HSPA6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HSPA6
Entrez Gene ID	3310
Full Name	heat shock protein family A (Hsp70) member 6
Synonyms	HSP70B'
General protein information	Preferred Names heat shock protein family A (Hsp70) member 6 Names heat shock 70 kDa protein 6 heat shock 70 kDa protein B' heat shock 70kD protein 6 (HSP70B') heat shock 70kDa protein 6 (HSP70B')
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q23.3
Disorder MIM:	140555

mRNA and Protein(s)

mRNA	Protein	Name
NM_002155.5	NP_002146.2	heat shock 70 kDa protein 6
NM_002155.4	NP_002146.2	heat shock 70 kDa protein 6

Pathways from BioSystems

Homologies

Homo sapiens (human)	HSPA6	NP_002146.2
Bos taurus (cattle)	HSPA6	XP_002685896.1

Gene Ontology
Bibliography

Related articles in PubMed

Knockdown of Heat Shock Proteins HSPA6 (Hsp70B') and HSPA1A (Hsp70-1) Sensitizes Differentiated Human Neuronal Cells to Cellular Stress.
Deane CAS, Brown IR
Neurochemical research(2017 Oct)

Court KA, Hatakeyama H, Wu SY, Lingegowda MS, Rodr?guez-Aguayo C, L?pez-Berestein G, Ju-Seog L, Rinaldi C, Juan EJ, Sood AK, Torres-Lugo M
Molecular cancer therapeutics16(5)966-976(2017 May)

1,4-Naphthoquinone activates the HSP90/HSF1 pathway through the S-arylation of HSP90 in A431 cells: Negative regulation of the redox signal transduction pathway by persulfides/polysulfides.
Abiko Y, Sha L, Shinkai Y, Unoki T, Luong NC, Tsuchiya Y, Watanabe Y, Hirose R, Akaike T, Kumagai Y
Free radical biology & medicine104118-128(2017 Mar)

Intracellular MMP3 Promotes HSP Gene Expression in Collaboration With Chromobox Proteins.
Eguchi T, Calderwood SK, Takigawa M, Kubota S, Kozaki KI
Journal of cellular biochemistry118(1)43-51(2017 Jan)

Dynamics of the association of heat shock protein HSPA6 (Hsp70B') and HSPA1A (Hsp70-1) with stress-sensitive cytoplasmic and nuclear structures in differentiated human neuronal cells.
Shorbagi S, Brown IR
Cell stress & chaperones21(6)993-1003(2016 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We found that HSF1 activation mediated by 1,4-NQ upregulated downstream genes, such as HSPA6. The results suggest that activation of the HSP90-HSF1 signal transduction pathway mediated by 1,4-NQ protects cells against 1,4-NQ and that per/polysulfides can diminish the reactivity of 1,4-NQ by forming sulfur adducts.
Title: 1,4-Naphthoquinone activates the HSP90/HSF1 pathway through the S-arylation of HSP90 in A431 cells: Negative regulation of the redox signal transduction pathway by persulfides/polysulfides.

mRNA levels of HSP family members (HSP70B', HSP72, HSP40/DNAJ, and HSP20/CRYAB) are upregulated by the intracellular MMP3 overload.
Title: Intracellular MMP3 Promotes HSP Gene Expression in Collaboration With Chromobox Proteins.

measurable HSP70B' was not associated with graft versus host disease following allogeneic hematopoietic cell transplantation
Title: Soluble heat shock protein 70 members in patients undergoing allogeneic hematopoietic cell transplantation.

endothelial nitric oxide synthase induces heat shock protein HSPA6 (HSP70B') in human arterial smooth muscle cells
Title: Endothelial nitric oxide synthase induces heat shock protein HSPA6 (HSP70B') in human arterial smooth muscle cells.

Data indicate that heat shock protein 90kD(HSP90) inhibition induces heat shock 70kD protein 6 (HSP70B') expression.
Title: Induction of heat shock protein HSPA6 (HSP70B') upon HSP90 inhibition in cancer cell lines.

The following HSPA6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HSPA6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu58325	NM_002155.5 Latest version!	Homo sapiens heat shock protein family A (Hsp70) member 6 (HSPA6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu58325	NM_002155.4	Homo sapiens heat shock protein family A (Hsp70) member 6 (HSPA6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HSPA6 ( NM_002155.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002146.2 Homo sapiens heat shock protein family A (Hsp70) member 6 (HSPA6), mRNA.

Price & Availability↑

CloneID	OHu58325
Clone ID Related Accession (Same CDS sequence)	NM_002155.5 , NM_002155.4
Accession Version	NM_002155.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1932bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	heat shock 70 kDa protein 6
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK093925.1, BC035665.1, AL590385.23 and CD366171.1. On Nov 23, 2018 this sequence version replaced NM_002155.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: SRR7346977.931148.1, SRR1803613.132626.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000309758.6/ ENSP00000310219.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAGGCCC CACGGGAGCT CGCGGTGGGC ATCGACCTGG GCACCACCTA CTCGTGCGTG 
GGCGTGTTTC AGCAGGGCCG CGTGGAGATC CTGGCCAACG ACCAGGGCAA CCGCACCACG 
CCCAGCTACG TGGCCTTCAC CGACACCGAG CGGCTGGTCG GGGACGCGGC CAAGAGCCAG 
GCGGCCCTGA ACCCCCACAA CACCGTGTTC GATGCCAAGC GGCTGATCGG GCGCAAGTTC 
GCGGACACCA CGGTGCAGTC GGACATGAAG CACTGGCCCT TCCGGGTGGT GAGCGAGGGC 
GGCAAGCCCA AGGTGCGCGT ATGCTACCGC GGGGAGGACA AGACGTTCTA CCCCGAGGAG 
ATCTCGTCCA TGGTGCTGAG CAAGATGAAG GAGACGGCCG AGGCGTACCT GGGCCAGCCC 
GTGAAGCACG CAGTGATCAC CGTGCCCGCC TATTTCAATG ACTCGCAGCG CCAGGCCACC 
AAGGACGCGG GGGCCATCGC GGGGCTCAAC GTGTTGCGGA TCATCAATGA GCCCACGGCA 
GCTGCCATCG CCTATGGGCT GGACCGGCGG GGCGCGGGAG AGCGCAACGT GCTCATTTTT 
GACCTGGGTG GGGGCACCTT CGATGTGTCG GTTCTCTCCA TTGACGCTGG TGTCTTTGAG 
GTGAAAGCCA CTGCTGGAGA TACCCACCTG GGAGGAGAGG ACTTCGACAA CCGGCTCGTG 
AACCACTTCA TGGAAGAATT CCGGCGGAAG CATGGGAAGG ACCTGAGCGG GAACAAGCGT 
GCCCTGCGCA GGCTGCGCAC AGCCTGTGAG CGCGCCAAGC GCACCCTGTC CTCCAGCACC 
CAGGCCACCC TGGAGATAGA CTCCCTGTTC GAGGGCGTGG ACTTCTACAC GTCCATCACT 
CGTGCCCGCT TTGAGGAACT GTGCTCAGAC CTCTTCCGCA GCACCCTGGA GCCGGTGGAG 
AAGGCCCTGC GGGATGCCAA GCTGGACAAG GCCCAGATTC ATGACGTCGT CCTGGTGGGG 
GGCTCCACAC GCATCCCCAA GGTGCAGAAG TTGCTGCAGG ACTTCTTCAA CGGCAAGGAG 
CTGAACAAGA GCATCAACCC TGATGAGGCT GTGGCCTATG GGGCTGCTGT GCAGGCGGCC 
GTGTTGATGG GGGACAAATG TGAGAAAGTG CAGGATCTCC TGCTGCTGGA TGTGGCTCCC 
CTGTCTCTGG GGCTGGAGAC AGCAGGTGGG GTGATGACCA CGCTGATCCA GAGGAACGCC 
ACTATCCCCA CCAAGCAGAC CCAGACTTTC ACCACCTACT CGGACAACCA GCCTGGGGTC 
TTCATCCAGG TGTATGAGGG TGAGAGGGCC ATGACCAAGG ACAACAACCT GCTGGGGCGT 
TTTGAACTCA GTGGCATCCC TCCTGCCCCA CGTGGAGTCC CCCAGATAGA GGTGACTTTT 
GACATTGATG CTAATGGCAT CCTGAGCGTG ACAGCCACTG ACAGGAGCAC AGGTAAGGCT 
AACAAGATCA CCATCACCAA TGACAAGGGC CGGCTGAGCA AGGAGGAGGT GGAGAGGATG 
GTTCATGAAG CCGAGCAGTA CAAGGCTGAG GATGAGGCCC AGAGGGACAG AGTGGCTGCC 
AAAAACTCGC TGGAGGCCCA TGTCTTCCAT GTGAAAGGTT CTTTGCAAGA GGAAAGCCTT 
AGGGACAAGA TTCCCGAAGA GGACAGGCGC AAAATGCAAG ACAAGTGTCG GGAAGTCCTT 
GCCTGGCTGG AGCACAACCA GCTGGCAGAG AAGGAGGAGT ATGAGCATCA GAAGAGGGAG 
CTGGAGCAAA TCTGTCGCCC CATCTTCTCC AGGCTCTATG GGGGGCCTGG TGTCCCTGGG 
GGCAGCAGTT GTGGCACTCA AGCCCGCCAG GGGGACCCCA GCACCGGCCC CATCATTGAG 
GAGGTTGATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002146.2
CDS	120..2051
Translation	MQAPRELAVGIDLGTTYSCVGVFQQGRVEILANDQGNRTTPSYVAFTDTERLVGDAAKSQAALNPHNTVFDAKRLIGRKFADTTVQSDMKHWPFRVVSEGGKPKVRVCYRGEDKTFYPEEISSMVLSKMKETAEAYLGQPVKHAVITVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDRRGAGERNVLIFDLGGGTFDVSVLSIDAGVFEVKATAGDTHLGGEDFDNRLVNHFMEEFRRKHGKDLSGNKRALRRLRTACERAKRTLSSSTQATLEIDSLFEGVDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDVVLVGGSTRIPKVQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAVLMGDKCEKVQDLLLLDVAPLSLGLETAGGVMTTLIQRNATIPTKQTQTFTTYSDNQPGVFIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILSVTATDRSTGKANKITITNDKGRLSKEEVERMVHEAEQYKAEDEAQRDRVAAKNSLEAHVFHVKGSLQEESLRDKIPEEDRRKMQDKCREVLAWLEHNQLAEKEEYEHQKRELEQICRPIFSRLYGGPGVPGGSSCGTQARQGDPSTGPIIEEVD

Target ORF information:

RefSeq Version	NM_002155.5
Organism	Homo sapiens(human)
Definition	Homo sapiens heat shock protein family A (Hsp70) member 6 (HSPA6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002155.5

ORF Insert Sequence:

ATGCAGGCCC CACGGGAGCT CGCGGTGGGC ATCGACCTGG GCACCACCTA CTCGTGCGTG 
GGCGTGTTTC AGCAGGGCCG CGTGGAGATC CTGGCCAACG ACCAGGGCAA CCGCACCACG 
CCCAGCTACG TGGCCTTCAC CGACACCGAG CGGCTGGTCG GGGACGCGGC CAAGAGCCAG 
GCGGCCCTGA ACCCCCACAA CACCGTGTTC GATGCCAAGC GGCTGATCGG GCGCAAGTTC 
GCGGACACCA CGGTGCAGTC GGACATGAAG CACTGGCCCT TCCGGGTGGT GAGCGAGGGC 
GGCAAGCCCA AGGTGCGCGT ATGCTACCGC GGGGAGGACA AGACGTTCTA CCCCGAGGAG 
ATCTCGTCCA TGGTGCTGAG CAAGATGAAG GAGACGGCCG AGGCGTACCT GGGCCAGCCC 
GTGAAGCACG CAGTGATCAC CGTGCCCGCC TATTTCAATG ACTCGCAGCG CCAGGCCACC 
AAGGACGCGG GGGCCATCGC GGGGCTCAAC GTGTTGCGGA TCATCAATGA GCCCACGGCA 
GCTGCCATCG CCTATGGGCT GGACCGGCGG GGCGCGGGAG AGCGCAACGT GCTCATTTTT 
GACCTGGGTG GGGGCACCTT CGATGTGTCG GTTCTCTCCA TTGACGCTGG TGTCTTTGAG 
GTGAAAGCCA CTGCTGGAGA TACCCACCTG GGAGGAGAGG ACTTCGACAA CCGGCTCGTG 
AACCACTTCA TGGAAGAATT CCGGCGGAAG CATGGGAAGG ACCTGAGCGG GAACAAGCGT 
GCCCTGCGCA GGCTGCGCAC AGCCTGTGAG CGCGCCAAGC GCACCCTGTC CTCCAGCACC 
CAGGCCACCC TGGAGATAGA CTCCCTGTTC GAGGGCGTGG ACTTCTACAC GTCCATCACT 
CGTGCCCGCT TTGAGGAACT GTGCTCAGAC CTCTTCCGCA GCACCCTGGA GCCGGTGGAG 
AAGGCCCTGC GGGATGCCAA GCTGGACAAG GCCCAGATTC ATGACGTCGT CCTGGTGGGG 
GGCTCCACAC GCATCCCCAA GGTGCAGAAG TTGCTGCAGG ACTTCTTCAA CGGCAAGGAG 
CTGAACAAGA GCATCAACCC TGATGAGGCT GTGGCCTATG GGGCTGCTGT GCAGGCGGCC 
GTGTTGATGG GGGACAAATG TGAGAAAGTG CAGGATCTCC TGCTGCTGGA TGTGGCTCCC 
CTGTCTCTGG GGCTGGAGAC AGCAGGTGGG GTGATGACCA CGCTGATCCA GAGGAACGCC 
ACTATCCCCA CCAAGCAGAC CCAGACTTTC ACCACCTACT CGGACAACCA GCCTGGGGTC 
TTCATCCAGG TGTATGAGGG TGAGAGGGCC ATGACCAAGG ACAACAACCT GCTGGGGCGT 
TTTGAACTCA GTGGCATCCC TCCTGCCCCA CGTGGAGTCC CCCAGATAGA GGTGACTTTT 
GACATTGATG CTAATGGCAT CCTGAGCGTG ACAGCCACTG ACAGGAGCAC AGGTAAGGCT 
AACAAGATCA CCATCACCAA TGACAAGGGC CGGCTGAGCA AGGAGGAGGT GGAGAGGATG 
GTTCATGAAG CCGAGCAGTA CAAGGCTGAG GATGAGGCCC AGAGGGACAG AGTGGCTGCC 
AAAAACTCGC TGGAGGCCCA TGTCTTCCAT GTGAAAGGTT CTTTGCAAGA GGAAAGCCTT 
AGGGACAAGA TTCCCGAAGA GGACAGGCGC AAAATGCAAG ACAAGTGTCG GGAAGTCCTT 
GCCTGGCTGG AGCACAACCA GCTGGCAGAG AAGGAGGAGT ATGAGCATCA GAAGAGGGAG 
CTGGAGCAAA TCTGTCGCCC CATCTTCTCC AGGCTCTATG GGGGGCCTGG TGTCCCTGGG 
GGCAGCAGTT GTGGCACTCA AGCCCGCCAG GGGGACCCCA GCACCGGCCC CATCATTGAG 
GAGGTTGATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HSPA6 ( NM_002155.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002146.2 Homo sapiens heat shock protein family A (Hsp70) member 6 (HSPA6), mRNA.

Price & Availability↑

CloneID	OHu58325
Clone ID Related Accession (Same CDS sequence)	NM_002155.5 , NM_002155.4
Accession Version	NM_002155.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1932bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-17
Organism	Homo sapiens(human)
Product	heat shock 70 kDa protein 6
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK093925.1, BC035665.1, AL590385.23, CD366171.1 and BQ008960.1. On Dec 11, 2014 this sequence version replaced NM_002155.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGCAGGCCC CACGGGAGCT CGCGGTGGGC ATCGACCTGG GCACCACCTA CTCGTGCGTG 
GGCGTGTTTC AGCAGGGCCG CGTGGAGATC CTGGCCAACG ACCAGGGCAA CCGCACCACG 
CCCAGCTACG TGGCCTTCAC CGACACCGAG CGGCTGGTCG GGGACGCGGC CAAGAGCCAG 
GCGGCCCTGA ACCCCCACAA CACCGTGTTC GATGCCAAGC GGCTGATCGG GCGCAAGTTC 
GCGGACACCA CGGTGCAGTC GGACATGAAG CACTGGCCCT TCCGGGTGGT GAGCGAGGGC 
GGCAAGCCCA AGGTGCGCGT ATGCTACCGC GGGGAGGACA AGACGTTCTA CCCCGAGGAG 
ATCTCGTCCA TGGTGCTGAG CAAGATGAAG GAGACGGCCG AGGCGTACCT GGGCCAGCCC 
GTGAAGCACG CAGTGATCAC CGTGCCCGCC TATTTCAATG ACTCGCAGCG CCAGGCCACC 
AAGGACGCGG GGGCCATCGC GGGGCTCAAC GTGTTGCGGA TCATCAATGA GCCCACGGCA 
GCTGCCATCG CCTATGGGCT GGACCGGCGG GGCGCGGGAG AGCGCAACGT GCTCATTTTT 
GACCTGGGTG GGGGCACCTT CGATGTGTCG GTTCTCTCCA TTGACGCTGG TGTCTTTGAG 
GTGAAAGCCA CTGCTGGAGA TACCCACCTG GGAGGAGAGG ACTTCGACAA CCGGCTCGTG 
AACCACTTCA TGGAAGAATT CCGGCGGAAG CATGGGAAGG ACCTGAGCGG GAACAAGCGT 
GCCCTGCGCA GGCTGCGCAC AGCCTGTGAG CGCGCCAAGC GCACCCTGTC CTCCAGCACC 
CAGGCCACCC TGGAGATAGA CTCCCTGTTC GAGGGCGTGG ACTTCTACAC GTCCATCACT 
CGTGCCCGCT TTGAGGAACT GTGCTCAGAC CTCTTCCGCA GCACCCTGGA GCCGGTGGAG 
AAGGCCCTGC GGGATGCCAA GCTGGACAAG GCCCAGATTC ATGACGTCGT CCTGGTGGGG 
GGCTCCACAC GCATCCCCAA GGTGCAGAAG TTGCTGCAGG ACTTCTTCAA CGGCAAGGAG 
CTGAACAAGA GCATCAACCC TGATGAGGCT GTGGCCTATG GGGCTGCTGT GCAGGCGGCC 
GTGTTGATGG GGGACAAATG TGAGAAAGTG CAGGATCTCC TGCTGCTGGA TGTGGCTCCC 
CTGTCTCTGG GGCTGGAGAC AGCAGGTGGG GTGATGACCA CGCTGATCCA GAGGAACGCC 
ACTATCCCCA CCAAGCAGAC CCAGACTTTC ACCACCTACT CGGACAACCA GCCTGGGGTC 
TTCATCCAGG TGTATGAGGG TGAGAGGGCC ATGACCAAGG ACAACAACCT GCTGGGGCGT 
TTTGAACTCA GTGGCATCCC TCCTGCCCCA CGTGGAGTCC CCCAGATAGA GGTGACTTTT 
GACATTGATG CTAATGGCAT CCTGAGCGTG ACAGCCACTG ACAGGAGCAC AGGTAAGGCT 
AACAAGATCA CCATCACCAA TGACAAGGGC CGGCTGAGCA AGGAGGAGGT GGAGAGGATG 
GTTCATGAAG CCGAGCAGTA CAAGGCTGAG GATGAGGCCC AGAGGGACAG AGTGGCTGCC 
AAAAACTCGC TGGAGGCCCA TGTCTTCCAT GTGAAAGGTT CTTTGCAAGA GGAAAGCCTT 
AGGGACAAGA TTCCCGAAGA GGACAGGCGC AAAATGCAAG ACAAGTGTCG GGAAGTCCTT 
GCCTGGCTGG AGCACAACCA GCTGGCAGAG AAGGAGGAGT ATGAGCATCA GAAGAGGGAG 
CTGGAGCAAA TCTGTCGCCC CATCTTCTCC AGGCTCTATG GGGGGCCTGG TGTCCCTGGG 
GGCAGCAGTT GTGGCACTCA AGCCCGCCAG GGGGACCCCA GCACCGGCCC CATCATTGAG 
GAGGTTGATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002146.2
CDS	120..2051
Translation	MQAPRELAVGIDLGTTYSCVGVFQQGRVEILANDQGNRTTPSYVAFTDTERLVGDAAKSQAALNPHNTVFDAKRLIGRKFADTTVQSDMKHWPFRVVSEGGKPKVRVCYRGEDKTFYPEEISSMVLSKMKETAEAYLGQPVKHAVITVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDRRGAGERNVLIFDLGGGTFDVSVLSIDAGVFEVKATAGDTHLGGEDFDNRLVNHFMEEFRRKHGKDLSGNKRALRRLRTACERAKRTLSSSTQATLEIDSLFEGVDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDVVLVGGSTRIPKVQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAVLMGDKCEKVQDLLLLDVAPLSLGLETAGGVMTTLIQRNATIPTKQTQTFTTYSDNQPGVFIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILSVTATDRSTGKANKITITNDKGRLSKEEVERMVHEAEQYKAEDEAQRDRVAAKNSLEAHVFHVKGSLQEESLRDKIPEEDRRKMQDKCREVLAWLEHNQLAEKEEYEHQKRELEQICRPIFSRLYGGPGVPGGSSCGTQARQGDPSTGPIIEEVD

Target ORF information:

RefSeq Version	NM_002155.4
Organism	Homo sapiens(human)
Definition	Homo sapiens heat shock protein family A (Hsp70) member 6 (HSPA6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002155.4

ORF Insert Sequence:

ATGCAGGCCC CACGGGAGCT CGCGGTGGGC ATCGACCTGG GCACCACCTA CTCGTGCGTG 
GGCGTGTTTC AGCAGGGCCG CGTGGAGATC CTGGCCAACG ACCAGGGCAA CCGCACCACG 
CCCAGCTACG TGGCCTTCAC CGACACCGAG CGGCTGGTCG GGGACGCGGC CAAGAGCCAG 
GCGGCCCTGA ACCCCCACAA CACCGTGTTC GATGCCAAGC GGCTGATCGG GCGCAAGTTC 
GCGGACACCA CGGTGCAGTC GGACATGAAG CACTGGCCCT TCCGGGTGGT GAGCGAGGGC 
GGCAAGCCCA AGGTGCGCGT ATGCTACCGC GGGGAGGACA AGACGTTCTA CCCCGAGGAG 
ATCTCGTCCA TGGTGCTGAG CAAGATGAAG GAGACGGCCG AGGCGTACCT GGGCCAGCCC 
GTGAAGCACG CAGTGATCAC CGTGCCCGCC TATTTCAATG ACTCGCAGCG CCAGGCCACC 
AAGGACGCGG GGGCCATCGC GGGGCTCAAC GTGTTGCGGA TCATCAATGA GCCCACGGCA 
GCTGCCATCG CCTATGGGCT GGACCGGCGG GGCGCGGGAG AGCGCAACGT GCTCATTTTT 
GACCTGGGTG GGGGCACCTT CGATGTGTCG GTTCTCTCCA TTGACGCTGG TGTCTTTGAG 
GTGAAAGCCA CTGCTGGAGA TACCCACCTG GGAGGAGAGG ACTTCGACAA CCGGCTCGTG 
AACCACTTCA TGGAAGAATT CCGGCGGAAG CATGGGAAGG ACCTGAGCGG GAACAAGCGT 
GCCCTGCGCA GGCTGCGCAC AGCCTGTGAG CGCGCCAAGC GCACCCTGTC CTCCAGCACC 
CAGGCCACCC TGGAGATAGA CTCCCTGTTC GAGGGCGTGG ACTTCTACAC GTCCATCACT 
CGTGCCCGCT TTGAGGAACT GTGCTCAGAC CTCTTCCGCA GCACCCTGGA GCCGGTGGAG 
AAGGCCCTGC GGGATGCCAA GCTGGACAAG GCCCAGATTC ATGACGTCGT CCTGGTGGGG 
GGCTCCACAC GCATCCCCAA GGTGCAGAAG TTGCTGCAGG ACTTCTTCAA CGGCAAGGAG 
CTGAACAAGA GCATCAACCC TGATGAGGCT GTGGCCTATG GGGCTGCTGT GCAGGCGGCC 
GTGTTGATGG GGGACAAATG TGAGAAAGTG CAGGATCTCC TGCTGCTGGA TGTGGCTCCC 
CTGTCTCTGG GGCTGGAGAC AGCAGGTGGG GTGATGACCA CGCTGATCCA GAGGAACGCC 
ACTATCCCCA CCAAGCAGAC CCAGACTTTC ACCACCTACT CGGACAACCA GCCTGGGGTC 
TTCATCCAGG TGTATGAGGG TGAGAGGGCC ATGACCAAGG ACAACAACCT GCTGGGGCGT 
TTTGAACTCA GTGGCATCCC TCCTGCCCCA CGTGGAGTCC CCCAGATAGA GGTGACTTTT 
GACATTGATG CTAATGGCAT CCTGAGCGTG ACAGCCACTG ACAGGAGCAC AGGTAAGGCT 
AACAAGATCA CCATCACCAA TGACAAGGGC CGGCTGAGCA AGGAGGAGGT GGAGAGGATG 
GTTCATGAAG CCGAGCAGTA CAAGGCTGAG GATGAGGCCC AGAGGGACAG AGTGGCTGCC 
AAAAACTCGC TGGAGGCCCA TGTCTTCCAT GTGAAAGGTT CTTTGCAAGA GGAAAGCCTT 
AGGGACAAGA TTCCCGAAGA GGACAGGCGC AAAATGCAAG ACAAGTGTCG GGAAGTCCTT 
GCCTGGCTGG AGCACAACCA GCTGGCAGAG AAGGAGGAGT ATGAGCATCA GAAGAGGGAG 
CTGGAGCAAA TCTGTCGCCC CATCTTCTCC AGGCTCTATG GGGGGCCTGG TGTCCCTGGG 
GGCAGCAGTT GTGGCACTCA AGCCCGCCAG GGGGACCCCA GCACCGGCCC CATCATTGAG 
GAGGTTGATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Knockdown of Heat Shock Proteins HSPA6 (Hsp70B') and HSPA1A (Hsp70-1) Sensitizes Differentiated Human Neuronal Cells to Cellular Stress.
Neurochemical research(2017 Oct)
Deane CAS,Brown IR

Molecular cancer therapeutics16(5)966-976(2017 May)
Court KA,Hatakeyama H,Wu SY,Lingegowda MS,Rodr?guez-Aguayo C,L?pez-Berestein G,Ju-Seog L,Rinaldi C,Juan EJ,Sood AK,Torres-Lugo M

1,4-Naphthoquinone activates the HSP90/HSF1 pathway through the S-arylation of HSP90 in A431 cells: Negative regulation of the redox signal transduction pathway by persulfides/polysulfides.
Free radical biology & medicine104118-128(2017 Mar)
Abiko Y,Sha L,Shinkai Y,Unoki T,Luong NC,Tsuchiya Y,Watanabe Y,Hirose R,Akaike T,Kumagai Y

Intracellular MMP3 Promotes HSP Gene Expression in Collaboration With Chromobox Proteins.
Journal of cellular biochemistry118(1)43-51(2017 Jan)
Eguchi T,Calderwood SK,Takigawa M,Kubota S,Kozaki KI

Dynamics of the association of heat shock protein HSPA6 (Hsp70B') and HSPA1A (Hsp70-1) with stress-sensitive cytoplasmic and nuclear structures in differentiated human neuronal cells.
Cell stress & chaperones21(6)993-1003(2016 Nov)
Shorbagi S,Brown IR

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HSPA6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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