MRPS28 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MRPS28
Entrez Gene ID	28957
Full Name	mitochondrial ribosomal protein S28
Synonyms	HSPC007,MRP-S28,MRP-S35,MRPS35
General protein information	Preferred Names mitochondrial ribosomal protein S28 Names 28S ribosomal protein S28, mitochondrial 28S ribosomal protein S35, mitochondrial S28mt S35mt mitochondrial 28S ribosomal protein S35 mitochondrial small ribosomal subunit protein bS1m
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q21.13
Summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has been called mitochondrial ribosomal protein S35 in the literature. [provided by RefSeq, Jul 2008].
Disorder MIM:	611990

mRNA and Protein(s)

mRNA	Protein	Name
NM_014018.3	NP_054737.1	28S ribosomal protein S28, mitochondrial
NM_014018.2	NP_054737.1	28S ribosomal protein S28, mitochondrial

Pathways from BioSystems

Homologies

Homo sapiens (human)	MRPS28	NP_054737.1
Canis lupus familiaris (dog)	MRPS28	XP_535109.2
Danio rerio (zebrafish)	mrps28	NP_001071258.1
Drosophila melanogaster (fruit fly)	mRpS28	NP_523785.2
	MRPS28	XP_001090591.1
Bos taurus (cattle)	MRPS28	NP_001039866.1
Xenopus tropicalis (tropical clawed frog)	LOC100124857	NP_001096286.1
Pan troglodytes (chimpanzee)	MRPS28	XP_519824.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006650	XP_316680.3
Mus musculus (house mouse)	Mrps28	NP_079710.3

Gene Ontology
Bibliography

Related articles in PubMed

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.
Zhang Z, Gerstein M
Genomics81(5)468-80(2003 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following MRPS28 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MRPS28 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13121	NM_014018.3 Latest version!	Homo sapiens mitochondrial ribosomal protein S28 (MRPS28), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu13121	NM_014018.2	Homo sapiens mitochondrial ribosomal protein S28 (MRPS28), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MRPS28 ( NM_014018.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_054737.1 Homo sapiens mitochondrial ribosomal protein S28 (MRPS28), mRNA.

Price & Availability↑

CloneID	OHu13121
Clone ID Related Accession (Same CDS sequence)	NM_014018.3 , NM_014018.2
Accession Version	NM_014018.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 564bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Homo sapiens(human)
Product	28S ribosomal protein S28, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC010150.1 and AC036214.9. On Nov 22, 2018 this sequence version replaced NM_014018.2. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.75156.1, SRR5189658.31207.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000276585.9/ ENSP00000276585.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCGC TGTGTCGGAC CCGTGCTGTG GCTGCCGAGA GCCATTTTCT GCGAGTGTTT 
CTCTTCTTCA GGCCCTTTCG GGGTGTAGGC ACTGAGAGTG GATCCGAAAG TGGTAGTTCC 
AATGCCAAGG AGCCTAAGAC GCGCGCAGGC GGTTTCGCGA GCGCGTTGGA GCGGCACTCG 
GAGCTTCTAC AGAAGGTGGA GCCCCTACAG AAGGGTTCTC CAAAAAATGT GGAATCCTTT 
GCATCTATGC TGAGACATTC TCCTCTTACA CAGATGGGAC CTGCAAAGGA TAAACTGGTC 
ATTGGACGGA TCTTTCATAT TGTGGAGAAT GATCTGTACA TAGATTTTGG TGGAAAGTTT 
CATTGTGTAT GTAGAAGACC AGAAGTGGAT GGAGAGAAAT ACCAGAAAGG AACCAGGGTC 
CGGTTGCGGC TATTAGATCT TGAACTTACG TCTAGGTTCC TGGGAGCAAC AACAGATACA 
ACTGTACTAG AGGCTAATGC AGTTCTCTTG GGAATCCAGG AGAGTAAAGA CTCAAGATCG 
AAAGAAGAAC ATCATGAAAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_054737.1
CDS	12..575
Translation	MAALCRTRAVAAESHFLRVFLFFRPFRGVGTESGSESGSSNAKEPKTRAGGFASALERHSELLQKVEPLQKGSPKNVESFASMLRHSPLTQMGPAKDKLVIGRIFHIVENDLYIDFGGKFHCVCRRPEVDGEKYQKGTRVRLRLLDLELTSRFLGATTDTTVLEANAVLLGIQESKDSRSKEEHHEK

Target ORF information:

RefSeq Version	NM_014018.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein S28 (MRPS28), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014018.3

ORF Insert Sequence:

ATGGCGGCGC TGTGTCGGAC CCGTGCTGTG GCTGCCGAGA GCCATTTTCT GCGAGTGTTT 
CTCTTCTTCA GGCCCTTTCG GGGTGTAGGC ACTGAGAGTG GATCCGAAAG TGGTAGTTCC 
AATGCCAAGG AGCCTAAGAC GCGCGCAGGC GGTTTCGCGA GCGCGTTGGA GCGGCACTCG 
GAGCTTCTAC AGAAGGTGGA GCCCCTACAG AAGGGTTCTC CAAAAAATGT GGAATCCTTT 
GCATCTATGC TGAGACATTC TCCTCTTACA CAGATGGGAC CTGCAAAGGA TAAACTGGTC 
ATTGGACGGA TCTTTCATAT TGTGGAGAAT GATCTGTACA TAGATTTTGG TGGAAAGTTT 
CATTGTGTAT GTAGAAGACC AGAAGTGGAT GGAGAGAAAT ACCAGAAAGG AACCAGGGTC 
CGGTTGCGGC TATTAGATCT TGAACTTACG TCTAGGTTCC TGGGAGCAAC AACAGATACA 
ACTGTACTAG AGGCTAATGC AGTTCTCTTG GGAATCCAGG AGAGTAAAGA CTCAAGATCG 
AAAGAAGAAC ATCATGAAAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPS28 ( NM_014018.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_054737.1 Homo sapiens mitochondrial ribosomal protein S28 (MRPS28), mRNA.

Price & Availability↑

CloneID	OHu13121
Clone ID Related Accession (Same CDS sequence)	NM_014018.3 , NM_014018.2
Accession Version	NM_014018.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 564bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	28S ribosomal protein S28, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC010150.1. On Nov 1, 2001 this sequence version replaced NM_014018.1. ##Evidence-Data-START## Transcript exon combination :: BC010150.1, SRR1163655.516056.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGC TGTGTCGGAC CCGTGCTGTG GCTGCCGAGA GCCATTTTCT GCGAGTGTTT 
CTCTTCTTCA GGCCCTTTCG GGGTGTAGGC ACTGAGAGTG GATCCGAAAG TGGTAGTTCC 
AATGCCAAGG AGCCTAAGAC GCGCGCAGGC GGTTTCGCGA GCGCGTTGGA GCGGCACTCG 
GAGCTTCTAC AGAAGGTGGA GCCCCTACAG AAGGGTTCTC CAAAAAATGT GGAATCCTTT 
GCATCTATGC TGAGACATTC TCCTCTTACA CAGATGGGAC CTGCAAAGGA TAAACTGGTC 
ATTGGACGGA TCTTTCATAT TGTGGAGAAT GATCTGTACA TAGATTTTGG TGGAAAGTTT 
CATTGTGTAT GTAGAAGACC AGAAGTGGAT GGAGAGAAAT ACCAGAAAGG AACCAGGGTC 
CGGTTGCGGC TATTAGATCT TGAACTTACG TCTAGGTTCC TGGGAGCAAC AACAGATACA 
ACTGTACTAG AGGCTAATGC AGTTCTCTTG GGAATCCAGG AGAGTAAAGA CTCAAGATCG 
AAAGAAGAAC ATCATGAAAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_054737.1
CDS	24..587
Translation	MAALCRTRAVAAESHFLRVFLFFRPFRGVGTESGSESGSSNAKEPKTRAGGFASALERHSELLQKVEPLQKGSPKNVESFASMLRHSPLTQMGPAKDKLVIGRIFHIVENDLYIDFGGKFHCVCRRPEVDGEKYQKGTRVRLRLLDLELTSRFLGATTDTTVLEANAVLLGIQESKDSRSKEEHHEK

Target ORF information:

RefSeq Version	NM_014018.2
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein S28 (MRPS28), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014018.2

ORF Insert Sequence:

ATGGCGGCGC TGTGTCGGAC CCGTGCTGTG GCTGCCGAGA GCCATTTTCT GCGAGTGTTT 
CTCTTCTTCA GGCCCTTTCG GGGTGTAGGC ACTGAGAGTG GATCCGAAAG TGGTAGTTCC 
AATGCCAAGG AGCCTAAGAC GCGCGCAGGC GGTTTCGCGA GCGCGTTGGA GCGGCACTCG 
GAGCTTCTAC AGAAGGTGGA GCCCCTACAG AAGGGTTCTC CAAAAAATGT GGAATCCTTT 
GCATCTATGC TGAGACATTC TCCTCTTACA CAGATGGGAC CTGCAAAGGA TAAACTGGTC 
ATTGGACGGA TCTTTCATAT TGTGGAGAAT GATCTGTACA TAGATTTTGG TGGAAAGTTT 
CATTGTGTAT GTAGAAGACC AGAAGTGGAT GGAGAGAAAT ACCAGAAAGG AACCAGGGTC 
CGGTTGCGGC TATTAGATCT TGAACTTACG TCTAGGTTCC TGGGAGCAAC AACAGATACA 
ACTGTACTAG AGGCTAATGC AGTTCTCTTG GGAATCCAGG AGAGTAAAGA CTCAAGATCG 
AAAGAAGAAC ATCATGAAAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.
Genomics81(5)468-80(2003 May)
Zhang Z,Gerstein M

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MRPS28 cDNA ORF clone, Homo sapiens(human)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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