCTTT TGTGTCTCCG 
CCACCACCCA CTGCCTCACC TCATTCCAAC CGGACCACAC CGCCTGAAGC GGCCCAGAAT 
GGCCAGTCCC CCATGGCAGC CCTGATCTTA GTAGCAGACA ATGCAGGGGG CAGTCATGCC 
TCAAAAGATG CCAACCAGGT TCACTCCACT ACCAGGAGGA ATAGCAACAG TCCGCCCTCT 
CCGTCCTCTA TGAACCAAAG AAGGCTGGGC CCCAGAGAGG TGGGGGGCCA GGGAGCAGGC 
AACACAGGAG GACTGGAGCC AGTGCACCCT GCCAGCCTCC CGGACTCCTC TCTGGCAACC 
AGTGCCCCGC TGTGCTGCAC CCTCTGCCAC GAGCGGCTGG AGGACACCCA TTTTGTGCAG 
TGCCCGTCCG TCCCTTCGCA CAAGTTCTGC TTCCCTTGCT CCAGACAAAG CATCAAACAG 
CAGGGAGCTA GTGGAGAGGT CTATTGTCCC AGTGGGGAAA AATGCCCTCT TGTGGGCTCC 
AATGTCCCCT GGGCCTTTAT GCAAGGGGAA ATTGCAACCA TCCTTGCTGG AGATGTGAAA 
GTGAAAAAAG AGAGAGACTC GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IRF2BP2 ( NM_001077397.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001070865.1 Homo sapiens interferon regulatory factor 2 binding protein 2 (IRF2BP2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu24794
Clone ID Related Accession (Same CDS sequence)	NM_001077397.1
Accession Version	NM_001077397.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1716bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-07
Organism	Homo sapiens(human)
Product	interferon regulatory factor 2-binding protein 2 isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY278024.1, BE408503.1, CD640986.1 and BC020516.1. Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform B). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY278024.1, SRR1803612.145574.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGCGG CGGTGGCGGT GGCGGCCGCG TCCCGGCGGC AGTCGTGCTA CCTGTGTGAC 
CTGCCCCGCA TGCCCTGGGC CATGATCTGG GACTTCACCG AACCCGTCTG CCGCGGCTGC 
GTCAACTACG AGGGCGCCGA CCGCGTCGAG TTCGTCATCG AGACGGCGCG GCAGCTCAAG 
CGGGCGCACG GCTGCTTCCC GGAGGGTCGC TCCCCACCCG GCGCCGCGGC CTCGGCCGCC 
GCCAAGCCGC CGCCGCTCTC CGCCAAGGAC ATCCTTTTGC AGCAGCAGCA GCAGCTTGGC 
CACGGCGGCC CCGAGGCGGC CCCGCGCGCG CCGCAGGCCT TGGAGCGCTA CCCGTTGGCG 
GCCGCGGCCG AGAGGCCCCC GCGCCTCGGC TCTGACTTCG GCAGCAGCCG CCCGGCAGCG 
AGCCTGGCCC AGCCGCCGAC GCCGCAGCCG CCGCCCGTGA ACGGCATCCT GGTGCCCAAC 
GGCTTCTCCA AGCTAGAGGA GCCGCCCGAG CTGAATCGCC AGAGCCCGAA CCCGCGGCGC 
GGCCACGCGG TGCCGCCCAC CCTGGTGCCG CTCATGAACG GCTCGGCCAC GCCGCTGCCC 
ACCGCGCTCG GCCTCGGCGG CCGCGCTGCC GCCTCCTTAG CCGCGGTGTC CGGAACCGCG 
GCCGCCAGCC TGGGCTCCGC GCAGCCCACC GATCTGGGCG CCCACAAGCG GCCGGCATCC 
GTGTCGAGCA GCGCTGCCGT GGAGCACGAG CAGCGTGAGG CGGCAGCCAA GGAGAAACAA 
CCGCCGCCGC CTGCGCACCG GGGCCCGGCC GACAGCCTGT CCACCGCGGC CGGGGCCGCC 
GAGCTGAGCG CGGAAGGTGC GGGCAAGAGC CGCGGGTCTG GAGAGCAGGA CTGGGTCAAC 
AGGCCCAAGA CCGTGCGCGA CACGCTGCTG GCGCTGCACC AGCACGGCCA CTCGGGGCCC 
TTCGAGAGCA AGTTTAAGAA GGAGCCGGCC CTGACTGCAG TTGCAAGAAC AGCAAGGAAA 
AGGAAGCCCT CTCCAGAACC AGAAGGTGAA GTCGGGCCCC CTAAGATCAA CGGAGAGGCC 
CAGCCGTGGC TGTCCACATC CACAGAGGGG CTCAAGATCC CCATGACTCC TACATCCTCT 
TTTGTGTCTC CGCCACCACC CACTGCCTCA CCTCATTCCA ACCGGACCAC ACCGCCTGAA 
GCGGCCCAGA ATGGCCAGTC CCCCATGGCA GCCCTGATCT TAGTAGCAGA CAATGCAGGG 
GGCAGTCATG CCTCAAAAGA TGCCAACCAG GTTCACTCCA CTACCAGGAG GAATAGCAAC 
AGTCCGCCCT CTCCGTCCTC TATGAACCAA AGAAGGCTGG GCCCCAGAGA GGTGGGGGGC 
CAGGGAGCAG GCAACACAGG AGGACTGGAG CCAGTGCACC CTGCCAGCCT CCCGGACTCC 
TCTCTGGCAA CCAGTGCCCC GCTGTGCTGC ACCCTCTGCC ACGAGCGGCT GGAGGACACC 
CATTTTGTGC AGTGCCCGTC CGTCCCTTCG CACAAGTTCT GCTTCCCTTG CTCCAGACAA 
AGCATCAAAC AGCAGGGAGC TAGTGGAGAG GTCTATTGTC CCAGTGGGGA AAAATGCCCT 
CTTGTGGGCT CCAATGTCCC CTGGGCCTTT ATGCAAGGGG AAATTGCAAC CATCCTTGCT 
GGAGATGTGA AAGTGAAAAA AGAGAGAGAC TCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001070865.1
CDS	32..1747
Translation	MAAAVAVAAASRRQSCYLCDLPRMPWAMIWDFTEPVCRGCVNYEGADRVEFVIETARQLKRAHGCFPEGRSPPGAAASAAAKPPPLSAKDILLQQQQQLGHGGPEAAPRAPQALERYPLAAAAERPPRLGSDFGSSRPAASLAQPPTPQPPPVNGILVPNGFSKLEEPPELNRQSPNPRRGHAVPPTLVPLMNGSATPLPTALGLGGRAAASLAAVSGTAAASLGSAQPTDLGAHKRPASVSSSAAVEHEQREAAAKEKQPPPPAHRGPADSLSTAAGAAELSAEGAGKSRGSGEQDWVNRPKTVRDTLLALHQHGHSGPFESKFKKEPALTAVARTARKRKPSPEPEGEVGPPKINGEAQPWLSTSTEGLKIPMTPTSSFVSPPPPTASPHSNRTTPPEAAQNGQSPMAALILVADNAGGSHASKDANQVHSTTRRNSNSPPSPSSMNQRRLGPREVGGQGAGNTGGLEPVHPASLPDSSLATSAPLCCTLCHERLEDTHFVQCPSVPSHKFCFPCSRQSIKQQGASGEVYCPSGEKCPLVGSNVPWAFMQGEIATILAGDVKVKKERDS

Target ORF information:

RefSeq Version	NM_001077397.1
Organism	Homo sapiens(human)
Definition	Homo sapiens interferon regulatory factor 2 binding protein 2 (IRF2BP2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001077397.1

ORF Insert Sequence:

ATGGCCGCGG CGGTGGCGGT GGCGGCCGCG TCCCGGCGGC AGTCGTGCTA CCTGTGTGAC 
CTGCCCCGCA TGCCCTGGGC CATGATCTGG GACTTCACCG AACCCGTCTG CCGCGGCTGC 
GTCAACTACG AGGGCGCCGA CCGCGTCGAG TTCGTCATCG AGACGGCGCG GCAGCTCAAG 
CGGGCGCACG GCTGCTTCCC GGAGGGTCGC TCCCCACCCG GCGCCGCGGC CTCGGCCGCC 
GCCAAGCCGC CGCCGCTCTC CGCCAAGGAC ATCCTTTTGC AGCAGCAGCA GCAGCTTGGC 
CACGGCGGCC CCGAGGCGGC CCCGCGCGCG CCGCAGGCCT TGGAGCGCTA CCCGTTGGCG 
GCCGCGGCCG AGAGGCCCCC GCGCCTCGGC TCTGACTTCG GCAGCAGCCG CCCGGCAGCG 
AGCCTGGCCC AGCCGCCGAC GCCGCAGCCG CCGCCCGTGA ACGGCATCCT GGTGCCCAAC 
GGCTTCTCCA AGCTAGAGGA GCCGCCCGAG CTGAATCGCC AGAGCCCGAA CCCGCGGCGC 
GGCCACGCGG TGCCGCCCAC CCTGGTGCCG CTCATGAACG GCTCGGCCAC GCCGCTGCCC 
ACCGCGCTCG GCCTCGGCGG CCGCGCTGCC GCCTCCTTAG CCGCGGTGTC CGGAACCGCG 
GCCGCCAGCC TGGGCTCCGC GCAGCCCACC GATCTGGGCG CCCACAAGCG GCCGGCATCC 
GTGTCGAGCA GCGCTGCCGT GGAGCACGAG CAGCGTGAGG CGGCAGCCAA GGAGAAACAA 
CCGCCGCCGC CTGCGCACCG GGGCCCGGCC GACAGCCTGT CCACCGCGGC CGGGGCCGCC 
GAGCTGAGCG CGGAAGGTGC GGGCAAGAGC CGCGGGTCTG GAGAGCAGGA CTGGGTCAAC 
AGGCCCAAGA CCGTGCGCGA CACGCTGCTG GCGCTGCACC AGCACGGCCA CTCGGGGCCC 
TTCGAGAGCA AGTTTAAGAA GGAGCCGGCC CTGACTGCAG TTGCAAGAAC AGCAAGGAAA 
AGGAAGCCCT CTCCAGAACC AGAAGGTGAA GTCGGGCCCC CTAAGATCAA CGGAGAGGCC 
CAGCCGTGGC TGTCCACATC CACAGAGGGG CTCAAGATCC CCATGACTCC TACATCCTCT 
TTTGTGTCTC CGCCACCACC CACTGCCTCA CCTCATTCCA ACCGGACCAC ACCGCCTGAA 
GCGGCCCAGA ATGGCCAGTC CCCCATGGCA GCCCTGATCT TAGTAGCAGA CAATGCAGGG 
GGCAGTCATG CCTCAAAAGA TGCCAACCAG GTTCACTCCA CTACCAGGAG GAATAGCAAC 
AGTCCGCCCT CTCCGTCCTC TATGAACCAA AGAAGGCTGG GCCCCAGAGA GGTGGGGGGC 
CAGGGAGCAG GCAACACAGG AGGACTGGAG CCAGTGCACC CTGCCAGCCT CCCGGACTCC 
TCTCTGGCAA CCAGTGCCCC GCTGTGCTGC ACCCTCTGCC ACGAGCGGCT GGAGGACACC 
CATTTTGTGC AGTGCCCGTC CGTCCCTTCG CACAAGTTCT GCTTCCCTTG CTCCAGACAA 
AGCATCAAAC AGCAGGGAGC TAGTGGAGAG GTCTATTGTC CCAGTGGGGA AAAATGCCCT 
CTTGTGGGCT CCAATGTCCC CTGGGCCTTT ATGCAAGGGG AAATTGCAAC CATCCTTGCT 
GGAGATGTGA AAGTGAAAAA AGAGAGAGAC TCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The cryptic IRF2BP2-RARA fusion transforms hematopoietic stem/progenitor cells and induces retinoid-sensitive acute promyelocytic leukemia.
Leukemia31(3)747-751(2017 Mar)
Jovanovic JV,Chill?n MC,Vincent-Fabert C,Dillon R,Voisset E,Guti?rrez NC,Sanz RG,Lopez AA,Morgan YG,Lok J,Solomon E,Duprez E,D?az MG,Grimwade D

Mutation in IRF2BP2 is responsible for a familial form of common variable immunodeficiency disorder.
The Journal of allergy and clinical immunology138(2)544-550.e4(2016 Aug)
Keller MD,Pandey R,Li D,Glessner J,Tian L,Henrickson SE,Chinn IK,Monaco-Shawver L,Heimall J,Hou C,Otieno FG,Jyonouchi S,Calabrese L,van Montfrans J,Orange JS,Hakonarson H

Control of developmentally primed erythroid genes by combinatorial co-repressor actions.
Nature communications68893(2015 Nov)
Stadhouders R,Cico A,Stephen T,Thongjuea S,Kolovos P,Baymaz HI,Yu X,Demmers J,Bezstarosti K,Maas A,Barroca V,Kockx C,Ozgur Z,van Ijcken W,Arcangeli ML,Andrieu-Soler C,Lenhard B,Grosveld F,Soler E

IRF2BP2 Reduces Macrophage Inflammation and Susceptibility to Atherosclerosis.
Circulation research117(8)671-83(2015 Sep)
Chen HH,Keyhanian K,Zhou X,Vilmundarson RO,Almontashiri NA,Cruz SA,Pandey NR,Lerma Yap N,Ho T,Stewart CA,Huang H,Hari A,Geoffrion M,McPherson R,Rayner KJ,Stewart AF

Discovery and refinement of loci associated with lipid levels.
Nature genetics45(11)1274-1283(2013 Nov)
Willer CJ,Schmidt EM,Sengupta S,Peloso GM,Gustafsson S,Kanoni S,Ganna A,Chen J,Buchkovich ML,Mora S,Beckmann JS,Bragg-Gresham JL,Chang HY,Demirkan A,Den Hertog HM,Do R,Donnelly LA,Ehret GB,Esko T,Feitosa MF,Ferreira T,Fischer K,Fontanillas P,Fraser RM,Freitag DF,Gurdasani D,Heikkil? K,Hypp?nen E,Isaacs A,Jackson AU,Johansson ?,Johnson T,Kaakinen M,Kettunen J,Kleber ME,Li X,Luan J,Lyytik?inen LP,Magnusson PKE,Mangino M,Mihailov E,Montasser ME,M?ller-Nurasyid M,Nolte IM,O'Connell JR,Palmer CD,Perola M,Petersen AK,Sanna S,Saxena R,Service SK,Shah S,Shungin D,Sidore C,Song C,Strawbridge RJ,Surakka I,Tanaka T,Teslovich TM,Thorleifsson G,Van den Herik EG,Voight BF,Volcik KA,Waite LL,Wong A,Wu Y,Zhang W,Absher D,Asiki G,Barroso I,Been LF,Bolton JL,Bonnycastle LL,Brambilla P,Burnett MS,Cesana G,Dimitriou M,Doney ASF,D?ring A,Elliott P,Epstein SE,Ingi Eyjolfsson G,Gigante B,Goodarzi MO,Grallert H,Gravito ML,Groves CJ,Hallmans G,Hartikainen AL,Hayward C,Hernandez D,Hicks AA,Holm H,Hung YJ,Illig T,Jones MR,Kaleebu P,Kastelein JJP,Khaw KT,Kim E,Klopp N,Komulainen P,Kumari M,Langenberg C,Lehtim?ki T,Lin SY,Lindstr?m J,Loos RJF,Mach F,McArdle WL,Meisinger C,Mitchell BD,M?ller G,Nagaraja R,Narisu N,Nieminen TVM,Nsubuga RN,Olafsson I,Ong KK,Palotie A,Papamarkou T,Pomilla C,Pouta A,Rader DJ,Reilly MP,Ridker PM,Rivadeneira F,Rudan I,Ruokonen A,Samani N,Scharnagl H,Seeley J,Silander K,Stan??kov? A,Stirrups K,Swift AJ,Tiret L,Uitterlinden AG,van Pelt LJ,Vedantam S,Wainwright N,Wijmenga C,Wild SH,Willemsen G,Wilsgaard T,Wilson JF,Young EH,Zhao JH,Adair LS,Arveiler D,Assimes TL,Bandinelli S,Bennett F,Bochud M,Boehm BO,Boomsma DI,Borecki IB,Bornstein SR,Bovet P,Burnier M,Campbell H,Chakravarti A,Chambers JC,Chen YI,Collins FS,Cooper RS,Danesh J,Dedoussis G,de Faire U,Feranil AB,Ferri?res J,Ferrucci L,Freimer NB,Gieger C,Groop LC,Gudnason V,Gyllensten U,Hamsten A,Harris TB,Hingorani A,Hirschhorn JN,Hofman A,Hovingh GK,Hsiung CA,Humphries SE,Hunt SC,Hveem K,Iribarren C,J?rvelin MR,Jula A,K?h?nen M,Kaprio J,Kes?niemi A,Kivimaki M,Kooner JS,Koudstaal PJ,Krauss RM,Kuh D,Kuusisto J,Kyvik KO,Laakso M,Lakka TA,Lind L,Lindgren CM,Martin NG,M?rz W,McCarthy MI,McKenzie CA,Meneton P,Metspalu A,Moilanen L,Morris AD,Munroe PB,Nj?lstad I,Pedersen NL,Power C,Pramstaller PP,Price JF,Psaty BM,Quertermous T,Rauramaa R,Saleheen D,Salomaa V,Sanghera DK,Saramies J,Schwarz PEH,Sheu WH,Shuldiner AR,Siegbahn A,Spector TD,Stefansson K,Strachan DP,Tayo BO,Tremoli E,Tuomilehto J,Uusitupa M,van Duijn CM,Vollenweider P,Wallentin L,Wareham NJ,Whitfield JB,Wolffenbuttel BHR,Ordovas JM,Boerwinkle E,Palmer CNA,Thorsteinsdottir U,Chasman DI,Rotter JI,Franks PW,Ripatti S,Cupples LA,Sandhu MS,Rich SS,Boehnke M,Deloukas P,Kathiresan S,Mohlke KL,Ingelsson E,Abecasis GR,

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IRF2BP2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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