FIGLA cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FIGLA
Entrez Gene ID	344018
Full Name	folliculogenesis specific bHLH transcription factor
Synonyms	BHLHC8,FIGALPHA,POF6
General protein information	Preferred Names folliculogenesis specific bHLH transcription factor Names factor in the germline alpha class C basic helix-loop-helix protein 8 folliculogenesis-specific basic helix-loop-helix protein transcription factor FIGa
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p13.3
Summary	This gene encodes a protein that functions in postnatal oocyte-specific gene expression. The protein is a basic helix-loop-helix transcription factor that regulates multiple oocyte-specific genes, including genes involved in folliculogenesis and those that encode the zona pellucida. Mutations in this gene cause premature ovarian failure type 6. [provided by RefSeq, Sep 2009].
Disorder MIM:	608697
Disorder Html:	Premature ovarian failure 6, 612310 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001004311.3	NP_001004311.2	factor in the germline alpha

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	FIGLA	XP_001138053.1
Bos taurus (cattle)	FIGLA	XP_002691278.2
	LOC710606	XP_001099273.1
Mus musculus (house mouse)	Figla	NP_036143.1
Homo sapiens (human)	FIGLA	NP_001004311.2
Canis lupus familiaris (dog)	FIGLA	XP_005626316.1
Rattus norvegicus (Norway rat)	Figla	XP_575589.1

Gene Ontology
Bibliography

Related articles in PubMed

Mutational analysis of the FIGLA gene in women with idiopathic premature ovarian failure.
Tosh D, Rani HS, Murty US, Deenadayal A, Grover P
Menopause (New York, N.Y.)22(5)520-6(2015 May)

Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
Navarini AA, Simpson MA, Weale M, Knight J, Carlavan I, Reiniche P, Burden DA, Layton A, Bataille V, Allen M, Pleass R, Pink A, Creamer D, English J, Munn S, Walton S, , Willis C, D?ret S, Voegel JJ, Spector T, Smith CH, Trembath RC, Barker JN
Nature communications54020(2014 Jun)

Premature ovarian failure and gene polymorphisms.
van Dooren MF, Bertoli-Avellab AM, Oldenburg RA
Current opinion in obstetrics & gynecology21(4)313-7(2009 Aug)

A census of human transcription factors: function, expression and evolution.
Vaquerizas JM, Kummerfeld SK, Teichmann SA, Luscombe NM
Nature reviews. Genetics10(4)252-63(2009 04)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

study identified an association between FIGLA gene variants and the occurrence of premature ovarian failure(POF) in the Indian population; findings suggest that the c.427G->C and c.557C->T alleles lead to an increased risk of POF in Indian women
Title: Mutational analysis of the FIGLA gene in women with idiopathic premature ovarian failure.

may have a role in the development of primordial follicle before zona pellucida formation
Title: Zona pellucida components are present in human fetal ovary before follicle formation.

the p.140 delN mutation disrupted FIGLA binding to the TCF3 helix-loop-helix (HLH) domain. Our findings show that a subset of Chinese women with sporadic, premature ovarian failure harbor mutations in FIGLA.
Title: Transcription factor FIGLA is mutated in patients with premature ovarian failure.

These results suggest that FIGLA is involved in continued oocyte survival as primordial follicles form in the human as in the rodent ovary.
Title: Increased expression of the FIGLA transcription factor is associated with primordial follicle formation in the human fetal ovary.

Expression of mRNA observed in ovarian follicles, mature oocytes, and less frequently in preimplantation embryos.
Title: Isolation, characterization and expression of the human Factor In the Germline alpha (FIGLA) gene in ovarian follicles and oocytes.

The following FIGLA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FIGLA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu21875	NM_001004311.3 Latest version!	Homo sapiens folliculogenesis specific bHLH transcription factor (FIGLA), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FIGLA ( NM_001004311.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001004311.2 Homo sapiens folliculogenesis specific bHLH transcription factor (FIGLA), mRNA.

Price & Availability↑

CloneID	OHu21875
Clone ID Related Accession (Same CDS sequence)	NM_001004311.3
Accession Version	NM_001004311.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 660bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-21
Organism	Homo sapiens(human)
Product	factor in the germline alpha
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY541030.1 and AC007395.4. This sequence is a reference standard in the RefSeqGene project. On Sep 11, 2009 this sequence version replaced NM_001004311.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY541030.1, BC039536.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2158188 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000332372.6/ ENSP00000333097.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGACCCCG CGCCCGGCGT CCTAGATCCC CGCGCCGCGC CGCCCGCGCT CCTGGGCACC 
CCGCAAGCCG AGGTGCTGGA GGACGTGTTG CGGGAGCAGT TCGGGCCGCT GCCCCAGCTG 
GCCGCTGTCT GCCGGCTCAA GCGGCTGCCC TCGGGCGGCT ACTCGTCCAC TGAAAACCTC 
CAGTTGGTGC TGGAGCGGCG GCGTGTGGCC AACGCCAAGG AGCGTGAGCG GATAAAAAAT 
CTCAACCGTG GTTTTGCCAG ATTGAAGGCA CTTGTGCCAT TTCTTCCCCA AAGCAGGAAG 
CCCAGCAAAG TTGATATCCT TAAAGGTGCG ACTGAATATA TACAGGTTCT CAGTGATCTT 
TTGGAAGGAG CCAAAGACTC AAAGAAACAA GACCCAGATG AGCAGAGCTA TAGTAACAAC 
AGTTCTGAAT CACATACATC CTCGGCAAGA CAGCTGTCAA GAAACATCAC CCAACATATC 
AGCTGTGCTT TCGGCTTGAA GAATGAAGAG GAAGGGCCTT GGGCAGATGG TGGCAGTGGT 
GAGCCAGCAC ACGCTTGTCG CCACAGTGTG ATGTCTACGA CTGAAATTAT CTCCCCAACC 
AGAAGTCTGG ATAGATTCCC AGAAGTAGAA CTGCTGAGTC ACAGACTTCC ACAAGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001004311.2
CDS	6..665
Translation	MDPAPGVLDPRAAPPALLGTPQAEVLEDVLREQFGPLPQLAAVCRLKRLPSGGYSSTENLQLVLERRRVANAKERERIKNLNRGFARLKALVPFLPQSRKPSKVDILKGATEYIQVLSDLLEGAKDSKKQDPDEQSYSNNSSESHTSSARQLSRNITQHISCAFGLKNEEEGPWADGGSGEPAHACRHSVMSTTEIISPTRSLDRFPEVELLSHRLPQV

Target ORF information:

RefSeq Version	NM_001004311.3
Organism	Homo sapiens(human)
Definition	Homo sapiens folliculogenesis specific bHLH transcription factor (FIGLA), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001004311.3

ORF Insert Sequence:

ATGGACCCCG CGCCCGGCGT CCTAGATCCC CGCGCCGCGC CGCCCGCGCT CCTGGGCACC 
CCGCAAGCCG AGGTGCTGGA GGACGTGTTG CGGGAGCAGT TCGGGCCGCT GCCCCAGCTG 
GCCGCTGTCT GCCGGCTCAA GCGGCTGCCC TCGGGCGGCT ACTCGTCCAC TGAAAACCTC 
CAGTTGGTGC TGGAGCGGCG GCGTGTGGCC AACGCCAAGG AGCGTGAGCG GATAAAAAAT 
CTCAACCGTG GTTTTGCCAG ATTGAAGGCA CTTGTGCCAT TTCTTCCCCA AAGCAGGAAG 
CCCAGCAAAG TTGATATCCT TAAAGGTGCG ACTGAATATA TACAGGTTCT CAGTGATCTT 
TTGGAAGGAG CCAAAGACTC AAAGAAACAA GACCCAGATG AGCAGAGCTA TAGTAACAAC 
AGTTCTGAAT CACATACATC CTCGGCAAGA CAGCTGTCAA GAAACATCAC CCAACATATC 
AGCTGTGCTT TCGGCTTGAA GAATGAAGAG GAAGGGCCTT GGGCAGATGG TGGCAGTGGT 
GAGCCAGCAC ACGCTTGTCG CCACAGTGTG ATGTCTACGA CTGAAATTAT CTCCCCAACC 
AGAAGTCTGG ATAGATTCCC AGAAGTAGAA CTGCTGAGTC ACAGACTTCC ACAAGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutational analysis of the FIGLA gene in women with idiopathic premature ovarian failure.
Menopause (New York, N.Y.)22(5)520-6(2015 May)
Tosh D,Rani HS,Murty US,Deenadayal A,Grover P

Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
Nature communications54020(2014 Jun)
Navarini AA,Simpson MA,Weale M,Knight J,Carlavan I,Reiniche P,Burden DA,Layton A,Bataille V,Allen M,Pleass R,Pink A,Creamer D,English J,Munn S,Walton S,,Willis C,D?ret S,Voegel JJ,Spector T,Smith CH,Trembath RC,Barker JN

Premature ovarian failure and gene polymorphisms.
Current opinion in obstetrics & gynecology21(4)313-7(2009 Aug)
van Dooren MF,Bertoli-Avellab AM,Oldenburg RA

A census of human transcription factors: function, expression and evolution.
Nature reviews. Genetics10(4)252-63(2009 04)
Vaquerizas JM,Kummerfeld SK,Teichmann SA,Luscombe NM

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FIGLA cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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