NKX2-8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NKX2-8
Entrez Gene ID	26257
Full Name	NK2 homeobox 8
Synonyms	NKX2.8,NKX2H,Nkx2-9
General protein information	Preferred Names NK2 homeobox 8 Names homeobox protein Nkx-2.8 NK-2 homolog 8 NK-2 homolog H NK2 transcription factor related, locus 8 homeobox protein NK-2 homolog H
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q13.3
Summary	The protein encoded by this gene is a homeobox-containing developmental regulator associated with liver development. The encoded protein binds to the alpha-fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung carcinomas, and acts as a tumor suppressor in esophageal cancer. Mutations in this gene may also be a cause of neural tube defects. [provided by RefSeq, Dec 2015].
Disorder MIM:	603245

mRNA and Protein(s)

mRNA	Protein	Name
NM_014360.3	NP_055175.2	homeobox protein Nkx-2.8
NM_014360.2	NP_055175.2	homeobox protein Nkx-2.8
NM_014360.4	NP_055175.2	homeobox protein Nkx-2.8

Pathways from BioSystems

Homologies

Homo sapiens (human)	NKX2-8	NP_055175.2
Pan troglodytes (chimpanzee)	NKX2-8	XP_522995.2
Bos taurus (cattle)	NKX2-8	NP_001179092.1
Gallus gallus (chicken)	NKX2-8	XP_003641408.1
Rattus norvegicus (Norway rat)	Nkx2-8	NP_001100202.1
Xenopus tropicalis (tropical clawed frog)	nkx2-8	NP_988951.1
	LOC696564	XP_001085187.1
Danio rerio (zebrafish)	nkx2.9	NP_001093073.1
Canis lupus familiaris (dog)	NKX2-8	XP_852202.1
Mus musculus (house mouse)	Nkx2-9	NP_032727.2

Gene Ontology
Bibliography

Related articles in PubMed

Nkx2.8 inhibits epithelial-mesenchymal transition in bladder urothelial carcinoma via transcriptional repression of Twist1.
Yu C, Liu Z, Chen Q, Li Y, Jiang L, Zhang Z, Zhou F
Cancer research(2018 Jan)

Dynamic changes in DNA methylation and hydroxymethylation when hES cells undergo differentiation toward a neuronal lineage.
Kim M, Park YK, Kang TW, Lee SH, Rhee YH, Park JL, Kim HJ, Lee D, Lee D, Kim SY, Kim YS
Human molecular genetics23(3)657-67(2014 Feb)

Methylation-specific digital karyotyping of HPV16E6E7-expressing human keratinocytes identifies novel methylation events in cervical carcinogenesis.
Steenbergen RD, Ongenaert M, Snellenberg S, Trooskens G, van der Meide WF, Pandey D, Bloushtain-Qimron N, Polyak K, Meijer CJ, Snijders PJ, Van Criekinge W
The Journal of pathology231(1)53-62(2013 Sep)

Genome-wide association mapping in dogs enables identification of the homeobox gene, NKX2-8, as a genetic component of neural tube defects in humans.
Safra N, Bassuk AG, Ferguson PJ, Aguilar M, Coulson RL, Thomas N, Hitchens PL, Dickinson PJ, Vernau KM, Wolf ZT, Bannasch DL
PLoS genetics9(7)e1003646(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results show that Nkx2-8 functions as a tumor suppressor in esophageal squamous cell carcinoma (ESCC), the downregulation of which contributes to NF-kappaB P65 activation and ESCC angiogenesis.
Title: Nkx2-8 downregulation promotes angiogenesis and activates NF-?B in esophageal cancer.

overexpression of Nkx2.8 resulted in downregulation of p-FOXO3a and inhibition of MEK/ERK pathway activity. silencing Nkx2.8 led to upregulation of p-FOXO3a and increase of MEK/ERK pathway activity.
Title: The tumor-suppressor gene Nkx2.8 suppresses bladder cancer proliferation through upregulation of FOXO3a and inhibition of the MEK/ERK signaling pathway.

Most tumors have low expression of Nkx2-8, and its expression can inhibit growth of some lung cancer cells.
Title: Both gene amplification and allelic loss occur at 14q13.3 in lung cancer.

Coactivation of the TTF-1 and NKX2-8 pathways identified a cluster of lung cancer patients with poor survival and were shown to exhibit resistance to cisplatin
Title: Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer.

A murine Nkx2.8 was isolated from the Hepal-6 cell line and showed oligonucleotide binding competitive with fetoprotein transcription factor.
Title: Regulation of alpha-fetoprotein expression by Nkx2.8.

The following NKX2-8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NKX2-8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06330	NM_014360.4 Latest version!	Homo sapiens NK2 homeobox 8 (NKX2-8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu06330	NM_014360.2	Homo sapiens NK2 homeobox 8 (NKX2-8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu06330	NM_014360.3	Homo sapiens NK2 homeobox 8 (NKX2-8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NKX2-8 ( NM_014360.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055175.2 Homo sapiens NK2 homeobox 8 (NKX2-8), mRNA.

Price & Availability↑

CloneID	OHu06330
Clone ID Related Accession (Same CDS sequence)	NM_014360.3 , NM_014360.2 , NM_014360.4
Accession Version	NM_014360.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 720bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Homo sapiens(human)
Product	homeobox protein Nkx-2.8
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA438523.1, AK313537.1 and BC041090.1. On Dec 16, 2015 this sequence version replaced NM_014360.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC041090.1, AF000295.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCACCT CTGGACGCCT GAGCTTCACC GTGCGCAGCC TTCTAGATTT ACCCGAGCAG 
GACGCGCAAC ACCTGCCGAG GCGGGAGCCA GAACCACGCG CCCCCCAGCC CGACCCCTGC 
GCCGCCTGGC TGGATTCGGA GCGCGGCCAC TACCCTTCCT CGGACGAGAG CAGCCTGGAG 
ACCAGCCCGC CAGACTCGTC GCAGCGGCCG TCCGCTAGGC CCGCGTCTCC GGGCTCGGAC 
GCCGAGAAAA GGAAGAAGCG GCGGGTGCTA TTCTCCAAGG CGCAGACGCT GGAGTTGGAG 
CGGCGCTTCC GGCAGCAGCG GTACCTGTCT GCGCCCGAGC GCGAGCAGCT GGCGAGCCTG 
CTTCGCCTCA CGCCCACGCA GGTCAAGATC TGGTTCCAGA ATCATCGCTA CAAGCTGAAG 
CGCGCTCGCG CTCCAGGGGC GGCGGAGTCG CCTGACCTGG CAGCATCCGC CGAGCTGCAC 
GCCGCGCCCG GCCTGCTGCG TCGCGTGGTG GTGCCGGTGC TTGTTCGCGA CGGGCAGCCG 
TGCGGCGGCG GCGGCGGTGG CGAGGTGGGA ACCGCCGCGG CCCAGGAGAA GTGCGGCGCC 
CCTCCAGCCG CCGCCTGCCC TCTGCCGGGC TACCCTGCCT TCGGTCCCGG CTCGGCGCTT 
GGCCTCTTCC CCGCCTACCA GCACTTAGCA TCCCCCGCCC TGGTCTCCTG GAACTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055175.2
CDS	226..945
Translation	MATSGRLSFTVRSLLDLPEQDAQHLPRREPEPRAPQPDPCAAWLDSERGHYPSSDESSLETSPPDSSQRPSARPASPGSDAEKRKKRRVLFSKAQTLELERRFRQQRYLSAPEREQLASLLRLTPTQVKIWFQNHRYKLKRARAPGAAESPDLAASAELHAAPGLLRRVVVPVLVRDGQPCGGGGGGEVGTAAAQEKCGAPPAAACPLPGYPAFGPGSALGLFPAYQHLASPALVSWNW

Target ORF information:

RefSeq Version	NM_014360.3
Organism	Homo sapiens(human)
Definition	Homo sapiens NK2 homeobox 8 (NKX2-8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014360.3

ORF Insert Sequence:

ATGGCCACCT CTGGACGCCT GAGCTTCACC GTGCGCAGCC TTCTAGATTT ACCCGAGCAG 
GACGCGCAAC ACCTGCCGAG GCGGGAGCCA GAACCACGCG CCCCCCAGCC CGACCCCTGC 
GCCGCCTGGC TGGATTCGGA GCGCGGCCAC TACCCTTCCT CGGACGAGAG CAGCCTGGAG 
ACCAGCCCGC CAGACTCGTC GCAGCGGCCG TCCGCTAGGC CCGCGTCTCC GGGCTCGGAC 
GCCGAGAAAA GGAAGAAGCG GCGGGTGCTA TTCTCCAAGG CGCAGACGCT GGAGTTGGAG 
CGGCGCTTCC GGCAGCAGCG GTACCTGTCT GCGCCCGAGC GCGAGCAGCT GGCGAGCCTG 
CTTCGCCTCA CGCCCACGCA GGTCAAGATC TGGTTCCAGA ATCATCGCTA CAAGCTGAAG 
CGCGCTCGCG CTCCAGGGGC GGCGGAGTCG CCTGACCTGG CAGCATCCGC CGAGCTGCAC 
GCCGCGCCCG GCCTGCTGCG TCGCGTGGTG GTGCCGGTGC TTGTTCGCGA CGGGCAGCCG 
TGCGGCGGCG GCGGCGGTGG CGAGGTGGGA ACCGCCGCGG CCCAGGAGAA GTGCGGCGCC 
CCTCCAGCCG CCGCCTGCCC TCTGCCGGGC TACCCTGCCT TCGGTCCCGG CTCGGCGCTT 
GGCCTCTTCC CCGCCTACCA GCACTTAGCA TCCCCCGCCC TGGTCTCCTG GAACTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NKX2-8 ( NM_014360.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_055175.2 Homo sapiens NK2 homeobox 8 (NKX2-8), mRNA.

Price & Availability↑

CloneID	OHu06330
Clone ID Related Accession (Same CDS sequence)	NM_014360.3 , NM_014360.2 , NM_014360.4
Accession Version	NM_014360.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 720bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	homeobox protein Nkx-2.8
Comment

ATGGCCACCT CTGGACGCCT GAGCTTCACC GTGCGCAGCC TTCTAGATTT ACCCGAGCAG 
GACGCGCAAC ACCTGCCGAG GCGGGAGCCA GAACCACGCG CCCCCCAGCC CGACCCCTGC 
GCCGCCTGGC TGGATTCGGA GCGCGGCCAC TACCCTTCCT CGGACGAGAG CAGCCTGGAG 
ACCAGCCCGC CAGACTCGTC GCAGCGGCCG TCCGCTAGGC CCGCGTCTCC GGGCTCGGAC 
GCCGAGAAAA GGAAGAAGCG GCGGGTGCTA TTCTCCAAGG CGCAGACGCT GGAGTTGGAG 
CGGCGCTTCC GGCAGCAGCG GTACCTGTCT GCGCCCGAGC GCGAGCAGCT GGCGAGCCTG 
CTTCGCCTCA CGCCCACGCA GGTCAAGATC TGGTTCCAGA ATCATCGCTA CAAGCTGAAG 
CGCGCTCGCG CTCCAGGGGC GGCGGAGTCG CCTGACCTGG CAGCATCCGC CGAGCTGCAC 
GCCGCGCCCG GCCTGCTGCG TCGCGTGGTG GTGCCGGTGC TTGTTCGCGA CGGGCAGCCG 
TGCGGCGGCG GCGGCGGTGG CGAGGTGGGA ACCGCCGCGG CCCAGGAGAA GTGCGGCGCC 
CCTCCAGCCG CCGCCTGCCC TCTGCCGGGC TACCCTGCCT TCGGTCCCGG CTCGGCGCTT 
GGCCTCTTCC CCGCCTACCA GCACTTAGCA TCCCCCGCCC TGGTCTCCTG GAACTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055175.2
Translation	MATSGRLSFTVRSLLDLPEQDAQHLPRREPEPRAPQPDPCAAWLDSERGHYPSSDESSLETSPPDSSQRPSARPASPGSDAEKRKKRRVLFSKAQTLELERRFRQQRYLSAPEREQLASLLRLTPTQVKIWFQNHRYKLKRARAPGAAESPDLAASAELHAAPGLLRRVVVPVLVRDGQPCGGGGGGEVGTAAAQEKCGAPPAAACPLPGYPAFGPGSALGLFPAYQHLASPALVSWNW

Target ORF information:

RefSeq Version	NM_014360.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens NK2 homeobox 8 (NKX2-8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014360.2

ORF Insert Sequence:

ATGGCCACCT CTGGACGCCT GAGCTTCACC GTGCGCAGCC TTCTAGATTT ACCCGAGCAG 
GACGCGCAAC ACCTGCCGAG GCGGGAGCCA GAACCACGCG CCCCCCAGCC CGACCCCTGC 
GCCGCCTGGC TGGATTCGGA GCGCGGCCAC TACCCTTCCT CGGACGAGAG CAGCCTGGAG 
ACCAGCCCGC CAGACTCGTC GCAGCGGCCG TCCGCTAGGC CCGCGTCTCC GGGCTCGGAC 
GCCGAGAAAA GGAAGAAGCG GCGGGTGCTA TTCTCCAAGG CGCAGACGCT GGAGTTGGAG 
CGGCGCTTCC GGCAGCAGCG GTACCTGTCT GCGCCCGAGC GCGAGCAGCT GGCGAGCCTG 
CTTCGCCTCA CGCCCACGCA GGTCAAGATC TGGTTCCAGA ATCATCGCTA CAAGCTGAAG 
CGCGCTCGCG CTCCAGGGGC GGCGGAGTCG CCTGACCTGG CAGCATCCGC CGAGCTGCAC 
GCCGCGCCCG GCCTGCTGCG TCGCGTGGTG GTGCCGGTGC TTGTTCGCGA CGGGCAGCCG 
TGCGGCGGCG GCGGCGGTGG CGAGGTGGGA ACCGCCGCGG CCCAGGAGAA GTGCGGCGCC 
CCTCCAGCCG CCGCCTGCCC TCTGCCGGGC TACCCTGCCT TCGGTCCCGG CTCGGCGCTT 
GGCCTCTTCC CCGCCTACCA GCACTTAGCA TCCCCCGCCC TGGTCTCCTG GAACTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NKX2-8 ( NM_014360.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055175.2 Homo sapiens NK2 homeobox 8 (NKX2-8), mRNA.

Price & Availability↑

CloneID	OHu06330
Clone ID Related Accession (Same CDS sequence)	NM_014360.3 , NM_014360.2 , NM_014360.4
Accession Version	NM_014360.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 720bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	homeobox protein Nkx-2.8
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA438523.1, AK313537.1, BC041090.1 and AL079303.3. On May 17, 2019 this sequence version replaced NM_014360.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC041090.1, AF000295.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000258829.6/ ENSP00000258829.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCACCT CTGGACGCCT GAGCTTCACC GTGCGCAGCC TTCTAGATTT ACCCGAGCAG 
GACGCGCAAC ACCTGCCGAG GCGGGAGCCA GAACCACGCG CCCCCCAGCC CGACCCCTGC 
GCCGCCTGGC TGGATTCGGA GCGCGGCCAC TACCCTTCCT CGGACGAGAG CAGCCTGGAG 
ACCAGCCCGC CAGACTCGTC GCAGCGGCCG TCCGCTAGGC CCGCGTCTCC GGGCTCGGAC 
GCCGAGAAAA GGAAGAAGCG GCGGGTGCTA TTCTCCAAGG CGCAGACGCT GGAGTTGGAG 
CGGCGCTTCC GGCAGCAGCG GTACCTGTCT GCGCCCGAGC GCGAGCAGCT GGCGAGCCTG 
CTTCGCCTCA CGCCCACGCA GGTCAAGATC TGGTTCCAGA ATCATCGCTA CAAGCTGAAG 
CGCGCTCGCG CTCCAGGGGC GGCGGAGTCG CCTGACCTGG CAGCATCCGC CGAGCTGCAC 
GCCGCGCCCG GCCTGCTGCG TCGCGTGGTG GTGCCGGTGC TTGTTCGCGA CGGGCAGCCG 
TGCGGCGGCG GCGGCGGTGG CGAGGTGGGA ACCGCCGCGG CCCAGGAGAA GTGCGGCGCC 
CCTCCAGCCG CCGCCTGCCC TCTGCCGGGC TACCCTGCCT TCGGTCCCGG CTCGGCGCTT 
GGCCTCTTCC CCGCCTACCA GCACTTAGCA TCCCCCGCCC TGGTCTCCTG GAACTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055175.2
CDS	226..945
Translation	MATSGRLSFTVRSLLDLPEQDAQHLPRREPEPRAPQPDPCAAWLDSERGHYPSSDESSLETSPPDSSQRPSARPASPGSDAEKRKKRRVLFSKAQTLELERRFRQQRYLSAPEREQLASLLRLTPTQVKIWFQNHRYKLKRARAPGAAESPDLAASAELHAAPGLLRRVVVPVLVRDGQPCGGGGGGEVGTAAAQEKCGAPPAAACPLPGYPAFGPGSALGLFPAYQHLASPALVSWNW

Target ORF information:

RefSeq Version	NM_014360.4
Organism	Homo sapiens(human)
Definition	Homo sapiens NK2 homeobox 8 (NKX2-8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014360.4

ORF Insert Sequence:

ATGGCCACCT CTGGACGCCT GAGCTTCACC GTGCGCAGCC TTCTAGATTT ACCCGAGCAG 
GACGCGCAAC ACCTGCCGAG GCGGGAGCCA GAACCACGCG CCCCCCAGCC CGACCCCTGC 
GCCGCCTGGC TGGATTCGGA GCGCGGCCAC TACCCTTCCT CGGACGAGAG CAGCCTGGAG 
ACCAGCCCGC CAGACTCGTC GCAGCGGCCG TCCGCTAGGC CCGCGTCTCC GGGCTCGGAC 
GCCGAGAAAA GGAAGAAGCG GCGGGTGCTA TTCTCCAAGG CGCAGACGCT GGAGTTGGAG 
CGGCGCTTCC GGCAGCAGCG GTACCTGTCT GCGCCCGAGC GCGAGCAGCT GGCGAGCCTG 
CTTCGCCTCA CGCCCACGCA GGTCAAGATC TGGTTCCAGA ATCATCGCTA CAAGCTGAAG 
CGCGCTCGCG CTCCAGGGGC GGCGGAGTCG CCTGACCTGG CAGCATCCGC CGAGCTGCAC 
GCCGCGCCCG GCCTGCTGCG TCGCGTGGTG GTGCCGGTGC TTGTTCGCGA CGGGCAGCCG 
TGCGGCGGCG GCGGCGGTGG CGAGGTGGGA ACCGCCGCGG CCCAGGAGAA GTGCGGCGCC 
CCTCCAGCCG CCGCCTGCCC TCTGCCGGGC TACCCTGCCT TCGGTCCCGG CTCGGCGCTT 
GGCCTCTTCC CCGCCTACCA GCACTTAGCA TCCCCCGCCC TGGTCTCCTG GAACTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Nkx2.8 inhibits epithelial-mesenchymal transition in bladder urothelial carcinoma via transcriptional repression of Twist1.
Cancer research(2018 Jan)
Yu C,Liu Z,Chen Q,Li Y,Jiang L,Zhang Z,Zhou F

Dynamic changes in DNA methylation and hydroxymethylation when hES cells undergo differentiation toward a neuronal lineage.
Human molecular genetics23(3)657-67(2014 Feb)
Kim M,Park YK,Kang TW,Lee SH,Rhee YH,Park JL,Kim HJ,Lee D,Lee D,Kim SY,Kim YS

Methylation-specific digital karyotyping of HPV16E6E7-expressing human keratinocytes identifies novel methylation events in cervical carcinogenesis.
The Journal of pathology231(1)53-62(2013 Sep)
Steenbergen RD,Ongenaert M,Snellenberg S,Trooskens G,van der Meide WF,Pandey D,Bloushtain-Qimron N,Polyak K,Meijer CJ,Snijders PJ,Van Criekinge W

Genome-wide association mapping in dogs enables identification of the homeobox gene, NKX2-8, as a genetic component of neural tube defects in humans.
PLoS genetics9(7)e1003646(2013)
Safra N,Bassuk AG,Ferguson PJ,Aguilar M,Coulson RL,Thomas N,Hitchens PL,Dickinson PJ,Vernau KM,Wolf ZT,Bannasch DL

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

NKX2-8 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報