LSM3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LSM3
Entrez Gene ID	27258
Full Name	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
Synonyms	SMX4,USS2,YLR438C
General protein information	Preferred Names LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated Names U6 snRNA-associated Sm-like protein LSm3 LSM3 U6 small nuclear RNA and mRNA degradation associated LSM3 homolog, U6 small nuclear RNA associated
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3p25.1
Summary	Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004].
Disorder MIM:	607283

mRNA and Protein(s)

mRNA	Protein	Name
NM_014463.3	NP_055278.1	U6 snRNA-associated Sm-like protein LSm3
NM_014463.2	NP_055278.1	U6 snRNA-associated Sm-like protein LSm3

Pathways from BioSystems

Homologies

Homo sapiens (human)	LSM3	NP_055278.1
Pan troglodytes (chimpanzee)	LSM3	XP_001157526.1
Bos taurus (cattle)	LSM3	NP_001032564.1
Gallus gallus (chicken)	LSM3	NP_001264791.1
Xenopus tropicalis (tropical clawed frog)	lsm3	NP_001165758.1
Caenorhabditis elegans (roundworm)	lsm-3	NP_502579.1
Arabidopsis thaliana (thale cress)	AT1G76860	NP_177812.1
Mus musculus (house mouse)	Lsm3	NP_080585.1
Danio rerio (zebrafish)	LOC100535720	XP_003201179.1
Drosophila melanogaster (fruit fly)	LSm3	NP_001163707.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP013519	XP_003435864.1
Arabidopsis thaliana (thale cress)	AT1G21190	NP_173542.1
Oryza sativa (rice)	Os01g0866700	NP_001044909.1
	LSM3	XP_001099845.1
Canis lupus familiaris (dog)	LSM3	XP_849275.1
Rattus norvegicus (Norway rat)	Lsm3	NP_001100081.1

Gene Ontology
Bibliography

Related articles in PubMed

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
Bertram K, Agafonov DE, Dybkov O, Haselbach D, Leelaram MN, Will CL, Urlaub H, Kastner B, L?hrmann R, Stark H
Cell170(4)701-713.e11(2017 Aug)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Yachie N, Petsalaki E, Mellor JC, Weile J, Jacob Y, Verby M, Ozturk SB, Li S, Cote AG, Mosca R, Knapp JJ, Ko M, Yu A, Gebbia M, Sahni N, Yi S, Tyagi T, Sheykhkarimli D, Roth JF, Wong C, Musa L, Snider J, Liu YC, Yu H, Braun P, Stagljar I, Hao T, Calderwood MA, Pelletier L, Aloy P, Hill DE, Vidal M, Roth FP
Molecular systems biology12(4)863(2016 Apr)

Molecular architecture of the human U4/U6.U5 tri-snRNP.
Agafonov DE, Kastner B, Dybkov O, Hofele RV, Liu WT, Urlaub H, L?hrmann R, Stark H
Science (New York, N.Y.)351(6280)1416-20(2016 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

LSm1-7 proteins colocalize with DCP1,DCP2 and Xrn1 in cytoplasmic foci
Title: The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci.

The following LSM3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LSM3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu55657	NM_014463.3 Latest version!	Homo sapiens LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu55657	NM_014463.2	Homo sapiens LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LSM3 ( NM_014463.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055278.1 Homo sapiens LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM3), mRNA.

Price & Availability↑

CloneID	OHu55657
Clone ID Related Accession (Same CDS sequence)	NM_014463.3 , NM_014463.2
Accession Version	NM_014463.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	U6 snRNA-associated Sm-like protein LSm3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB499707.1, AF182418.1, DB289601.1 and AC093495.2. On Nov 23, 2018 this sequence version replaced NM_014463.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM693722.1, SRR1660803.47170.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000306024.4/ ENSP00000302160.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGACG ACGTAGACCA GCAACAAACT ACCAACACTG TAGAGGAGCC CCTGGATCTT 
ATCAGGCTCA GCCTAGATGA GCGAATTTAT GTGAAAATGA GAAATGACCG AGAGCTTCGA 
GGCAGATTAC ATGCTTATGA TCAACATTTA AATATGATCT TGGGAGATGT GGAAGAAACT 
GTGACTACTA TAGAAATTGA TGAAGAAACA TATGAAGAGA TATATAAATC AACGAAACGG 
AATATTCCAA TGCTCTTTGT CCGGGGAGAT GGCGTTGTCC TGGTTGCCCC TCCACTGAGA 
GTTGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055278.1
CDS	45..353
Translation	MADDVDQQQTTNTVEEPLDLIRLSLDERIYVKMRNDRELRGRLHAYDQHLNMILGDVEETVTTIEIDEETYEEIYKSTKRNIPMLFVRGDGVVLVAPPLRVG

Target ORF information:

RefSeq Version	NM_014463.3
Organism	Homo sapiens(human)
Definition	Homo sapiens LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014463.3

ORF Insert Sequence:

ATGGCGGACG ACGTAGACCA GCAACAAACT ACCAACACTG TAGAGGAGCC CCTGGATCTT 
ATCAGGCTCA GCCTAGATGA GCGAATTTAT GTGAAAATGA GAAATGACCG AGAGCTTCGA 
GGCAGATTAC ATGCTTATGA TCAACATTTA AATATGATCT TGGGAGATGT GGAAGAAACT 
GTGACTACTA TAGAAATTGA TGAAGAAACA TATGAAGAGA TATATAAATC AACGAAACGG 
AATATTCCAA TGCTCTTTGT CCGGGGAGAT GGCGTTGTCC TGGTTGCCCC TCCACTGAGA 
GTTGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LSM3 ( NM_014463.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_055278.1 Homo sapiens LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM3), mRNA.

Price & Availability↑

CloneID	OHu55657
Clone ID Related Accession (Same CDS sequence)	NM_014463.3 , NM_014463.2
Accession Version	NM_014463.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-27
Organism	Homo sapiens(human)
Product	U6 snRNA-associated Sm-like protein LSm3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB499707.1, AF182418.1 and DB289601.1. On Sep 17, 2009 this sequence version replaced NM_014463.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DB172400.1, SRR1803611.363164.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGACG ACGTAGACCA GCAACAAACT ACCAACACTG TAGAGGAGCC CCTGGATCTT 
ATCAGGCTCA GCCTAGATGA GCGAATTTAT GTGAAAATGA GAAATGACCG AGAGCTTCGA 
GGCAGATTAC ATGCTTATGA TCAACATTTA AATATGATCT TGGGAGATGT GGAAGAAACT 
GTGACTACTA TAGAAATTGA TGAAGAAACA TATGAAGAGA TATATAAATC AACGAAACGG 
AATATTCCAA TGCTCTTTGT CCGGGGAGAT GGCGTTGTCC TGGTTGCCCC TCCACTGAGA 
GTTGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055278.1
CDS	134..442
Translation	MADDVDQQQTTNTVEEPLDLIRLSLDERIYVKMRNDRELRGRLHAYDQHLNMILGDVEETVTTIEIDEETYEEIYKSTKRNIPMLFVRGDGVVLVAPPLRVG

Target ORF information:

RefSeq Version	NM_014463.2
Organism	Homo sapiens(human)
Definition	Homo sapiens LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014463.2

ORF Insert Sequence:

ATGGCGGACG ACGTAGACCA GCAACAAACT ACCAACACTG TAGAGGAGCC CCTGGATCTT 
ATCAGGCTCA GCCTAGATGA GCGAATTTAT GTGAAAATGA GAAATGACCG AGAGCTTCGA 
GGCAGATTAC ATGCTTATGA TCAACATTTA AATATGATCT TGGGAGATGT GGAAGAAACT 
GTGACTACTA TAGAAATTGA TGAAGAAACA TATGAAGAGA TATATAAATC AACGAAACGG 
AATATTCCAA TGCTCTTTGT CCGGGGAGAT GGCGTTGTCC TGGTTGCCCC TCCACTGAGA 
GTTGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
Cell170(4)701-713.e11(2017 Aug)
Bertram K,Agafonov DE,Dybkov O,Haselbach D,Leelaram MN,Will CL,Urlaub H,Kastner B,L?hrmann R,Stark H

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Molecular systems biology12(4)863(2016 Apr)
Yachie N,Petsalaki E,Mellor JC,Weile J,Jacob Y,Verby M,Ozturk SB,Li S,Cote AG,Mosca R,Knapp JJ,Ko M,Yu A,Gebbia M,Sahni N,Yi S,Tyagi T,Sheykhkarimli D,Roth JF,Wong C,Musa L,Snider J,Liu YC,Yu H,Braun P,Stagljar I,Hao T,Calderwood MA,Pelletier L,Aloy P,Hill DE,Vidal M,Roth FP

Molecular architecture of the human U4/U6.U5 tri-snRNP.
Science (New York, N.Y.)351(6280)1416-20(2016 Mar)
Agafonov DE,Kastner B,Dybkov O,Hofele RV,Liu WT,Urlaub H,L?hrmann R,Stark H

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LSM3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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