HPCA cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HPCA
Entrez Gene ID	3208
Full Name	hippocalcin
Synonyms	BDR2,DYT2
General protein information	Preferred Names hippocalcin Names neuron-specific calcium-binding protein hippocalcin calcium-binding protein BDR-2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p35.1
Summary	The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain. This protein is associated with the plasma membrane. It has similarities to proteins located in the photoreceptor cells that regulate photosignal transduction in a calcium-sensitive manner. This protein displays recoverin activity and a calcium-dependent inhibition of rhodopsin kinase. It is identical to the rat and mouse hippocalcin proteins and thought to play an important role in neurons of the central nervous system in a number of species. [provided by RefSeq, Jul 2008].
Disorder MIM:	142622
Disorder Html:	Dystonia 2, torsion, autosomal recessive, 224500 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_017001118.1	XP_016856607.1	neuron-specific calcium-binding protein hippocalcin isoform X1
XM_005270792.3	XP_005270849.1	neuron-specific calcium-binding protein hippocalcin isoform X1
NM_002143.3	NP_002134.2	neuron-specific calcium-binding protein hippocalcin
XM_005270792.2	XP_005270849.1	neuron-specific calcium-binding protein hippocalcin isoform X1
NM_002143.2	NP_002134.2	neuron-specific calcium-binding protein hippocalcin
XM_017001118.2	XP_016856607.1	neuron-specific calcium-binding protein hippocalcin isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	HPCA	NP_002134.2
Rattus norvegicus (Norway rat)	Hpca	NP_058818.1
Xenopus tropicalis (tropical clawed frog)	hpca	NP_001037936.1
Gallus gallus (chicken)	HPCA	XP_001233529.1
Canis lupus familiaris (dog)	HPCA	XP_854592.2
Bos taurus (cattle)	HPCA	NP_001020499.1
Mus musculus (house mouse)	Hpca	NP_001273012.1
Pan troglodytes (chimpanzee)	HPCA	XP_001155509.2
	HPCA	XP_001098851.2
Danio rerio (zebrafish)	hpca	NP_957017.1

Gene Ontology
Bibliography

Related articles in PubMed

Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia.
Helassa N, Antonyuk SV, Lian LY, Haynes LP, Burgoyne RD
Human molecular genetics26(13)2426-2435(2017 07)

DYT2 screening in early-onset isolated dystonia.
Carecchio M, Reale C, Invernizzi F, Monti V, Petrucci S, Ginevrino M, Morgante F, Zorzi G, Zibordi F, Bentivoglio AR, Valente EM, Nardocci N, Garavaglia B
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society21(2)269-271(2017 Mar)

HPCA-related dystonia: Too rare to be found?
Dobri?i? V, Kresojevi? N, Marjanovi? A, Tomi? A, Svetel M, Novakovi? I, Kosti? VS
Movement disorders : official journal of the Movement Disorder Society31(7)1071(2016 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

hippocalcin forms oligomers upon calcium binding and directly interacts with VGCCs. The dystonia-causing mutations did not affect protein stability or folding. In common for both T71N and A190T mutants was an impaired calcium-dependent oligomerisation and increased intracellular calcium influx after KCl depolarisation.
Title: Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia.

None of the patients enrolled was found to carry HPCA mutations, rising suspicion that these probably represent a very rare cause of dystonia in childhood-adolescence.
Title: DYT2 screening in early-onset isolated dystonia.

Mutations in HPCA cause autosomal-recessive primary isolated dystonia.
Title: Mutations in HPCA cause autosomal-recessive primary isolated dystonia.

analysis of a novel acetylation cycle of transcription co-activator Yes-associated protein that is downstream of Hippo pathway is triggered in response to SN2 alkylating agents
Title: A novel acetylation cycle of transcription co-activator Yes-associated protein that is downstream of Hippo pathway is triggered in response to SN2 alkylating agents.

diminished hippocalcin expression does not contribute to Huntington disease-related neurodegeneration
Title: Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons.

The following HPCA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HPCA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29412	NM_002143.3 Latest version!	Homo sapiens hippocalcin (HPCA), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu29412	XM_017001118.2 Latest version!	Homo sapiens hippocalcin (HPCA), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu29412	XM_005270792.3 Latest version!	Homo sapiens hippocalcin (HPCA), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu29412	XM_005270792.2	Homo sapiens hippocalcin (HPCA), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu29412	NM_002143.2	Homo sapiens hippocalcin (HPCA), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu29412	XM_017001118.1	Homo sapiens hippocalcin (HPCA), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HPCA ( NM_002143.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002134.2 Homo sapiens hippocalcin (HPCA), mRNA.

Price & Availability↑

CloneID	OHu29412
Clone ID Related Accession (Same CDS sequence)	XM_017001118.1 , XM_005270792.3 , NM_002143.3 , XM_005270792.2 , NM_002143.2 , XM_017001118.2
Accession Version	NM_002143.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	neuron-specific calcium-binding protein hippocalcin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC114493.3 and BC001777.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_002143.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.170379.1, SRR3476690.961056.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000373467.4/ ENSP00000362566.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCAAGC AGAACAGCAA GCTGCGGCCC GAGATGTTGC AGGACCTGCG AGAGAACACA 
GAGTTCTCAG AGCTGGAGCT GCAGGAGTGG TACAAGGGCT TCCTCAAGGA CTGCCCCACA 
GGAATCCTCA ATGTGGATGA GTTCAAGAAG ATCTACGCCA ACTTCTTTCC CTATGGTGAC 
GCCTCCAAGT TTGCCGAGCA CGTCTTCCGC ACCTTTGACA CCAACAGCGA TGGCACCATA 
GACTTTCGGG AGTTCATCAT TGCGCTGAGC GTGACCTCGC GCGGCCGCCT GGAGCAGAAG 
CTCATGTGGG CCTTCAGCAT GTATGACCTG GACGGCAACG GCTACATCAG CCGGGAGGAG 
ATGCTGGAGA TCGTGCAGGC CATTTACAAG ATGGTTTCGT CCGTGATGAA GATGCCGGAG 
GACGAGTCGA CCCCGGAAAA GAGGACTGAG AAAATCTTCC GCCAAATGGA CACAAACAAC 
GACGGCAAGC TGTCCTTGGA GGAGTTCATC CGCGGGGCCA AAAGCGACCC GTCCATCGTG 
CGTCTGCTGC AGTGCGACCC CAGCAGCGCC TCCCAGTTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002134.2
CDS	47..628
Translation	MGKQNSKLRPEMLQDLRENTEFSELELQEWYKGFLKDCPTGILNVDEFKKIYANFFPYGDASKFAEHVFRTFDTNSDGTIDFREFIIALSVTSRGRLEQKLMWAFSMYDLDGNGYISREEMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFRQMDTNNDGKLSLEEFIRGAKSDPSIVRLLQCDPSSASQF

Target ORF information:

RefSeq Version	NM_002143.3
Organism	Homo sapiens(human)
Definition	Homo sapiens hippocalcin (HPCA), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002143.3

ORF Insert Sequence:

ATGGGCAAGC AGAACAGCAA GCTGCGGCCC GAGATGTTGC AGGACCTGCG AGAGAACACA 
GAGTTCTCAG AGCTGGAGCT GCAGGAGTGG TACAAGGGCT TCCTCAAGGA CTGCCCCACA 
GGAATCCTCA ATGTGGATGA GTTCAAGAAG ATCTACGCCA ACTTCTTTCC CTATGGTGAC 
GCCTCCAAGT TTGCCGAGCA CGTCTTCCGC ACCTTTGACA CCAACAGCGA TGGCACCATA 
GACTTTCGGG AGTTCATCAT TGCGCTGAGC GTGACCTCGC GCGGCCGCCT GGAGCAGAAG 
CTCATGTGGG CCTTCAGCAT GTATGACCTG GACGGCAACG GCTACATCAG CCGGGAGGAG 
ATGCTGGAGA TCGTGCAGGC CATTTACAAG ATGGTTTCGT CCGTGATGAA GATGCCGGAG 
GACGAGTCGA CCCCGGAAAA GAGGACTGAG AAAATCTTCC GCCAAATGGA CACAAACAAC 
GACGGCAAGC TGTCCTTGGA GGAGTTCATC CGCGGGGCCA AAAGCGACCC GTCCATCGTG 
CGTCTGCTGC AGTGCGACCC CAGCAGCGCC TCCCAGTTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HPCA ( NM_002143.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002134.2 Homo sapiens hippocalcin (HPCA), mRNA.

Price & Availability↑

CloneID	OHu29412
Clone ID Related Accession (Same CDS sequence)	XM_017001118.1 , XM_005270792.3 , NM_002143.3 , XM_005270792.2 , NM_002143.2 , XM_017001118.2
Accession Version	NM_002143.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-11
Organism	Homo sapiens(human)
Product	neuron-specific calcium-binding protein hippocalcin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC001777.1. This sequence is a reference standard in the RefSeqGene project. On Apr 3, 2002 this sequence version replaced NM_002143.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC001777.1, BG701268.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCAAGC AGAACAGCAA GCTGCGGCCC GAGATGTTGC AGGACCTGCG AGAGAACACA 
GAGTTCTCAG AGCTGGAGCT GCAGGAGTGG TACAAGGGCT TCCTCAAGGA CTGCCCCACA 
GGAATCCTCA ATGTGGATGA GTTCAAGAAG ATCTACGCCA ACTTCTTTCC CTATGGTGAC 
GCCTCCAAGT TTGCCGAGCA CGTCTTCCGC ACCTTTGACA CCAACAGCGA TGGCACCATA 
GACTTTCGGG AGTTCATCAT TGCGCTGAGC GTGACCTCGC GCGGCCGCCT GGAGCAGAAG 
CTCATGTGGG CCTTCAGCAT GTATGACCTG GACGGCAACG GCTACATCAG CCGGGAGGAG 
ATGCTGGAGA TCGTGCAGGC CATTTACAAG ATGGTTTCGT CCGTGATGAA GATGCCGGAG 
GACGAGTCGA CCCCGGAAAA GAGGACTGAG AAAATCTTCC GCCAAATGGA CACAAACAAC 
GACGGCAAGC TGTCCTTGGA GGAGTTCATC CGCGGGGCCA AAAGCGACCC GTCCATCGTG 
CGTCTGCTGC AGTGCGACCC CAGCAGCGCC TCCCAGTTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002134.2
CDS	41..622
Translation	MGKQNSKLRPEMLQDLRENTEFSELELQEWYKGFLKDCPTGILNVDEFKKIYANFFPYGDASKFAEHVFRTFDTNSDGTIDFREFIIALSVTSRGRLEQKLMWAFSMYDLDGNGYISREEMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFRQMDTNNDGKLSLEEFIRGAKSDPSIVRLLQCDPSSASQF

Target ORF information:

RefSeq Version	NM_002143.2
Organism	Homo sapiens(human)
Definition	Homo sapiens hippocalcin (HPCA), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002143.2

ORF Insert Sequence:

ATGGGCAAGC AGAACAGCAA GCTGCGGCCC GAGATGTTGC AGGACCTGCG AGAGAACACA 
GAGTTCTCAG AGCTGGAGCT GCAGGAGTGG TACAAGGGCT TCCTCAAGGA CTGCCCCACA 
GGAATCCTCA ATGTGGATGA GTTCAAGAAG ATCTACGCCA ACTTCTTTCC CTATGGTGAC 
GCCTCCAAGT TTGCCGAGCA CGTCTTCCGC ACCTTTGACA CCAACAGCGA TGGCACCATA 
GACTTTCGGG AGTTCATCAT TGCGCTGAGC GTGACCTCGC GCGGCCGCCT GGAGCAGAAG 
CTCATGTGGG CCTTCAGCAT GTATGACCTG GACGGCAACG GCTACATCAG CCGGGAGGAG 
ATGCTGGAGA TCGTGCAGGC CATTTACAAG ATGGTTTCGT CCGTGATGAA GATGCCGGAG 
GACGAGTCGA CCCCGGAAAA GAGGACTGAG AAAATCTTCC GCCAAATGGA CACAAACAAC 
GACGGCAAGC TGTCCTTGGA GGAGTTCATC CGCGGGGCCA AAAGCGACCC GTCCATCGTG 
CGTCTGCTGC AGTGCGACCC CAGCAGCGCC TCCCAGTTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HPCA ( XM_017001118.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016856607.1 Homo sapiens hippocalcin (HPCA), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu29412
Clone ID Related Accession (Same CDS sequence)	XM_017001118.1 , XM_005270792.3 , NM_002143.3 , XM_005270792.2 , NM_002143.2 , XM_017001118.2
Accession Version	XM_017001118.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	neuron-specific calcium-binding protein hippocalcin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCAAGC AGAACAGCAA GCTGCGGCCC GAGATGTTGC AGGACCTGCG AGAGAACACA 
GAGTTCTCAG AGCTGGAGCT GCAGGAGTGG TACAAGGGCT TCCTCAAGGA CTGCCCCACA 
GGAATCCTCA ATGTGGATGA GTTCAAGAAG ATCTACGCCA ACTTCTTTCC CTATGGTGAC 
GCCTCCAAGT TTGCCGAGCA CGTCTTCCGC ACCTTTGACA CCAACAGCGA TGGCACCATA 
GACTTTCGGG AGTTCATCAT TGCGCTGAGC GTGACCTCGC GCGGCCGCCT GGAGCAGAAG 
CTCATGTGGG CCTTCAGCAT GTATGACCTG GACGGCAACG GCTACATCAG CCGGGAGGAG 
ATGCTGGAGA TCGTGCAGGC CATTTACAAG ATGGTTTCGT CCGTGATGAA GATGCCGGAG 
GACGAGTCGA CCCCGGAAAA GAGGACTGAG AAAATCTTCC GCCAAATGGA CACAAACAAC 
GACGGCAAGC TGTCCTTGGA GGAGTTCATC CGCGGGGCCA AAAGCGACCC GTCCATCGTG 
CGTCTGCTGC AGTGCGACCC CAGCAGCGCC TCCCAGTTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016856607.1
CDS	513..1094
Translation	MGKQNSKLRPEMLQDLRENTEFSELELQEWYKGFLKDCPTGILNVDEFKKIYANFFPYGDASKFAEHVFRTFDTNSDGTIDFREFIIALSVTSRGRLEQKLMWAFSMYDLDGNGYISREEMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFRQMDTNNDGKLSLEEFIRGAKSDPSIVRLLQCDPSSASQF

Target ORF information:

RefSeq Version	XM_017001118.1
Organism	Homo sapiens(human)
Definition	Homo sapiens hippocalcin (HPCA), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017001118.1

ORF Insert Sequence:

ATGGGCAAGC AGAACAGCAA GCTGCGGCCC GAGATGTTGC AGGACCTGCG AGAGAACACA 
GAGTTCTCAG AGCTGGAGCT GCAGGAGTGG TACAAGGGCT TCCTCAAGGA CTGCCCCACA 
GGAATCCTCA ATGTGGATGA GTTCAAGAAG ATCTACGCCA ACTTCTTTCC CTATGGTGAC 
GCCTCCAAGT TTGCCGAGCA CGTCTTCCGC ACCTTTGACA CCAACAGCGA TGGCACCATA 
GACTTTCGGG AGTTCATCAT TGCGCTGAGC GTGACCTCGC GCGGCCGCCT GGAGCAGAAG 
CTCATGTGGG CCTTCAGCAT GTATGACCTG GACGGCAACG GCTACATCAG CCGGGAGGAG 
ATGCTGGAGA TCGTGCAGGC CATTTACAAG ATGGTTTCGT CCGTGATGAA GATGCCGGAG 
GACGAGTCGA CCCCGGAAAA GAGGACTGAG AAAATCTTCC GCCAAATGGA CACAAACAAC 
GACGGCAAGC TGTCCTTGGA GGAGTTCATC CGCGGGGCCA AAAGCGACCC GTCCATCGTG 
CGTCTGCTGC AGTGCGACCC CAGCAGCGCC TCCCAGTTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HPCA ( XM_005270792.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005270849.1 Homo sapiens hippocalcin (HPCA), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu29412
Clone ID Related Accession (Same CDS sequence)	XM_017001118.1 , XM_005270792.3 , NM_002143.3 , XM_005270792.2 , NM_002143.2 , XM_017001118.2
Accession Version	XM_005270792.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	neuron-specific calcium-binding protein hippocalcin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005270792.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCAAGC AGAACAGCAA GCTGCGGCCC GAGATGTTGC AGGACCTGCG AGAGAACACA 
GAGTTCTCAG AGCTGGAGCT GCAGGAGTGG TACAAGGGCT TCCTCAAGGA CTGCCCCACA 
GGAATCCTCA ATGTGGATGA GTTCAAGAAG ATCTACGCCA ACTTCTTTCC CTATGGTGAC 
GCCTCCAAGT TTGCCGAGCA CGTCTTCCGC ACCTTTGACA CCAACAGCGA TGGCACCATA 
GACTTTCGGG AGTTCATCAT TGCGCTGAGC GTGACCTCGC GCGGCCGCCT GGAGCAGAAG 
CTCATGTGGG CCTTCAGCAT GTATGACCTG GACGGCAACG GCTACATCAG CCGGGAGGAG 
ATGCTGGAGA TCGTGCAGGC CATTTACAAG ATGGTTTCGT CCGTGATGAA GATGCCGGAG 
GACGAGTCGA CCCCGGAAAA GAGGACTGAG AAAATCTTCC GCCAAATGGA CACAAACAAC 
GACGGCAAGC TGTCCTTGGA GGAGTTCATC CGCGGGGCCA AAAGCGACCC GTCCATCGTG 
CGTCTGCTGC AGTGCGACCC CAGCAGCGCC TCCCAGTTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005270849.1
CDS	177..758
Translation	MGKQNSKLRPEMLQDLRENTEFSELELQEWYKGFLKDCPTGILNVDEFKKIYANFFPYGDASKFAEHVFRTFDTNSDGTIDFREFIIALSVTSRGRLEQKLMWAFSMYDLDGNGYISREEMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFRQMDTNNDGKLSLEEFIRGAKSDPSIVRLLQCDPSSASQF

Target ORF information:

RefSeq Version	XM_005270792.3
Organism	Homo sapiens(human)
Definition	Homo sapiens hippocalcin (HPCA), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005270792.3

ORF Insert Sequence:

ATGGGCAAGC AGAACAGCAA GCTGCGGCCC GAGATGTTGC AGGACCTGCG AGAGAACACA 
GAGTTCTCAG AGCTGGAGCT GCAGGAGTGG TACAAGGGCT TCCTCAAGGA CTGCCCCACA 
GGAATCCTCA ATGTGGATGA GTTCAAGAAG ATCTACGCCA ACTTCTTTCC CTATGGTGAC 
GCCTCCAAGT TTGCCGAGCA CGTCTTCCGC ACCTTTGACA CCAACAGCGA TGGCACCATA 
GACTTTCGGG AGTTCATCAT TGCGCTGAGC GTGACCTCGC GCGGCCGCCT GGAGCAGAAG 
CTCATGTGGG CCTTCAGCAT GTATGACCTG GACGGCAACG GCTACATCAG CCGGGAGGAG 
ATGCTGGAGA TCGTGCAGGC CATTTACAAG ATGGTTTCGT CCGTGATGAA GATGCCGGAG 
GACGAGTCGA CCCCGGAAAA GAGGACTGAG AAAATCTTCC GCCAAATGGA CACAAACAAC 
GACGGCAAGC TGTCCTTGGA GGAGTTCATC CGCGGGGCCA AAAGCGACCC GTCCATCGTG 
CGTCTGCTGC AGTGCGACCC CAGCAGCGCC TCCCAGTTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HPCA ( XM_005270792.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005270849.1 Homo sapiens hippocalcin (HPCA), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu29412
Clone ID Related Accession (Same CDS sequence)	XM_017001118.1 , XM_005270792.3 , NM_002143.3 , XM_005270792.2 , NM_002143.2 , XM_017001118.2
Accession Version	XM_005270792.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	neuron-specific calcium-binding protein hippocalcin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005270792.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCAAGC AGAACAGCAA GCTGCGGCCC GAGATGTTGC AGGACCTGCG AGAGAACACA 
GAGTTCTCAG AGCTGGAGCT GCAGGAGTGG TACAAGGGCT TCCTCAAGGA CTGCCCCACA 
GGAATCCTCA ATGTGGATGA GTTCAAGAAG ATCTACGCCA ACTTCTTTCC CTATGGTGAC 
GCCTCCAAGT TTGCCGAGCA CGTCTTCCGC ACCTTTGACA CCAACAGCGA TGGCACCATA 
GACTTTCGGG AGTTCATCAT TGCGCTGAGC GTGACCTCGC GCGGCCGCCT GGAGCAGAAG 
CTCATGTGGG CCTTCAGCAT GTATGACCTG GACGGCAACG GCTACATCAG CCGGGAGGAG 
ATGCTGGAGA TCGTGCAGGC CATTTACAAG ATGGTTTCGT CCGTGATGAA GATGCCGGAG 
GACGAGTCGA CCCCGGAAAA GAGGACTGAG AAAATCTTCC GCCAAATGGA CACAAACAAC 
GACGGCAAGC TGTCCTTGGA GGAGTTCATC CGCGGGGCCA AAAGCGACCC GTCCATCGTG 
CGTCTGCTGC AGTGCGACCC CAGCAGCGCC TCCCAGTTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005270849.1
CDS	177..758
Translation	MGKQNSKLRPEMLQDLRENTEFSELELQEWYKGFLKDCPTGILNVDEFKKIYANFFPYGDASKFAEHVFRTFDTNSDGTIDFREFIIALSVTSRGRLEQKLMWAFSMYDLDGNGYISREEMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFRQMDTNNDGKLSLEEFIRGAKSDPSIVRLLQCDPSSASQF

Target ORF information:

RefSeq Version	XM_005270792.2
Organism	Homo sapiens(human)
Definition	Homo sapiens hippocalcin (HPCA), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005270792.2

ORF Insert Sequence:

ATGGGCAAGC AGAACAGCAA GCTGCGGCCC GAGATGTTGC AGGACCTGCG AGAGAACACA 
GAGTTCTCAG AGCTGGAGCT GCAGGAGTGG TACAAGGGCT TCCTCAAGGA CTGCCCCACA 
GGAATCCTCA ATGTGGATGA GTTCAAGAAG ATCTACGCCA ACTTCTTTCC CTATGGTGAC 
GCCTCCAAGT TTGCCGAGCA CGTCTTCCGC ACCTTTGACA CCAACAGCGA TGGCACCATA 
GACTTTCGGG AGTTCATCAT TGCGCTGAGC GTGACCTCGC GCGGCCGCCT GGAGCAGAAG 
CTCATGTGGG CCTTCAGCAT GTATGACCTG GACGGCAACG GCTACATCAG CCGGGAGGAG 
ATGCTGGAGA TCGTGCAGGC CATTTACAAG ATGGTTTCGT CCGTGATGAA GATGCCGGAG 
GACGAGTCGA CCCCGGAAAA GAGGACTGAG AAAATCTTCC GCCAAATGGA CACAAACAAC 
GACGGCAAGC TGTCCTTGGA GGAGTTCATC CGCGGGGCCA AAAGCGACCC GTCCATCGTG 
CGTCTGCTGC AGTGCGACCC CAGCAGCGCC TCCCAGTTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HPCA ( XM_017001118.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016856607.1 Homo sapiens hippocalcin (HPCA), transcript variant X2, mRNA.

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CloneID	OHu29412
Clone ID Related Accession (Same CDS sequence)	XM_017001118.1 , XM_005270792.3 , NM_002143.3 , XM_005270792.2 , NM_002143.2 , XM_017001118.2
Accession Version	XM_017001118.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	neuron-specific calcium-binding protein hippocalcin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017001118.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCAAGC AGAACAGCAA GCTGCGGCCC GAGATGTTGC AGGACCTGCG AGAGAACACA 
GAGTTCTCAG AGCTGGAGCT GCAGGAGTGG TACAAGGGCT TCCTCAAGGA CTGCCCCACA 
GGAATCCTCA ATGTGGATGA GTTCAAGAAG ATCTACGCCA ACTTCTTTCC CTATGGTGAC 
GCCTCCAAGT TTGCCGAGCA CGTCTTCCGC ACCTTTGACA CCAACAGCGA TGGCACCATA 
GACTTTCGGG AGTTCATCAT TGCGCTGAGC GTGACCTCGC GCGGCCGCCT GGAGCAGAAG 
CTCATGTGGG CCTTCAGCAT GTATGACCTG GACGGCAACG GCTACATCAG CCGGGAGGAG 
ATGCTGGAGA TCGTGCAGGC CATTTACAAG ATGGTTTCGT CCGTGATGAA GATGCCGGAG 
GACGAGTCGA CCCCGGAAAA GAGGACTGAG AAAATCTTCC GCCAAATGGA CACAAACAAC 
GACGGCAAGC TGTCCTTGGA GGAGTTCATC CGCGGGGCCA AAAGCGACCC GTCCATCGTG 
CGTCTGCTGC AGTGCGACCC CAGCAGCGCC TCCCAGTTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016856607.1
CDS	513..1094
Translation	MGKQNSKLRPEMLQDLRENTEFSELELQEWYKGFLKDCPTGILNVDEFKKIYANFFPYGDASKFAEHVFRTFDTNSDGTIDFREFIIALSVTSRGRLEQKLMWAFSMYDLDGNGYISREEMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFRQMDTNNDGKLSLEEFIRGAKSDPSIVRLLQCDPSSASQF

Target ORF information:

RefSeq Version	XM_017001118.2
Organism	Homo sapiens(human)
Definition	Homo sapiens hippocalcin (HPCA), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017001118.2

ORF Insert Sequence:

ATGGGCAAGC AGAACAGCAA GCTGCGGCCC GAGATGTTGC AGGACCTGCG AGAGAACACA 
GAGTTCTCAG AGCTGGAGCT GCAGGAGTGG TACAAGGGCT TCCTCAAGGA CTGCCCCACA 
GGAATCCTCA ATGTGGATGA GTTCAAGAAG ATCTACGCCA ACTTCTTTCC CTATGGTGAC 
GCCTCCAAGT TTGCCGAGCA CGTCTTCCGC ACCTTTGACA CCAACAGCGA TGGCACCATA 
GACTTTCGGG AGTTCATCAT TGCGCTGAGC GTGACCTCGC GCGGCCGCCT GGAGCAGAAG 
CTCATGTGGG CCTTCAGCAT GTATGACCTG GACGGCAACG GCTACATCAG CCGGGAGGAG 
ATGCTGGAGA TCGTGCAGGC CATTTACAAG ATGGTTTCGT CCGTGATGAA GATGCCGGAG 
GACGAGTCGA CCCCGGAAAA GAGGACTGAG AAAATCTTCC GCCAAATGGA CACAAACAAC 
GACGGCAAGC TGTCCTTGGA GGAGTTCATC CGCGGGGCCA AAAGCGACCC GTCCATCGTG 
CGTCTGCTGC AGTGCGACCC CAGCAGCGCC TCCCAGTTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia.
Human molecular genetics26(13)2426-2435(2017 07)
Helassa N,Antonyuk SV,Lian LY,Haynes LP,Burgoyne RD

DYT2 screening in early-onset isolated dystonia.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society21(2)269-271(2017 Mar)
Carecchio M,Reale C,Invernizzi F,Monti V,Petrucci S,Ginevrino M,Morgante F,Zorzi G,Zibordi F,Bentivoglio AR,Valente EM,Nardocci N,Garavaglia B

HPCA-related dystonia: Too rare to be found?
Movement disorders : official journal of the Movement Disorder Society31(7)1071(2016 Jul)
Dobri?i? V,Kresojevi? N,Marjanovi? A,Tomi? A,Svetel M,Novakovi? I,Kosti? VS

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HPCA cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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