HBQ1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HBQ1
Entrez Gene ID	3049
Full Name	hemoglobin subunit theta 1
Synonyms	HBQ
General protein information	Preferred Names hemoglobin subunit theta 1 Names hemoglobin subunit theta-1 hemoglobin theta-1 chain hemoglobin, theta 1 theta-1-globin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p13.3
Summary	Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-2 -pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue. [provided by RefSeq, Jul 2008].
Disorder MIM:	142240

mRNA and Protein(s)

mRNA	Protein	Name
NM_005331.5	NP_005322.1	hemoglobin subunit theta-1
NM_005331.4	NP_005322.1	hemoglobin subunit theta-1

Pathways from BioSystems

Homologies

Homo sapiens (human)	HBQ1	NP_005322.1
	HBQ1	XP_002802384.1
Mus musculus (house mouse)	Hbq1b	NP_001029153.1
Rattus norvegicus (Norway rat)	Hbq1b	XP_002727804.2
Bos taurus (cattle)	HBQ1	NP_001073802.1

Gene Ontology
Bibliography

Related articles in PubMed

[Molecular characterization of two new mutations of ?? thalassemia in two Spanish families (mutation --(ED) and --(GP))].
Villegas A, Ropero P, Anguita E, Hern?ndez A, Polo M, Ata?lfo Gonz?lez F
Medicina clinica136(15)674-7(2011 May)

A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter.
De Gobbi M, Viprakasit V, Hughes JR, Fisher C, Buckle VJ, Ayyub H, Gibbons RJ, Vernimmen D, Yoshinaga Y, de Jong P, Cheng JF, Rubin EM, Wood WG, Bowden D, Higgs DR
Science (New York, N.Y.)312(5777)1215-7(2006 May)

Molecular diagnosis of inherited disorders: lessons from hemoglobinopathies.
Patrinos GP, Kollia P, Papadakis MN
Human mutation26(5)399-412(2005 Nov)

Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.
Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR
Human molecular genetics10(4)339-52(2001 Feb)

The multiple functions of hemoglobin.
Giardina B, Messana I, Scatena R, Castagnola M
Critical reviews in biochemistry and molecular biology30(3)165-96(1995)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

2 new Spanish alpha-thalassemia mutations were found. In both mutations, both alpha genes were deleted, the gene theta; and the region HS40.
Title: [Molecular characterization of two new mutations of ?? thalassemia in two Spanish families (mutation --(ED) and --(GP))].

The following HBQ1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HBQ1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25695	NM_005331.5 Latest version!	Homo sapiens hemoglobin subunit theta 1 (HBQ1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu25695	NM_005331.4	Homo sapiens hemoglobin subunit theta 1 (HBQ1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HBQ1 ( NM_005331.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_005322.1 Homo sapiens hemoglobin subunit theta 1 (HBQ1), mRNA.

Price & Availability↑

CloneID	OHu25695
Clone ID Related Accession (Same CDS sequence)	NM_005331.5 , NM_005331.4
Accession Version	NM_005331.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	hemoglobin subunit theta-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z84721.1 and BC056686.1. On Nov 22, 2018 this sequence version replaced NM_005331.4. ##Evidence-Data-START## Transcript exon combination :: BC056686.1, CD580449.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000199708.3/ ENSP00000199708.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGCTGT CCGCGGAGGA CCGGGCGCTG GTGCGCGCCC TGTGGAAGAA GCTGGGCAGC 
AACGTCGGCG TCTACACGAC AGAGGCCCTG GAAAGGACCT TCCTGGCTTT CCCCGCCACG 
AAGACCTACT TCTCCCACCT GGACCTGAGC CCCGGCTCCT CACAAGTCAG AGCCCACGGC 
CAGAAGGTGG CGGACGCGCT GAGCCTCGCC GTGGAGCGCC TGGACGACCT ACCCCACGCG 
CTGTCCGCGC TGAGCCACCT GCACGCGTGC CAGCTGCGAG TGGACCCGGC CAGCTTCCAG 
CTCCTGGGCC ACTGCCTGCT GGTAACCCTC GCCCGGCACT ACCCCGGAGA CTTCAGCCCC 
GCGCTGCAGG CGTCGCTGGA CAAGTTCCTG AGCCACGTTA TCTCGGCGCT GGTTTCCGAG 
TACCGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005322.1
CDS	29..457
Translation	MALSAEDRALVRALWKKLGSNVGVYTTEALERTFLAFPATKTYFSHLDLSPGSSQVRAHGQKVADALSLAVERLDDLPHALSALSHLHACQLRVDPASFQLLGHCLLVTLARHYPGDFSPALQASLDKFLSHVISALVSEYR

Target ORF information:

RefSeq Version	NM_005331.5
Organism	Homo sapiens(human)
Definition	Homo sapiens hemoglobin subunit theta 1 (HBQ1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005331.5

ORF Insert Sequence:

ATGGCGCTGT CCGCGGAGGA CCGGGCGCTG GTGCGCGCCC TGTGGAAGAA GCTGGGCAGC 
AACGTCGGCG TCTACACGAC AGAGGCCCTG GAAAGGACCT TCCTGGCTTT CCCCGCCACG 
AAGACCTACT TCTCCCACCT GGACCTGAGC CCCGGCTCCT CACAAGTCAG AGCCCACGGC 
CAGAAGGTGG CGGACGCGCT GAGCCTCGCC GTGGAGCGCC TGGACGACCT ACCCCACGCG 
CTGTCCGCGC TGAGCCACCT GCACGCGTGC CAGCTGCGAG TGGACCCGGC CAGCTTCCAG 
CTCCTGGGCC ACTGCCTGCT GGTAACCCTC GCCCGGCACT ACCCCGGAGA CTTCAGCCCC 
GCGCTGCAGG CGTCGCTGGA CAAGTTCCTG AGCCACGTTA TCTCGGCGCT GGTTTCCGAG 
TACCGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HBQ1 ( NM_005331.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005322.1 Homo sapiens hemoglobin subunit theta 1 (HBQ1), mRNA.

Price & Availability↑

CloneID	OHu25695
Clone ID Related Accession (Same CDS sequence)	NM_005331.5 , NM_005331.4
Accession Version	NM_005331.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	hemoglobin subunit theta-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z84721.1 and BC056686.1. This sequence is a reference standard in the RefSeqGene project. On Dec 3, 2010 this sequence version replaced NM_005331.3. ##Evidence-Data-START## Transcript exon combination :: BC056686.1, CD580449.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCGCTGT CCGCGGAGGA CCGGGCGCTG GTGCGCGCCC TGTGGAAGAA GCTGGGCAGC 
AACGTCGGCG TCTACACGAC AGAGGCCCTG GAAAGGACCT TCCTGGCTTT CCCCGCCACG 
AAGACCTACT TCTCCCACCT GGACCTGAGC CCCGGCTCCT CACAAGTCAG AGCCCACGGC 
CAGAAGGTGG CGGACGCGCT GAGCCTCGCC GTGGAGCGCC TGGACGACCT ACCCCACGCG 
CTGTCCGCGC TGAGCCACCT GCACGCGTGC CAGCTGCGAG TGGACCCGGC CAGCTTCCAG 
CTCCTGGGCC ACTGCCTGCT GGTAACCCTC GCCCGGCACT ACCCCGGAGA CTTCAGCCCC 
GCGCTGCAGG CGTCGCTGGA CAAGTTCCTG AGCCACGTTA TCTCGGCGCT GGTTTCCGAG 
TACCGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005322.1
CDS	154..582
Translation	MALSAEDRALVRALWKKLGSNVGVYTTEALERTFLAFPATKTYFSHLDLSPGSSQVRAHGQKVADALSLAVERLDDLPHALSALSHLHACQLRVDPASFQLLGHCLLVTLARHYPGDFSPALQASLDKFLSHVISALVSEYR

Target ORF information:

RefSeq Version	NM_005331.4
Organism	Homo sapiens(human)
Definition	Homo sapiens hemoglobin subunit theta 1 (HBQ1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005331.4

ORF Insert Sequence:

ATGGCGCTGT CCGCGGAGGA CCGGGCGCTG GTGCGCGCCC TGTGGAAGAA GCTGGGCAGC 
AACGTCGGCG TCTACACGAC AGAGGCCCTG GAAAGGACCT TCCTGGCTTT CCCCGCCACG 
AAGACCTACT TCTCCCACCT GGACCTGAGC CCCGGCTCCT CACAAGTCAG AGCCCACGGC 
CAGAAGGTGG CGGACGCGCT GAGCCTCGCC GTGGAGCGCC TGGACGACCT ACCCCACGCG 
CTGTCCGCGC TGAGCCACCT GCACGCGTGC CAGCTGCGAG TGGACCCGGC CAGCTTCCAG 
CTCCTGGGCC ACTGCCTGCT GGTAACCCTC GCCCGGCACT ACCCCGGAGA CTTCAGCCCC 
GCGCTGCAGG CGTCGCTGGA CAAGTTCCTG AGCCACGTTA TCTCGGCGCT GGTTTCCGAG 
TACCGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

[Molecular characterization of two new mutations of ?? thalassemia in two Spanish families (mutation --(ED) and --(GP))].
Medicina clinica136(15)674-7(2011 May)
Villegas A,Ropero P,Anguita E,Hern?ndez A,Polo M,Ata?lfo Gonz?lez F

A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter.
Science (New York, N.Y.)312(5777)1215-7(2006 May)
De Gobbi M,Viprakasit V,Hughes JR,Fisher C,Buckle VJ,Ayyub H,Gibbons RJ,Vernimmen D,Yoshinaga Y,de Jong P,Cheng JF,Rubin EM,Wood WG,Bowden D,Higgs DR

Molecular diagnosis of inherited disorders: lessons from hemoglobinopathies.
Human mutation26(5)399-412(2005 Nov)
Patrinos GP,Kollia P,Papadakis MN

Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.
Human molecular genetics10(4)339-52(2001 Feb)
Daniels RJ,Peden JF,Lloyd C,Horsley SW,Clark K,Tufarelli C,Kearney L,Buckle VJ,Doggett NA,Flint J,Higgs DR

The multiple functions of hemoglobin.
Critical reviews in biochemistry and molecular biology30(3)165-96(1995)
Giardina B,Messana I,Scatena R,Castagnola M

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HBQ1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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