GPR35 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GPR35
Entrez Gene ID	2859
Full Name	G protein-coupled receptor 35
General protein information	Preferred Names G protein-coupled receptor 35 Names G-protein coupled receptor 35 KYNA receptor kynurenic acid receptor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q37.3
Disorder MIM:	602646

mRNA and Protein(s)

mRNA	Protein	Name
NM_001195381.1	NP_001182310.1	G-protein coupled receptor 35 isoform b
NM_001195382.1	NP_001182311.1	G-protein coupled receptor 35 isoform b
NM_001195381.2	NP_001182310.1	G-protein coupled receptor 35 isoform b
NM_005301.3	NP_005292.2	G-protein coupled receptor 35 isoform a
NM_001195382.2	NP_001182311.1	G-protein coupled receptor 35 isoform b

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Gpr35	NP_001032436.1
	GPR35	XP_001089719.1
Bos taurus (cattle)	GPR35	XP_005205124.1
Mus musculus (house mouse)	Gpr35	NP_071715.3
Gallus gallus (chicken)	LOC100857983	XP_004937084.1
Gallus gallus (chicken)	GPR35	XP_004937083.1
Pan troglodytes (chimpanzee)	GPR35	XP_516198.2
Canis lupus familiaris (dog)	LOC100855802	XP_005636011.1
Canis lupus familiaris (dog)	GPR35	XP_543326.2
Homo sapiens (human)	GPR35	NP_001182311.1

Gene Ontology
Bibliography

Related articles in PubMed

Exome array analysis identifies GPR35 as a novel susceptibility gene for anthracycline-induced cardiotoxicity in childhood cancer.
Ruiz-Pinto S, Pita G, Pati?o-Garc?a A, Alonso J, P?rez-Mart?nez A, Cart?n AJ, Guti?rrez-Larraya F, Alonso MR, Barnes DR, Dennis J, Michailidou K, G?mez-Santos C, Thompson DJ, Easton DF, Ben?tez J, Gonz?lez-Neira A
Pharmacogenetics and genomics27(12)445-453(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

GPR35 interacts with CXCL17 in breast cancer cells.
Title: The role and clinical significance of the CXCL17-CXCR8 (GPR35) axis in breast cancer.

Single-nucleotide polymorphism in GPR35 gene is associated with Crohn's disease.
Title: Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans.

This article shows that GPR35 is the receptor of CXCL17.
Title: Cutting edge: GPR35/CXCR8 is the receptor of the mucosal chemokine CXCL17.

Small molecules that stimulate or block GPR35 activity can modulate vascular proliferation and migration.
Title: G-Protein-Coupled Receptor 35 Mediates Human Saphenous Vein Vascular Smooth Muscle Cell Migration and Endothelial Cell Proliferation.

results clearly show that R4.60, R(164), R(167), and R6.58 play crucial roles in the agonist initiated activation of GPR35.
Title: Crucial positively charged residues for ligand activation of the GPR35 receptor.

The following GPR35 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GPR35 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24885	NM_001195381.2 Latest version!	Homo sapiens G protein-coupled receptor 35 (GPR35), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$144.50-$202.30 $289.00
OHu24885	NM_001195382.2 Latest version!	Homo sapiens G protein-coupled receptor 35 (GPR35), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$144.50-$202.30 $289.00
OHu25287	NM_005301.3 Latest version!	Homo sapiens G protein-coupled receptor 35 (GPR35), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu24885	NM_001195381.1	Homo sapiens G protein-coupled receptor 35 (GPR35), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$144.50-$202.30 $289.00
OHu24885	NM_001195382.1	Homo sapiens G protein-coupled receptor 35 (GPR35), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$144.50-$202.30 $289.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GPR35 ( NM_001195381.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001182310.1 Homo sapiens G protein-coupled receptor 35 (GPR35), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu24885
Clone ID Related Accession (Same CDS sequence)	NM_001195381.1 , NM_001195382.1 , NM_001195381.2 , NM_001195382.2
Accession Version	NM_001195381.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1023bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	G-protein coupled receptor 35 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB011311.1, AK172786.1, BM857130.1, BC095500.1 and AW000832.1. Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The resulting isoform (b, also known as GPR35b) is longer at the N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform (b). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK172786.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGAGTG GTTCCCGGGC TGTCCCCACT CCACACCGTG GCAGTGAAGA GCTGCTGAAG 
TACATGCTTC ATAGTCCTTG CGTCTCTCTG ACCATGAATG GCACCTACAA CACCTGTGGC 
TCCAGCGACC TCACCTGGCC CCCAGCGATC AAGCTGGGCT TCTACGCCTA CTTGGGCGTC 
CTGCTGGTGC TAGGCCTGCT GCTCAACAGC CTGGCGCTCT GGGTGTTCTG CTGCCGCATG 
CAGCAGTGGA CGGAGACCCG CATCTACATG ACCAACCTGG CGGTGGCCGA CCTCTGCCTG 
CTGTGCACCT TGCCCTTCGT GCTGCACTCC CTGCGAGACA CCTCAGACAC GCCGCTGTGC 
CAGCTCTCCC AGGGCATCTA CCTGACCAAC AGGTACATGA GCATCAGCCT GGTCACGGCC 
ATCGCCGTGG ACCGCTATGT GGCCGTGCGG CACCCGCTGC GTGCCCGCGG GCTGCGGTCC 
CCCAGGCAGG CTGCGGCCGT GTGCGCGGTC CTCTGGGTGC TGGTCATCGG CTCCCTGGTG 
GCTCGCTGGC TCCTGGGGAT TCAGGAGGGC GGCTTCTGCT TCAGGAGCAC CCGGCACAAT 
TTCAACTCCA TGGCGTTCCC GCTGCTGGGA TTCTACCTGC CCCTGGCCGT GGTGGTCTTC 
TGCTCCCTGA AGGTGGTGAC TGCCCTGGCC CAGAGGCCAC CCACCGACGT GGGGCAGGCA 
GAGGCCACCC GCAAGGCTGC CCGCATGGTC TGGGCCAACC TCCTGGTGTT CGTGGTCTGC 
TTCCTGCCCC TGCACGTGGG GCTGACAGTG CGCCTCGCAG TGGGCTGGAA CGCCTGTGCC 
CTCCTGGAGA CGATCCGTCG CGCCCTGTAC ATAACCAGCA AGCTCTCAGA TGCCAACTGC 
TGCCTGGACG CCATCTGCTA CTACTACATG GCCAAGGAGT TCCAGGAGGC GTCTGCACTG 
GCCGTGGCTC CCAGTGCTAA GGCCCACAAA AGCCAGGACT CTCTGTGCGT GACCCTCGCC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001182310.1
CDS	873..1895
Translation	MLSGSRAVPTPHRGSEELLKYMLHSPCVSLTMNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA

Target ORF information:

RefSeq Version	NM_001195381.1
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein-coupled receptor 35 (GPR35), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001195381.1

ORF Insert Sequence:

ATGCTGAGTG GTTCCCGGGC TGTCCCCACT CCACACCGTG GCAGTGAAGA GCTGCTGAAG 
TACATGCTTC ATAGTCCTTG CGTCTCTCTG ACCATGAATG GCACCTACAA CACCTGTGGC 
TCCAGCGACC TCACCTGGCC CCCAGCGATC AAGCTGGGCT TCTACGCCTA CTTGGGCGTC 
CTGCTGGTGC TAGGCCTGCT GCTCAACAGC CTGGCGCTCT GGGTGTTCTG CTGCCGCATG 
CAGCAGTGGA CGGAGACCCG CATCTACATG ACCAACCTGG CGGTGGCCGA CCTCTGCCTG 
CTGTGCACCT TGCCCTTCGT GCTGCACTCC CTGCGAGACA CCTCAGACAC GCCGCTGTGC 
CAGCTCTCCC AGGGCATCTA CCTGACCAAC AGGTACATGA GCATCAGCCT GGTCACGGCC 
ATCGCCGTGG ACCGCTATGT GGCCGTGCGG CACCCGCTGC GTGCCCGCGG GCTGCGGTCC 
CCCAGGCAGG CTGCGGCCGT GTGCGCGGTC CTCTGGGTGC TGGTCATCGG CTCCCTGGTG 
GCTCGCTGGC TCCTGGGGAT TCAGGAGGGC GGCTTCTGCT TCAGGAGCAC CCGGCACAAT 
TTCAACTCCA TGGCGTTCCC GCTGCTGGGA TTCTACCTGC CCCTGGCCGT GGTGGTCTTC 
TGCTCCCTGA AGGTGGTGAC TGCCCTGGCC CAGAGGCCAC CCACCGACGT GGGGCAGGCA 
GAGGCCACCC GCAAGGCTGC CCGCATGGTC TGGGCCAACC TCCTGGTGTT CGTGGTCTGC 
TTCCTGCCCC TGCACGTGGG GCTGACAGTG CGCCTCGCAG TGGGCTGGAA CGCCTGTGCC 
CTCCTGGAGA CGATCCGTCG CGCCCTGTAC ATAACCAGCA AGCTCTCAGA TGCCAACTGC 
TGCCTGGACG CCATCTGCTA CTACTACATG GCCAAGGAGT TCCAGGAGGC GTCTGCACTG 
GCCGTGGCTC CCAGTGCTAA GGCCCACAAA AGCCAGGACT CTCTGTGCGT GACCCTCGCC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GPR35 ( NM_001195382.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001182311.1 Homo sapiens G protein-coupled receptor 35 (GPR35), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu24885
Clone ID Related Accession (Same CDS sequence)	NM_001195381.1 , NM_001195382.1 , NM_001195381.2 , NM_001195382.2
Accession Version	NM_001195382.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1023bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-21
Organism	Homo sapiens(human)
Product	G-protein coupled receptor 35 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB011311.1, AK290256.1, BM857130.1, BC095500.1, AW000832.1 and AK172786.1. Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The resulting isoform (b, also known as GPR35b) is longer at the N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform (b). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK290256.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGAGTG GTTCCCGGGC TGTCCCCACT CCACACCGTG GCAGTGAAGA GCTGCTGAAG 
TACATGCTTC ATAGTCCTTG CGTCTCTCTG ACCATGAATG GCACCTACAA CACCTGTGGC 
TCCAGCGACC TCACCTGGCC CCCAGCGATC AAGCTGGGCT TCTACGCCTA CTTGGGCGTC 
CTGCTGGTGC TAGGCCTGCT GCTCAACAGC CTGGCGCTCT GGGTGTTCTG CTGCCGCATG 
CAGCAGTGGA CGGAGACCCG CATCTACATG ACCAACCTGG CGGTGGCCGA CCTCTGCCTG 
CTGTGCACCT TGCCCTTCGT GCTGCACTCC CTGCGAGACA CCTCAGACAC GCCGCTGTGC 
CAGCTCTCCC AGGGCATCTA CCTGACCAAC AGGTACATGA GCATCAGCCT GGTCACGGCC 
ATCGCCGTGG ACCGCTATGT GGCCGTGCGG CACCCGCTGC GTGCCCGCGG GCTGCGGTCC 
CCCAGGCAGG CTGCGGCCGT GTGCGCGGTC CTCTGGGTGC TGGTCATCGG CTCCCTGGTG 
GCTCGCTGGC TCCTGGGGAT TCAGGAGGGC GGCTTCTGCT TCAGGAGCAC CCGGCACAAT 
TTCAACTCCA TGGCGTTCCC GCTGCTGGGA TTCTACCTGC CCCTGGCCGT GGTGGTCTTC 
TGCTCCCTGA AGGTGGTGAC TGCCCTGGCC CAGAGGCCAC CCACCGACGT GGGGCAGGCA 
GAGGCCACCC GCAAGGCTGC CCGCATGGTC TGGGCCAACC TCCTGGTGTT CGTGGTCTGC 
TTCCTGCCCC TGCACGTGGG GCTGACAGTG CGCCTCGCAG TGGGCTGGAA CGCCTGTGCC 
CTCCTGGAGA CGATCCGTCG CGCCCTGTAC ATAACCAGCA AGCTCTCAGA TGCCAACTGC 
TGCCTGGACG CCATCTGCTA CTACTACATG GCCAAGGAGT TCCAGGAGGC GTCTGCACTG 
GCCGTGGCTC CCAGTGCTAA GGCCCACAAA AGCCAGGACT CTCTGTGCGT GACCCTCGCC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001182311.1
CDS	759..1781
Translation	MLSGSRAVPTPHRGSEELLKYMLHSPCVSLTMNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA

Target ORF information:

RefSeq Version	NM_001195382.1
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein-coupled receptor 35 (GPR35), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001195382.1

ORF Insert Sequence:

ATGCTGAGTG GTTCCCGGGC TGTCCCCACT CCACACCGTG GCAGTGAAGA GCTGCTGAAG 
TACATGCTTC ATAGTCCTTG CGTCTCTCTG ACCATGAATG GCACCTACAA CACCTGTGGC 
TCCAGCGACC TCACCTGGCC CCCAGCGATC AAGCTGGGCT TCTACGCCTA CTTGGGCGTC 
CTGCTGGTGC TAGGCCTGCT GCTCAACAGC CTGGCGCTCT GGGTGTTCTG CTGCCGCATG 
CAGCAGTGGA CGGAGACCCG CATCTACATG ACCAACCTGG CGGTGGCCGA CCTCTGCCTG 
CTGTGCACCT TGCCCTTCGT GCTGCACTCC CTGCGAGACA CCTCAGACAC GCCGCTGTGC 
CAGCTCTCCC AGGGCATCTA CCTGACCAAC AGGTACATGA GCATCAGCCT GGTCACGGCC 
ATCGCCGTGG ACCGCTATGT GGCCGTGCGG CACCCGCTGC GTGCCCGCGG GCTGCGGTCC 
CCCAGGCAGG CTGCGGCCGT GTGCGCGGTC CTCTGGGTGC TGGTCATCGG CTCCCTGGTG 
GCTCGCTGGC TCCTGGGGAT TCAGGAGGGC GGCTTCTGCT TCAGGAGCAC CCGGCACAAT 
TTCAACTCCA TGGCGTTCCC GCTGCTGGGA TTCTACCTGC CCCTGGCCGT GGTGGTCTTC 
TGCTCCCTGA AGGTGGTGAC TGCCCTGGCC CAGAGGCCAC CCACCGACGT GGGGCAGGCA 
GAGGCCACCC GCAAGGCTGC CCGCATGGTC TGGGCCAACC TCCTGGTGTT CGTGGTCTGC 
TTCCTGCCCC TGCACGTGGG GCTGACAGTG CGCCTCGCAG TGGGCTGGAA CGCCTGTGCC 
CTCCTGGAGA CGATCCGTCG CGCCCTGTAC ATAACCAGCA AGCTCTCAGA TGCCAACTGC 
TGCCTGGACG CCATCTGCTA CTACTACATG GCCAAGGAGT TCCAGGAGGC GTCTGCACTG 
GCCGTGGCTC CCAGTGCTAA GGCCCACAAA AGCCAGGACT CTCTGTGCGT GACCCTCGCC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GPR35 ( NM_001195381.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001182310.1 Homo sapiens G protein-coupled receptor 35 (GPR35), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu24885
Clone ID Related Accession (Same CDS sequence)	NM_001195381.1 , NM_001195382.1 , NM_001195381.2 , NM_001195382.2
Accession Version	NM_001195381.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1023bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-15
Organism	Homo sapiens(human)
Product	G-protein coupled receptor 35 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB011311.1, AK172786.1, BM857130.1, BC095500.1 and AW000832.1. On Jun 2, 2019 this sequence version replaced NM_001195381.1. Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The resulting isoform (b, also known as GPR35b) is longer at the N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform (b). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK172786.1, SRR6380200.3750.5 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGAGTG GTTCCCGGGC TGTCCCCACT CCACACCGTG GCAGTGAAGA GCTGCTGAAG 
TACATGCTTC ATAGTCCTTG CGTCTCTCTG ACCATGAATG GCACCTACAA CACCTGTGGC 
TCCAGCGACC TCACCTGGCC CCCAGCGATC AAGCTGGGCT TCTACGCCTA CTTGGGCGTC 
CTGCTGGTGC TAGGCCTGCT GCTCAACAGC CTGGCGCTCT GGGTGTTCTG CTGCCGCATG 
CAGCAGTGGA CGGAGACCCG CATCTACATG ACCAACCTGG CGGTGGCCGA CCTCTGCCTG 
CTGTGCACCT TGCCCTTCGT GCTGCACTCC CTGCGAGACA CCTCAGACAC GCCGCTGTGC 
CAGCTCTCCC AGGGCATCTA CCTGACCAAC AGGTACATGA GCATCAGCCT GGTCACGGCC 
ATCGCCGTGG ACCGCTATGT GGCCGTGCGG CACCCGCTGC GTGCCCGCGG GCTGCGGTCC 
CCCAGGCAGG CTGCGGCCGT GTGCGCGGTC CTCTGGGTGC TGGTCATCGG CTCCCTGGTG 
GCTCGCTGGC TCCTGGGGAT TCAGGAGGGC GGCTTCTGCT TCAGGAGCAC CCGGCACAAT 
TTCAACTCCA TGGCGTTCCC GCTGCTGGGA TTCTACCTGC CCCTGGCCGT GGTGGTCTTC 
TGCTCCCTGA AGGTGGTGAC TGCCCTGGCC CAGAGGCCAC CCACCGACGT GGGGCAGGCA 
GAGGCCACCC GCAAGGCTGC CCGCATGGTC TGGGCCAACC TCCTGGTGTT CGTGGTCTGC 
TTCCTGCCCC TGCACGTGGG GCTGACAGTG CGCCTCGCAG TGGGCTGGAA CGCCTGTGCC 
CTCCTGGAGA CGATCCGTCG CGCCCTGTAC ATAACCAGCA AGCTCTCAGA TGCCAACTGC 
TGCCTGGACG CCATCTGCTA CTACTACATG GCCAAGGAGT TCCAGGAGGC GTCTGCACTG 
GCCGTGGCTC CCAGTGCTAA GGCCCACAAA AGCCAGGACT CTCTGTGCGT GACCCTCGCC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001182310.1
CDS	851..1873
Translation	MLSGSRAVPTPHRGSEELLKYMLHSPCVSLTMNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA

Target ORF information:

RefSeq Version	NM_001195381.2
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein-coupled receptor 35 (GPR35), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001195381.2

ORF Insert Sequence:

ATGCTGAGTG GTTCCCGGGC TGTCCCCACT CCACACCGTG GCAGTGAAGA GCTGCTGAAG 
TACATGCTTC ATAGTCCTTG CGTCTCTCTG ACCATGAATG GCACCTACAA CACCTGTGGC 
TCCAGCGACC TCACCTGGCC CCCAGCGATC AAGCTGGGCT TCTACGCCTA CTTGGGCGTC 
CTGCTGGTGC TAGGCCTGCT GCTCAACAGC CTGGCGCTCT GGGTGTTCTG CTGCCGCATG 
CAGCAGTGGA CGGAGACCCG CATCTACATG ACCAACCTGG CGGTGGCCGA CCTCTGCCTG 
CTGTGCACCT TGCCCTTCGT GCTGCACTCC CTGCGAGACA CCTCAGACAC GCCGCTGTGC 
CAGCTCTCCC AGGGCATCTA CCTGACCAAC AGGTACATGA GCATCAGCCT GGTCACGGCC 
ATCGCCGTGG ACCGCTATGT GGCCGTGCGG CACCCGCTGC GTGCCCGCGG GCTGCGGTCC 
CCCAGGCAGG CTGCGGCCGT GTGCGCGGTC CTCTGGGTGC TGGTCATCGG CTCCCTGGTG 
GCTCGCTGGC TCCTGGGGAT TCAGGAGGGC GGCTTCTGCT TCAGGAGCAC CCGGCACAAT 
TTCAACTCCA TGGCGTTCCC GCTGCTGGGA TTCTACCTGC CCCTGGCCGT GGTGGTCTTC 
TGCTCCCTGA AGGTGGTGAC TGCCCTGGCC CAGAGGCCAC CCACCGACGT GGGGCAGGCA 
GAGGCCACCC GCAAGGCTGC CCGCATGGTC TGGGCCAACC TCCTGGTGTT CGTGGTCTGC 
TTCCTGCCCC TGCACGTGGG GCTGACAGTG CGCCTCGCAG TGGGCTGGAA CGCCTGTGCC 
CTCCTGGAGA CGATCCGTCG CGCCCTGTAC ATAACCAGCA AGCTCTCAGA TGCCAACTGC 
TGCCTGGACG CCATCTGCTA CTACTACATG GCCAAGGAGT TCCAGGAGGC GTCTGCACTG 
GCCGTGGCTC CCAGTGCTAA GGCCCACAAA AGCCAGGACT CTCTGTGCGT GACCCTCGCC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GPR35 ( NM_001195382.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001182311.1 Homo sapiens G protein-coupled receptor 35 (GPR35), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu24885
Clone ID Related Accession (Same CDS sequence)	NM_001195381.1 , NM_001195382.1 , NM_001195381.2 , NM_001195382.2
Accession Version	NM_001195382.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1023bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-15
Organism	Homo sapiens(human)
Product	G-protein coupled receptor 35 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB011311.1, AK290256.1, BM857130.1, BC095500.1, AW000832.1 and AK172786.1. On Jun 2, 2019 this sequence version replaced NM_001195382.1. Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The resulting isoform (b, also known as GPR35b) is longer at the N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform (b). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK290256.1, SRR6380200.19544.7 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGAGTG GTTCCCGGGC TGTCCCCACT CCACACCGTG GCAGTGAAGA GCTGCTGAAG 
TACATGCTTC ATAGTCCTTG CGTCTCTCTG ACCATGAATG GCACCTACAA CACCTGTGGC 
TCCAGCGACC TCACCTGGCC CCCAGCGATC AAGCTGGGCT TCTACGCCTA CTTGGGCGTC 
CTGCTGGTGC TAGGCCTGCT GCTCAACAGC CTGGCGCTCT GGGTGTTCTG CTGCCGCATG 
CAGCAGTGGA CGGAGACCCG CATCTACATG ACCAACCTGG CGGTGGCCGA CCTCTGCCTG 
CTGTGCACCT TGCCCTTCGT GCTGCACTCC CTGCGAGACA CCTCAGACAC GCCGCTGTGC 
CAGCTCTCCC AGGGCATCTA CCTGACCAAC AGGTACATGA GCATCAGCCT GGTCACGGCC 
ATCGCCGTGG ACCGCTATGT GGCCGTGCGG CACCCGCTGC GTGCCCGCGG GCTGCGGTCC 
CCCAGGCAGG CTGCGGCCGT GTGCGCGGTC CTCTGGGTGC TGGTCATCGG CTCCCTGGTG 
GCTCGCTGGC TCCTGGGGAT TCAGGAGGGC GGCTTCTGCT TCAGGAGCAC CCGGCACAAT 
TTCAACTCCA TGGCGTTCCC GCTGCTGGGA TTCTACCTGC CCCTGGCCGT GGTGGTCTTC 
TGCTCCCTGA AGGTGGTGAC TGCCCTGGCC CAGAGGCCAC CCACCGACGT GGGGCAGGCA 
GAGGCCACCC GCAAGGCTGC CCGCATGGTC TGGGCCAACC TCCTGGTGTT CGTGGTCTGC 
TTCCTGCCCC TGCACGTGGG GCTGACAGTG CGCCTCGCAG TGGGCTGGAA CGCCTGTGCC 
CTCCTGGAGA CGATCCGTCG CGCCCTGTAC ATAACCAGCA AGCTCTCAGA TGCCAACTGC 
TGCCTGGACG CCATCTGCTA CTACTACATG GCCAAGGAGT TCCAGGAGGC GTCTGCACTG 
GCCGTGGCTC CCAGTGCTAA GGCCCACAAA AGCCAGGACT CTCTGTGCGT GACCCTCGCC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001182311.1
CDS	737..1759
Translation	MLSGSRAVPTPHRGSEELLKYMLHSPCVSLTMNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA

Target ORF information:

RefSeq Version	NM_001195382.2
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein-coupled receptor 35 (GPR35), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001195382.2

ORF Insert Sequence:

ATGCTGAGTG GTTCCCGGGC TGTCCCCACT CCACACCGTG GCAGTGAAGA GCTGCTGAAG 
TACATGCTTC ATAGTCCTTG CGTCTCTCTG ACCATGAATG GCACCTACAA CACCTGTGGC 
TCCAGCGACC TCACCTGGCC CCCAGCGATC AAGCTGGGCT TCTACGCCTA CTTGGGCGTC 
CTGCTGGTGC TAGGCCTGCT GCTCAACAGC CTGGCGCTCT GGGTGTTCTG CTGCCGCATG 
CAGCAGTGGA CGGAGACCCG CATCTACATG ACCAACCTGG CGGTGGCCGA CCTCTGCCTG 
CTGTGCACCT TGCCCTTCGT GCTGCACTCC CTGCGAGACA CCTCAGACAC GCCGCTGTGC 
CAGCTCTCCC AGGGCATCTA CCTGACCAAC AGGTACATGA GCATCAGCCT GGTCACGGCC 
ATCGCCGTGG ACCGCTATGT GGCCGTGCGG CACCCGCTGC GTGCCCGCGG GCTGCGGTCC 
CCCAGGCAGG CTGCGGCCGT GTGCGCGGTC CTCTGGGTGC TGGTCATCGG CTCCCTGGTG 
GCTCGCTGGC TCCTGGGGAT TCAGGAGGGC GGCTTCTGCT TCAGGAGCAC CCGGCACAAT 
TTCAACTCCA TGGCGTTCCC GCTGCTGGGA TTCTACCTGC CCCTGGCCGT GGTGGTCTTC 
TGCTCCCTGA AGGTGGTGAC TGCCCTGGCC CAGAGGCCAC CCACCGACGT GGGGCAGGCA 
GAGGCCACCC GCAAGGCTGC CCGCATGGTC TGGGCCAACC TCCTGGTGTT CGTGGTCTGC 
TTCCTGCCCC TGCACGTGGG GCTGACAGTG CGCCTCGCAG TGGGCTGGAA CGCCTGTGCC 
CTCCTGGAGA CGATCCGTCG CGCCCTGTAC ATAACCAGCA AGCTCTCAGA TGCCAACTGC 
TGCCTGGACG CCATCTGCTA CTACTACATG GCCAAGGAGT TCCAGGAGGC GTCTGCACTG 
GCCGTGGCTC CCAGTGCTAA GGCCCACAAA AGCCAGGACT CTCTGTGCGT GACCCTCGCC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GPR35 ( NM_005301.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005292.2 Homo sapiens G protein-coupled receptor 35 (GPR35), transcript variant 1, mRNA.

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CloneID	OHu25287
Clone ID Related Accession (Same CDS sequence)	NM_005301.3
Accession Version	NM_005301.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 930bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	G-protein coupled receptor 35 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK314002.1, AC124862.4, BC095500.1, AK290256.1, AW000832.1 and AK172786.1. On Sep 3, 2010 this sequence version replaced NM_005301.2. Transcript Variant: This variant (1) represents the shortest transcript and encodes the shorter isoform (a, also known as GPR35a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK314002.1, HY091091.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAATGGCA CCTACAACAC CTGTGGCTCC AGCGACCTCA CCTGGCCCCC AGCGATCAAG 
CTGGGCTTCT ACGCCTACTT GGGCGTCCTG CTGGTGCTAG GCCTGCTGCT CAACAGCCTG 
GCGCTCTGGG TGTTCTGCTG CCGCATGCAG CAGTGGACGG AGACCCGCAT CTACATGACC 
AACCTGGCGG TGGCCGACCT CTGCCTGCTG TGCACCTTGC CCTTCGTGCT GCACTCCCTG 
CGAGACACCT CAGACACGCC GCTGTGCCAG CTCTCCCAGG GCATCTACCT GACCAACAGG 
TACATGAGCA TCAGCCTGGT CACGGCCATC GCCGTGGACC GCTATGTGGC CGTGCGGCAC 
CCGCTGCGTG CCCGCGGGCT GCGGTCCCCC AGGCAGGCTG CGGCCGTGTG CGCGGTCCTC 
TGGGTGCTGG TCATCGGCTC CCTGGTGGCT CGCTGGCTCC TGGGGATTCA GGAGGGCGGC 
TTCTGCTTCA GGAGCACCCG GCACAATTTC AACTCCATGG CGTTCCCGCT GCTGGGATTC 
TACCTGCCCC TGGCCGTGGT GGTCTTCTGC TCCCTGAAGG TGGTGACTGC CCTGGCCCAG 
AGGCCACCCA CCGACGTGGG GCAGGCAGAG GCCACCCGCA AGGCTGCCCG CATGGTCTGG 
GCCAACCTCC TGGTGTTCGT GGTCTGCTTC CTGCCCCTGC ACGTGGGGCT GACAGTGCGC 
CTCGCAGTGG GCTGGAACGC CTGTGCCCTC CTGGAGACGA TCCGTCGCGC CCTGTACATA 
ACCAGCAAGC TCTCAGATGC CAACTGCTGC CTGGACGCCA TCTGCTACTA CTACATGGCC 
AAGGAGTTCC AGGAGGCGTC TGCACTGGCC GTGGCTCCCA GTGCTAAGGC CCACAAAAGC 
CAGGACTCTC TGTGCGTGAC CCTCGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005292.2
CDS	329..1258
Translation	MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA

Target ORF information:

RefSeq Version	NM_005301.3
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein-coupled receptor 35 (GPR35), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005301.3

ORF Insert Sequence:

ATGAATGGCA CCTACAACAC CTGTGGCTCC AGCGACCTCA CCTGGCCCCC AGCGATCAAG 
CTGGGCTTCT ACGCCTACTT GGGCGTCCTG CTGGTGCTAG GCCTGCTGCT CAACAGCCTG 
GCGCTCTGGG TGTTCTGCTG CCGCATGCAG CAGTGGACGG AGACCCGCAT CTACATGACC 
AACCTGGCGG TGGCCGACCT CTGCCTGCTG TGCACCTTGC CCTTCGTGCT GCACTCCCTG 
CGAGACACCT CAGACACGCC GCTGTGCCAG CTCTCCCAGG GCATCTACCT GACCAACAGG 
TACATGAGCA TCAGCCTGGT CACGGCCATC GCCGTGGACC GCTATGTGGC CGTGCGGCAC 
CCGCTGCGTG CCCGCGGGCT GCGGTCCCCC AGGCAGGCTG CGGCCGTGTG CGCGGTCCTC 
TGGGTGCTGG TCATCGGCTC CCTGGTGGCT CGCTGGCTCC TGGGGATTCA GGAGGGCGGC 
TTCTGCTTCA GGAGCACCCG GCACAATTTC AACTCCATGG CGTTCCCGCT GCTGGGATTC 
TACCTGCCCC TGGCCGTGGT GGTCTTCTGC TCCCTGAAGG TGGTGACTGC CCTGGCCCAG 
AGGCCACCCA CCGACGTGGG GCAGGCAGAG GCCACCCGCA AGGCTGCCCG CATGGTCTGG 
GCCAACCTCC TGGTGTTCGT GGTCTGCTTC CTGCCCCTGC ACGTGGGGCT GACAGTGCGC 
CTCGCAGTGG GCTGGAACGC CTGTGCCCTC CTGGAGACGA TCCGTCGCGC CCTGTACATA 
ACCAGCAAGC TCTCAGATGC CAACTGCTGC CTGGACGCCA TCTGCTACTA CTACATGGCC 
AAGGAGTTCC AGGAGGCGTC TGCACTGGCC GTGGCTCCCA GTGCTAAGGC CCACAAAAGC 
CAGGACTCTC TGTGCGTGAC CCTCGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Exome array analysis identifies GPR35 as a novel susceptibility gene for anthracycline-induced cardiotoxicity in childhood cancer.
Pharmacogenetics and genomics27(12)445-453(2017 Dec)
Ruiz-Pinto S,Pita G,Pati?o-Garc?a A,Alonso J,P?rez-Mart?nez A,Cart?n AJ,Guti?rrez-Larraya F,Alonso MR,Barnes DR,Dennis J,Michailidou K,G?mez-Santos C,Thompson DJ,Easton DF,Ben?tez J,Gonz?lez-Neira A

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GPR35 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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FAX

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