ATXN10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ATXN10
Entrez Gene ID	25814
Full Name	ataxin 10
Synonyms	E46L,HUMEEP,SCA10
General protein information	Preferred Names ataxin 10 Names ataxin-10 brain protein E46 homolog spinocerebellar ataxia type 10 protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q13.31
Summary	This gene encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade. Expansion of an ATTCT repeat from 9-32 copies to 800-4500 copies in an intronic region of this locus has been associated with spinocerebellar ataxia, type 10. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jul 2016].
Disorder MIM:	611150
Disorder Html:	Spinocerebellar ataxia 10, 603516 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_013236.4	NP_037368.1	ataxin-10 isoform 1
NM_013236.3	NP_037368.1	ataxin-10 isoform 1
NM_001167621.1	NP_001161093.1	ataxin-10 isoform 2

Pathways from BioSystems

Homologies

	ATXN10	XP_001110207.1
Bos taurus (cattle)	ATXN10	NP_001070519.1
Mus musculus (house mouse)	Atxn10	NP_058539.2
Gallus gallus (chicken)	ATXN10	XP_416469.2
Danio rerio (zebrafish)	atxn10	NP_001124084.1
Rattus norvegicus (Norway rat)	Atxn10	NP_579847.1
Homo sapiens (human)	ATXN10	NP_037368.1
Pan troglodytes (chimpanzee)	ATXN10	XP_525623.3
Canis lupus familiaris (dog)	ATXN10	XP_531697.2
Xenopus tropicalis (tropical clawed frog)	atxn10	NP_001015825.1

Gene Ontology
Bibliography

Related articles in PubMed

Haplotype Study in SCA10 Families Provides Further Evidence for a Common Ancestral Origin of the Mutation.
Bampi GB, Bisso-Machado R, H?nemeier T, Gheno TC, Furtado GV, Veliz-Otani D, Cornejo-Olivas M, Mazzeti P, Bortolini MC, Jardim LB, Saraiva-Pereira ML,
Neuromolecular medicine19(4)501-509(2017 Dec)

Ataxin-10 is involved in Golgi membrane dynamics.
Tian J, Shi Y, Nai S, Geng Q, Zhang L, Wei GH, Xu X, Li J
Journal of genetics and genomics = Yi chuan xue bao44(11)549-552(2017 Nov)

Inheritance patterns of ATCCT repeat interruptions in spinocerebellar ataxia type 10 (SCA10) expansions.
Landrian I, McFarland KN, Liu J, Mulligan CJ, Rasmussen A, Ashizawa T
PloS one12(4)e0175958(2017)

First report of a Japanese family with spinocerebellar ataxia type 10: The second report from Asia after a report from China.
Naito H, Takahashi T, Kamada M, Morino H, Yoshino H, Hattori N, Maruyama H, Kawakami H, Matsumoto M
PloS one12(5)e0177955(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Inheritance patterns of ATCCT repeat interruptions in spinocerebellar ataxia type 10 expansions of ataxin-10 has been reported.
Title: Inheritance patterns of ATCCT repeat interruptions in spinocerebellar ataxia type 10 (SCA10) expansions.

Polymorphism in ATXN10 gene is associated with spinocerebellar ataxia type 10.
Title: First report of a Japanese family with spinocerebellar ataxia type 10: The second report from Asia after a report from China.

Data suggest precursor mRNA for SCA10 (crystalized using two model AUUCU SCA10 repeats) exhibits the following conformation: the two asymmetric RNA molecules are antiparallel to each other and the interaction is stabilized by multiple hydrogen bonds.
Title: Crystallographic and Computational Analyses of AUUCU Repeating RNA That Causes Spinocerebellar Ataxia Type 10 (SCA10).

Inhibition of Aurora B or expression of the S12A mutant renders reduced interaction between Ataxin-10 and polo-like kinase 1 (Plk1), a kinase previously identified to regulate Ataxin-10 in cytokinesis.
Title: Aurora B-dependent phosphorylation of Ataxin-10 promotes the interaction between Ataxin-10 and Plk1 in cytokinesis.

Single molecule real time sequencing of long tandem nucleotide repeats in spinocerebellar ataxia ATXN10 reveals unique insight of repeat expansion structure in three unrelated patients.
Title: SMRT Sequencing of Long Tandem Nucleotide Repeats in SCA10 Reveals Unique Insight of Repeat Expansion Structure.

The following ATXN10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ATXN10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26356	NM_013236.4 Latest version!	Homo sapiens ataxin 10 (ATXN10), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$265.30 $379.00
OHu27341	NM_001167621.1 Latest version!	Homo sapiens ataxin 10 (ATXN10), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu26356	NM_013236.3	Homo sapiens ataxin 10 (ATXN10), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$265.30 $379.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ATXN10 ( NM_013236.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_037368.1 Homo sapiens ataxin 10 (ATXN10), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu26356
Clone ID Related Accession (Same CDS sequence)	NM_013236.4 , NM_013236.3
Accession Version	NM_013236.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1428bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	ataxin-10 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB035174.1, BC007508.2, AK095309.1, DB548216.1 and R43701.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_013236.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.285016.1, SRR1803613.134517.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000252934.10/ ENSP00000252934.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCGC CCAGGCCGCC GCCTGCCAGG CTGTCGGGCG TCATGGTGCC GGCGCCCATC 
CAAGACCTGG AGGCCCTGCG CGCGCTCACG GCGCTCTTCA AAGAGCAGCG GAACCGAGAA 
ACAGCACCCA GGACTATCTT CCAAAGAGTT CTGGATATCC TAAAGAAATC TTCTCATGCT 
GTTGAGCTTG CCTGCAGAGA TCCATCCCAA GTGGAAAACC TGGCTTCCAG TCTGCAGTTA 
ATAACAGAAT GCTTCAGGTG TCTTCGCAAT GCTTGCATAG AGTGTTCTGT GAACCAGAAT 
TCAATCAGGA ACTTGGATAC GATTGGTGTT GCTGTTGATT TGATTCTTCT GTTTCGTGAA 
CTGCGAGTGG AACAGGAATC TCTGTTGACA GCTTTTCGCT GTGGCCTGCA GTTTTTAGGC 
AACATTGCCT CACGGAATGA AGATTCCCAG TCTATTGTTT GGGTGCATGC TTTCCCAGAA 
CTGTTTTTGT CTTGCTTAAA TCATCCGGAC AAAAAAATTG TTGCCTACTC TTCAATGATT 
TTGTTTACAT CCCTTAATCA TGAAAGAATG AAAGAACTGG AGGAGAACCT CAATATTGCA 
ATTGATGTCA TAGATGCTTA CCAAAAACAT CCTGAATCAG AATGGCCGTT CTTGATTATT 
ACAGACCTCT TTCTGAAAAG CCCGGAATTG GTACAAGCCA TGTTTCCCAA ACTGAACAAT 
CAAGAAAGAG TTACACTGTT AGACCTTATG ATAGCCAAGA TAACGAGTGA TGAGCCACTC 
ACCAAGGATG ACATCCCTGT GTTTTTGCGG CATGCTGAGT TGATTGCAAG CACCTTTGTG 
GATCAGTGCA AGACTGTGCT CAAGCTGGCC TCTGAGGAGC CTCCTGATGA TGAGGAGGCA 
CTGGCTACAA TTAGGCTTCT CGACGTCCTG TGCGAAATGA CTGTGAATAC TGAGCTGCTC 
GGCTATCTGC AGGTTTTCCC TGGCTTGCTG GAAAGAGTGA TTGATCTTTT GCGGGTGATT 
CATGTAGCTG GAAAAGAAAC CACAAACATC TTCAGTAATT GTGGTTGCGT GAGAGCAGAA 
GGTGACATCT CCAATGTGGC CAATGGGTTT AAGTCTCATC TCATTCGTCT GATTGGAAAT 
CTGTGTTACA AGAATAAAGA TAACCAAGAC AAGGTAAATG AGCTGGATGG TATCCCGTTG 
ATCCTGGACA ACTGCAACAT CAGTGACAGT AACCCCTTTC TGACCCAGTG GGTGATATAT 
GCCATCCGAA ACCTTACCGA AGACAACAGC CAAAACCAAG ATTTGATTGC AAAGATGGAG 
GAACAGGGGC TGGCAGATGC ATCCCTACTT AAAAAAGTGG GTTTTGAAGT TGAAAAGAAA 
GGCGAAAAGC TGATCCTGAA ATCTACTAGA GACACCCCTA AGCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037368.1
CDS	231..1658
Translation	MAAPRPPPARLSGVMVPAPIQDLEALRALTALFKEQRNRETAPRTIFQRVLDILKKSSHAVELACRDPSQVENLASSLQLITECFRCLRNACIECSVNQNSIRNLDTIGVAVDLILLFRELRVEQESLLTAFRCGLQFLGNIASRNEDSQSIVWVHAFPELFLSCLNHPDKKIVAYSSMILFTSLNHERMKELEENLNIAIDVIDAYQKHPESEWPFLIITDLFLKSPELVQAMFPKLNNQERVTLLDLMIAKITSDEPLTKDDIPVFLRHAELIASTFVDQCKTVLKLASEEPPDDEEALATIRLLDVLCEMTVNTELLGYLQVFPGLLERVIDLLRVIHVAGKETTNIFSNCGCVRAEGDISNVANGFKSHLIRLIGNLCYKNKDNQDKVNELDGIPLILDNCNISDSNPFLTQWVIYAIRNLTEDNSQNQDLIAKMEEQGLADASLLKKVGFEVEKKGEKLILKSTRDTPKP

Target ORF information:

RefSeq Version	NM_013236.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ataxin 10 (ATXN10), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013236.4

ORF Insert Sequence:

ATGGCGGCGC CCAGGCCGCC GCCTGCCAGG CTGTCGGGCG TCATGGTGCC GGCGCCCATC 
CAAGACCTGG AGGCCCTGCG CGCGCTCACG GCGCTCTTCA AAGAGCAGCG GAACCGAGAA 
ACAGCACCCA GGACTATCTT CCAAAGAGTT CTGGATATCC TAAAGAAATC TTCTCATGCT 
GTTGAGCTTG CCTGCAGAGA TCCATCCCAA GTGGAAAACC TGGCTTCCAG TCTGCAGTTA 
ATAACAGAAT GCTTCAGGTG TCTTCGCAAT GCTTGCATAG AGTGTTCTGT GAACCAGAAT 
TCAATCAGGA ACTTGGATAC GATTGGTGTT GCTGTTGATT TGATTCTTCT GTTTCGTGAA 
CTGCGAGTGG AACAGGAATC TCTGTTGACA GCTTTTCGCT GTGGCCTGCA GTTTTTAGGC 
AACATTGCCT CACGGAATGA AGATTCCCAG TCTATTGTTT GGGTGCATGC TTTCCCAGAA 
CTGTTTTTGT CTTGCTTAAA TCATCCGGAC AAAAAAATTG TTGCCTACTC TTCAATGATT 
TTGTTTACAT CCCTTAATCA TGAAAGAATG AAAGAACTGG AGGAGAACCT CAATATTGCA 
ATTGATGTCA TAGATGCTTA CCAAAAACAT CCTGAATCAG AATGGCCGTT CTTGATTATT 
ACAGACCTCT TTCTGAAAAG CCCGGAATTG GTACAAGCCA TGTTTCCCAA ACTGAACAAT 
CAAGAAAGAG TTACACTGTT AGACCTTATG ATAGCCAAGA TAACGAGTGA TGAGCCACTC 
ACCAAGGATG ACATCCCTGT GTTTTTGCGG CATGCTGAGT TGATTGCAAG CACCTTTGTG 
GATCAGTGCA AGACTGTGCT CAAGCTGGCC TCTGAGGAGC CTCCTGATGA TGAGGAGGCA 
CTGGCTACAA TTAGGCTTCT CGACGTCCTG TGCGAAATGA CTGTGAATAC TGAGCTGCTC 
GGCTATCTGC AGGTTTTCCC TGGCTTGCTG GAAAGAGTGA TTGATCTTTT GCGGGTGATT 
CATGTAGCTG GAAAAGAAAC CACAAACATC TTCAGTAATT GTGGTTGCGT GAGAGCAGAA 
GGTGACATCT CCAATGTGGC CAATGGGTTT AAGTCTCATC TCATTCGTCT GATTGGAAAT 
CTGTGTTACA AGAATAAAGA TAACCAAGAC AAGGTAAATG AGCTGGATGG TATCCCGTTG 
ATCCTGGACA ACTGCAACAT CAGTGACAGT AACCCCTTTC TGACCCAGTG GGTGATATAT 
GCCATCCGAA ACCTTACCGA AGACAACAGC CAAAACCAAG ATTTGATTGC AAAGATGGAG 
GAACAGGGGC TGGCAGATGC ATCCCTACTT AAAAAAGTGG GTTTTGAAGT TGAAAAGAAA 
GGCGAAAAGC TGATCCTGAA ATCTACTAGA GACACCCCTA AGCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATXN10 ( NM_013236.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_037368.1 Homo sapiens ataxin 10 (ATXN10), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu26356
Clone ID Related Accession (Same CDS sequence)	NM_013236.4 , NM_013236.3
Accession Version	NM_013236.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1428bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-08
Organism	Homo sapiens(human)
Product	ataxin-10 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB035174.1, BC007508.2, AK095309.1, DB548216.1 and R43701.1. This sequence is a reference standard in the RefSeqGene project. On Nov 11, 2009 this sequence version replaced NM_013236.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.71867.1, SRR1803613.134517.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGC CCAGGCCGCC GCCTGCCAGG CTGTCGGGCG TCATGGTGCC GGCGCCCATC 
CAAGACCTGG AGGCCCTGCG CGCGCTCACG GCGCTCTTCA AAGAGCAGCG GAACCGAGAA 
ACAGCACCCA GGACTATCTT CCAAAGAGTT CTGGATATCC TAAAGAAATC TTCTCATGCT 
GTTGAGCTTG CCTGCAGAGA TCCATCCCAA GTGGAAAACC TGGCTTCCAG TCTGCAGTTA 
ATAACAGAAT GCTTCAGGTG TCTTCGCAAT GCTTGCATAG AGTGTTCTGT GAACCAGAAT 
TCAATCAGGA ACTTGGATAC GATTGGTGTT GCTGTTGATT TGATTCTTCT GTTTCGTGAA 
CTGCGAGTGG AACAGGAATC TCTGTTGACA GCTTTTCGCT GTGGCCTGCA GTTTTTAGGC 
AACATTGCCT CACGGAATGA AGATTCCCAG TCTATTGTTT GGGTGCATGC TTTCCCAGAA 
CTGTTTTTGT CTTGCTTAAA TCATCCGGAC AAAAAAATTG TTGCCTACTC TTCAATGATT 
TTGTTTACAT CCCTTAATCA TGAAAGAATG AAAGAACTGG AGGAGAACCT CAATATTGCA 
ATTGATGTCA TAGATGCTTA CCAAAAACAT CCTGAATCAG AATGGCCGTT CTTGATTATT 
ACAGACCTCT TTCTGAAAAG CCCGGAATTG GTACAAGCCA TGTTTCCCAA ACTGAACAAT 
CAAGAAAGAG TTACACTGTT AGACCTTATG ATAGCCAAGA TAACGAGTGA TGAGCCACTC 
ACCAAGGATG ACATCCCTGT GTTTTTGCGG CATGCTGAGT TGATTGCAAG CACCTTTGTG 
GATCAGTGCA AGACTGTGCT CAAGCTGGCC TCTGAGGAGC CTCCTGATGA TGAGGAGGCA 
CTGGCTACAA TTAGGCTTCT CGACGTCCTG TGCGAAATGA CTGTGAATAC TGAGCTGCTC 
GGCTATCTGC AGGTTTTCCC TGGCTTGCTG GAAAGAGTGA TTGATCTTTT GCGGGTGATT 
CATGTAGCTG GAAAAGAAAC CACAAACATC TTCAGTAATT GTGGTTGCGT GAGAGCAGAA 
GGTGACATCT CCAATGTGGC CAATGGGTTT AAGTCTCATC TCATTCGTCT GATTGGAAAT 
CTGTGTTACA AGAATAAAGA TAACCAAGAC AAGGTAAATG AGCTGGATGG TATCCCGTTG 
ATCCTGGACA ACTGCAACAT CAGTGACAGT AACCCCTTTC TGACCCAGTG GGTGATATAT 
GCCATCCGAA ACCTTACCGA AGACAACAGC CAAAACCAAG ATTTGATTGC AAAGATGGAG 
GAACAGGGGC TGGCAGATGC ATCCCTACTT AAAAAAGTGG GTTTTGAAGT TGAAAAGAAA 
GGCGAAAAGC TGATCCTGAA ATCTACTAGA GACACCCCTA AGCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037368.1
CDS	267..1694
Translation	MAAPRPPPARLSGVMVPAPIQDLEALRALTALFKEQRNRETAPRTIFQRVLDILKKSSHAVELACRDPSQVENLASSLQLITECFRCLRNACIECSVNQNSIRNLDTIGVAVDLILLFRELRVEQESLLTAFRCGLQFLGNIASRNEDSQSIVWVHAFPELFLSCLNHPDKKIVAYSSMILFTSLNHERMKELEENLNIAIDVIDAYQKHPESEWPFLIITDLFLKSPELVQAMFPKLNNQERVTLLDLMIAKITSDEPLTKDDIPVFLRHAELIASTFVDQCKTVLKLASEEPPDDEEALATIRLLDVLCEMTVNTELLGYLQVFPGLLERVIDLLRVIHVAGKETTNIFSNCGCVRAEGDISNVANGFKSHLIRLIGNLCYKNKDNQDKVNELDGIPLILDNCNISDSNPFLTQWVIYAIRNLTEDNSQNQDLIAKMEEQGLADASLLKKVGFEVEKKGEKLILKSTRDTPKP

Target ORF information:

RefSeq Version	NM_013236.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ataxin 10 (ATXN10), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013236.3

ORF Insert Sequence:

ATGGCGGCGC CCAGGCCGCC GCCTGCCAGG CTGTCGGGCG TCATGGTGCC GGCGCCCATC 
CAAGACCTGG AGGCCCTGCG CGCGCTCACG GCGCTCTTCA AAGAGCAGCG GAACCGAGAA 
ACAGCACCCA GGACTATCTT CCAAAGAGTT CTGGATATCC TAAAGAAATC TTCTCATGCT 
GTTGAGCTTG CCTGCAGAGA TCCATCCCAA GTGGAAAACC TGGCTTCCAG TCTGCAGTTA 
ATAACAGAAT GCTTCAGGTG TCTTCGCAAT GCTTGCATAG AGTGTTCTGT GAACCAGAAT 
TCAATCAGGA ACTTGGATAC GATTGGTGTT GCTGTTGATT TGATTCTTCT GTTTCGTGAA 
CTGCGAGTGG AACAGGAATC TCTGTTGACA GCTTTTCGCT GTGGCCTGCA GTTTTTAGGC 
AACATTGCCT CACGGAATGA AGATTCCCAG TCTATTGTTT GGGTGCATGC TTTCCCAGAA 
CTGTTTTTGT CTTGCTTAAA TCATCCGGAC AAAAAAATTG TTGCCTACTC TTCAATGATT 
TTGTTTACAT CCCTTAATCA TGAAAGAATG AAAGAACTGG AGGAGAACCT CAATATTGCA 
ATTGATGTCA TAGATGCTTA CCAAAAACAT CCTGAATCAG AATGGCCGTT CTTGATTATT 
ACAGACCTCT TTCTGAAAAG CCCGGAATTG GTACAAGCCA TGTTTCCCAA ACTGAACAAT 
CAAGAAAGAG TTACACTGTT AGACCTTATG ATAGCCAAGA TAACGAGTGA TGAGCCACTC 
ACCAAGGATG ACATCCCTGT GTTTTTGCGG CATGCTGAGT TGATTGCAAG CACCTTTGTG 
GATCAGTGCA AGACTGTGCT CAAGCTGGCC TCTGAGGAGC CTCCTGATGA TGAGGAGGCA 
CTGGCTACAA TTAGGCTTCT CGACGTCCTG TGCGAAATGA CTGTGAATAC TGAGCTGCTC 
GGCTATCTGC AGGTTTTCCC TGGCTTGCTG GAAAGAGTGA TTGATCTTTT GCGGGTGATT 
CATGTAGCTG GAAAAGAAAC CACAAACATC TTCAGTAATT GTGGTTGCGT GAGAGCAGAA 
GGTGACATCT CCAATGTGGC CAATGGGTTT AAGTCTCATC TCATTCGTCT GATTGGAAAT 
CTGTGTTACA AGAATAAAGA TAACCAAGAC AAGGTAAATG AGCTGGATGG TATCCCGTTG 
ATCCTGGACA ACTGCAACAT CAGTGACAGT AACCCCTTTC TGACCCAGTG GGTGATATAT 
GCCATCCGAA ACCTTACCGA AGACAACAGC CAAAACCAAG ATTTGATTGC AAAGATGGAG 
GAACAGGGGC TGGCAGATGC ATCCCTACTT AAAAAAGTGG GTTTTGAAGT TGAAAAGAAA 
GGCGAAAAGC TGATCCTGAA ATCTACTAGA GACACCCCTA AGCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATXN10 ( NM_001167621.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001161093.1 Homo sapiens ataxin 10 (ATXN10), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu27341
Clone ID Related Accession (Same CDS sequence)	NM_001167621.1
Accession Version	NM_001167621.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1236bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	ataxin-10 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB035174.1, AK294348.1, BC007508.2, AK095309.1, DB548216.1 and R43701.1. Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK294348.1, SRR1803615.225570.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGC CCAGGCCGCC GCCTGCCAGG CTGTCGGGCG TCATGGTGCC GGCGCCCATC 
CAAGACCTGG AGGCCCTGCG CGCGCTCACG GCGCTCTTCA AAGAGCAGCG GAACCGGAAC 
TTGGATACGA TTGGTGTTGC TGTTGATTTG ATTCTTCTGT TTCGTGAACT GCGAGTGGAA 
CAGGAATCTC TGTTGACAGC TTTTCGCTGT GGCCTGCAGT TTTTAGGCAA CATTGCCTCA 
CGGAATGAAG ATTCCCAGTC TATTGTTTGG GTGCATGCTT TCCCAGAACT GTTTTTGTCT 
TGCTTAAATC ATCCGGACAA AAAAATTGTT GCCTACTCTT CAATGATTTT GTTTACATCC 
CTTAATCATG AAAGAATGAA AGAACTGGAG GAGAACCTCA ATATTGCAAT TGATGTCATA 
GATGCTTACC AAAAACATCC TGAATCAGAA TGGCCGTTCT TGATTATTAC AGACCTCTTT 
CTGAAAAGCC CGGAATTGGT ACAAGCCATG TTTCCCAAAC TGAACAATCA AGAAAGAGTT 
ACACTGTTAG ACCTTATGAT AGCCAAGATA ACGAGTGATG AGCCACTCAC CAAGGATGAC 
ATCCCTGTGT TTTTGCGGCA TGCTGAGTTG ATTGCAAGCA CCTTTGTGGA TCAGTGCAAG 
ACTGTGCTCA AGCTGGCCTC TGAGGAGCCT CCTGATGATG AGGAGGCACT GGCTACAATT 
AGGCTTCTCG ACGTCCTGTG CGAAATGACT GTGAATACTG AGCTGCTCGG CTATCTGCAG 
GTTTTCCCTG GCTTGCTGGA AAGAGTGATT GATCTTTTGC GGGTGATTCA TGTAGCTGGA 
AAAGAAACCA CAAACATCTT CAGTAATTGT GGTTGCGTGA GAGCAGAAGG TGACATCTCC 
AATGTGGCCA ATGGGTTTAA GTCTCATCTC ATTCGTCTGA TTGGAAATCT GTGTTACAAG 
AATAAAGATA ACCAAGACAA GGTAAATGAG CTGGATGGTA TCCCGTTGAT CCTGGACAAC 
TGCAACATCA GTGACAGTAA CCCCTTTCTG ACCCAGTGGG TGATATATGC CATCCGAAAC 
CTTACCGAAG ACAACAGCCA AAACCAAGAT TTGATTGCAA AGATGGAGGA ACAGGGGCTG 
GCAGATGCAT CCCTACTTAA AAAAGTGGGT TTTGAAGTTG AAAAGAAAGG CGAAAAGCTG 
ATCCTGAAAT CTACTAGAGA CACCCCTAAG CCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001161093.1
CDS	267..1502
Translation	MAAPRPPPARLSGVMVPAPIQDLEALRALTALFKEQRNRNLDTIGVAVDLILLFRELRVEQESLLTAFRCGLQFLGNIASRNEDSQSIVWVHAFPELFLSCLNHPDKKIVAYSSMILFTSLNHERMKELEENLNIAIDVIDAYQKHPESEWPFLIITDLFLKSPELVQAMFPKLNNQERVTLLDLMIAKITSDEPLTKDDIPVFLRHAELIASTFVDQCKTVLKLASEEPPDDEEALATIRLLDVLCEMTVNTELLGYLQVFPGLLERVIDLLRVIHVAGKETTNIFSNCGCVRAEGDISNVANGFKSHLIRLIGNLCYKNKDNQDKVNELDGIPLILDNCNISDSNPFLTQWVIYAIRNLTEDNSQNQDLIAKMEEQGLADASLLKKVGFEVEKKGEKLILKSTRDTPKP

Target ORF information:

RefSeq Version	NM_001167621.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ataxin 10 (ATXN10), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001167621.1

ORF Insert Sequence:

ATGGCGGCGC CCAGGCCGCC GCCTGCCAGG CTGTCGGGCG TCATGGTGCC GGCGCCCATC 
CAAGACCTGG AGGCCCTGCG CGCGCTCACG GCGCTCTTCA AAGAGCAGCG GAACCGGAAC 
TTGGATACGA TTGGTGTTGC TGTTGATTTG ATTCTTCTGT TTCGTGAACT GCGAGTGGAA 
CAGGAATCTC TGTTGACAGC TTTTCGCTGT GGCCTGCAGT TTTTAGGCAA CATTGCCTCA 
CGGAATGAAG ATTCCCAGTC TATTGTTTGG GTGCATGCTT TCCCAGAACT GTTTTTGTCT 
TGCTTAAATC ATCCGGACAA AAAAATTGTT GCCTACTCTT CAATGATTTT GTTTACATCC 
CTTAATCATG AAAGAATGAA AGAACTGGAG GAGAACCTCA ATATTGCAAT TGATGTCATA 
GATGCTTACC AAAAACATCC TGAATCAGAA TGGCCGTTCT TGATTATTAC AGACCTCTTT 
CTGAAAAGCC CGGAATTGGT ACAAGCCATG TTTCCCAAAC TGAACAATCA AGAAAGAGTT 
ACACTGTTAG ACCTTATGAT AGCCAAGATA ACGAGTGATG AGCCACTCAC CAAGGATGAC 
ATCCCTGTGT TTTTGCGGCA TGCTGAGTTG ATTGCAAGCA CCTTTGTGGA TCAGTGCAAG 
ACTGTGCTCA AGCTGGCCTC TGAGGAGCCT CCTGATGATG AGGAGGCACT GGCTACAATT 
AGGCTTCTCG ACGTCCTGTG CGAAATGACT GTGAATACTG AGCTGCTCGG CTATCTGCAG 
GTTTTCCCTG GCTTGCTGGA AAGAGTGATT GATCTTTTGC GGGTGATTCA TGTAGCTGGA 
AAAGAAACCA CAAACATCTT CAGTAATTGT GGTTGCGTGA GAGCAGAAGG TGACATCTCC 
AATGTGGCCA ATGGGTTTAA GTCTCATCTC ATTCGTCTGA TTGGAAATCT GTGTTACAAG 
AATAAAGATA ACCAAGACAA GGTAAATGAG CTGGATGGTA TCCCGTTGAT CCTGGACAAC 
TGCAACATCA GTGACAGTAA CCCCTTTCTG ACCCAGTGGG TGATATATGC CATCCGAAAC 
CTTACCGAAG ACAACAGCCA AAACCAAGAT TTGATTGCAA AGATGGAGGA ACAGGGGCTG 
GCAGATGCAT CCCTACTTAA AAAAGTGGGT TTTGAAGTTG AAAAGAAAGG CGAAAAGCTG 
ATCCTGAAAT CTACTAGAGA CACCCCTAAG CCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Haplotype Study in SCA10 Families Provides Further Evidence for a Common Ancestral Origin of the Mutation.
Neuromolecular medicine19(4)501-509(2017 Dec)
Bampi GB,Bisso-Machado R,H?nemeier T,Gheno TC,Furtado GV,Veliz-Otani D,Cornejo-Olivas M,Mazzeti P,Bortolini MC,Jardim LB,Saraiva-Pereira ML,

Ataxin-10 is involved in Golgi membrane dynamics.
Journal of genetics and genomics = Yi chuan xue bao44(11)549-552(2017 Nov)
Tian J,Shi Y,Nai S,Geng Q,Zhang L,Wei GH,Xu X,Li J

Inheritance patterns of ATCCT repeat interruptions in spinocerebellar ataxia type 10 (SCA10) expansions.
PloS one12(4)e0175958(2017)
Landrian I,McFarland KN,Liu J,Mulligan CJ,Rasmussen A,Ashizawa T

First report of a Japanese family with spinocerebellar ataxia type 10: The second report from Asia after a report from China.
PloS one12(5)e0177955(2017)
Naito H,Takahashi T,Kamada M,Morino H,Yoshino H,Hattori N,Maruyama H,Kawakami H,Matsumoto M