IFNA16 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IFNA16
Entrez Gene ID	3449
Full Name	interferon alpha 16
Synonyms	IFN-alpha-16,IFN-alphaO
General protein information	Preferred Names interferon alpha 16 Names interferon alpha-16 IFN-alpha-N-protein interferon alpha-WA
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p21.3
Disorder MIM:	147580

mRNA and Protein(s)

mRNA	Protein	Name
NM_002173.2	NP_002164.1	interferon alpha-16 precursor
NM_002173.3	NP_002164.1	interferon alpha-16 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LOC100683045	XP_003435475.1
Bos taurus (cattle)	IFNAD	XP_005209953.1
Bos taurus (cattle)	IFNAC	NP_776510.1
Bos taurus (cattle)	LOC538620	XP_002707881.1
Bos taurus (cattle)	IFNAH	NP_001165512.1
Canis lupus familiaris (dog)	LOC100688005	XP_003431692.1
Bos taurus (cattle)	LOC100335490	XP_003586414.1
Bos taurus (cattle)	INFAF	NP_001165513.1
Pan troglodytes (chimpanzee)	IFNA16	XP_001152006.1
	LOC710568	XP_001107635.1
Canis lupus familiaris (dog)	IFNA5	NP_001006648.1
Canis lupus familiaris (dog)	IFNA7	NP_001006655.1
Canis lupus familiaris (dog)	LOC100683123	XP_003435476.1
Canis lupus familiaris (dog)	LOC611406	XP_854169.1
Bos taurus (cattle)	IFNAG	NP_001165511.1
Bos taurus (cattle)	LOC618947	XP_002689560.1
Homo sapiens (human)	IFNA16	NP_002164.1
Canis lupus familiaris (dog)	LOC100683567	XP_003435480.1
Canis lupus familiaris (dog)	LOC100682977	XP_003435474.1
Canis lupus familiaris (dog)	LOC100688084	XP_003431693.1
Canis lupus familiaris (dog)	LOC100683265	XP_003435478.1
Canis lupus familiaris (dog)	LOC100683202	XP_003435477.1
Canis lupus familiaris (dog)	LOC102154989	XP_005642465.1
Canis lupus familiaris (dog)	LOC100687692	XP_003431688.1
Canis lupus familiaris (dog)	LOC100687778	XP_003431689.1
Canis lupus familiaris (dog)	LOC100687857	XP_003431690.1
Canis lupus familiaris (dog)	LOC100687928	XP_003431691.1
Canis lupus familiaris (dog)	LOC100685213	XP_003431605.1
Bos taurus (cattle)	IFNA16	XP_002689601.1
Bos taurus (cattle)	LOC523244	XP_002689553.1
Bos taurus (cattle)	LOC783912	XP_002689579.1

Gene Ontology
Bibliography

Related articles in PubMed

Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations.
Yang XR, Liang X, Pfeiffer RM, Wheeler W, Maeder D, Burdette L, Yeager M, Chanock S, Tucker MA, Goldstein AM
Familial cancer9(4)625-33(2010 Dec)

TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B.
Myers MP, Andersen JN, Cheng A, Tremblay ML, Horvath CM, Parisien JP, Salmeen A, Barford D, Tonks NK
The Journal of biological chemistry276(51)47771-4(2001 Dec)

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions.
Shuai K, Horvath CM, Huang LH, Qureshi SA, Cowburn D, Darnell JE Jr
Cell76(5)821-8(1994 Mar)

Pseudogene IFN-alpha L: removal of the stop codon in the signal sequence permits expression of active human interferon.
Fuke M, Hendrix LC, Bollon AP
Gene32(1-2)135-40(1984 Dec)

Novel human leukocyte interferon subtype and structural comparison of alpha interferon genes.
Gren E, Berzin V, Jansone I, Tsimanis A, Vishnevsky Y, Apsalons U
Journal of interferon research4(4)609-17(1984)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations.

Observational study of gene-disease association. (HuGE Navigator)
Title: Dengue hemorrhagic fever is associated with polymorphisms in JAK1.

The following IFNA16 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IFNA16 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29927	NM_002173.3 Latest version!	Homo sapiens interferon alpha 16 (IFNA16), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu29927	NM_002173.2	Homo sapiens interferon, alpha 16 (IFNA16), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IFNA16 ( NM_002173.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002164.1 Homo sapiens interferon, alpha 16 (IFNA16), mRNA.

Price & Availability↑

CloneID	OHu29927
Clone ID Related Accession (Same CDS sequence)	NM_002173.2 , NM_002173.3
Accession Version	NM_002173.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2014-01-25
Organism	Homo sapiens(Human)
Product	interferon alpha-16 precursor
Comment

ATGGCCCTGT CCTTTTCTTT ACTGATGGCC GTGCTGGTGC TCAGCTACAA ATCCATCTGT 
TCTCTGGGCT GTGATCTGCC TCAGACTCAC AGCCTGGGTA ATAGGAGGGC CTTGATACTC 
CTGGCACAAA TGGGAAGAAT CTCTCATTTC TCCTGCCTGA AGGACAGATA TGATTTCGGA 
TTCCCCCAGG AGGTGTTTGA TGGCAACCAG TTCCAGAAGG CTCAAGCCAT CTCTGCCTTC 
CATGAGATGA TCCAGCAGAC CTTCAATCTC TTCAGCACAA AGGATTCATC TGCTGCTTGG 
GATGAGACCC TCCTAGACAA ATTCTACATT GAACTTTTCC AGCAACTGAA TGACCTAGAA 
GCCTGTGTGA CACAGGAGGT TGGGGTGGAA GAGATTGCCC TGATGAATGA GGACTCCATC 
CTGGCTGTGA GGAAATACTT TCAAAGAATC ACTCTTTATC TGATGGGGAA GAAATACAGC 
CCTTGTGCCT GGGAGGTTGT CAGAGCAGAA ATCATGAGAT CCTTCTCTTT TTCAACAAAC 
TTGCAAAAAG GATTAAGAAG GAAGGATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002164.1
Translation	MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQMGRISHFSCLKDRYDFGFPQEVFDGNQFQKAQAISAFHEMIQQTFNLFSTKDSSAAWDETLLDKFYIELFQQLNDLEACVTQEVGVEEIALMNEDSILAVRKYFQRITLYLMGKKYSPCAWEVVRAEIMRSFSFSTNLQKGLRRKD

Target ORF information:

RefSeq Version	NM_002173.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens interferon, alpha 16 (IFNA16), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002173.2

ORF Insert Sequence:

ATGGCCCTGT CCTTTTCTTT ACTGATGGCC GTGCTGGTGC TCAGCTACAA ATCCATCTGT 
TCTCTGGGCT GTGATCTGCC TCAGACTCAC AGCCTGGGTA ATAGGAGGGC CTTGATACTC 
CTGGCACAAA TGGGAAGAAT CTCTCATTTC TCCTGCCTGA AGGACAGATA TGATTTCGGA 
TTCCCCCAGG AGGTGTTTGA TGGCAACCAG TTCCAGAAGG CTCAAGCCAT CTCTGCCTTC 
CATGAGATGA TCCAGCAGAC CTTCAATCTC TTCAGCACAA AGGATTCATC TGCTGCTTGG 
GATGAGACCC TCCTAGACAA ATTCTACATT GAACTTTTCC AGCAACTGAA TGACCTAGAA 
GCCTGTGTGA CACAGGAGGT TGGGGTGGAA GAGATTGCCC TGATGAATGA GGACTCCATC 
CTGGCTGTGA GGAAATACTT TCAAAGAATC ACTCTTTATC TGATGGGGAA GAAATACAGC 
CCTTGTGCCT GGGAGGTTGT CAGAGCAGAA ATCATGAGAT CCTTCTCTTT TTCAACAAAC 
TTGCAAAAAG GATTAAGAAG GAAGGATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IFNA16 ( NM_002173.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002164.1 Homo sapiens interferon alpha 16 (IFNA16), mRNA.

Price & Availability↑

CloneID	OHu29927
Clone ID Related Accession (Same CDS sequence)	NM_002173.2 , NM_002173.3
Accession Version	NM_002173.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Homo sapiens(human)
Product	interferon alpha-16 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from M28585.1 and AL512606.6. On Nov 14, 2015 this sequence version replaced NM_002173.2. ##Evidence-Data-START## Transcript is intronless :: M28585.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000380216.1/ ENSP00000369564.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCCCTGT CCTTTTCTTT ACTGATGGCC GTGCTGGTGC TCAGCTACAA ATCCATCTGT 
TCTCTGGGCT GTGATCTGCC TCAGACTCAC AGCCTGGGTA ATAGGAGGGC CTTGATACTC 
CTGGCACAAA TGGGAAGAAT CTCTCATTTC TCCTGCCTGA AGGACAGATA TGATTTCGGA 
TTCCCCCAGG AGGTGTTTGA TGGCAACCAG TTCCAGAAGG CTCAAGCCAT CTCTGCCTTC 
CATGAGATGA TCCAGCAGAC CTTCAATCTC TTCAGCACAA AGGATTCATC TGCTGCTTGG 
GATGAGACCC TCCTAGACAA ATTCTACATT GAACTTTTCC AGCAACTGAA TGACCTAGAA 
GCCTGTGTGA CACAGGAGGT TGGGGTGGAA GAGATTGCCC TGATGAATGA GGACTCCATC 
CTGGCTGTGA GGAAATACTT TCAAAGAATC ACTCTTTATC TGATGGGGAA GAAATACAGC 
CCTTGTGCCT GGGAGGTTGT CAGAGCAGAA ATCATGAGAT CCTTCTCTTT TTCAACAAAC 
TTGCAAAAAG GATTAAGAAG GAAGGATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002164.1
CDS	7..576
Translation	MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQMGRISHFSCLKDRYDFGFPQEVFDGNQFQKAQAISAFHEMIQQTFNLFSTKDSSAAWDETLLDKFYIELFQQLNDLEACVTQEVGVEEIALMNEDSILAVRKYFQRITLYLMGKKYSPCAWEVVRAEIMRSFSFSTNLQKGLRRKD

Target ORF information:

RefSeq Version	NM_002173.3
Organism	Homo sapiens(human)
Definition	Homo sapiens interferon alpha 16 (IFNA16), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002173.3

ORF Insert Sequence:

ATGGCCCTGT CCTTTTCTTT ACTGATGGCC GTGCTGGTGC TCAGCTACAA ATCCATCTGT 
TCTCTGGGCT GTGATCTGCC TCAGACTCAC AGCCTGGGTA ATAGGAGGGC CTTGATACTC 
CTGGCACAAA TGGGAAGAAT CTCTCATTTC TCCTGCCTGA AGGACAGATA TGATTTCGGA 
TTCCCCCAGG AGGTGTTTGA TGGCAACCAG TTCCAGAAGG CTCAAGCCAT CTCTGCCTTC 
CATGAGATGA TCCAGCAGAC CTTCAATCTC TTCAGCACAA AGGATTCATC TGCTGCTTGG 
GATGAGACCC TCCTAGACAA ATTCTACATT GAACTTTTCC AGCAACTGAA TGACCTAGAA 
GCCTGTGTGA CACAGGAGGT TGGGGTGGAA GAGATTGCCC TGATGAATGA GGACTCCATC 
CTGGCTGTGA GGAAATACTT TCAAAGAATC ACTCTTTATC TGATGGGGAA GAAATACAGC 
CCTTGTGCCT GGGAGGTTGT CAGAGCAGAA ATCATGAGAT CCTTCTCTTT TTCAACAAAC 
TTGCAAAAAG GATTAAGAAG GAAGGATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations.
Familial cancer9(4)625-33(2010 Dec)
Yang XR,Liang X,Pfeiffer RM,Wheeler W,Maeder D,Burdette L,Yeager M,Chanock S,Tucker MA,Goldstein AM

TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B.
The Journal of biological chemistry276(51)47771-4(2001 Dec)
Myers MP,Andersen JN,Cheng A,Tremblay ML,Horvath CM,Parisien JP,Salmeen A,Barford D,Tonks NK

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions.
Cell76(5)821-8(1994 Mar)
Shuai K,Horvath CM,Huang LH,Qureshi SA,Cowburn D,Darnell JE Jr

Pseudogene IFN-alpha L: removal of the stop codon in the signal sequence permits expression of active human interferon.
Gene32(1-2)135-40(1984 Dec)
Fuke M,Hendrix LC,Bollon AP

Novel human leukocyte interferon subtype and structural comparison of alpha interferon genes.
Journal of interferon research4(4)609-17(1984)
Gren E,Berzin V,Jansone I,Tsimanis A,Vishnevsky Y,Apsalons U