HSPA1B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HSPA1B
Entrez Gene ID	3304
Full Name	heat shock protein family A (Hsp70) member 1B
Synonyms	HSP70-1B,HSP70-2,HSP70.2
General protein information	Preferred Names heat shock protein family A (Hsp70) member 1B Names heat shock 70 kDa protein 1B HSP70-1/HSP70-2 HSP70.1/HSP70.2 heat shock 70 kDa protein 1/2 heat shock 70 kDa protein 1A/1B heat shock 70 kDa protein 2 heat shock 70kD protein 1B heat shock 70kDa protein 1B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.33
Summary	This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008].
Disorder MIM:	603012

mRNA and Protein(s)

mRNA	Protein	Name
NM_005346.6	NP_005337.2	heat shock 70 kDa protein 1B
NM_005346.5	NP_005337.2	heat shock 70 kDa protein 1B
NM_005346.4	NP_005337.2	heat shock 70 kDa protein 1B

Pathways from BioSystems

Homologies

Homo sapiens (human)	HSPA1B	NP_005337.2
Bos taurus (cattle)	HSPA1A	NP_976067.2
Mus musculus (house mouse)	Hspa1a	NP_034609.2
Rattus norvegicus (Norway rat)	Hspa1a	NP_114177.2
Drosophila melanogaster (fruit fly)	Hsp70Bbb	NP_788663.1
Arabidopsis thaliana (thale cress)	AT5G02490	NP_195869.1
	HSPA1B	XP_001115060.2
Danio rerio (zebrafish)	hsc70	NP_956908.1
Drosophila melanogaster (fruit fly)	Hsc70-2	NP_524339.1
Saccharomyces cerevisiae (baker's yeast)	SSA4	NP_011029.3
Saccharomyces cerevisiae (baker's yeast)	SSA3	NP_009478.1
Xenopus tropicalis (tropical clawed frog)	hspa1l	NP_001072429.1
Homo sapiens (human)	HSPA1A	NP_005336.3
Drosophila melanogaster (fruit fly)	Hsp70Ba	NP_731716.1
Drosophila melanogaster (fruit fly)	Hsp70Bc	NP_650209.1
Kluyveromyces lactis	KLLA0E20527g	XP_454878.1
Pan troglodytes (chimpanzee)	HSPA1A	XP_003311223.1
Canis lupus familiaris (dog)	LOC102155697	XP_005627221.1
Rattus norvegicus (Norway rat)	Hspa1b	NP_997669.1
Drosophila melanogaster (fruit fly)	Hsp70Ab	NP_524798.2
Drosophila melanogaster (fruit fly)	Hsp68	NP_524474.1
Drosophila melanogaster (fruit fly)	Hsp70Aa	NP_731651.1
Drosophila melanogaster (fruit fly)	Hsp70Bb	NP_524927.2
Eremothecium gossypii	AGOS_AER187W	NP_985044.2
Xenopus tropicalis (tropical clawed frog)	LOC100485441	XP_002937685.1
Xenopus tropicalis (tropical clawed frog)	hsp70	NP_001106370.1

Gene Ontology
Bibliography

Related articles in PubMed

Downregulation of Heat Shock Protein 70 Impairs Osteogenic and Chondrogenic Differentiation in Human Mesenchymal Stem Cells.
Li C, Sunderic K, Nicoll SB, Wang S
Scientific reports8(1)553(2018 Jan)

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.
Sokolina K, Kittanakom S, Snider J, Kotlyar M, Maurice P, Gand?a J, Benleulmi-Chaachoua A, Tadagaki K, Oishi A, Wong V, Malty RH, Deineko V, Aoki H, Amin S, Yao Z, Morat? X, Otasek D, Kobayashi H, Menendez J, Auerbach D, Angers S, Pr?ulj N, Bouvier M, Babu M, Ciruela F, Jockers R, Jurisica I, Stagljar I
Molecular systems biology13(3)918(2017 03)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The rs2763979 locus of the HSP70 genes may be associated with susceptibility to noise-induced hearing loss (NIHL) in Chinese individuals, and other HSP70 genes may also be susceptibility genes for NIHL, but the results must be further replicated in additional independent sample sets.
Title: Polymorphisms of heat shock protein 70 genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility of noise-induced hearing loss in a Chinese population: A case-control study.

The 1267HSP70-2 polymorphism is associated with obesity in an ian population, supporting a possible potential genetic link between obesity and cardiovascular diseases.
Title: Association of heat shock protein70-2 (HSP70-2) gene polymorphism with obesity.

Heat shock protein 70-2 (HSP70-2) expression was detected in 78 % of colorectal cancer (CRC) patients.
Title: Heat shock protein 70-2 (HSP70-2) is a novel therapeutic target for colorectal cancer and is associated with tumor growth.

HSPA1B was down-regulated in atrial fibrillation subjects who suffered a stroke.
Title: Hsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis without increased bleeding risk.

Polymorphism of HSP70 A1B gene is associated with the development of esophageal Carcinoma.
Title: Polymorphisms in Heat Shock Proteins A1B and A1L (HOM) as Risk Factors for Oesophageal Carcinoma in Northeast India.

The following HSPA1B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HSPA1B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26976	NM_005346.5 Latest version!	Homo sapiens heat shock protein family A (Hsp70) member 1B (HSPA1B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu109388	NM_005346.6 Latest version!	Homo sapiens heat shock protein family A (Hsp70) member 1B (HSPA1B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
View Old Accession Versions >>
OHu26976	NM_005346.4	Homo sapiens heat shock protein family A (Hsp70) member 1B (HSPA1B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HSPA1B ( NM_005346.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_005337.2 Homo sapiens heat shock protein family A (Hsp70) member 1B (HSPA1B), mRNA.

Price & Availability↑

CloneID	OHu26976
Clone ID Related Accession (Same CDS sequence)	NM_005346.5 , NM_005346.4
Accession Version	NM_005346.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1926bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-20
Organism	Homo sapiens(human)
Product	heat shock 70 kDa protein 1B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB015158.1, BC063507.1 and AL671762.10. On Nov 22, 2018 this sequence version replaced NM_005346.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC063507.1, SRR7346977.1152369.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCAAAG CCGCGGCGAT CGGCATCGAC CTGGGCACCA CCTACTCCTG CGTGGGGGTG 
TTCCAACACG GCAAGGTGGA GATCATCGCC AACGACCAGG GCAACCGCAC CACCCCCAGC 
TACGTGGCCT TCACGGACAC CGAGCGGCTC ATCGGGGATG CGGCCAAGAA CCAGGTGGCG 
CTGAACCCGC AGAACACCGT GTTTGACGCG AAGCGGCTGA TCGGCCGCAA GTTCGGCGAC 
CCGGTGGTGC AGTCGGACAT GAAGCACTGG CCTTTCCAGG TGATCAACGA CGGAGACAAG 
CCCAAGGTGC AGGTGAGCTA CAAGGGGGAG ACCAAGGCAT TCTACCCCGA GGAGATCTCG 
TCCATGGTGC TGACCAAGAT GAAGGAGATC GCCGAGGCGT ACCTGGGCTA CCCGGTGACC 
AACGCGGTGA TCACCGTGCC GGCCTACTTC AACGACTCGC AGCGCCAGGC CACCAAGGAT 
GCGGGTGTGA TCGCGGGGCT CAACGTGCTG CGGATCATCA ACGAGCCCAC GGCCGCCGCC 
ATCGCCTACG GCCTGGACAG AACGGGCAAG GGGGAGCGCA ACGTGCTCAT CTTTGACCTG 
GGCGGGGGCA CCTTCGACGT GTCCATCCTG ACGATCGACG ACGGCATCTT CGAGGTGAAG 
GCCACGGCCG GGGACACCCA CCTGGGTGGG GAGGACTTTG ACAACAGGCT GGTGAACCAC 
TTCGTGGAGG AGTTCAAGAG AAAACACAAG AAGGACATCA GCCAGAACAA GCGAGCCGTG 
AGGCGGCTGC GCACCGCCTG CGAGAGGGCC AAGAGGACCC TGTCGTCCAG CACCCAGGCC 
AGCCTGGAGA TCGACTCCCT GTTTGAGGGC ATCGACTTCT ACACGTCCAT CACCAGGGCG 
AGGTTCGAGG AGCTGTGCTC CGACCTGTTC CGAAGCACCC TGGAGCCCGT GGAGAAGGCT 
CTGCGCGACG CCAAGCTGGA CAAGGCCCAG ATTCACGACC TGGTCCTGGT CGGGGGCTCC 
ACCCGCATCC CCAAGGTGCA GAAGCTGCTG CAGGACTTCT TCAACGGGCG CGACCTGAAC 
AAGAGCATCA ACCCCGACGA GGCTGTGGCC TACGGGGCGG CGGTGCAGGC GGCCATCCTG 
ATGGGGGACA AGTCCGAGAA CGTGCAGGAC CTGCTGCTGC TGGACGTGGC TCCCCTGTCG 
CTGGGGCTGG AGACGGCCGG AGGCGTGATG ACTGCCCTGA TCAAGCGCAA CTCCACCATC 
CCCACCAAGC AGACGCAGAT CTTCACCACC TACTCCGACA ACCAACCCGG GGTGCTGATC 
CAGGTGTACG AGGGCGAGAG GGCCATGACG AAAGACAACA ATCTGTTGGG GCGCTTCGAG 
CTGAGCGGCA TCCCTCCGGC CCCCAGGGGC GTGCCCCAGA TCGAGGTGAC CTTCGACATC 
GATGCCAACG GCATCCTGAA CGTCACGGCC ACGGACAAGA GCACCGGCAA GGCCAACAAG 
ATCACCATCA CCAACGACAA GGGCCGCCTG AGCAAGGAGG AGATCGAGCG CATGGTGCAG 
GAGGCGGAGA AGTACAAAGC GGAGGACGAG GTGCAGCGCG AGAGGGTGTC AGCCAAGAAC 
GCCCTGGAGT CCTACGCCTT CAACATGAAG AGCGCCGTGG AGGATGAGGG GCTCAAGGGC 
AAGATCAGCG AGGCGGACAA GAAGAAGGTT CTGGACAAGT GTCAAGAGGT CATCTCGTGG 
CTGGACGCCA ACACCTTGGC CGAGAAGGAC GAGTTTGAGC ACAAGAGGAA GGAGCTGGAG 
CAGGTGTGTA ACCCCATCAT CAGCGGACTG TACCAGGGTG CCGGTGGTCC CGGGCCTGGC 
GGCTTCGGGG CTCAGGGTCC CAAGGGAGGG TCTGGGTCAG GCCCTACCAT TGAGGAGGTG 
GATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005337.2
CDS	214..2139
Translation	MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD

Target ORF information:

RefSeq Version	NM_005346.5
Organism	Homo sapiens(human)
Definition	Homo sapiens heat shock protein family A (Hsp70) member 1B (HSPA1B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005346.5

ORF Insert Sequence:

ATGGCCAAAG CCGCGGCGAT CGGCATCGAC CTGGGCACCA CCTACTCCTG CGTGGGGGTG 
TTCCAACACG GCAAGGTGGA GATCATCGCC AACGACCAGG GCAACCGCAC CACCCCCAGC 
TACGTGGCCT TCACGGACAC CGAGCGGCTC ATCGGGGATG CGGCCAAGAA CCAGGTGGCG 
CTGAACCCGC AGAACACCGT GTTTGACGCG AAGCGGCTGA TCGGCCGCAA GTTCGGCGAC 
CCGGTGGTGC AGTCGGACAT GAAGCACTGG CCTTTCCAGG TGATCAACGA CGGAGACAAG 
CCCAAGGTGC AGGTGAGCTA CAAGGGGGAG ACCAAGGCAT TCTACCCCGA GGAGATCTCG 
TCCATGGTGC TGACCAAGAT GAAGGAGATC GCCGAGGCGT ACCTGGGCTA CCCGGTGACC 
AACGCGGTGA TCACCGTGCC GGCCTACTTC AACGACTCGC AGCGCCAGGC CACCAAGGAT 
GCGGGTGTGA TCGCGGGGCT CAACGTGCTG CGGATCATCA ACGAGCCCAC GGCCGCCGCC 
ATCGCCTACG GCCTGGACAG AACGGGCAAG GGGGAGCGCA ACGTGCTCAT CTTTGACCTG 
GGCGGGGGCA CCTTCGACGT GTCCATCCTG ACGATCGACG ACGGCATCTT CGAGGTGAAG 
GCCACGGCCG GGGACACCCA CCTGGGTGGG GAGGACTTTG ACAACAGGCT GGTGAACCAC 
TTCGTGGAGG AGTTCAAGAG AAAACACAAG AAGGACATCA GCCAGAACAA GCGAGCCGTG 
AGGCGGCTGC GCACCGCCTG CGAGAGGGCC AAGAGGACCC TGTCGTCCAG CACCCAGGCC 
AGCCTGGAGA TCGACTCCCT GTTTGAGGGC ATCGACTTCT ACACGTCCAT CACCAGGGCG 
AGGTTCGAGG AGCTGTGCTC CGACCTGTTC CGAAGCACCC TGGAGCCCGT GGAGAAGGCT 
CTGCGCGACG CCAAGCTGGA CAAGGCCCAG ATTCACGACC TGGTCCTGGT CGGGGGCTCC 
ACCCGCATCC CCAAGGTGCA GAAGCTGCTG CAGGACTTCT TCAACGGGCG CGACCTGAAC 
AAGAGCATCA ACCCCGACGA GGCTGTGGCC TACGGGGCGG CGGTGCAGGC GGCCATCCTG 
ATGGGGGACA AGTCCGAGAA CGTGCAGGAC CTGCTGCTGC TGGACGTGGC TCCCCTGTCG 
CTGGGGCTGG AGACGGCCGG AGGCGTGATG ACTGCCCTGA TCAAGCGCAA CTCCACCATC 
CCCACCAAGC AGACGCAGAT CTTCACCACC TACTCCGACA ACCAACCCGG GGTGCTGATC 
CAGGTGTACG AGGGCGAGAG GGCCATGACG AAAGACAACA ATCTGTTGGG GCGCTTCGAG 
CTGAGCGGCA TCCCTCCGGC CCCCAGGGGC GTGCCCCAGA TCGAGGTGAC CTTCGACATC 
GATGCCAACG GCATCCTGAA CGTCACGGCC ACGGACAAGA GCACCGGCAA GGCCAACAAG 
ATCACCATCA CCAACGACAA GGGCCGCCTG AGCAAGGAGG AGATCGAGCG CATGGTGCAG 
GAGGCGGAGA AGTACAAAGC GGAGGACGAG GTGCAGCGCG AGAGGGTGTC AGCCAAGAAC 
GCCCTGGAGT CCTACGCCTT CAACATGAAG AGCGCCGTGG AGGATGAGGG GCTCAAGGGC 
AAGATCAGCG AGGCGGACAA GAAGAAGGTT CTGGACAAGT GTCAAGAGGT CATCTCGTGG 
CTGGACGCCA ACACCTTGGC CGAGAAGGAC GAGTTTGAGC ACAAGAGGAA GGAGCTGGAG 
CAGGTGTGTA ACCCCATCAT CAGCGGACTG TACCAGGGTG CCGGTGGTCC CGGGCCTGGC 
GGCTTCGGGG CTCAGGGTCC CAAGGGAGGG TCTGGGTCAG GCCCTACCAT TGAGGAGGTG 
GATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HSPA1B ( NM_005346.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005337.2 Homo sapiens heat shock protein family A (Hsp70) member 1B (HSPA1B), mRNA.

Price & Availability↑

CloneID	OHu26976
Clone ID Related Accession (Same CDS sequence)	NM_005346.5 , NM_005346.4
Accession Version	NM_005346.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1926bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-29
Organism	Homo sapiens(human)
Product	heat shock 70 kDa protein 1B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB015158.1, BC063507.1 and AL671762.10. On Feb 8, 2008 this sequence version replaced NM_005346.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC063507.1 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCAAAG CCGCGGCGAT CGGCATCGAC CTGGGCACCA CCTACTCCTG CGTGGGGGTG 
TTCCAACACG GCAAGGTGGA GATCATCGCC AACGACCAGG GCAACCGCAC CACCCCCAGC 
TACGTGGCCT TCACGGACAC CGAGCGGCTC ATCGGGGATG CGGCCAAGAA CCAGGTGGCG 
CTGAACCCGC AGAACACCGT GTTTGACGCG AAGCGGCTGA TCGGCCGCAA GTTCGGCGAC 
CCGGTGGTGC AGTCGGACAT GAAGCACTGG CCTTTCCAGG TGATCAACGA CGGAGACAAG 
CCCAAGGTGC AGGTGAGCTA CAAGGGGGAG ACCAAGGCAT TCTACCCCGA GGAGATCTCG 
TCCATGGTGC TGACCAAGAT GAAGGAGATC GCCGAGGCGT ACCTGGGCTA CCCGGTGACC 
AACGCGGTGA TCACCGTGCC GGCCTACTTC AACGACTCGC AGCGCCAGGC CACCAAGGAT 
GCGGGTGTGA TCGCGGGGCT CAACGTGCTG CGGATCATCA ACGAGCCCAC GGCCGCCGCC 
ATCGCCTACG GCCTGGACAG AACGGGCAAG GGGGAGCGCA ACGTGCTCAT CTTTGACCTG 
GGCGGGGGCA CCTTCGACGT GTCCATCCTG ACGATCGACG ACGGCATCTT CGAGGTGAAG 
GCCACGGCCG GGGACACCCA CCTGGGTGGG GAGGACTTTG ACAACAGGCT GGTGAACCAC 
TTCGTGGAGG AGTTCAAGAG AAAACACAAG AAGGACATCA GCCAGAACAA GCGAGCCGTG 
AGGCGGCTGC GCACCGCCTG CGAGAGGGCC AAGAGGACCC TGTCGTCCAG CACCCAGGCC 
AGCCTGGAGA TCGACTCCCT GTTTGAGGGC ATCGACTTCT ACACGTCCAT CACCAGGGCG 
AGGTTCGAGG AGCTGTGCTC CGACCTGTTC CGAAGCACCC TGGAGCCCGT GGAGAAGGCT 
CTGCGCGACG CCAAGCTGGA CAAGGCCCAG ATTCACGACC TGGTCCTGGT CGGGGGCTCC 
ACCCGCATCC CCAAGGTGCA GAAGCTGCTG CAGGACTTCT TCAACGGGCG CGACCTGAAC 
AAGAGCATCA ACCCCGACGA GGCTGTGGCC TACGGGGCGG CGGTGCAGGC GGCCATCCTG 
ATGGGGGACA AGTCCGAGAA CGTGCAGGAC CTGCTGCTGC TGGACGTGGC TCCCCTGTCG 
CTGGGGCTGG AGACGGCCGG AGGCGTGATG ACTGCCCTGA TCAAGCGCAA CTCCACCATC 
CCCACCAAGC AGACGCAGAT CTTCACCACC TACTCCGACA ACCAACCCGG GGTGCTGATC 
CAGGTGTACG AGGGCGAGAG GGCCATGACG AAAGACAACA ATCTGTTGGG GCGCTTCGAG 
CTGAGCGGCA TCCCTCCGGC CCCCAGGGGC GTGCCCCAGA TCGAGGTGAC CTTCGACATC 
GATGCCAACG GCATCCTGAA CGTCACGGCC ACGGACAAGA GCACCGGCAA GGCCAACAAG 
ATCACCATCA CCAACGACAA GGGCCGCCTG AGCAAGGAGG AGATCGAGCG CATGGTGCAG 
GAGGCGGAGA AGTACAAAGC GGAGGACGAG GTGCAGCGCG AGAGGGTGTC AGCCAAGAAC 
GCCCTGGAGT CCTACGCCTT CAACATGAAG AGCGCCGTGG AGGATGAGGG GCTCAAGGGC 
AAGATCAGCG AGGCGGACAA GAAGAAGGTT CTGGACAAGT GTCAAGAGGT CATCTCGTGG 
CTGGACGCCA ACACCTTGGC CGAGAAGGAC GAGTTTGAGC ACAAGAGGAA GGAGCTGGAG 
CAGGTGTGTA ACCCCATCAT CAGCGGACTG TACCAGGGTG CCGGTGGTCC CGGGCCTGGC 
GGCTTCGGGG CTCAGGGTCC CAAGGGAGGG TCTGGGTCAG GCCCTACCAT TGAGGAGGTG 
GATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005337.2
CDS	217..2142
Translation	MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD

Target ORF information:

RefSeq Version	NM_005346.4
Organism	Homo sapiens(human)
Definition	Homo sapiens heat shock protein family A (Hsp70) member 1B (HSPA1B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005346.4

ORF Insert Sequence:

ATGGCCAAAG CCGCGGCGAT CGGCATCGAC CTGGGCACCA CCTACTCCTG CGTGGGGGTG 
TTCCAACACG GCAAGGTGGA GATCATCGCC AACGACCAGG GCAACCGCAC CACCCCCAGC 
TACGTGGCCT TCACGGACAC CGAGCGGCTC ATCGGGGATG CGGCCAAGAA CCAGGTGGCG 
CTGAACCCGC AGAACACCGT GTTTGACGCG AAGCGGCTGA TCGGCCGCAA GTTCGGCGAC 
CCGGTGGTGC AGTCGGACAT GAAGCACTGG CCTTTCCAGG TGATCAACGA CGGAGACAAG 
CCCAAGGTGC AGGTGAGCTA CAAGGGGGAG ACCAAGGCAT TCTACCCCGA GGAGATCTCG 
TCCATGGTGC TGACCAAGAT GAAGGAGATC GCCGAGGCGT ACCTGGGCTA CCCGGTGACC 
AACGCGGTGA TCACCGTGCC GGCCTACTTC AACGACTCGC AGCGCCAGGC CACCAAGGAT 
GCGGGTGTGA TCGCGGGGCT CAACGTGCTG CGGATCATCA ACGAGCCCAC GGCCGCCGCC 
ATCGCCTACG GCCTGGACAG AACGGGCAAG GGGGAGCGCA ACGTGCTCAT CTTTGACCTG 
GGCGGGGGCA CCTTCGACGT GTCCATCCTG ACGATCGACG ACGGCATCTT CGAGGTGAAG 
GCCACGGCCG GGGACACCCA CCTGGGTGGG GAGGACTTTG ACAACAGGCT GGTGAACCAC 
TTCGTGGAGG AGTTCAAGAG AAAACACAAG AAGGACATCA GCCAGAACAA GCGAGCCGTG 
AGGCGGCTGC GCACCGCCTG CGAGAGGGCC AAGAGGACCC TGTCGTCCAG CACCCAGGCC 
AGCCTGGAGA TCGACTCCCT GTTTGAGGGC ATCGACTTCT ACACGTCCAT CACCAGGGCG 
AGGTTCGAGG AGCTGTGCTC CGACCTGTTC CGAAGCACCC TGGAGCCCGT GGAGAAGGCT 
CTGCGCGACG CCAAGCTGGA CAAGGCCCAG ATTCACGACC TGGTCCTGGT CGGGGGCTCC 
ACCCGCATCC CCAAGGTGCA GAAGCTGCTG CAGGACTTCT TCAACGGGCG CGACCTGAAC 
AAGAGCATCA ACCCCGACGA GGCTGTGGCC TACGGGGCGG CGGTGCAGGC GGCCATCCTG 
ATGGGGGACA AGTCCGAGAA CGTGCAGGAC CTGCTGCTGC TGGACGTGGC TCCCCTGTCG 
CTGGGGCTGG AGACGGCCGG AGGCGTGATG ACTGCCCTGA TCAAGCGCAA CTCCACCATC 
CCCACCAAGC AGACGCAGAT CTTCACCACC TACTCCGACA ACCAACCCGG GGTGCTGATC 
CAGGTGTACG AGGGCGAGAG GGCCATGACG AAAGACAACA ATCTGTTGGG GCGCTTCGAG 
CTGAGCGGCA TCCCTCCGGC CCCCAGGGGC GTGCCCCAGA TCGAGGTGAC CTTCGACATC 
GATGCCAACG GCATCCTGAA CGTCACGGCC ACGGACAAGA GCACCGGCAA GGCCAACAAG 
ATCACCATCA CCAACGACAA GGGCCGCCTG AGCAAGGAGG AGATCGAGCG CATGGTGCAG 
GAGGCGGAGA AGTACAAAGC GGAGGACGAG GTGCAGCGCG AGAGGGTGTC AGCCAAGAAC 
GCCCTGGAGT CCTACGCCTT CAACATGAAG AGCGCCGTGG AGGATGAGGG GCTCAAGGGC 
AAGATCAGCG AGGCGGACAA GAAGAAGGTT CTGGACAAGT GTCAAGAGGT CATCTCGTGG 
CTGGACGCCA ACACCTTGGC CGAGAAGGAC GAGTTTGAGC ACAAGAGGAA GGAGCTGGAG 
CAGGTGTGTA ACCCCATCAT CAGCGGACTG TACCAGGGTG CCGGTGGTCC CGGGCCTGGC 
GGCTTCGGGG CTCAGGGTCC CAAGGGAGGG TCTGGGTCAG GCCCTACCAT TGAGGAGGTG 
GATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HSPA1B ( NM_005346.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_005337.2 Homo sapiens heat shock protein family A (Hsp70) member 1B (HSPA1B), mRNA.

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CloneID	OHu109388
Clone ID Related Accession (Same CDS sequence)	NM_005346.6
Accession Version	NM_005346.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1926bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	heat shock 70 kDa protein 1B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL671762.10. On Aug 31, 2019 this sequence version replaced NM_005346.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC063507.1, SRR7346977.1145010.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000375650.5/ ENSP00000364801.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCAAAG CCGCGGCGAT CGGCATCGAC CTGGGCACCA CCTACTCCTG CGTGGGGGTG 
TTCCAACACG GCAAGGTGGA GATCATCGCC AACGACCAGG GCAACCGCAC CACCCCCAGC 
TACGTGGCCT TCACGGACAC CGAGCGGCTC ATCGGGGATG CGGCCAAGAA CCAGGTGGCG 
CTGAACCCGC AGAACACCGT GTTTGACGCG AAGCGGCTGA TTGGCCGCAA GTTCGGCGAC 
CCGGTGGTGC AGTCGGACAT GAAGCACTGG CCTTTCCAGG TGATCAACGA CGGAGACAAG 
CCCAAGGTGC AGGTGAGCTA CAAGGGGGAG ACCAAGGCAT TCTACCCCGA GGAGATCTCG 
TCCATGGTGC TGACCAAGAT GAAGGAGATC GCCGAGGCGT ACCTGGGCTA CCCGGTGACC 
AACGCGGTGA TCACCGTGCC GGCCTACTTC AACGACTCGC AGCGCCAGGC CACCAAGGAT 
GCGGGTGTGA TCGCGGGGCT CAACGTGCTG CGGATCATCA ACGAGCCCAC GGCCGCCGCC 
ATCGCCTACG GCCTGGACAG AACGGGCAAG GGGGAGCGCA ACGTGCTCAT CTTTGACCTG 
GGCGGGGGCA CCTTCGACGT GTCCATCCTG ACGATCGACG ACGGCATCTT CGAGGTGAAG 
GCCACGGCCG GGGACACCCA CCTGGGTGGG GAGGACTTTG ACAACAGGCT GGTGAACCAC 
TTCGTGGAGG AGTTCAAGAG AAAACACAAG AAGGACATCA GCCAGAACAA GCGAGCCGTG 
AGGCGGCTGC GCACCGCCTG CGAGAGGGCC AAGAGGACCC TGTCGTCCAG CACCCAGGCC 
AGCCTGGAGA TCGACTCCCT GTTTGAGGGC ATCGACTTCT ACACGTCCAT CACCAGGGCG 
AGGTTCGAGG AGCTGTGCTC CGACCTGTTC CGAAGCACCC TGGAGCCCGT GGAGAAGGCT 
CTGCGCGACG CCAAGCTGGA CAAGGCCCAG ATTCACGACC TGGTCCTGGT CGGGGGCTCC 
ACCCGCATCC CCAAGGTGCA GAAGCTGCTG CAGGACTTCT TCAACGGGCG CGACCTGAAC 
AAGAGCATCA ACCCCGACGA GGCTGTGGCC TACGGGGCGG CGGTGCAGGC GGCCATCCTG 
ATGGGGGACA AGTCCGAGAA CGTGCAGGAC CTGCTGCTGC TGGACGTGGC TCCCCTGTCG 
CTGGGGCTGG AGACGGCCGG AGGCGTGATG ACTGCCCTGA TCAAGCGCAA CTCCACCATC 
CCCACCAAGC AGACGCAGAT CTTCACCACC TACTCCGACA ACCAACCCGG GGTGCTGATC 
CAGGTGTACG AGGGCGAGAG GGCCATGACG AAAGACAACA ATCTGTTGGG GCGCTTCGAG 
CTGAGCGGCA TCCCTCCGGC CCCCAGGGGC GTGCCCCAGA TCGAGGTGAC CTTCGACATC 
GATGCCAACG GCATCCTGAA CGTCACGGCC ACGGACAAGA GCACCGGCAA GGCCAACAAG 
ATCACCATCA CCAACGACAA GGGCCGCCTG AGCAAGGAGG AGATCGAGCG CATGGTGCAG 
GAGGCGGAGA AGTACAAAGC GGAGGACGAG GTGCAGCGCG AGAGGGTGTC AGCCAAGAAC 
GCCCTGGAGT CCTACGCCTT CAACATGAAG AGCGCCGTGG AGGATGAGGG GCTCAAGGGC 
AAGATCAGCG AGGCGGACAA GAAGAAGGTT CTGGACAAGT GTCAAGAGGT CATCTCGTGG 
CTGGACGCCA ACACCTTGGC CGAGAAGGAC GAGTTTGAGC ACAAGAGGAA GGAGCTGGAG 
CAGGTGTGTA ACCCCATCAT CAGCGGACTG TACCAGGGTG CCGGTGGTCC CGGGCCTGGC 
GGCTTCGGGG CTCAGGGTCC CAAGGGAGGG TCTGGGTCAG GCCCTACCAT TGAGGAGGTG 
GATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005337.2
CDS	214..2139
Translation	MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD

Target ORF information:

RefSeq Version	NM_005346.6
Organism	Homo sapiens(human)
Definition	Homo sapiens heat shock protein family A (Hsp70) member 1B (HSPA1B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005346.6

ORF Insert Sequence:

ATGGCCAAAG CCGCGGCGAT CGGCATCGAC CTGGGCACCA CCTACTCCTG CGTGGGGGTG 
TTCCAACACG GCAAGGTGGA GATCATCGCC AACGACCAGG GCAACCGCAC CACCCCCAGC 
TACGTGGCCT TCACGGACAC CGAGCGGCTC ATCGGGGATG CGGCCAAGAA CCAGGTGGCG 
CTGAACCCGC AGAACACCGT GTTTGACGCG AAGCGGCTGA TTGGCCGCAA GTTCGGCGAC 
CCGGTGGTGC AGTCGGACAT GAAGCACTGG CCTTTCCAGG TGATCAACGA CGGAGACAAG 
CCCAAGGTGC AGGTGAGCTA CAAGGGGGAG ACCAAGGCAT TCTACCCCGA GGAGATCTCG 
TCCATGGTGC TGACCAAGAT GAAGGAGATC GCCGAGGCGT ACCTGGGCTA CCCGGTGACC 
AACGCGGTGA TCACCGTGCC GGCCTACTTC AACGACTCGC AGCGCCAGGC CACCAAGGAT 
GCGGGTGTGA TCGCGGGGCT CAACGTGCTG CGGATCATCA ACGAGCCCAC GGCCGCCGCC 
ATCGCCTACG GCCTGGACAG AACGGGCAAG GGGGAGCGCA ACGTGCTCAT CTTTGACCTG 
GGCGGGGGCA CCTTCGACGT GTCCATCCTG ACGATCGACG ACGGCATCTT CGAGGTGAAG 
GCCACGGCCG GGGACACCCA CCTGGGTGGG GAGGACTTTG ACAACAGGCT GGTGAACCAC 
TTCGTGGAGG AGTTCAAGAG AAAACACAAG AAGGACATCA GCCAGAACAA GCGAGCCGTG 
AGGCGGCTGC GCACCGCCTG CGAGAGGGCC AAGAGGACCC TGTCGTCCAG CACCCAGGCC 
AGCCTGGAGA TCGACTCCCT GTTTGAGGGC ATCGACTTCT ACACGTCCAT CACCAGGGCG 
AGGTTCGAGG AGCTGTGCTC CGACCTGTTC CGAAGCACCC TGGAGCCCGT GGAGAAGGCT 
CTGCGCGACG CCAAGCTGGA CAAGGCCCAG ATTCACGACC TGGTCCTGGT CGGGGGCTCC 
ACCCGCATCC CCAAGGTGCA GAAGCTGCTG CAGGACTTCT TCAACGGGCG CGACCTGAAC 
AAGAGCATCA ACCCCGACGA GGCTGTGGCC TACGGGGCGG CGGTGCAGGC GGCCATCCTG 
ATGGGGGACA AGTCCGAGAA CGTGCAGGAC CTGCTGCTGC TGGACGTGGC TCCCCTGTCG 
CTGGGGCTGG AGACGGCCGG AGGCGTGATG ACTGCCCTGA TCAAGCGCAA CTCCACCATC 
CCCACCAAGC AGACGCAGAT CTTCACCACC TACTCCGACA ACCAACCCGG GGTGCTGATC 
CAGGTGTACG AGGGCGAGAG GGCCATGACG AAAGACAACA ATCTGTTGGG GCGCTTCGAG 
CTGAGCGGCA TCCCTCCGGC CCCCAGGGGC GTGCCCCAGA TCGAGGTGAC CTTCGACATC 
GATGCCAACG GCATCCTGAA CGTCACGGCC ACGGACAAGA GCACCGGCAA GGCCAACAAG 
ATCACCATCA CCAACGACAA GGGCCGCCTG AGCAAGGAGG AGATCGAGCG CATGGTGCAG 
GAGGCGGAGA AGTACAAAGC GGAGGACGAG GTGCAGCGCG AGAGGGTGTC AGCCAAGAAC 
GCCCTGGAGT CCTACGCCTT CAACATGAAG AGCGCCGTGG AGGATGAGGG GCTCAAGGGC 
AAGATCAGCG AGGCGGACAA GAAGAAGGTT CTGGACAAGT GTCAAGAGGT CATCTCGTGG 
CTGGACGCCA ACACCTTGGC CGAGAAGGAC GAGTTTGAGC ACAAGAGGAA GGAGCTGGAG 
CAGGTGTGTA ACCCCATCAT CAGCGGACTG TACCAGGGTG CCGGTGGTCC CGGGCCTGGC 
GGCTTCGGGG CTCAGGGTCC CAAGGGAGGG TCTGGGTCAG GCCCTACCAT TGAGGAGGTG 
GATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Downregulation of Heat Shock Protein 70 Impairs Osteogenic and Chondrogenic Differentiation in Human Mesenchymal Stem Cells.
Scientific reports8(1)553(2018 Jan)
Li C,Sunderic K,Nicoll SB,Wang S

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.
Molecular systems biology13(3)918(2017 03)
Sokolina K,Kittanakom S,Snider J,Kotlyar M,Maurice P,Gand?a J,Benleulmi-Chaachoua A,Tadagaki K,Oishi A,Wong V,Malty RH,Deineko V,Aoki H,Amin S,Yao Z,Morat? X,Otasek D,Kobayashi H,Menendez J,Auerbach D,Angers S,Pr?ulj N,Bouvier M,Babu M,Ciruela F,Jockers R,Jurisica I,Stagljar I

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HSPA1B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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