TNPO3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TNPO3
Entrez Gene ID	23534
Full Name	transportin 3
Synonyms	IPO12,LGMD1F,MTR10A,TRN-SR,TRN-SR2,TRNSR
General protein information	Preferred Names transportin 3 Names transportin-3 imp12 importin 12 limb girdle muscular dystrophy 1F (autosomal dominant) transportin-SR
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q32.1
Summary	The protein encoded by this gene is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the splicing factors SFRS1 and SFRS2. The encoded protein has also been shown to be involved in HIV-1 infection, apparently through interaction with the HIV-1 capsid protein. Two transcript variants encoding different isoforms as well as a noncoding transcript have been found for this gene.[provided by RefSeq, Jul 2010].
Disorder MIM:	610032
Disorder Html:	Muscular dystrophy, limb-girdle, type 1F, 608423 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011515989.2	XP_011514291.1	transportin-3 isoform X1
NM_012470.3	NP_036602.1	transportin-3 isoform 1
NM_001191028.2	NP_001177957.2	transportin-3 isoform 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	TNPO3	NP_036602.1
	TNPO3	XP_001092689.1
Rattus norvegicus (Norway rat)	Tnpo3	NP_001100057.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003576	XP_562427.1
Magnaporthe oryzae (rice blast fungus)	MGG_01449	XP_003714402.1
Neurospora crassa	NCU06355	XP_962389.1
Canis lupus familiaris (dog)	TNPO3	XP_005628468.1
Bos taurus (cattle)	TNPO3	NP_001091559.1
Gallus gallus (chicken)	TNPO3	XP_423940.4
Drosophila melanogaster (fruit fly)	Trn-SR	NP_608708.2
Eremothecium gossypii	AGOS_AAR115C	NP_982657.2
Oryza sativa (rice)	Os10g0477800	NP_001176208.1
Schizosaccharomyces pombe (fission yeast)	mtr10	NP_595725.2
Arabidopsis thaliana (thale cress)	AT5G62600	NP_201066.2
Pan troglodytes (chimpanzee)	TNPO3	XP_001154805.2
Danio rerio (zebrafish)	tnpo3	NP_957381.1
Saccharomyces cerevisiae (baker's yeast)	MTR10	NP_014803.1
Xenopus tropicalis (tropical clawed frog)	tnpo3	XP_002931906.2
Mus musculus (house mouse)	Tnpo3	NP_796270.2
Caenorhabditis elegans (roundworm)	tsr-1	NP_494279.3
Kluyveromyces lactis	KLLA0A02321g	XP_451103.1

Gene Ontology
Bibliography

Related articles in PubMed

N-terminal half of transportin SR2 interacts with HIV integrase.
Tsirkone VG, Blokken J, De Wit F, Breemans J, De Houwer S, Debyser Z, Christ F, Strelkov SV
The Journal of biological chemistry292(23)9699-9710(2017 06)

The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share.
Kottyan LC, Zoller EE, Bene J, Lu X, Kelly JA, Rupert AM, Lessard CJ, Vaughn SE, Marion M, Weirauch MT, Namjou B, Adler A, Rasmussen A, Glenn S, Montgomery CG, Hirschfield GM, Xie G, Coltescu C, Amos C, Li H, Ice JA, Nath SK, Mariette X, Bowman S, , Rischmueller M, Lester S, Brun JG, G?ransson LG, Harboe E, Omdal R, Cunninghame-Graham DS, Vyse T, Miceli-Richard C, Brennan MT, Lessard JA, Wahren-Herlenius M, Kvarnstr?m M, Illei GG, Witte T, Jonsson R, Eriksson P, Nordmark G, Ng WF, , Anaya JM, Rhodus NL, Segal BM, Merrill JT, James JA, Guthridge JM, Scofield RH, Alarcon-Riquelme M, Bae SC, Boackle SA, Criswell LA, Gilkeson G, Kamen DL, Jacob CO, Kimberly R, Brown E, Edberg J, Alarc?n GS, Reveille JD, Vil? LM, Petri M, Ramsey-Goldman R, Freedman BI, Niewold T, Stevens AM, Tsao BP, Ying J, Mayes MD, Gorlova OY, Wakeland W, Radstake T, Martin E, Martin J, Siminovitch K, Moser Sivils KL, Gaffney PM, Langefeld CD, Harley JB, Kaufman KM
Human molecular genetics24(2)582-96(2015 Jan)

The HIV-1 integrase mutant R263A/K264A is 2-fold defective for TRN-SR2 binding and viral nuclear import.
De Houwer S, Demeulemeester J, Thys W, Rocha S, Dirix L, Gijsbers R, Christ F, Debyser Z
The Journal of biological chemistry289(36)25351-61(2014 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Combining these results with small-angle X-ray scattering data for the complex of TRN-SR2 with truncated integrase, we propose a molecular model of the complex. We speculate that nuclear import of the PIC may proceed concurrently with the normal nuclear transport.
Title: N-terminal half of transportin SR2 interacts with HIV integrase.

IRF5-TNPO3 genetic variation is associated systemic lupus erythematosus.
Title: The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share.

Data suggest that the HIV-1 integrase (IN)/transportin-SR2 (TRN-SR2) interaction interface is a potential target for antiviral therapy.
Title: The HIV-1 integrase mutant R263A/K264A is 2-fold defective for TRN-SR2 binding and viral nuclear import.

Tnpo3 mutants that are not able to interact with cleavage and polyadenylation specificity factor 6 do not facilitate HIV-1 infectivity, suggesting a potential route of pharmacological intervention in the treatment of AIDS.
Title: Structural basis for nuclear import of splicing factors by human Transportin 3.

a model wherein one monomer of TRN-SR2 is bound to one monomer of RanGTP.
Title: Interaction of transportin-SR2 with Ras-related nuclear protein (Ran) GTPase.

The following TNPO3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TNPO3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18970	NM_012470.3 Latest version!	Homo sapiens transportin 3 (TNPO3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$464.50-$650.30 $929.00
OHu16939	NM_001191028.2 Latest version!	Homo sapiens transportin 3 (TNPO3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$608.30 $869.00
OHu66285	XM_011515989.2 Latest version!	Homo sapiens transportin 3 (TNPO3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TNPO3 ( NM_012470.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036602.1 Homo sapiens transportin 3 (TNPO3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18970
Clone ID Related Accession (Same CDS sequence)	NM_012470.3
Accession Version	NM_012470.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2772bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	transportin-3 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA720844.1, AJ133769.1, AK022910.1, BQ774864.1 and AW051835.1. This sequence is a reference standard in the RefSeqGene project. On Jul 17, 2010 this sequence version replaced NM_012470.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.204953.1, SRR1803614.169757.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAAGGAG CAAAGCCGAC ATTGCAGCTC GTGTACCAGG CAGTGCAGGC GCTTTACCAC 
GACCCAGATC CCAGCGGAAA GGAGCGCGCC TCTTTTTGGC TTGGGGAGCT GCAGCGTTCG 
GTTCATGCAT GGGAGATCTC AGACCAGTTG TTACAGATCC GGCAGGATGT GGAGTCATGC 
TATTTTGCTG CACAGACCAT GAAAATGAAG ATTCAGACCT CATTTTATGA GCTCCCCACA 
GACTCTCATG CCTCTTTACG GGACTCATTG CTAACCCATA TCCAGAACTT GAAAGACTTG 
TCACCTGTTA TTGTAACGCA GCTGGCTTTA GCAATAGCAG ATCTTGCCCT ACAGATGCCT 
TCCTGGAAGG GATGTGTGCA AACACTGGTG GAAAAATACA GCAATGATGT GACTTCTTTG 
CCTTTTTTGC TGGAGATCCT TACAGTGTTA CCTGAAGAAG TACATAGTCG TTCCTTACGA 
ATTGGAGCTA ATCGGCGCAC AGAAATTATA GAAGATTTGG CCTTCTACTC TAGTACAGTA 
GTATCTCTAT TGATGACCTG TGTAGAAAAA GCAGGAACAG ATGAGAAAAT GCTTATGAAG 
GTTTTTCGCT GTTTGGGAAG TTGGTTTAAC TTGGGAGTTT TGGACAGTAA CTTCATGGCT 
AACAATAAAT TACTAGCACT CCTTTTTGAG GTTTTGCAAC AGGATAAGAC CTCGTCTAAC 
CTACATGAAG CTGCTTCGGA CTGTGTATGC TCAGCTCTCT ATGCCATTGA GAATGTGGAG 
ACTAACTTGC CATTAGCCAT GCAACTTTTT CAGGGAGTGC TGACATTGGA GACTGCCTAT 
CATATGGCCG TGGCACGTGA AGATTTAGAC AAAGTTCTGA ATTACTGCCG TATTTTCACT 
GAACTATGTG AAACTTTTCT TGAAAAAATT GTTTGTACTC CAGGCCAAGG TCTTGGGGAC 
CTTCGAACTC TGGAGCTGCT GCTTATCTGT GCAGGCCATC CTCAATATGA GGTAGTAGAA 
ATTTCATTTA ACTTTTGGTA CCGACTGGGG GAACATTTGT ACAAAACTAA CGATGAAGTT 
ATTCATGGCA TCTTCAAAGC TTACATTCAG AGGCTGCTTC ACGCCTTGGC TCGACACTGC 
CAGCTGGAAC CAGACCATGA GGGGGTTCCT GAGGAGACTG ATGACTTTGG GGAGTTTCGC 
ATGAGGGTAT CAGACCTGGT AAAGGACTTG ATTTTCTTGA TAGGGTCTAT GGAGTGTTTT 
GCTCAGTTAT ATTCTACTCT GAAAGAAGGC AACCCACCCT GGGAGGTGAC AGAAGCGGTT 
CTCTTTATCA TGGCTGCTAT AGCAAAGAGT GTTGATCCGG AAAACAATCC AACACTTGTG 
GAAGTCCTAG AAGGAGTTGT CCGCCTCCCG GAGACCGTAC ATACGGCTGT GCGATACACC 
AGCATTGAAT TGGTTGGAGA GATGAGTGAA GTCGTTGATC GAAATCCTCA GTTCCTTGAC 
CCTGTGTTGG GCTATTTGAT GAAAGGCCTG TGTGAAAAGC CCCTGGCTTC TGCTGCAGCC 
AAAGCCATTC ATAACATTTG CTCTGTCTGC CGAGATCACA TGGCTCAGCA CTTTAATGGA 
CTCCTGGAGA TTGCCCGCTC CCTCGATTCC TTCCTGTTGT CTCCAGAAGC TGCTGTGGGC 
TTGCTAAAAG GGACAGCACT TGTCCTAGCC CGATTACCTT TGGATAAGAT TACCGAATGT 
CTTAGTGAAC TATGTTCTGT TCAGGTTATG GCATTGAAAA AGCTGTTGTC TCAAGAGCCC 
AGCAATGGCA TATCCTCAGA TCCCACAGTG TTCTTAGATC GCCTTGCAGT GATATTTAGG 
CATACCAATC CCATTGTGGA AAATGGACAG ACTCATCCGT GTCAGAAAGT CATACAGGAA 
ATATGGCCAG TTTTATCCGA GACTCTAAAT AAGCACCGAG CTGATAATCG GATTGTAGAG 
CGTTGTTGCA GGTGCCTGCG CTTTGCTGTT CGCTGTGTAG GCAAAGGATC TGCAGCACTG 
CTGCAGCCAC TAGTCACACA GATGGTGAAT GTGTACCACG TACATCAGCA TTCCTGCTTC 
CTGTACCTTG GCAGTATCCT TGTGGATGAA TATGGCATGG AAGAAGGCTG TCGGCAGGGA 
CTGCTAGACA TGCTCCAGGC ACTGTGCATC CCCACCTTTC AGCTCCTAGA ACAGCAGAAT 
GGTCTCCAGA ATCACCCTGA CACTGTAGAT GACCTGTTCC GGCTAGCCAC CAGGTTTATT 
CAGCGTAGCC CTGTCACCTT GCTGCGGAGC CAAGTGGTCA TCCCTATCTT ACAGTGGGCC 
ATTGCCTCTA CTACCCTGGA CCACCGGGAT GCCAATTGTA GTGTCATGAG GTTTCTACGA 
GACCTCATTC ATACAGGGGT AGCCAATGAT CATGAAGAAG ACTTTGAATT ACGGAAAGAA 
CTGATTGGAC AGGTGATGAA CCAGCTTGGA CAGCAGCTTG TCAGCCAGCT GCTGCACACC 
TGCTGCTTTT GCCTCCCCCC CTATACCCTA CCAGATGTGG CTGAAGTGCT CTGGGAGATC 
ATGCAGGTTG ACAGACCGAC TTTTTGTCGA TGGTTAGAAA ATTCCTTAAA AGGTTTGCCA 
AAGGAAACAA CCGTGGGAGC CGTCACAGTG ACACACAAAC AACTTACAGA CTTCCACAAG 
CAAGTCACTA GTGCTGAGGA ATGTAAACAA GTTTGCTGGG CCTTGCGAGA CTTCACCAGG 
TTGTTTCGAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036602.1
CDS	404..3175
Translation	MEGAKPTLQLVYQAVQALYHDPDPSGKERASFWLGELQRSVHAWEISDQLLQIRQDVESCYFAAQTMKMKIQTSFYELPTDSHASLRDSLLTHIQNLKDLSPVIVTQLALAIADLALQMPSWKGCVQTLVEKYSNDVTSLPFLLEILTVLPEEVHSRSLRIGANRRTEIIEDLAFYSSTVVSLLMTCVEKAGTDEKMLMKVFRCLGSWFNLGVLDSNFMANNKLLALLFEVLQQDKTSSNLHEAASDCVCSALYAIENVETNLPLAMQLFQGVLTLETAYHMAVAREDLDKVLNYCRIFTELCETFLEKIVCTPGQGLGDLRTLELLLICAGHPQYEVVEISFNFWYRLGEHLYKTNDEVIHGIFKAYIQRLLHALARHCQLEPDHEGVPEETDDFGEFRMRVSDLVKDLIFLIGSMECFAQLYSTLKEGNPPWEVTEAVLFIMAAIAKSVDPENNPTLVEVLEGVVRLPETVHTAVRYTSIELVGEMSEVVDRNPQFLDPVLGYLMKGLCEKPLASAAAKAIHNICSVCRDHMAQHFNGLLEIARSLDSFLLSPEAAVGLLKGTALVLARLPLDKITECLSELCSVQVMALKKLLSQEPSNGISSDPTVFLDRLAVIFRHTNPIVENGQTHPCQKVIQEIWPVLSETLNKHRADNRIVERCCRCLRFAVRCVGKGSAALLQPLVTQMVNVYHVHQHSCFLYLGSILVDEYGMEEGCRQGLLDMLQALCIPTFQLLEQQNGLQNHPDTVDDLFRLATRFIQRSPVTLLRSQVVIPILQWAIASTTLDHRDANCSVMRFLRDLIHTGVANDHEEDFELRKELIGQVMNQLGQQLVSQLLHTCCFCLPPYTLPDVAEVLWEIMQVDRPTFCRWLENSLKGLPKETTVGAVTVTHKQLTDFHKQVTSAEECKQVCWALRDFTRLFR

Target ORF information:

RefSeq Version	NM_012470.3
Organism	Homo sapiens(human)
Definition	Homo sapiens transportin 3 (TNPO3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012470.3

ORF Insert Sequence:

ATGGAAGGAG CAAAGCCGAC ATTGCAGCTC GTGTACCAGG CAGTGCAGGC GCTTTACCAC 
GACCCAGATC CCAGCGGAAA GGAGCGCGCC TCTTTTTGGC TTGGGGAGCT GCAGCGTTCG 
GTTCATGCAT GGGAGATCTC AGACCAGTTG TTACAGATCC GGCAGGATGT GGAGTCATGC 
TATTTTGCTG CACAGACCAT GAAAATGAAG ATTCAGACCT CATTTTATGA GCTCCCCACA 
GACTCTCATG CCTCTTTACG GGACTCATTG CTAACCCATA TCCAGAACTT GAAAGACTTG 
TCACCTGTTA TTGTAACGCA GCTGGCTTTA GCAATAGCAG ATCTTGCCCT ACAGATGCCT 
TCCTGGAAGG GATGTGTGCA AACACTGGTG GAAAAATACA GCAATGATGT GACTTCTTTG 
CCTTTTTTGC TGGAGATCCT TACAGTGTTA CCTGAAGAAG TACATAGTCG TTCCTTACGA 
ATTGGAGCTA ATCGGCGCAC AGAAATTATA GAAGATTTGG CCTTCTACTC TAGTACAGTA 
GTATCTCTAT TGATGACCTG TGTAGAAAAA GCAGGAACAG ATGAGAAAAT GCTTATGAAG 
GTTTTTCGCT GTTTGGGAAG TTGGTTTAAC TTGGGAGTTT TGGACAGTAA CTTCATGGCT 
AACAATAAAT TACTAGCACT CCTTTTTGAG GTTTTGCAAC AGGATAAGAC CTCGTCTAAC 
CTACATGAAG CTGCTTCGGA CTGTGTATGC TCAGCTCTCT ATGCCATTGA GAATGTGGAG 
ACTAACTTGC CATTAGCCAT GCAACTTTTT CAGGGAGTGC TGACATTGGA GACTGCCTAT 
CATATGGCCG TGGCACGTGA AGATTTAGAC AAAGTTCTGA ATTACTGCCG TATTTTCACT 
GAACTATGTG AAACTTTTCT TGAAAAAATT GTTTGTACTC CAGGCCAAGG TCTTGGGGAC 
CTTCGAACTC TGGAGCTGCT GCTTATCTGT GCAGGCCATC CTCAATATGA GGTAGTAGAA 
ATTTCATTTA ACTTTTGGTA CCGACTGGGG GAACATTTGT ACAAAACTAA CGATGAAGTT 
ATTCATGGCA TCTTCAAAGC TTACATTCAG AGGCTGCTTC ACGCCTTGGC TCGACACTGC 
CAGCTGGAAC CAGACCATGA GGGGGTTCCT GAGGAGACTG ATGACTTTGG GGAGTTTCGC 
ATGAGGGTAT CAGACCTGGT AAAGGACTTG ATTTTCTTGA TAGGGTCTAT GGAGTGTTTT 
GCTCAGTTAT ATTCTACTCT GAAAGAAGGC AACCCACCCT GGGAGGTGAC AGAAGCGGTT 
CTCTTTATCA TGGCTGCTAT AGCAAAGAGT GTTGATCCGG AAAACAATCC AACACTTGTG 
GAAGTCCTAG AAGGAGTTGT CCGCCTCCCG GAGACCGTAC ATACGGCTGT GCGATACACC 
AGCATTGAAT TGGTTGGAGA GATGAGTGAA GTCGTTGATC GAAATCCTCA GTTCCTTGAC 
CCTGTGTTGG GCTATTTGAT GAAAGGCCTG TGTGAAAAGC CCCTGGCTTC TGCTGCAGCC 
AAAGCCATTC ATAACATTTG CTCTGTCTGC CGAGATCACA TGGCTCAGCA CTTTAATGGA 
CTCCTGGAGA TTGCCCGCTC CCTCGATTCC TTCCTGTTGT CTCCAGAAGC TGCTGTGGGC 
TTGCTAAAAG GGACAGCACT TGTCCTAGCC CGATTACCTT TGGATAAGAT TACCGAATGT 
CTTAGTGAAC TATGTTCTGT TCAGGTTATG GCATTGAAAA AGCTGTTGTC TCAAGAGCCC 
AGCAATGGCA TATCCTCAGA TCCCACAGTG TTCTTAGATC GCCTTGCAGT GATATTTAGG 
CATACCAATC CCATTGTGGA AAATGGACAG ACTCATCCGT GTCAGAAAGT CATACAGGAA 
ATATGGCCAG TTTTATCCGA GACTCTAAAT AAGCACCGAG CTGATAATCG GATTGTAGAG 
CGTTGTTGCA GGTGCCTGCG CTTTGCTGTT CGCTGTGTAG GCAAAGGATC TGCAGCACTG 
CTGCAGCCAC TAGTCACACA GATGGTGAAT GTGTACCACG TACATCAGCA TTCCTGCTTC 
CTGTACCTTG GCAGTATCCT TGTGGATGAA TATGGCATGG AAGAAGGCTG TCGGCAGGGA 
CTGCTAGACA TGCTCCAGGC ACTGTGCATC CCCACCTTTC AGCTCCTAGA ACAGCAGAAT 
GGTCTCCAGA ATCACCCTGA CACTGTAGAT GACCTGTTCC GGCTAGCCAC CAGGTTTATT 
CAGCGTAGCC CTGTCACCTT GCTGCGGAGC CAAGTGGTCA TCCCTATCTT ACAGTGGGCC 
ATTGCCTCTA CTACCCTGGA CCACCGGGAT GCCAATTGTA GTGTCATGAG GTTTCTACGA 
GACCTCATTC ATACAGGGGT AGCCAATGAT CATGAAGAAG ACTTTGAATT ACGGAAAGAA 
CTGATTGGAC AGGTGATGAA CCAGCTTGGA CAGCAGCTTG TCAGCCAGCT GCTGCACACC 
TGCTGCTTTT GCCTCCCCCC CTATACCCTA CCAGATGTGG CTGAAGTGCT CTGGGAGATC 
ATGCAGGTTG ACAGACCGAC TTTTTGTCGA TGGTTAGAAA ATTCCTTAAA AGGTTTGCCA 
AAGGAAACAA CCGTGGGAGC CGTCACAGTG ACACACAAAC AACTTACAGA CTTCCACAAG 
CAAGTCACTA GTGCTGAGGA ATGTAAACAA GTTTGCTGGG CCTTGCGAGA CTTCACCAGG 
TTGTTTCGAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TNPO3 ( NM_001191028.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001177957.2 Homo sapiens transportin 3 (TNPO3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu16939
Clone ID Related Accession (Same CDS sequence)	NM_001191028.2
Accession Version	NM_001191028.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2580bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	transportin-3 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA720844.1, AJ133769.1, AK022910.1, BQ774864.1 and AW051835.1. On Jul 21, 2010 this sequence version replaced NM_001191028.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK225999.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAGGAG CAAAGCCGAC ATTGCAGCTC GTGTACCAGG CAGTGCAGGC GCTTTACCAC 
GACCCAGATC CCAGCGGAAA GGAGCGCGCC TCTTTTTGGC TTGGGGAGCT GCAGCGTTCG 
GTTCATGCAT GGGAGATCTC AGACCAGTTG TTACAGATCC GGCAGGATGT GGAGTCATGC 
TATTTTGCTG CACAGACCAT GAAAATGAAG ATTCAGACCT CATTTTATGA GCTCCCCACA 
GACTCTCATG CCTCTTTACG GGACTCATTG CTAACCCATA TCCAGAACTT GAAAGACTTG 
TCACCTGTTA TTGTAACGCA GCTGGCTTTA GCAATAGCAG ATCTTGCCCT ACAGATGCCT 
TCCTGGAAGG GATGTGTGCA AACACTGGTG GAAAAATACA GCAATGATGT GACTTCTTTG 
CCTTTTTTGC TGGAGATCCT TACAGTGTTA CCTGAAGAAG TACATAGTCG TTCCTTACGA 
ATTGGAGCTA ATCGGCGCAC AGAAATTATA GAAGATTTGG CCTTCTACTC TAGTACAGTA 
GTATCTCTAT TGATGACCTG TGTAGAAAAA GCAGGAACAG ATGAGAAAAT GCTTATGAAG 
GTTTTTCGCT GTTTGGGAAG TTGGTTTAAC TTGGGAGTTT TGGACAGTAA CTTCATGGCT 
AACAATAAAT TACTAGCACT CCTTTTTGAG GTTTTGCAAC AGGATAAGAC CTCGTCTAAC 
CTACATGAAG CTGCTTCGGA CTGTGTATGC TCAGCTCTCT ATGCCATTGA GAATGTGGAG 
ACTAACTTGC CATTAGCCAT GCAACTTTTT CAGGGAGTGC TGACATTGGA GACTGCCTAT 
CATATGGCCG TGGCACGTGA AGATTTAGAC AAAGTTCTGA ATTACTGCCG TATTTTCACT 
GAACTATGTG AAACTTTTCT TGAAAAAATT GTTTGTACTC CAGGCCAAGG TCTTGGGGAC 
CTTCGAACTC TGGAGCTGCT GCTTATCTGT GCAGGCCATC CTCAATATGA GGTAGTAGAA 
ATTTCATTTA ACTTTTGGTA CCGACTGGGG GAACATTTGT ACAAAACTAA CGATGAAGTT 
ATTCATGGCA TCTTCAAAGC TTACATTCAG AGGCTGCTTC ACGCCTTGGC TCGACACTGC 
CAGCTGGAAC CAGACCATGA GGGGGTTCCT GAGGAGACTG ATGACTTTGG GGAGTTTCGC 
ATGAGGGTAT CAGACCTGGT AAAGGACTTG ATTTTCTTGA TAGGGTCTAT GGAGTGTTTT 
GCTCAGTTAT ATTCTACTCT GAAAGAAGGC AACCCACCCT GGGAGGTGAC AGAAGCGGTT 
CTCTTTATCA TGGCTGCTAT AGCAAAGAGT GTTGATCCGG AAAACAATCC AACACTTGTG 
GAAGTCCTAG AAGGAGTTGT CCGCCTCCCG GAGACCGTAC ATACGGCTGT GCGATACACC 
AGCATTGAAT TGGTTGGAGA GATGAGTGAA GTCGTTGATC GAAATCCTCA GTTCCTTGGG 
ACAGCACTTG TCCTAGCCCG ATTACCTTTG GATAAGATTA CCGAATGTCT TAGTGAACTA 
TGTTCTGTTC AGGTTATGGC ATTGAAAAAG CTGTTGTCTC AAGAGCCCAG CAATGGCATA 
TCCTCAGATC CCACAGTGTT CTTAGATCGC CTTGCAGTGA TATTTAGGCA TACCAATCCC 
ATTGTGGAAA ATGGACAGAC TCATCCGTGT CAGAAAGTCA TACAGGAAAT ATGGCCAGTT 
TTATCCGAGA CTCTAAATAA GCACCGAGCT GATAATCGGA TTGTAGAGCG TTGTTGCAGG 
TGCCTGCGCT TTGCTGTTCG CTGTGTAGGC AAAGGATCTG CAGCACTGCT GCAGCCACTA 
GTCACACAGA TGGTGAATGT GTACCACGTA CATCAGCATT CCTGCTTCCT GTACCTTGGC 
AGTATCCTTG TGGATGAATA TGGCATGGAA GAAGGCTGTC GGCAGGGACT GCTAGACATG 
CTCCAGGCAC TGTGCATCCC CACCTTTCAG CTCCTAGAAC AGCAGAATGG TCTCCAGAAT 
CACCCTGACA CTGTAGATGA CCTGTTCCGG CTAGCCACCA GGTTTATTCA GCGTAGCCCT 
GTCACCTTGC TGCGGAGCCA AGTGGTCATC CCTATCTTAC AGTGGGCCAT TGCCTCTACT 
ACCCTGGACC ACCGGGATGC CAATTGTAGT GTCATGAGGT TTCTACGAGA CCTCATTCAT 
ACAGGGGTAG CCAATGATCA TGAAGAAGAC TTTGAATTAC GGAAAGAACT GATTGGACAG 
GTGATGAACC AGCTTGGACA GCAGCTTGTC AGCCAGCTGC TGCACACCTG CTGCTTTTGC 
CTCCCCCCCT ATACCCTACC AGATGTGGCT GAAGTGCTCT GGGAGATCAT GCAGGTTGAC 
AGACCGACTT TTTGTCGATG GTTAGAAAAT TCCTTAAAAG GTTTGCCAAA GGAAACAACC 
GTGGGAGCCG TCACAGTGAC ACACAAACAA CTTACAGACT TCCACAAGCA AGTCACTAGT 
GCTGAGGAAT GTAAACAAGT TTGCTGGGCC TTGCGAGACT TCACCAGGTT GTTTCGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001177957.2
CDS	404..2983
Translation	MEGAKPTLQLVYQAVQALYHDPDPSGKERASFWLGELQRSVHAWEISDQLLQIRQDVESCYFAAQTMKMKIQTSFYELPTDSHASLRDSLLTHIQNLKDLSPVIVTQLALAIADLALQMPSWKGCVQTLVEKYSNDVTSLPFLLEILTVLPEEVHSRSLRIGANRRTEIIEDLAFYSSTVVSLLMTCVEKAGTDEKMLMKVFRCLGSWFNLGVLDSNFMANNKLLALLFEVLQQDKTSSNLHEAASDCVCSALYAIENVETNLPLAMQLFQGVLTLETAYHMAVAREDLDKVLNYCRIFTELCETFLEKIVCTPGQGLGDLRTLELLLICAGHPQYEVVEISFNFWYRLGEHLYKTNDEVIHGIFKAYIQRLLHALARHCQLEPDHEGVPEETDDFGEFRMRVSDLVKDLIFLIGSMECFAQLYSTLKEGNPPWEVTEAVLFIMAAIAKSVDPENNPTLVEVLEGVVRLPETVHTAVRYTSIELVGEMSEVVDRNPQFLGTALVLARLPLDKITECLSELCSVQVMALKKLLSQEPSNGISSDPTVFLDRLAVIFRHTNPIVENGQTHPCQKVIQEIWPVLSETLNKHRADNRIVERCCRCLRFAVRCVGKGSAALLQPLVTQMVNVYHVHQHSCFLYLGSILVDEYGMEEGCRQGLLDMLQALCIPTFQLLEQQNGLQNHPDTVDDLFRLATRFIQRSPVTLLRSQVVIPILQWAIASTTLDHRDANCSVMRFLRDLIHTGVANDHEEDFELRKELIGQVMNQLGQQLVSQLLHTCCFCLPPYTLPDVAEVLWEIMQVDRPTFCRWLENSLKGLPKETTVGAVTVTHKQLTDFHKQVTSAEECKQVCWALRDFTRLFR

Target ORF information:

RefSeq Version	NM_001191028.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transportin 3 (TNPO3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001191028.2

ORF Insert Sequence:

ATGGAAGGAG CAAAGCCGAC ATTGCAGCTC GTGTACCAGG CAGTGCAGGC GCTTTACCAC 
GACCCAGATC CCAGCGGAAA GGAGCGCGCC TCTTTTTGGC TTGGGGAGCT GCAGCGTTCG 
GTTCATGCAT GGGAGATCTC AGACCAGTTG TTACAGATCC GGCAGGATGT GGAGTCATGC 
TATTTTGCTG CACAGACCAT GAAAATGAAG ATTCAGACCT CATTTTATGA GCTCCCCACA 
GACTCTCATG CCTCTTTACG GGACTCATTG CTAACCCATA TCCAGAACTT GAAAGACTTG 
TCACCTGTTA TTGTAACGCA GCTGGCTTTA GCAATAGCAG ATCTTGCCCT ACAGATGCCT 
TCCTGGAAGG GATGTGTGCA AACACTGGTG GAAAAATACA GCAATGATGT GACTTCTTTG 
CCTTTTTTGC TGGAGATCCT TACAGTGTTA CCTGAAGAAG TACATAGTCG TTCCTTACGA 
ATTGGAGCTA ATCGGCGCAC AGAAATTATA GAAGATTTGG CCTTCTACTC TAGTACAGTA 
GTATCTCTAT TGATGACCTG TGTAGAAAAA GCAGGAACAG ATGAGAAAAT GCTTATGAAG 
GTTTTTCGCT GTTTGGGAAG TTGGTTTAAC TTGGGAGTTT TGGACAGTAA CTTCATGGCT 
AACAATAAAT TACTAGCACT CCTTTTTGAG GTTTTGCAAC AGGATAAGAC CTCGTCTAAC 
CTACATGAAG CTGCTTCGGA CTGTGTATGC TCAGCTCTCT ATGCCATTGA GAATGTGGAG 
ACTAACTTGC CATTAGCCAT GCAACTTTTT CAGGGAGTGC TGACATTGGA GACTGCCTAT 
CATATGGCCG TGGCACGTGA AGATTTAGAC AAAGTTCTGA ATTACTGCCG TATTTTCACT 
GAACTATGTG AAACTTTTCT TGAAAAAATT GTTTGTACTC CAGGCCAAGG TCTTGGGGAC 
CTTCGAACTC TGGAGCTGCT GCTTATCTGT GCAGGCCATC CTCAATATGA GGTAGTAGAA 
ATTTCATTTA ACTTTTGGTA CCGACTGGGG GAACATTTGT ACAAAACTAA CGATGAAGTT 
ATTCATGGCA TCTTCAAAGC TTACATTCAG AGGCTGCTTC ACGCCTTGGC TCGACACTGC 
CAGCTGGAAC CAGACCATGA GGGGGTTCCT GAGGAGACTG ATGACTTTGG GGAGTTTCGC 
ATGAGGGTAT CAGACCTGGT AAAGGACTTG ATTTTCTTGA TAGGGTCTAT GGAGTGTTTT 
GCTCAGTTAT ATTCTACTCT GAAAGAAGGC AACCCACCCT GGGAGGTGAC AGAAGCGGTT 
CTCTTTATCA TGGCTGCTAT AGCAAAGAGT GTTGATCCGG AAAACAATCC AACACTTGTG 
GAAGTCCTAG AAGGAGTTGT CCGCCTCCCG GAGACCGTAC ATACGGCTGT GCGATACACC 
AGCATTGAAT TGGTTGGAGA GATGAGTGAA GTCGTTGATC GAAATCCTCA GTTCCTTGGG 
ACAGCACTTG TCCTAGCCCG ATTACCTTTG GATAAGATTA CCGAATGTCT TAGTGAACTA 
TGTTCTGTTC AGGTTATGGC ATTGAAAAAG CTGTTGTCTC AAGAGCCCAG CAATGGCATA 
TCCTCAGATC CCACAGTGTT CTTAGATCGC CTTGCAGTGA TATTTAGGCA TACCAATCCC 
ATTGTGGAAA ATGGACAGAC TCATCCGTGT CAGAAAGTCA TACAGGAAAT ATGGCCAGTT 
TTATCCGAGA CTCTAAATAA GCACCGAGCT GATAATCGGA TTGTAGAGCG TTGTTGCAGG 
TGCCTGCGCT TTGCTGTTCG CTGTGTAGGC AAAGGATCTG CAGCACTGCT GCAGCCACTA 
GTCACACAGA TGGTGAATGT GTACCACGTA CATCAGCATT CCTGCTTCCT GTACCTTGGC 
AGTATCCTTG TGGATGAATA TGGCATGGAA GAAGGCTGTC GGCAGGGACT GCTAGACATG 
CTCCAGGCAC TGTGCATCCC CACCTTTCAG CTCCTAGAAC AGCAGAATGG TCTCCAGAAT 
CACCCTGACA CTGTAGATGA CCTGTTCCGG CTAGCCACCA GGTTTATTCA GCGTAGCCCT 
GTCACCTTGC TGCGGAGCCA AGTGGTCATC CCTATCTTAC AGTGGGCCAT TGCCTCTACT 
ACCCTGGACC ACCGGGATGC CAATTGTAGT GTCATGAGGT TTCTACGAGA CCTCATTCAT 
ACAGGGGTAG CCAATGATCA TGAAGAAGAC TTTGAATTAC GGAAAGAACT GATTGGACAG 
GTGATGAACC AGCTTGGACA GCAGCTTGTC AGCCAGCTGC TGCACACCTG CTGCTTTTGC 
CTCCCCCCCT ATACCCTACC AGATGTGGCT GAAGTGCTCT GGGAGATCAT GCAGGTTGAC 
AGACCGACTT TTTGTCGATG GTTAGAAAAT TCCTTAAAAG GTTTGCCAAA GGAAACAACC 
GTGGGAGCCG TCACAGTGAC ACACAAACAA CTTACAGACT TCCACAAGCA AGTCACTAGT 
GCTGAGGAAT GTAAACAAGT TTGCTGGGCC TTGCGAGACT TCACCAGGTT GTTTCGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TNPO3 ( XM_011515989.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011514291.1 Homo sapiens transportin 3 (TNPO3), transcript variant X1, mRNA.

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CloneID	OHu66285
Clone ID Related Accession (Same CDS sequence)	XM_011515989.2
Accession Version	XM_011515989.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2574bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	transportin-3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011515989.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAAATGA AGATTCAGAC CTCATTTTAT GAGCTCCCCA CAGACTCTCA TGCCTCTTTA 
CGGGACTCAT TGCTAACCCA TATCCAGAAC TTGAAAGACT TGTCACCTGT TATTGTAACG 
CAGCTGGCTT TAGCAATAGC AGATCTTGCC CTACAGATGC CTTCCTGGAA GGGATGTGTG 
CAAACACTGG TGGAAAAATA CAGCAATGAT GTGACTTCTT TGCCTTTTTT GCTGGAGATC 
CTTACAGTGT TACCTGAAGA AGTACATAGT CGTTCCTTAC GAATTGGAGC TAATCGGCGC 
ACAGAAATTA TAGAAGATTT GGCCTTCTAC TCTAGTACAG TAGTATCTCT ATTGATGACC 
TGTGTAGAAA AAGCAGGAAC AGATGAGAAA ATGCTTATGA AGGTTTTTCG CTGTTTGGGA 
AGTTGGTTTA ACTTGGGAGT TTTGGACAGT AACTTCATGG CTAACAATAA ATTACTAGCA 
CTCCTTTTTG AGGTTTTGCA ACAGGATAAG ACCTCGTCTA ACCTACATGA AGCTGCTTCG 
GACTGTGTAT GCTCAGCTCT CTATGCCATT GAGAATGTGG AGACTAACTT GCCATTAGCC 
ATGCAACTTT TTCAGGGAGT GCTGACATTG GAGACTGCCT ATCATATGGC CGTGGCACGT 
GAAGATTTAG ACAAAGTTCT GAATTACTGC CGTATTTTCA CTGAACTATG TGAAACTTTT 
CTTGAAAAAA TTGTTTGTAC TCCAGGCCAA GGTCTTGGGG ACCTTCGAAC TCTGGAGCTG 
CTGCTTATCT GTGCAGGCCA TCCTCAATAT GAGGTAGTAG AAATTTCATT TAACTTTTGG 
TACCGACTGG GGGAACATTT GTACAAAACT AACGATGAAG TTATTCATGG CATCTTCAAA 
GCTTACATTC AGAGGCTGCT TCACGCCTTG GCTCGACACT GCCAGCTGGA ACCAGACCAT 
GAGGGGGTTC CTGAGGAGAC TGATGACTTT GGGGAGTTTC GCATGAGGGT ATCAGACCTG 
GTAAAGGACT TGATTTTCTT GATAGGGTCT ATGGAGTGTT TTGCTCAGTT ATATTCTACT 
CTGAAAGAAG GCAACCCACC CTGGGAGGTG ACAGAAGCGG TTCTCTTTAT CATGGCTGCT 
ATAGCAAAGA GTGTTGATCC GGAAAACAAT CCAACACTTG TGGAAGTCCT AGAAGGAGTT 
GTCCGCCTCC CGGAGACCGT ACATACGGCT GTGCGATACA CCAGCATTGA ATTGGTTGGA 
GAGATGAGTG AAGTCGTTGA TCGAAATCCT CAGTTCCTTG ACCCTGTGTT GGGCTATTTG 
ATGAAAGGCC TGTGTGAAAA GCCCCTGGCT TCTGCTGCAG CCAAAGCCAT TCATAACATT 
TGCTCTGTCT GCCGAGATCA CATGGCTCAG CACTTTAATG GACTCCTGGA GATTGCCCGC 
TCCCTCGATT CCTTCCTGTT GTCTCCAGAA GCTGCTGTGG GCTTGCTAAA AGGGACAGCA 
CTTGTCCTAG CCCGATTACC TTTGGATAAG ATTACCGAAT GTCTTAGTGA ACTATGTTCT 
GTTCAGGTTA TGGCATTGAA AAAGCTGTTG TCTCAAGAGC CCAGCAATGG CATATCCTCA 
GATCCCACAG TGTTCTTAGA TCGCCTTGCA GTGATATTTA GGCATACCAA TCCCATTGTG 
GAAAATGGAC AGACTCATCC GTGTCAGAAA GTCATACAGG AAATATGGCC AGTTTTATCC 
GAGACTCTAA ATAAGCACCG AGCTGATAAT CGGATTGTAG AGCGTTGTTG CAGGTGCCTG 
CGCTTTGCTG TTCGCTGTGT AGGCAAAGGA TCTGCAGCAC TGCTGCAGCC ACTAGTCACA 
CAGATGGTGA ATGTGTACCA CGTACATCAG CATTCCTGCT TCCTGTACCT TGGCAGTATC 
CTTGTGGATG AATATGGCAT GGAAGAAGGC TGTCGGCAGG GACTGCTAGA CATGCTCCAG 
GCACTGTGCA TCCCCACCTT TCAGCTCCTA GAACAGCAGA ATGGTCTCCA GAATCACCCT 
GACACTGTAG ATGACCTGTT CCGGCTAGCC ACCAGGTTTA TTCAGCGTAG CCCTGTCACC 
TTGCTGCGGA GCCAAGTGGT CATCCCTATC TTACAGTGGG CCATTGCCTC TACTACCCTG 
GACCACCGGG ATGCCAATTG TAGTGTCATG AGGTTTCTAC GAGACCTCAT TCATACAGGG 
GTAGCCAATG ATCATGAAGA AGACTTTGAA TTACGGAAAG AACTGATTGG ACAGGTGATG 
AACCAGCTTG GACAGCAGCT TGTCAGCCAG CTGCTGCACA CCTGCTGCTT TTGCCTCCCC 
CCCTATACCC TACCAGATGT GGCTGAAGTG CTCTGGGAGA TCATGCAGGT TGACAGACCG 
ACTTTTTGTC GATGGTTAGA AAATTCCTTA AAAGGTTTGC CAAAGGAAAC AACCGTGGGA 
GCCGTCACAG TGACACACAA ACAACTTACA GACTTCCACA AGCAAGTCAC TAGTGCTGAG 
GAATGTAAAC AAGTTTGCTG GGCCTTGCGA GACTTCACCA GGTTGTTTCG ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011514291.1
CDS	204..2777
Translation	MKMKIQTSFYELPTDSHASLRDSLLTHIQNLKDLSPVIVTQLALAIADLALQMPSWKGCVQTLVEKYSNDVTSLPFLLEILTVLPEEVHSRSLRIGANRRTEIIEDLAFYSSTVVSLLMTCVEKAGTDEKMLMKVFRCLGSWFNLGVLDSNFMANNKLLALLFEVLQQDKTSSNLHEAASDCVCSALYAIENVETNLPLAMQLFQGVLTLETAYHMAVAREDLDKVLNYCRIFTELCETFLEKIVCTPGQGLGDLRTLELLLICAGHPQYEVVEISFNFWYRLGEHLYKTNDEVIHGIFKAYIQRLLHALARHCQLEPDHEGVPEETDDFGEFRMRVSDLVKDLIFLIGSMECFAQLYSTLKEGNPPWEVTEAVLFIMAAIAKSVDPENNPTLVEVLEGVVRLPETVHTAVRYTSIELVGEMSEVVDRNPQFLDPVLGYLMKGLCEKPLASAAAKAIHNICSVCRDHMAQHFNGLLEIARSLDSFLLSPEAAVGLLKGTALVLARLPLDKITECLSELCSVQVMALKKLLSQEPSNGISSDPTVFLDRLAVIFRHTNPIVENGQTHPCQKVIQEIWPVLSETLNKHRADNRIVERCCRCLRFAVRCVGKGSAALLQPLVTQMVNVYHVHQHSCFLYLGSILVDEYGMEEGCRQGLLDMLQALCIPTFQLLEQQNGLQNHPDTVDDLFRLATRFIQRSPVTLLRSQVVIPILQWAIASTTLDHRDANCSVMRFLRDLIHTGVANDHEEDFELRKELIGQVMNQLGQQLVSQLLHTCCFCLPPYTLPDVAEVLWEIMQVDRPTFCRWLENSLKGLPKETTVGAVTVTHKQLTDFHKQVTSAEECKQVCWALRDFTRLFR

Target ORF information:

RefSeq Version	XM_011515989.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transportin 3 (TNPO3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011515989.2

ORF Insert Sequence:

ATGAAAATGA AGATTCAGAC CTCATTTTAT GAGCTCCCCA CAGACTCTCA TGCCTCTTTA 
CGGGACTCAT TGCTAACCCA TATCCAGAAC TTGAAAGACT TGTCACCTGT TATTGTAACG 
CAGCTGGCTT TAGCAATAGC AGATCTTGCC CTACAGATGC CTTCCTGGAA GGGATGTGTG 
CAAACACTGG TGGAAAAATA CAGCAATGAT GTGACTTCTT TGCCTTTTTT GCTGGAGATC 
CTTACAGTGT TACCTGAAGA AGTACATAGT CGTTCCTTAC GAATTGGAGC TAATCGGCGC 
ACAGAAATTA TAGAAGATTT GGCCTTCTAC TCTAGTACAG TAGTATCTCT ATTGATGACC 
TGTGTAGAAA AAGCAGGAAC AGATGAGAAA ATGCTTATGA AGGTTTTTCG CTGTTTGGGA 
AGTTGGTTTA ACTTGGGAGT TTTGGACAGT AACTTCATGG CTAACAATAA ATTACTAGCA 
CTCCTTTTTG AGGTTTTGCA ACAGGATAAG ACCTCGTCTA ACCTACATGA AGCTGCTTCG 
GACTGTGTAT GCTCAGCTCT CTATGCCATT GAGAATGTGG AGACTAACTT GCCATTAGCC 
ATGCAACTTT TTCAGGGAGT GCTGACATTG GAGACTGCCT ATCATATGGC CGTGGCACGT 
GAAGATTTAG ACAAAGTTCT GAATTACTGC CGTATTTTCA CTGAACTATG TGAAACTTTT 
CTTGAAAAAA TTGTTTGTAC TCCAGGCCAA GGTCTTGGGG ACCTTCGAAC TCTGGAGCTG 
CTGCTTATCT GTGCAGGCCA TCCTCAATAT GAGGTAGTAG AAATTTCATT TAACTTTTGG 
TACCGACTGG GGGAACATTT GTACAAAACT AACGATGAAG TTATTCATGG CATCTTCAAA 
GCTTACATTC AGAGGCTGCT TCACGCCTTG GCTCGACACT GCCAGCTGGA ACCAGACCAT 
GAGGGGGTTC CTGAGGAGAC TGATGACTTT GGGGAGTTTC GCATGAGGGT ATCAGACCTG 
GTAAAGGACT TGATTTTCTT GATAGGGTCT ATGGAGTGTT TTGCTCAGTT ATATTCTACT 
CTGAAAGAAG GCAACCCACC CTGGGAGGTG ACAGAAGCGG TTCTCTTTAT CATGGCTGCT 
ATAGCAAAGA GTGTTGATCC GGAAAACAAT CCAACACTTG TGGAAGTCCT AGAAGGAGTT 
GTCCGCCTCC CGGAGACCGT ACATACGGCT GTGCGATACA CCAGCATTGA ATTGGTTGGA 
GAGATGAGTG AAGTCGTTGA TCGAAATCCT CAGTTCCTTG ACCCTGTGTT GGGCTATTTG 
ATGAAAGGCC TGTGTGAAAA GCCCCTGGCT TCTGCTGCAG CCAAAGCCAT TCATAACATT 
TGCTCTGTCT GCCGAGATCA CATGGCTCAG CACTTTAATG GACTCCTGGA GATTGCCCGC 
TCCCTCGATT CCTTCCTGTT GTCTCCAGAA GCTGCTGTGG GCTTGCTAAA AGGGACAGCA 
CTTGTCCTAG CCCGATTACC TTTGGATAAG ATTACCGAAT GTCTTAGTGA ACTATGTTCT 
GTTCAGGTTA TGGCATTGAA AAAGCTGTTG TCTCAAGAGC CCAGCAATGG CATATCCTCA 
GATCCCACAG TGTTCTTAGA TCGCCTTGCA GTGATATTTA GGCATACCAA TCCCATTGTG 
GAAAATGGAC AGACTCATCC GTGTCAGAAA GTCATACAGG AAATATGGCC AGTTTTATCC 
GAGACTCTAA ATAAGCACCG AGCTGATAAT CGGATTGTAG AGCGTTGTTG CAGGTGCCTG 
CGCTTTGCTG TTCGCTGTGT AGGCAAAGGA TCTGCAGCAC TGCTGCAGCC ACTAGTCACA 
CAGATGGTGA ATGTGTACCA CGTACATCAG CATTCCTGCT TCCTGTACCT TGGCAGTATC 
CTTGTGGATG AATATGGCAT GGAAGAAGGC TGTCGGCAGG GACTGCTAGA CATGCTCCAG 
GCACTGTGCA TCCCCACCTT TCAGCTCCTA GAACAGCAGA ATGGTCTCCA GAATCACCCT 
GACACTGTAG ATGACCTGTT CCGGCTAGCC ACCAGGTTTA TTCAGCGTAG CCCTGTCACC 
TTGCTGCGGA GCCAAGTGGT CATCCCTATC TTACAGTGGG CCATTGCCTC TACTACCCTG 
GACCACCGGG ATGCCAATTG TAGTGTCATG AGGTTTCTAC GAGACCTCAT TCATACAGGG 
GTAGCCAATG ATCATGAAGA AGACTTTGAA TTACGGAAAG AACTGATTGG ACAGGTGATG 
AACCAGCTTG GACAGCAGCT TGTCAGCCAG CTGCTGCACA CCTGCTGCTT TTGCCTCCCC 
CCCTATACCC TACCAGATGT GGCTGAAGTG CTCTGGGAGA TCATGCAGGT TGACAGACCG 
ACTTTTTGTC GATGGTTAGA AAATTCCTTA AAAGGTTTGC CAAAGGAAAC AACCGTGGGA 
GCCGTCACAG TGACACACAA ACAACTTACA GACTTCCACA AGCAAGTCAC TAGTGCTGAG 
GAATGTAAAC AAGTTTGCTG GGCCTTGCGA GACTTCACCA GGTTGTTTCG ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

N-terminal half of transportin SR2 interacts with HIV integrase.
The Journal of biological chemistry292(23)9699-9710(2017 06)
Tsirkone VG,Blokken J,De Wit F,Breemans J,De Houwer S,Debyser Z,Christ F,Strelkov SV

The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share.
Human molecular genetics24(2)582-96(2015 Jan)
Kottyan LC,Zoller EE,Bene J,Lu X,Kelly JA,Rupert AM,Lessard CJ,Vaughn SE,Marion M,Weirauch MT,Namjou B,Adler A,Rasmussen A,Glenn S,Montgomery CG,Hirschfield GM,Xie G,Coltescu C,Amos C,Li H,Ice JA,Nath SK,Mariette X,Bowman S,,Rischmueller M,Lester S,Brun JG,G?ransson LG,Harboe E,Omdal R,Cunninghame-Graham DS,Vyse T,Miceli-Richard C,Brennan MT,Lessard JA,Wahren-Herlenius M,Kvarnstr?m M,Illei GG,Witte T,Jonsson R,Eriksson P,Nordmark G,Ng WF,,Anaya JM,Rhodus NL,Segal BM,Merrill JT,James JA,Guthridge JM,Scofield RH,Alarcon-Riquelme M,Bae SC,Boackle SA,Criswell LA,Gilkeson G,Kamen DL,Jacob CO,Kimberly R,Brown E,Edberg J,Alarc?n GS,Reveille JD,Vil? LM,Petri M,Ramsey-Goldman R,Freedman BI,Niewold T,Stevens AM,Tsao BP,Ying J,Mayes MD,Gorlova OY,Wakeland W,Radstake T,Martin E,Martin J,Siminovitch K,Moser Sivils KL,Gaffney PM,Langefeld CD,Harley JB,Kaufman KM

The HIV-1 integrase mutant R263A/K264A is 2-fold defective for TRN-SR2 binding and viral nuclear import.
The Journal of biological chemistry289(36)25351-61(2014 Sep)
De Houwer S,Demeulemeester J,Thys W,Rocha S,Dirix L,Gijsbers R,Christ F,Debyser Z

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TNPO3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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