GDF10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GDF10
Entrez Gene ID	2662
Full Name	growth differentiation factor 10
Synonyms	BIP,BMP-3b,BMP3B
General protein information	Preferred Names growth differentiation factor 10 Names growth/differentiation factor 10 bone morphogenetic protein 3B bone-inducing protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q11.22
Summary	This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This promotes neural repair after stroke. Additionally, this protein may act as a tumor suppressor and reduced expression of this gene is associated with oral cancer. [provided by RefSeq, Jul 2016].
Disorder MIM:	601361

mRNA and Protein(s)

mRNA	Protein	Name
NM_004962.4	NP_004953.1	growth/differentiation factor 10 preproprotein
NM_004962.5	NP_004953.1	growth/differentiation factor 10 preproprotein

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	gdf10a	XP_691459.3
Mus musculus (house mouse)	Gdf10	NP_665684.2
Pan troglodytes (chimpanzee)	GDF10	XP_001135281.2
Rattus norvegicus (Norway rat)	Gdf10	NP_077351.1
Homo sapiens (human)	GDF10	NP_004953.1
	GDF10	XP_001109475.1
Canis lupus familiaris (dog)	GDF10	XP_853904.2
Bos taurus (cattle)	GDF10	NP_001069635.1
Gallus gallus (chicken)	GDF10	XP_421648.3
Xenopus tropicalis (tropical clawed frog)	gdf10	XP_004915891.1

Gene Ontology
Bibliography

Related articles in PubMed

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Barallobre-Barreiro J, Oklu R, Lynch M, Fava M, Baig F, Yin X, Barwari T, Potier DN, Albadawi H, Jahangiri M, Porter KE, Watkins MT, Misra S, Stoughton J, Mayr M
Cardiovascular research110(3)419-30(2016 06)

Loss of GDF10/BMP3b as a prognostic marker collaborates with TGFBR3 to enhance chemotherapy resistance and epithelial-mesenchymal transition in oral squamous cell carcinoma.
Cheng CW, Hsiao JR, Fan CC, Lo YK, Tzen CY, Wu LW, Fang WY, Cheng AJ, Chen CH, Chang IS, Jiang SS, Chang JY, Lee AY
Molecular carcinogenesis55(5)499-513(2016 May)

GDF10 is a signal for axonal sprouting and functional recovery after stroke.
Li S, Nie EH, Yin Y, Benowitz LI, Tung S, Vinters HV, Bahjat FR, Stenzel-Poore MP, Kawaguchi R, Coppola G, Carmichael ST
Nature neuroscience18(12)1737-45(2015 Dec)

The aberrant promoter methylation of BMP3b and BMP6 in malignant pleural mesotheliomas.
Kimura K, Toyooka S, Tsukuda K, Yamamoto H, Suehisa H, Soh J, Otani H, Kubo T, Aoe K, Fujimoto N, Kishimoto T, Sano Y, Pass HI, Date H
Oncology reports20(5)1265-8(2008 Nov)

Hypoxia promotes the differentiated human articular chondrocyte phenotype through SOX9-dependent and -independent pathways.
Lafont JE, Talma S, Hopfgarten C, Murphy CL
The Journal of biological chemistry283(8)4778-86(2008 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study shows that GDF10 is down-regulated in patients with oral squamous cell carcinoma, and is an independent risk factor for overall survival. Its expression is regulated by TGFBR3 which shares the signaling inhibiting epithelial-mesenchymal transition.
Title: Loss of GDF10/BMP3b as a prognostic marker collaborates with TGFBR3 to enhance chemotherapy resistance and epithelial-mesenchymal transition in oral squamous cell carcinoma.

GDF10 is a stroke-induced signal for axonal sprouting and functional recovery.
Title: GDF10 is a signal for axonal sprouting and functional recovery after stroke.

Observational study of gene-disease association. (HuGE Navigator)
Title: A large-scale candidate gene association study of age at menarche and age at natural menopause.

Observational study of gene-disease association. (HuGE Navigator)
Title: New genetic associations detected in a host response study to hepatitis B vaccine.

BMP3b and BMP6 genes were suppressed by DNA methylation and methylation of BMP3b is significantly frequent in Japanese malignant pleural mesotheliomas (MPMs), suggesting its pathogenic role and the ethnic difference in MPMs.
Title: The aberrant promoter methylation of BMP3b and BMP6 in malignant pleural mesotheliomas.

The following GDF10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GDF10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04691	NM_004962.5 Latest version!	Homo sapiens growth differentiation factor 10 (GDF10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$286.30 $409.00
View Old Accession Versions >>
OHu04691	NM_004962.4	Homo sapiens growth differentiation factor 10 (GDF10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$286.30 $409.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GDF10 ( NM_004962.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004953.1 Homo sapiens growth differentiation factor 10 (GDF10), mRNA.

Price & Availability↑

CloneID	OHu04691
Clone ID Related Accession (Same CDS sequence)	NM_004962.4 , NM_004962.5
Accession Version	NM_004962.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1437bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-03
Organism	Homo sapiens(human)
Product	growth/differentiation factor 10 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA165700.1, D49492.1 and BU678075.1. This sequence is a reference standard in the RefSeqGene project. On Jul 30, 2016 this sequence version replaced NM_004962.3. ##Evidence-Data-START## Transcript exon combination :: D49492.1, SRR1803616.63086.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCATG TCCCCGCTCG GACCAGCCCG GGACCCGGGC CCCAGCTGCT GCTGCTGCTG 
CTGCCGTTGT TTCTGCTGTT GCTCCGGGAT GTGGCCGGCA GCCACAGGGC CCCCGCCTGG 
TCCGCACTGC CCGCGGCCGC CGACGGCCTG CAGGGGGACA GGGATCTCCA GCGGCACCCT 
GGGGACGCGG CCGCCACGTT GGGCCCCAGC GCCCAGGACA TGGTCGCTGT CCACATGCAC 
AGGCTCTATG AGAAGTACAG CCGGCAGGGC GCGCGGCCGG GAGGGGGCAA CACGGTCCGC 
AGCTTCAGGG CCAGGCTGGA AGTGGTCGAC CAGAAGGCCG TGTATTTCTT CAACCTGACT 
TCCATGCAAG ACTCGGAAAT GATCCTTACG GCCACTTTCC ACTTCTACTC AGAGCCGCCT 
CGGTGGCCTC GAGCGCTCGA GGTGCTATGC AAGCCGCGGG CCAAGAACGC TTCAGGCCGC 
CCGCTGCCCC TGGGCCCGCC CACACGCCAG CACCTGCTCT TCCGCAGCCT CTCGCAGAAC 
ACGGCCACAC AGGGGCTACT CCGCGGGGCC ATGGCCCTGG CGCCCCCACC GCGCGGCCTG 
TGGCAGGCCA AGGACATCTC CCCCATCGTC AAGGCGGCCC GCCGGGATGG CGAGCTGCTC 
CTCTCCGCCC AGCTGGATTC TGAGGAGAGG GACCCGGGGG TGCCCCGGCC CAGCCCCTAT 
GCGCCCTACA TCCTAGTCTA TGCCAACGAT CTGGCCATCT CGGAGCCCAA CAGCGTGGCA 
GTGACGCTGC AGAGATACGA CCCCTTCCCT GCCGGAGACC CCGAGCCCCG CGCAGCCCCC 
AACAACTCAG CGGACCCCCG CGTGCGCCGA GCCGCGCAGG CCACTGGGCC CCTCCAGGAC 
AACGAGCTGC CGGGGCTGGA TGAGAGGCCG CCGCGCGCCC ACGCACAGCA CTTCCACAAG 
CACCAGCTGT GGCCCAGCCC CTTCCGGGCG CTGAAACCCC GGCCAGGGCG CAAAGACCGC 
AGGAAGAAGG GCCAGGAGGT GTTCATGGCC GCCTCGCAGG TGCTGGACTT TGACGAGAAG 
ACGATGCAGA AAGCCCGGAG GAAGCAGTGG GATGAGCCGA GGGTGTGCTC CCGGAGGTAC 
CTGAAGGTGG ACTTCGCAGA CATCGGCTGG AATGAATGGA TAATCTCACC GAAATCTTTT 
GATGCCTACT ACTGCGCGGG AGCATGTGAG TTCCCCATGC CTAAGATCGT TCGTCCATCC 
AACCATGCCA CCATCCAGAG CATTGTCAGG GCTGTGGGCA TCATCCCTGG CATCCCAGAG 
CCCTGCTGTG TTCCCGATAA GATGAACTCC CTTGGGGTCC TCTTCCTGGA TGAGAATCGG 
AATGTGGTTC TGAAGGTGTA CCCCAACATG TCCGTGGACA CCTGTGCCTG CCGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004953.1
CDS	429..1865
Translation	MAHVPARTSPGPGPQLLLLLLPLFLLLLRDVAGSHRAPAWSALPAAADGLQGDRDLQRHPGDAAATLGPSAQDMVAVHMHRLYEKYSRQGARPGGGNTVRSFRARLEVVDQKAVYFFNLTSMQDSEMILTATFHFYSEPPRWPRALEVLCKPRAKNASGRPLPLGPPTRQHLLFRSLSQNTATQGLLRGAMALAPPPRGLWQAKDISPIVKAARRDGELLLSAQLDSEERDPGVPRPSPYAPYILVYANDLAISEPNSVAVTLQRYDPFPAGDPEPRAAPNNSADPRVRRAAQATGPLQDNELPGLDERPPRAHAQHFHKHQLWPSPFRALKPRPGRKDRRKKGQEVFMAASQVLDFDEKTMQKARRKQWDEPRVCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGIIPGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCACR

Target ORF information:

RefSeq Version	NM_004962.4
Organism	Homo sapiens(human)
Definition	Homo sapiens growth differentiation factor 10 (GDF10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004962.4

ORF Insert Sequence:

ATGGCTCATG TCCCCGCTCG GACCAGCCCG GGACCCGGGC CCCAGCTGCT GCTGCTGCTG 
CTGCCGTTGT TTCTGCTGTT GCTCCGGGAT GTGGCCGGCA GCCACAGGGC CCCCGCCTGG 
TCCGCACTGC CCGCGGCCGC CGACGGCCTG CAGGGGGACA GGGATCTCCA GCGGCACCCT 
GGGGACGCGG CCGCCACGTT GGGCCCCAGC GCCCAGGACA TGGTCGCTGT CCACATGCAC 
AGGCTCTATG AGAAGTACAG CCGGCAGGGC GCGCGGCCGG GAGGGGGCAA CACGGTCCGC 
AGCTTCAGGG CCAGGCTGGA AGTGGTCGAC CAGAAGGCCG TGTATTTCTT CAACCTGACT 
TCCATGCAAG ACTCGGAAAT GATCCTTACG GCCACTTTCC ACTTCTACTC AGAGCCGCCT 
CGGTGGCCTC GAGCGCTCGA GGTGCTATGC AAGCCGCGGG CCAAGAACGC TTCAGGCCGC 
CCGCTGCCCC TGGGCCCGCC CACACGCCAG CACCTGCTCT TCCGCAGCCT CTCGCAGAAC 
ACGGCCACAC AGGGGCTACT CCGCGGGGCC ATGGCCCTGG CGCCCCCACC GCGCGGCCTG 
TGGCAGGCCA AGGACATCTC CCCCATCGTC AAGGCGGCCC GCCGGGATGG CGAGCTGCTC 
CTCTCCGCCC AGCTGGATTC TGAGGAGAGG GACCCGGGGG TGCCCCGGCC CAGCCCCTAT 
GCGCCCTACA TCCTAGTCTA TGCCAACGAT CTGGCCATCT CGGAGCCCAA CAGCGTGGCA 
GTGACGCTGC AGAGATACGA CCCCTTCCCT GCCGGAGACC CCGAGCCCCG CGCAGCCCCC 
AACAACTCAG CGGACCCCCG CGTGCGCCGA GCCGCGCAGG CCACTGGGCC CCTCCAGGAC 
AACGAGCTGC CGGGGCTGGA TGAGAGGCCG CCGCGCGCCC ACGCACAGCA CTTCCACAAG 
CACCAGCTGT GGCCCAGCCC CTTCCGGGCG CTGAAACCCC GGCCAGGGCG CAAAGACCGC 
AGGAAGAAGG GCCAGGAGGT GTTCATGGCC GCCTCGCAGG TGCTGGACTT TGACGAGAAG 
ACGATGCAGA AAGCCCGGAG GAAGCAGTGG GATGAGCCGA GGGTGTGCTC CCGGAGGTAC 
CTGAAGGTGG ACTTCGCAGA CATCGGCTGG AATGAATGGA TAATCTCACC GAAATCTTTT 
GATGCCTACT ACTGCGCGGG AGCATGTGAG TTCCCCATGC CTAAGATCGT TCGTCCATCC 
AACCATGCCA CCATCCAGAG CATTGTCAGG GCTGTGGGCA TCATCCCTGG CATCCCAGAG 
CCCTGCTGTG TTCCCGATAA GATGAACTCC CTTGGGGTCC TCTTCCTGGA TGAGAATCGG 
AATGTGGTTC TGAAGGTGTA CCCCAACATG TCCGTGGACA CCTGTGCCTG CCGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GDF10 ( NM_004962.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_004953.1 Homo sapiens growth differentiation factor 10 (GDF10), mRNA.

Price & Availability↑

CloneID	OHu04691
Clone ID Related Accession (Same CDS sequence)	NM_004962.4 , NM_004962.5
Accession Version	NM_004962.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1437bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	growth/differentiation factor 10 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL731561.12, DA165700.1, D49492.1 and BU678075.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_004962.4. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.1017024.1, D49492.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000580279.2/ ENSP00000464145.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTCATG TCCCCGCTCG GACCAGCCCG GGACCCGGGC CCCAGCTGCT GCTGCTGCTG 
CTGCCGTTGT TTCTGCTGTT GCTCCGGGAT GTGGCCGGCA GCCACAGGGC CCCCGCCTGG 
TCCGCACTGC CCGCGGCCGC CGACGGCCTG CAGGGGGACA GGGATCTCCA GCGGCACCCT 
GGGGACGCGG CCGCCACGTT GGGCCCCAGC GCCCAGGACA TGGTCGCTGT CCACATGCAC 
AGGCTCTATG AGAAGTACAG CCGGCAGGGC GCGCGGCCGG GAGGGGGCAA CACGGTCCGC 
AGCTTCAGGG CCAGGCTGGA AGTGGTCGAC CAGAAGGCCG TGTATTTCTT CAACCTGACT 
TCCATGCAAG ACTCGGAAAT GATCCTTACG GCCACTTTCC ACTTCTACTC AGAGCCGCCT 
CGGTGGCCTC GAGCGCTCGA GGTGCTATGC AAGCCGCGGG CCAAGAACGC TTCAGGCCGC 
CCGCTGCCCC TGGGCCCGCC CACACGCCAG CACCTGCTCT TCCGCAGCCT CTCGCAGAAC 
ACGGCCACAC AGGGGCTACT CCGCGGGGCC ATGGCCCTGG CGCCCCCACC GCGCGGCCTG 
TGGCAGGCCA AGGACATCTC CCCCATCGTC AAGGCGGCCC GCCGGGATGG CGAGCTGCTC 
CTCTCCGCCC AGCTGGATTC TGAGGAGAGG GACCCGGGGG TGCCCCGGCC CAGCCCCTAT 
GCGCCCTACA TCCTAGTCTA TGCCAACGAT CTGGCCATCT CGGAGCCCAA CAGCGTGGCA 
GTGACGCTGC AGAGATACGA CCCCTTCCCT GCCGGAGACC CCGAGCCCCG CGCAGCCCCC 
AACAACTCAG CGGACCCCCG CGTGCGCCGA GCCGCGCAGG CCACTGGGCC CCTCCAGGAC 
AACGAGCTGC CGGGGCTGGA TGAGAGGCCG CCGCGCGCCC ACGCACAGCA CTTCCACAAG 
CACCAGCTGT GGCCCAGCCC CTTCCGGGCG CTGAAACCCC GGCCAGGGCG CAAAGACCGC 
AGGAAGAAGG GCCAGGAGGT GTTCATGGCC GCCTCGCAGG TGCTGGACTT TGACGAGAAG 
ACGATGCAGA AAGCCCGGAG GAAGCAGTGG GATGAGCCGA GGGTGTGCTC CCGGAGGTAC 
CTGAAGGTGG ACTTCGCAGA CATCGGCTGG AATGAATGGA TAATCTCACC GAAATCTTTT 
GATGCCTACT ACTGCGCGGG AGCATGTGAG TTCCCCATGC CTAAGATCGT TCGTCCATCC 
AACCATGCCA CCATCCAGAG CATTGTCAGG GCTGTGGGCA TCATCCCTGG CATCCCAGAG 
CCCTGCTGTG TTCCCGATAA GATGAACTCC CTTGGGGTCC TCTTCCTGGA TGAGAATCGG 
AATGTGGTTC TGAAGGTGTA CCCCAACATG TCCGTGGACA CCTGTGCCTG CCGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004953.1
CDS	456..1892
Translation	MAHVPARTSPGPGPQLLLLLLPLFLLLLRDVAGSHRAPAWSALPAAADGLQGDRDLQRHPGDAAATLGPSAQDMVAVHMHRLYEKYSRQGARPGGGNTVRSFRARLEVVDQKAVYFFNLTSMQDSEMILTATFHFYSEPPRWPRALEVLCKPRAKNASGRPLPLGPPTRQHLLFRSLSQNTATQGLLRGAMALAPPPRGLWQAKDISPIVKAARRDGELLLSAQLDSEERDPGVPRPSPYAPYILVYANDLAISEPNSVAVTLQRYDPFPAGDPEPRAAPNNSADPRVRRAAQATGPLQDNELPGLDERPPRAHAQHFHKHQLWPSPFRALKPRPGRKDRRKKGQEVFMAASQVLDFDEKTMQKARRKQWDEPRVCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGIIPGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCACR

Target ORF information:

RefSeq Version	NM_004962.5
Organism	Homo sapiens(human)
Definition	Homo sapiens growth differentiation factor 10 (GDF10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004962.5

ORF Insert Sequence:

ATGGCTCATG TCCCCGCTCG GACCAGCCCG GGACCCGGGC CCCAGCTGCT GCTGCTGCTG 
CTGCCGTTGT TTCTGCTGTT GCTCCGGGAT GTGGCCGGCA GCCACAGGGC CCCCGCCTGG 
TCCGCACTGC CCGCGGCCGC CGACGGCCTG CAGGGGGACA GGGATCTCCA GCGGCACCCT 
GGGGACGCGG CCGCCACGTT GGGCCCCAGC GCCCAGGACA TGGTCGCTGT CCACATGCAC 
AGGCTCTATG AGAAGTACAG CCGGCAGGGC GCGCGGCCGG GAGGGGGCAA CACGGTCCGC 
AGCTTCAGGG CCAGGCTGGA AGTGGTCGAC CAGAAGGCCG TGTATTTCTT CAACCTGACT 
TCCATGCAAG ACTCGGAAAT GATCCTTACG GCCACTTTCC ACTTCTACTC AGAGCCGCCT 
CGGTGGCCTC GAGCGCTCGA GGTGCTATGC AAGCCGCGGG CCAAGAACGC TTCAGGCCGC 
CCGCTGCCCC TGGGCCCGCC CACACGCCAG CACCTGCTCT TCCGCAGCCT CTCGCAGAAC 
ACGGCCACAC AGGGGCTACT CCGCGGGGCC ATGGCCCTGG CGCCCCCACC GCGCGGCCTG 
TGGCAGGCCA AGGACATCTC CCCCATCGTC AAGGCGGCCC GCCGGGATGG CGAGCTGCTC 
CTCTCCGCCC AGCTGGATTC TGAGGAGAGG GACCCGGGGG TGCCCCGGCC CAGCCCCTAT 
GCGCCCTACA TCCTAGTCTA TGCCAACGAT CTGGCCATCT CGGAGCCCAA CAGCGTGGCA 
GTGACGCTGC AGAGATACGA CCCCTTCCCT GCCGGAGACC CCGAGCCCCG CGCAGCCCCC 
AACAACTCAG CGGACCCCCG CGTGCGCCGA GCCGCGCAGG CCACTGGGCC CCTCCAGGAC 
AACGAGCTGC CGGGGCTGGA TGAGAGGCCG CCGCGCGCCC ACGCACAGCA CTTCCACAAG 
CACCAGCTGT GGCCCAGCCC CTTCCGGGCG CTGAAACCCC GGCCAGGGCG CAAAGACCGC 
AGGAAGAAGG GCCAGGAGGT GTTCATGGCC GCCTCGCAGG TGCTGGACTT TGACGAGAAG 
ACGATGCAGA AAGCCCGGAG GAAGCAGTGG GATGAGCCGA GGGTGTGCTC CCGGAGGTAC 
CTGAAGGTGG ACTTCGCAGA CATCGGCTGG AATGAATGGA TAATCTCACC GAAATCTTTT 
GATGCCTACT ACTGCGCGGG AGCATGTGAG TTCCCCATGC CTAAGATCGT TCGTCCATCC 
AACCATGCCA CCATCCAGAG CATTGTCAGG GCTGTGGGCA TCATCCCTGG CATCCCAGAG 
CCCTGCTGTG TTCCCGATAA GATGAACTCC CTTGGGGTCC TCTTCCTGGA TGAGAATCGG 
AATGTGGTTC TGAAGGTGTA CCCCAACATG TCCGTGGACA CCTGTGCCTG CCGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Cardiovascular research110(3)419-30(2016 06)
Barallobre-Barreiro J,Oklu R,Lynch M,Fava M,Baig F,Yin X,Barwari T,Potier DN,Albadawi H,Jahangiri M,Porter KE,Watkins MT,Misra S,Stoughton J,Mayr M

Loss of GDF10/BMP3b as a prognostic marker collaborates with TGFBR3 to enhance chemotherapy resistance and epithelial-mesenchymal transition in oral squamous cell carcinoma.
Molecular carcinogenesis55(5)499-513(2016 May)
Cheng CW,Hsiao JR,Fan CC,Lo YK,Tzen CY,Wu LW,Fang WY,Cheng AJ,Chen CH,Chang IS,Jiang SS,Chang JY,Lee AY

GDF10 is a signal for axonal sprouting and functional recovery after stroke.
Nature neuroscience18(12)1737-45(2015 Dec)
Li S,Nie EH,Yin Y,Benowitz LI,Tung S,Vinters HV,Bahjat FR,Stenzel-Poore MP,Kawaguchi R,Coppola G,Carmichael ST

The aberrant promoter methylation of BMP3b and BMP6 in malignant pleural mesotheliomas.
Oncology reports20(5)1265-8(2008 Nov)
Kimura K,Toyooka S,Tsukuda K,Yamamoto H,Suehisa H,Soh J,Otani H,Kubo T,Aoe K,Fujimoto N,Kishimoto T,Sano Y,Pass HI,Date H

Hypoxia promotes the differentiated human articular chondrocyte phenotype through SOX9-dependent and -independent pathways.
The Journal of biological chemistry283(8)4778-86(2008 Feb)
Lafont JE,Talma S,Hopfgarten C,Murphy CL