MAGEH1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MAGEH1
Entrez Gene ID	28986
Full Name	MAGE family member H1
Synonyms	APR-1,APR1,MAGEH
General protein information	Preferred Names MAGE family member H1 Names melanoma-associated antigen H1 apoptosis-related protein 1 melanoma antigen family H, 1 melanoma antigen family H1 restin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp11.21
Summary	This gene belongs to the non-CT (non cancer/testis) subgroup of the melanoma-associated antigen (MAGE) superfamily. The encoded protein is likely associated with apoptosis, cell cycle arrest, growth inhibition or cell differentiation. The protein may be involved in the atRA (all-trans retinoic acid) signaling through the STAT1-alpha (signal transducer and activator of transcription 1-alpha) pathway. [provided by RefSeq, Aug 2013].
Disorder MIM:	300548

mRNA and Protein(s)

mRNA	Protein	Name
NM_014061.4	NP_054780.2	melanoma-associated antigen H1
NM_014061.5	NP_054780.2	melanoma-associated antigen H1

Pathways from BioSystems

Homologies

Homo sapiens (human)	MAGEH1	NP_054780.2
Canis lupus familiaris (dog)	MAGEH1	XP_549024.1
Bos taurus (cattle)	MAGEH1	NP_001074197.1
Mus musculus (house mouse)	Mageh1	NP_076277.1
	MAGEH1	XP_001093392.1
Rattus norvegicus (Norway rat)	Mageh1	NP_001013268.1

Gene Ontology
Bibliography

Related articles in PubMed

Downregulation of MAGE family member H1 enhances hepatocellular carcinoma progression and serves as a biomarker for patient prognosis.
Wang PC, Hu ZQ, Zhou SL, Zhan H, Zhou ZJ, Luo CB, Huang XW
Future oncology (London, England)(2018 Jan)

Apoptosis-related protein-1 acts as a tumor suppressor in cholangiocarcinoma cells by inducing cell cycle arrest via downregulation of cyclin-dependent kinase subunits.
Zheng J, Li Q, Wang W, Wang Y, Fu X, Wang W, Fan L, Yan W
Oncology reports35(2)809-16(2016 Feb)

Neonatal detection of Turner syndrome by real-time PCR gene quantification of the ARSE and MAGEH1 genes.
Corr?a SC, Rocha MN, Richeti F, Kochi C, Silva E Lima LA, Magalh?es M, Longui CA
Genetics and molecular research : GMR13(4)9068-76(2014 Oct)

Genome-wide association study of smoking behaviours among Bangladeshi adults.
Argos M, Tong L, Pierce BL, Rakibuz-Zaman M, Ahmed A, Islam T, Rahman M, Paul-Brutus R, Rahaman R, Roy S, Jasmine F, Kibriya MG, Ahsan H
Journal of medical genetics51(5)327-33(2014 May)

Apoptosis related protein-1 triggers melanoma cell death via interaction with the juxtamembrane region of p75 neurotrophin receptor.
Selimovic D, Sprenger A, Hannig M, Ha?kel Y, Hassan M
Journal of cellular and molecular medicine16(2)349-61(2012 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

our data showed that Apr-1 plays a crucial role in cell proliferation by controlling cell cycle progression, implying a tumor-suppressor function of Apr-1 in cholangiocarcinoma carcinogenesis
Title: Apoptosis-related protein-1 acts as a tumor suppressor in cholangiocarcinoma cells by inducing cell cycle arrest via downregulation of cyclin-dependent kinase subunits.

Data indicate that the neonatal detection test sensitivity obtained was 95% with a positive predictive value of 1 in the analyses for both the arylsulfatase E (ARSE) and melanoma antigen family H1 (MAGEH1) genes.
Title: Neonatal detection of Turner syndrome by real-time PCR gene quantification of the ARSE and MAGEH1 genes.

The induction of APR-1 expression caused apoptosis of melanoma cells via the interaction with the juxtamembrane region of p75 neurotrophin receptor.
Title: Apoptosis related protein-1 triggers melanoma cell death via interaction with the juxtamembrane region of p75 neurotrophin receptor.

The following MAGEH1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAGEH1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21244	NM_014061.5 Latest version!	Homo sapiens MAGE family member H1 (MAGEH1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu21244	NM_014061.4	Homo sapiens MAGE family member H1 (MAGEH1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MAGEH1 ( NM_014061.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_054780.2 Homo sapiens MAGE family member H1 (MAGEH1), mRNA.

Price & Availability↑

CloneID	OHu21244
Clone ID Related Accession (Same CDS sequence)	NM_014061.4 , NM_014061.5
Accession Version	NM_014061.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 660bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-22
Organism	Homo sapiens(human)
Product	melanoma-associated antigen H1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI916425.1, AF143235.4, AA634056.1 and AI191172.1. This sequence is a reference standard in the RefSeqGene project. On Aug 2, 2013 this sequence version replaced NM_014061.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGCCTCGGG GACGAAAGAG TCGGCGCCGC CGTAATGCGA GAGCCGCAGA AGAGAACCGC 
AACAATCGCA AAATCCAGGC CTCAGAGGCC TCCGAGACCC CTATGGCCGC CTCTGTGGTA 
GCGAGCACCC CCGAAGACGA CCTGAGCGGC CCCGAGGAAG ACCCGAGCAC TCCAGAGGAG 
GCCTCTACCA CCCCTGAAGA AGCCTCGAGC ACTGCCCAAG CACAAAAGCC TTCAGTGCCC 
CGGAGCAATT TTCAGGGCAC CAAGAAAAGT CTCCTGATGT CTATATTAGC GCTCATCTTC 
ATCATGGGCA ACAGCGCCAA GGAAGCTCTG GTCTGGAAAG TGCTGGGGAA GTTAGGAATG 
CAGCCTGGAC GTCAGCACAG CATCTTTGGA GATCCGAAGA AGATCGTCAC AGAAGAGTTT 
GTGCGCAGAG GGTACCTGAT TTATAAACCG GTGCCCCGTA GCAGTCCGGT GGAGTATGAG 
TTCTTCTGGG GGCCCCGAGC ACACGTGGAA TCGAGCAAAC TGAAAGTCAT GCATTTTGTG 
GCAAGGGTTC GTAACCGATG CTCTAAAGAC TGGCCTTGTA ATTATGACTG GGATTCGGAC 
GATGATGCAG AGGTTGAGGC TATCCTCAAT TCAGGTGCTA GGGGTTATTC CGCCCCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_054780.2
CDS	287..946
Translation	MPRGRKSRRRRNARAAEENRNNRKIQASEASETPMAASVVASTPEDDLSGPEEDPSTPEEASTTPEEASSTAQAQKPSVPRSNFQGTKKSLLMSILALIFIMGNSAKEALVWKVLGKLGMQPGRQHSIFGDPKKIVTEEFVRRGYLIYKPVPRSSPVEYEFFWGPRAHVESSKLKVMHFVARVRNRCSKDWPCNYDWDSDDDAEVEAILNSGARGYSAP

Target ORF information:

RefSeq Version	NM_014061.4
Organism	Homo sapiens(human)
Definition	Homo sapiens MAGE family member H1 (MAGEH1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014061.4

ORF Insert Sequence:

ATGCCTCGGG GACGAAAGAG TCGGCGCCGC CGTAATGCGA GAGCCGCAGA AGAGAACCGC 
AACAATCGCA AAATCCAGGC CTCAGAGGCC TCCGAGACCC CTATGGCCGC CTCTGTGGTA 
GCGAGCACCC CCGAAGACGA CCTGAGCGGC CCCGAGGAAG ACCCGAGCAC TCCAGAGGAG 
GCCTCTACCA CCCCTGAAGA AGCCTCGAGC ACTGCCCAAG CACAAAAGCC TTCAGTGCCC 
CGGAGCAATT TTCAGGGCAC CAAGAAAAGT CTCCTGATGT CTATATTAGC GCTCATCTTC 
ATCATGGGCA ACAGCGCCAA GGAAGCTCTG GTCTGGAAAG TGCTGGGGAA GTTAGGAATG 
CAGCCTGGAC GTCAGCACAG CATCTTTGGA GATCCGAAGA AGATCGTCAC AGAAGAGTTT 
GTGCGCAGAG GGTACCTGAT TTATAAACCG GTGCCCCGTA GCAGTCCGGT GGAGTATGAG 
TTCTTCTGGG GGCCCCGAGC ACACGTGGAA TCGAGCAAAC TGAAAGTCAT GCATTTTGTG 
GCAAGGGTTC GTAACCGATG CTCTAAAGAC TGGCCTTGTA ATTATGACTG GGATTCGGAC 
GATGATGCAG AGGTTGAGGC TATCCTCAAT TCAGGTGCTA GGGGTTATTC CGCCCCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MAGEH1 ( NM_014061.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_054780.2 Homo sapiens MAGE family member H1 (MAGEH1), mRNA.

Price & Availability↑

CloneID	OHu21244
Clone ID Related Accession (Same CDS sequence)	NM_014061.4 , NM_014061.5
Accession Version	NM_014061.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 660bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	melanoma-associated antigen H1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF143235.4 and AA634056.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_014061.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: SRR7410570.689902.1, AF320912.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000342972.3/ ENSP00000343706.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCTCGGG GACGAAAGAG TCGGCGCCGC CGTAATGCGA GAGCCGCAGA AGAGAACCGC 
AACAATCGCA AAATCCAGGC CTCAGAGGCC TCCGAGACCC CTATGGCCGC CTCTGTGGTA 
GCGAGCACCC CCGAAGACGA CCTGAGCGGC CCCGAGGAAG ACCCGAGCAC TCCAGAGGAG 
GCCTCTACCA CCCCTGAAGA AGCCTCGAGC ACTGCCCAAG CACAAAAGCC TTCAGTGCCC 
CGGAGCAATT TTCAGGGCAC CAAGAAAAGT CTCCTGATGT CTATATTAGC GCTCATCTTC 
ATCATGGGCA ACAGCGCCAA GGAAGCTCTG GTCTGGAAAG TGCTGGGGAA GTTAGGAATG 
CAGCCTGGAC GTCAGCACAG CATCTTTGGA GATCCGAAGA AGATCGTCAC AGAAGAGTTT 
GTGCGCAGAG GGTACCTGAT TTATAAACCG GTGCCCCGTA GCAGTCCGGT GGAGTATGAG 
TTCTTCTGGG GGCCCCGAGC ACACGTGGAA TCGAGCAAAC TGAAAGTCAT GCATTTTGTG 
GCAAGGGTTC GTAACCGATG CTCTAAAGAC TGGCCTTGTA ATTATGACTG GGATTCGGAC 
GATGATGCAG AGGTTGAGGC TATCCTCAAT TCAGGTGCTA GGGGTTATTC CGCCCCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_054780.2
CDS	249..908
Translation	MPRGRKSRRRRNARAAEENRNNRKIQASEASETPMAASVVASTPEDDLSGPEEDPSTPEEASTTPEEASSTAQAQKPSVPRSNFQGTKKSLLMSILALIFIMGNSAKEALVWKVLGKLGMQPGRQHSIFGDPKKIVTEEFVRRGYLIYKPVPRSSPVEYEFFWGPRAHVESSKLKVMHFVARVRNRCSKDWPCNYDWDSDDDAEVEAILNSGARGYSAP

Target ORF information:

RefSeq Version	NM_014061.5
Organism	Homo sapiens(human)
Definition	Homo sapiens MAGE family member H1 (MAGEH1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014061.5

ORF Insert Sequence:

ATGCCTCGGG GACGAAAGAG TCGGCGCCGC CGTAATGCGA GAGCCGCAGA AGAGAACCGC 
AACAATCGCA AAATCCAGGC CTCAGAGGCC TCCGAGACCC CTATGGCCGC CTCTGTGGTA 
GCGAGCACCC CCGAAGACGA CCTGAGCGGC CCCGAGGAAG ACCCGAGCAC TCCAGAGGAG 
GCCTCTACCA CCCCTGAAGA AGCCTCGAGC ACTGCCCAAG CACAAAAGCC TTCAGTGCCC 
CGGAGCAATT TTCAGGGCAC CAAGAAAAGT CTCCTGATGT CTATATTAGC GCTCATCTTC 
ATCATGGGCA ACAGCGCCAA GGAAGCTCTG GTCTGGAAAG TGCTGGGGAA GTTAGGAATG 
CAGCCTGGAC GTCAGCACAG CATCTTTGGA GATCCGAAGA AGATCGTCAC AGAAGAGTTT 
GTGCGCAGAG GGTACCTGAT TTATAAACCG GTGCCCCGTA GCAGTCCGGT GGAGTATGAG 
TTCTTCTGGG GGCCCCGAGC ACACGTGGAA TCGAGCAAAC TGAAAGTCAT GCATTTTGTG 
GCAAGGGTTC GTAACCGATG CTCTAAAGAC TGGCCTTGTA ATTATGACTG GGATTCGGAC 
GATGATGCAG AGGTTGAGGC TATCCTCAAT TCAGGTGCTA GGGGTTATTC CGCCCCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Downregulation of MAGE family member H1 enhances hepatocellular carcinoma progression and serves as a biomarker for patient prognosis.
Future oncology (London, England)(2018 Jan)
Wang PC,Hu ZQ,Zhou SL,Zhan H,Zhou ZJ,Luo CB,Huang XW

Apoptosis-related protein-1 acts as a tumor suppressor in cholangiocarcinoma cells by inducing cell cycle arrest via downregulation of cyclin-dependent kinase subunits.
Oncology reports35(2)809-16(2016 Feb)
Zheng J,Li Q,Wang W,Wang Y,Fu X,Wang W,Fan L,Yan W

Neonatal detection of Turner syndrome by real-time PCR gene quantification of the ARSE and MAGEH1 genes.
Genetics and molecular research : GMR13(4)9068-76(2014 Oct)
Corr?a SC,Rocha MN,Richeti F,Kochi C,Silva E Lima LA,Magalh?es M,Longui CA

Genome-wide association study of smoking behaviours among Bangladeshi adults.
Journal of medical genetics51(5)327-33(2014 May)
Argos M,Tong L,Pierce BL,Rakibuz-Zaman M,Ahmed A,Islam T,Rahman M,Paul-Brutus R,Rahaman R,Roy S,Jasmine F,Kibriya MG,Ahsan H

Apoptosis related protein-1 triggers melanoma cell death via interaction with the juxtamembrane region of p75 neurotrophin receptor.
Journal of cellular and molecular medicine16(2)349-61(2012 Feb)
Selimovic D,Sprenger A,Hannig M,Ha?kel Y,Hassan M