GPX7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GPX7
Entrez Gene ID	2882
Full Name	glutathione peroxidase 7
Synonyms	CL683,GPX6,GPx-7,GSHPx-7,NPGPx
General protein information	Preferred Names glutathione peroxidase 7 Names glutathione peroxidase 7 glutathione peroxidase 6 non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p32.3
Disorder MIM:	615784

mRNA and Protein(s)

mRNA	Protein	Name
NM_015696.4	NP_056511.2	glutathione peroxidase 7 precursor
NM_015696.5	NP_056511.2	glutathione peroxidase 7 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	GPX7	NP_056511.2
Pan troglodytes (chimpanzee)	GPX7	NP_001139309.1
Canis lupus familiaris (dog)	GPX7	XP_005629467.1
Bos taurus (cattle)	GPX7	NP_001094583.1
Danio rerio (zebrafish)	gpx7	NP_001018337.1
Magnaporthe oryzae (rice blast fungus)	MGG_07460	XP_003711364.1
Kluyveromyces lactis	KLLA0F06732g	XP_455385.1
Saccharomyces cerevisiae (baker's yeast)	HYR1	NP_012303.1
	GPX7	NP_001152840.1
Mus musculus (house mouse)	Gpx7	NP_077160.1
Rattus norvegicus (Norway rat)	Gpx7	NP_001100143.1
Gallus gallus (chicken)	GPX7	NP_001156717.1
Eremothecium gossypii	AGOS_AFL039C	NP_985509.1
Schizosaccharomyces pombe (fission yeast)	gpx1	NP_596146.1
Neurospora crassa	NCU09534	XP_957919.1
Xenopus tropicalis (tropical clawed frog)	gpx7	NP_001072404.1

Gene Ontology
Bibliography

Related articles in PubMed

GPX4 and GPX7 over-expression in human hepatocellular carcinoma tissues.
Guerriero E, Capone F, Accardo M, Sorice A, Costantini M, Colonna G, Castello G, Costantini S
European journal of histochemistry : EJH59(4)2540(2015 Dec)

Candidate pathway-based genetic association study of platinum and platinum-taxane related toxicity in a cohort of primary lung cancer patients.
Johnson C, Pankratz VS, Velazquez AI, Aakre JA, Loprinzi CL, Staff NP, Windebank AJ, Yang P
Journal of the neurological sciences349(1-2)124-8(2015 Feb)

Loss of glutathione peroxidase 7 promotes TNF-?-induced NF-?B activation in Barrett's carcinogenesis.
Peng DF, Hu TL, Soutto M, Belkhiri A, El-Rifai W
Carcinogenesis35(7)1620-8(2014 Jul)

Glutathione peroxidase 7 utilizes hydrogen peroxide generated by Ero1? to promote oxidative protein folding.
Wang L, Zhang L, Niu Y, Sitia R, Wang CC
Antioxidants & redox signaling20(4)545-56(2014 Feb)

Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human.
Chang YC, Yu YH, Shew JY, Lee WJ, Hwang JJ, Chen YH, Chen YR, Wei PC, Chuang LM, Lee WH
EMBO molecular medicine5(8)1165-79(2013 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

use GPX4 and GPX7 as possible markers for improving HCC diagnosis/prognosis.
Title: GPX4 and GPX7 over-expression in human hepatocellular carcinoma tissues.

SNPs most associated with Chemotherapy-induced peripheral neuropathy were in ATP-binding cassette sub-family C member 4 (ABCC4) gene.
Title: Candidate pathway-based genetic association study of platinum and platinum-taxane related toxicity in a cohort of primary lung cancer patients.

Loss of glutathione peroxidase 7 promotes TNF-alpha-induced NF-kappaB activation in Barrett's carcinogenesis.
Title: Loss of glutathione peroxidase 7 promotes TNF-?-induced NF-?B activation in Barrett's carcinogenesis.

GPx7 promotes oxidative protein folding, directly utilizing Ero1alpha-generated hydrogen peroxide in the early secretory compartment.
Title: Glutathione peroxidase 7 utilizes hydrogen peroxide generated by Ero1? to promote oxidative protein folding.

NPGPx protects against fat accumulation in mice and human via modulating ROS
Title: Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human.

The following GPX7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GPX7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23248	NM_015696.5 Latest version!	Homo sapiens glutathione peroxidase 7 (GPX7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu23248	NM_015696.4	Homo sapiens glutathione peroxidase 7 (GPX7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GPX7 ( NM_015696.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_056511.2 Homo sapiens glutathione peroxidase 7 (GPX7), mRNA.

Price & Availability↑

CloneID	OHu23248
Clone ID Related Accession (Same CDS sequence)	NM_015696.4 , NM_015696.5
Accession Version	NM_015696.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 564bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	glutathione peroxidase 7 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI550170.1, AK027683.1 and BU627166.1. On Jul 9, 2009 this sequence version replaced NM_015696.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.71100.1, AK027683.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGGCGG CGACGGTGGC AGCGGCGTGG CTGCTCCTGT GGGCTGCGGC CTGCGCGCAG 
CAGGAGCAGG ACTTCTACGA CTTCAAGGCG GTCAACATCC GGGGCAAACT GGTGTCGCTG 
GAGAAGTACC GCGGATCGGT GTCCCTGGTG GTGAATGTGG CCAGCGAGTG CGGCTTCACA 
GACCAGCACT ACCGAGCCCT GCAGCAGCTG CAGCGAGACC TGGGCCCCCA CCACTTTAAC 
GTGCTCGCCT TCCCCTGCAA CCAGTTTGGC CAACAGGAGC CTGACAGCAA CAAGGAGATT 
GAGAGCTTTG CCCGCCGCAC CTACAGTGTC TCATTCCCCA TGTTTAGCAA GATTGCAGTC 
ACCGGTACTG GTGCCCATCC TGCCTTCAAG TACCTGGCCC AGACTTCTGG GAAGGAGCCC 
ACCTGGAACT TCTGGAAGTA CCTAGTAGCC CCAGATGGAA AGGTGGTAGG GGCTTGGGAC 
CCAACTGTGT CAGTGGAGGA GGTCAGACCC CAGATCACAG CGCTCGTGAG GAAGCTCATC 
CTACTGAAGC GAGAAGACTT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056511.2
CDS	40..603
Translation	MVAATVAAAWLLLWAAACAQQEQDFYDFKAVNIRGKLVSLEKYRGSVSLVVNVASECGFTDQHYRALQQLQRDLGPHHFNVLAFPCNQFGQQEPDSNKEIESFARRTYSVSFPMFSKIAVTGTGAHPAFKYLAQTSGKEPTWNFWKYLVAPDGKVVGAWDPTVSVEEVRPQITALVRKLILLKREDL

Target ORF information:

RefSeq Version	NM_015696.4
Organism	Homo sapiens(human)
Definition	Homo sapiens glutathione peroxidase 7 (GPX7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015696.4

ORF Insert Sequence:

ATGGTGGCGG CGACGGTGGC AGCGGCGTGG CTGCTCCTGT GGGCTGCGGC CTGCGCGCAG 
CAGGAGCAGG ACTTCTACGA CTTCAAGGCG GTCAACATCC GGGGCAAACT GGTGTCGCTG 
GAGAAGTACC GCGGATCGGT GTCCCTGGTG GTGAATGTGG CCAGCGAGTG CGGCTTCACA 
GACCAGCACT ACCGAGCCCT GCAGCAGCTG CAGCGAGACC TGGGCCCCCA CCACTTTAAC 
GTGCTCGCCT TCCCCTGCAA CCAGTTTGGC CAACAGGAGC CTGACAGCAA CAAGGAGATT 
GAGAGCTTTG CCCGCCGCAC CTACAGTGTC TCATTCCCCA TGTTTAGCAA GATTGCAGTC 
ACCGGTACTG GTGCCCATCC TGCCTTCAAG TACCTGGCCC AGACTTCTGG GAAGGAGCCC 
ACCTGGAACT TCTGGAAGTA CCTAGTAGCC CCAGATGGAA AGGTGGTAGG GGCTTGGGAC 
CCAACTGTGT CAGTGGAGGA GGTCAGACCC CAGATCACAG CGCTCGTGAG GAAGCTCATC 
CTACTGAAGC GAGAAGACTT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GPX7 ( NM_015696.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_056511.2 Homo sapiens glutathione peroxidase 7 (GPX7), mRNA.

Price & Availability↑

CloneID	OHu23248
Clone ID Related Accession (Same CDS sequence)	NM_015696.4 , NM_015696.5
Accession Version	NM_015696.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 564bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	glutathione peroxidase 7 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI550170.1, AK027683.1 and BU627166.1. On Nov 23, 2018 this sequence version replaced NM_015696.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY358402.1, AK027683.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000361314.5/ ENSP00000354677.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTGGCGG CGACGGTGGC AGCGGCGTGG CTGCTCCTGT GGGCTGCGGC CTGCGCGCAG 
CAGGAGCAGG ACTTCTACGA CTTCAAGGCG GTCAACATCC GGGGCAAACT GGTGTCGCTG 
GAGAAGTACC GCGGATCGGT GTCCCTGGTG GTGAATGTGG CCAGCGAGTG CGGCTTCACA 
GACCAGCACT ACCGAGCCCT GCAGCAGCTG CAGCGAGACC TGGGCCCCCA CCACTTTAAC 
GTGCTCGCCT TCCCCTGCAA CCAGTTTGGC CAACAGGAGC CTGACAGCAA CAAGGAGATT 
GAGAGCTTTG CCCGCCGCAC CTACAGTGTC TCATTCCCCA TGTTTAGCAA GATTGCAGTC 
ACCGGTACTG GTGCCCATCC TGCCTTCAAG TACCTGGCCC AGACTTCTGG GAAGGAGCCC 
ACCTGGAACT TCTGGAAGTA CCTAGTAGCC CCAGATGGAA AGGTGGTAGG GGCTTGGGAC 
CCAACTGTGT CAGTGGAGGA GGTCAGACCC CAGATCACAG CGCTCGTGAG GAAGCTCATC 
CTACTGAAGC GAGAAGACTT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056511.2
CDS	40..603
Translation	MVAATVAAAWLLLWAAACAQQEQDFYDFKAVNIRGKLVSLEKYRGSVSLVVNVASECGFTDQHYRALQQLQRDLGPHHFNVLAFPCNQFGQQEPDSNKEIESFARRTYSVSFPMFSKIAVTGTGAHPAFKYLAQTSGKEPTWNFWKYLVAPDGKVVGAWDPTVSVEEVRPQITALVRKLILLKREDL

Target ORF information:

RefSeq Version	NM_015696.5
Organism	Homo sapiens(human)
Definition	Homo sapiens glutathione peroxidase 7 (GPX7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015696.5

ORF Insert Sequence:

ATGGTGGCGG CGACGGTGGC AGCGGCGTGG CTGCTCCTGT GGGCTGCGGC CTGCGCGCAG 
CAGGAGCAGG ACTTCTACGA CTTCAAGGCG GTCAACATCC GGGGCAAACT GGTGTCGCTG 
GAGAAGTACC GCGGATCGGT GTCCCTGGTG GTGAATGTGG CCAGCGAGTG CGGCTTCACA 
GACCAGCACT ACCGAGCCCT GCAGCAGCTG CAGCGAGACC TGGGCCCCCA CCACTTTAAC 
GTGCTCGCCT TCCCCTGCAA CCAGTTTGGC CAACAGGAGC CTGACAGCAA CAAGGAGATT 
GAGAGCTTTG CCCGCCGCAC CTACAGTGTC TCATTCCCCA TGTTTAGCAA GATTGCAGTC 
ACCGGTACTG GTGCCCATCC TGCCTTCAAG TACCTGGCCC AGACTTCTGG GAAGGAGCCC 
ACCTGGAACT TCTGGAAGTA CCTAGTAGCC CCAGATGGAA AGGTGGTAGG GGCTTGGGAC 
CCAACTGTGT CAGTGGAGGA GGTCAGACCC CAGATCACAG CGCTCGTGAG GAAGCTCATC 
CTACTGAAGC GAGAAGACTT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

GPX4 and GPX7 over-expression in human hepatocellular carcinoma tissues.
European journal of histochemistry : EJH59(4)2540(2015 Dec)
Guerriero E,Capone F,Accardo M,Sorice A,Costantini M,Colonna G,Castello G,Costantini S

Candidate pathway-based genetic association study of platinum and platinum-taxane related toxicity in a cohort of primary lung cancer patients.
Journal of the neurological sciences349(1-2)124-8(2015 Feb)
Johnson C,Pankratz VS,Velazquez AI,Aakre JA,Loprinzi CL,Staff NP,Windebank AJ,Yang P

Loss of glutathione peroxidase 7 promotes TNF-?-induced NF-?B activation in Barrett's carcinogenesis.
Carcinogenesis35(7)1620-8(2014 Jul)
Peng DF,Hu TL,Soutto M,Belkhiri A,El-Rifai W

Glutathione peroxidase 7 utilizes hydrogen peroxide generated by Ero1? to promote oxidative protein folding.
Antioxidants & redox signaling20(4)545-56(2014 Feb)
Wang L,Zhang L,Niu Y,Sitia R,Wang CC

Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human.
EMBO molecular medicine5(8)1165-79(2013 Aug)
Chang YC,Yu YH,Shew JY,Lee WJ,Hwang JJ,Chen YH,Chen YR,Wei PC,Chuang LM,Lee WH