QPRT cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	QPRT
Entrez Gene ID	23475
Full Name	quinolinate phosphoribosyltransferase
Synonyms	HEL-S-90n,QPRTase
General protein information	Preferred Names quinolinate phosphoribosyltransferase Names nicotinate-nucleotide pyrophosphorylase [carboxylating] epididymis secretory sperm binding protein Li 90n nicotinate-nucleotide pyrophosphorylase (carboxylating)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p11.2
Summary	This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
Disorder MIM:	606248

mRNA and Protein(s)

mRNA	Protein	Name
NM_001318250.1	NP_001305179.1	nicotinate-nucleotide pyrophosphorylase [carboxylating] isoform 3 precursor
NM_001318249.1	NP_001305178.1	nicotinate-nucleotide pyrophosphorylase [carboxylating] isoform 2
NM_014298.4	NP_055113.2	nicotinate-nucleotide pyrophosphorylase [carboxylating] isoform 1 precursor
XM_005255223.3	XP_005255280.2	nicotinate-nucleotide pyrophosphorylase [carboxylating] isoform X1
NM_014298.3	NP_055113.2	nicotinate-nucleotide pyrophosphorylase [carboxylating] precursor
XM_017023101.1	XP_016878590.1	nicotinate-nucleotide pyrophosphorylase [carboxylating] isoform X2
NM_014298.5	NP_055113.2	nicotinate-nucleotide pyrophosphorylase [carboxylating] isoform 1 precursor

Pathways from BioSystems

Homologies

Oryza sativa (rice)	Os09g0553600	NP_001063881.1
Pan troglodytes (chimpanzee)	QPRT	XP_523333.4
Saccharomyces cerevisiae (baker's yeast)	BNA6	NP_602317.3
Neurospora crassa	NCU02998	XP_965384.2
	LOC708784	XP_001097266.2
Eremothecium gossypii	AGOS_AFR271W	NP_985818.2
Arabidopsis thaliana (thale cress)	QPT	NP_001077865.1
Xenopus tropicalis (tropical clawed frog)	LOC100495332	XP_002940636.1
Magnaporthe oryzae (rice blast fungus)	MGG_03028	XP_003720659.1
Homo sapiens (human)	QPRT	NP_055113.2
Canis lupus familiaris (dog)	QPRT	XP_849515.1
Bos taurus (cattle)	QPRT	NP_001030523.1
Mus musculus (house mouse)	Qprt	NP_598447.1
Rattus norvegicus (Norway rat)	Qprt	NP_001009646.1

Gene Ontology
Bibliography

Related articles in PubMed

Quinolinate Phosphoribosyltransferase is an Antiviral Host Factor Against Hepatitis C Virus Infection.
Wang Z, Gao Y, Zhang C, Hu H, Guo D, Xu Y, Xu Q, Zhang W, Deng S, Lv P, Yang Y, Ding Y, Li Q, Weng C, Chen X, Gong S, Chen H, Niu J, Tang H
Scientific reports7(1)5876(2017 Jul)

Anti-apoptotic quinolinate phosphoribosyltransferase (QPRT) is a target gene of Wilms' tumor gene 1 (WT1) protein in leukemic cells.
Ullmark T, Montano G, J?rvstr?t L, Jernmark Nilsson H, H?kansson E, Drott K, Nilsson B, Vidovic K, Gullberg U
Biochemical and biophysical research communications482(4)802-807(2017 Jan)

Structural Insights into the Quaternary Catalytic Mechanism of Hexameric Human Quinolinate Phosphoribosyltransferase, a Key Enzyme in de novo NAD Biosynthesis.
Youn HS, Kim TG, Kim MK, Kang GB, Kang JY, Lee JG, An JY, Park KR, Lee Y, Im YJ, Lee JH, Eom SH
Scientific reports619681(2016 Jan)

Expression of the Kynurenine Pathway in Human Peripheral Blood Mononuclear Cells: Implications for Inflammatory and Neurodegenerative Disease.
Jones SP, Franco NF, Varney B, Sundaram G, Brown DA, de Bie J, Lim CK, Guillemin GJ, Brew BJ
PloS one10(6)e0131389(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

WT1 knock-down gave a corresponding decrease in QPRT gene and protein expression. Chromatin-immunoprecipitation revealed WT1 binding to a conserved site in the first intron of the QPRT gene.
Title: Anti-apoptotic quinolinate phosphoribosyltransferase (QPRT) is a target gene of Wilms' tumor gene 1 (WT1) protein in leukemic cells.

The structural features, size distribution, heat aggregation and ITC studies of the full-length enzyme and the enzyme lacking helix alpha1 strongly suggest that human QPRT acts as a hexamer for cooperative reactant binding via three dimeric subunits and maintaining stability.
Title: Structural Insights into the Quaternary Catalytic Mechanism of Hexameric Human Quinolinate Phosphoribosyltransferase, a Key Enzyme in de novo NAD Biosynthesis.

Report of the crystal structure of human QPRT bound to its inhibitor phthalic acid (PHT) and kinetic analysis of PHT inhibition of human QPRT.
Title: The crystal structure of human quinolinic acid phosphoribosyltransferase in complex with its inhibitor phthalic acid.

QPRT is a potential new marker for the immunohistochemical screening of follicular thyroid nodules.
Title: QPRT: a potential marker for follicular thyroid carcinoma including minimal invasive variant; a gene expression, RNA and immunohistochemical study.

The following QPRT gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the QPRT cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17075	NM_014298.5 Latest version!	Homo sapiens quinolinate phosphoribosyltransferase (QPRT), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu66212	XM_005255223.3 Latest version!	Homo sapiens quinolinate phosphoribosyltransferase (QPRT), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu100457	NM_001318250.1 Latest version!	Homo sapiens quinolinate phosphoribosyltransferase (QPRT), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu82785	NM_001318249.1 Latest version!	Homo sapiens quinolinate phosphoribosyltransferase (QPRT), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu85950	XM_017023101.1 Latest version!	Homo sapiens quinolinate phosphoribosyltransferase (QPRT), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OHu17075	NM_014298.3	Homo sapiens quinolinate phosphoribosyltransferase (QPRT), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu17075	NM_014298.4	Homo sapiens quinolinate phosphoribosyltransferase (QPRT), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

QPRT ( NM_014298.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055113.2 Homo sapiens quinolinate phosphoribosyltransferase (QPRT), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17075
Clone ID Related Accession (Same CDS sequence)	NM_014298.4 , NM_014298.3 , NM_014298.5
Accession Version	NM_014298.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 894bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	nicotinate-nucleotide pyrophosphorylase [carboxylating] isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK293195.1, BC010033.2, BX508036.1, AL563955.3 and BG576832.1. On Dec 31, 2015 this sequence version replaced NM_014298.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.228886.1, SRR1163655.583377.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACGCTG AAGGCCTGGC GCTGCTGCTG CCGCCCGTCA CCCTGGCAGC CCTGGTGGAC 
AGCTGGCTCC GAGAGGACTG CCCAGGGCTC AACTACGCAG CCTTGGTCAG CGGGGCAGGC 
CCCTCGCAGG CGGCGCTGTG GGCCAAATCC CCTGGGGTAC TGGCAGGGCA GCCTTTCTTC 
GATGCCATAT TTACCCAACT CAACTGCCAA GTCTCCTGGT TCCTCCCCGA GGGATCGAAG 
CTGGTGCCGG TGGCCAGAGT GGCCGAGGTC CGGGGCCCTG CCCACTGCCT GCTGCTGGGG 
GAACGGGTGG CCCTCAACAC GCTGGCCCGC TGCAGTGGCA TTGCCAGTGC TGCCGCCGCT 
GCAGTGGAGG CCGCCAGGGG GGCCGGCTGG ACTGGGCACG TGGCAGGCAC GAGGAAGACC 
ACGCCAGGCT TCCGGCTGGT GGAGAAGTAT GGGCTCCTGG TGGGCGGGGC CGCCTCGCAC 
CGCTACGACC TGGGAGGGCT GGTGATGGTG AAGGATAACC ATGTGGTGGC CGCCGGTGGC 
GTGGAGAAGG CGGTGCGGGC GGCCAGACAG GCGGCTGACT TCGCTCTGAA GGTGGAAGTG 
GAATGCAGCA GCCTGCAGGA GGCCGTGCAG GCAGCTGAGG CTGGTGCCGA CCTTGTCCTG 
CTGGACAACT TCAAGCCAGA GGAGCTGCAC CCCACGGCCA CCGTGCTGAA GGCCCAGTTC 
CCGAGTGTGG CTGTGGAAGC CAGTGGGGGC ATCACCCTGG ACAACCTCCC CCAGTTCTGC 
GGGCCGCACA TAGACGTCAT CTCCATGGGG ATGCTGACCC AGGCGGCCCC AGCCCTTGAT 
TTCTCCCTCA AGCTGTTTGC CAAAGAGGTG GCTCCAGTGC CCAAAATCCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055113.2
CDS	191..1084
Translation	MDAEGLALLLPPVTLAALVDSWLREDCPGLNYAALVSGAGPSQAALWAKSPGVLAGQPFFDAIFTQLNCQVSWFLPEGSKLVPVARVAEVRGPAHCLLLGERVALNTLARCSGIASAAAAAVEAARGAGWTGHVAGTRKTTPGFRLVEKYGLLVGGAASHRYDLGGLVMVKDNHVVAAGGVEKAVRAARQAADFALKVEVECSSLQEAVQAAEAGADLVLLDNFKPEELHPTATVLKAQFPSVAVEASGGITLDNLPQFCGPHIDVISMGMLTQAAPALDFSLKLFAKEVAPVPKIH

Target ORF information:

RefSeq Version	NM_014298.4
Organism	Homo sapiens(human)
Definition	Homo sapiens quinolinate phosphoribosyltransferase (QPRT), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014298.4

ORF Insert Sequence:

ATGGACGCTG AAGGCCTGGC GCTGCTGCTG CCGCCCGTCA CCCTGGCAGC CCTGGTGGAC 
AGCTGGCTCC GAGAGGACTG CCCAGGGCTC AACTACGCAG CCTTGGTCAG CGGGGCAGGC 
CCCTCGCAGG CGGCGCTGTG GGCCAAATCC CCTGGGGTAC TGGCAGGGCA GCCTTTCTTC 
GATGCCATAT TTACCCAACT CAACTGCCAA GTCTCCTGGT TCCTCCCCGA GGGATCGAAG 
CTGGTGCCGG TGGCCAGAGT GGCCGAGGTC CGGGGCCCTG CCCACTGCCT GCTGCTGGGG 
GAACGGGTGG CCCTCAACAC GCTGGCCCGC TGCAGTGGCA TTGCCAGTGC TGCCGCCGCT 
GCAGTGGAGG CCGCCAGGGG GGCCGGCTGG ACTGGGCACG TGGCAGGCAC GAGGAAGACC 
ACGCCAGGCT TCCGGCTGGT GGAGAAGTAT GGGCTCCTGG TGGGCGGGGC CGCCTCGCAC 
CGCTACGACC TGGGAGGGCT GGTGATGGTG AAGGATAACC ATGTGGTGGC CGCCGGTGGC 
GTGGAGAAGG CGGTGCGGGC GGCCAGACAG GCGGCTGACT TCGCTCTGAA GGTGGAAGTG 
GAATGCAGCA GCCTGCAGGA GGCCGTGCAG GCAGCTGAGG CTGGTGCCGA CCTTGTCCTG 
CTGGACAACT TCAAGCCAGA GGAGCTGCAC CCCACGGCCA CCGTGCTGAA GGCCCAGTTC 
CCGAGTGTGG CTGTGGAAGC CAGTGGGGGC ATCACCCTGG ACAACCTCCC CCAGTTCTGC 
GGGCCGCACA TAGACGTCAT CTCCATGGGG ATGCTGACCC AGGCGGCCCC AGCCCTTGAT 
TTCTCCCTCA AGCTGTTTGC CAAAGAGGTG GCTCCAGTGC CCAAAATCCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

QPRT ( NM_014298.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055113.2 Homo sapiens quinolinate phosphoribosyltransferase (QPRT), mRNA.

Price & Availability↑

CloneID	OHu17075
Clone ID Related Accession (Same CDS sequence)	NM_014298.4 , NM_014298.3 , NM_014298.5
Accession Version	NM_014298.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 894bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	nicotinate-nucleotide pyrophosphorylase [carboxylating] precursor
Comment

ATGGACGCTG AAGGCCTGGC GCTGCTGCTG CCGCCCGTCA CCCTGGCAGC CCTGGTGGAC 
AGCTGGCTCC GAGAGGACTG CCCAGGGCTC AACTACGCAG CCTTGGTCAG CGGGGCAGGC 
CCCTCGCAGG CGGCGCTGTG GGCCAAATCC CCTGGGGTAC TGGCAGGGCA GCCTTTCTTC 
GATGCCATAT TTACCCAACT CAACTGCCAA GTCTCCTGGT TCCTCCCCGA GGGATCGAAG 
CTGGTGCCGG TGGCCAGAGT GGCCGAGGTC CGGGGCCCTG CCCACTGCCT GCTGCTGGGG 
GAACGGGTGG CCCTCAACAC GCTGGCCCGC TGCAGTGGCA TTGCCAGTGC TGCCGCCGCT 
GCAGTGGAGG CCGCCAGGGG GGCCGGCTGG ACTGGGCACG TGGCAGGCAC GAGGAAGACC 
ACGCCAGGCT TCCGGCTGGT GGAGAAGTAT GGGCTCCTGG TGGGCGGGGC CGCCTCGCAC 
CGCTACGACC TGGGAGGGCT GGTGATGGTG AAGGATAACC ATGTGGTGGC CGCCGGTGGC 
GTGGAGAAGG CGGTGCGGGC GGCCAGACAG GCGGCTGACT TCGCTCTGAA GGTGGAAGTG 
GAATGCAGCA GCCTGCAGGA GGCCGTGCAG GCAGCTGAGG CTGGTGCCGA CCTTGTCCTG 
CTGGACAACT TCAAGCCAGA GGAGCTGCAC CCCACGGCCA CCGTGCTGAA GGCCCAGTTC 
CCGAGTGTGG CTGTGGAAGC CAGTGGGGGC ATCACCCTGG ACAACCTCCC CCAGTTCTGC 
GGGCCGCACA TAGACGTCAT CTCCATGGGG ATGCTGACCC AGGCGGCCCC AGCCCTTGAT 
TTCTCCCTCA AGCTGTTTGC CAAAGAGGTG GCTCCAGTGC CCAAAATCCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055113.2
Translation	MDAEGLALLLPPVTLAALVDSWLREDCPGLNYAALVSGAGPSQAALWAKSPGVLAGQPFFDAIFTQLNCQVSWFLPEGSKLVPVARVAEVRGPAHCLLLGERVALNTLARCSGIASAAAAAVEAARGAGWTGHVAGTRKTTPGFRLVEKYGLLVGGAASHRYDLGGLVMVKDNHVVAAGGVEKAVRAARQAADFALKVEVECSSLQEAVQAAEAGADLVLLDNFKPEELHPTATVLKAQFPSVAVEASGGITLDNLPQFCGPHIDVISMGMLTQAAPALDFSLKLFAKEVAPVPKIH

Target ORF information:

RefSeq Version	NM_014298.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens quinolinate phosphoribosyltransferase (QPRT), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014298.3

ORF Insert Sequence:

ATGGACGCTG AAGGCCTGGC GCTGCTGCTG CCGCCCGTCA CCCTGGCAGC CCTGGTGGAC 
AGCTGGCTCC GAGAGGACTG CCCAGGGCTC AACTACGCAG CCTTGGTCAG CGGGGCAGGC 
CCCTCGCAGG CGGCGCTGTG GGCCAAATCC CCTGGGGTAC TGGCAGGGCA GCCTTTCTTC 
GATGCCATAT TTACCCAACT CAACTGCCAA GTCTCCTGGT TCCTCCCCGA GGGATCGAAG 
CTGGTGCCGG TGGCCAGAGT GGCCGAGGTC CGGGGCCCTG CCCACTGCCT GCTGCTGGGG 
GAACGGGTGG CCCTCAACAC GCTGGCCCGC TGCAGTGGCA TTGCCAGTGC TGCCGCCGCT 
GCAGTGGAGG CCGCCAGGGG GGCCGGCTGG ACTGGGCACG TGGCAGGCAC GAGGAAGACC 
ACGCCAGGCT TCCGGCTGGT GGAGAAGTAT GGGCTCCTGG TGGGCGGGGC CGCCTCGCAC 
CGCTACGACC TGGGAGGGCT GGTGATGGTG AAGGATAACC ATGTGGTGGC CGCCGGTGGC 
GTGGAGAAGG CGGTGCGGGC GGCCAGACAG GCGGCTGACT TCGCTCTGAA GGTGGAAGTG 
GAATGCAGCA GCCTGCAGGA GGCCGTGCAG GCAGCTGAGG CTGGTGCCGA CCTTGTCCTG 
CTGGACAACT TCAAGCCAGA GGAGCTGCAC CCCACGGCCA CCGTGCTGAA GGCCCAGTTC 
CCGAGTGTGG CTGTGGAAGC CAGTGGGGGC ATCACCCTGG ACAACCTCCC CCAGTTCTGC 
GGGCCGCACA TAGACGTCAT CTCCATGGGG ATGCTGACCC AGGCGGCCCC AGCCCTTGAT 
TTCTCCCTCA AGCTGTTTGC CAAAGAGGTG GCTCCAGTGC CCAAAATCCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

QPRT ( NM_014298.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_055113.2 Homo sapiens quinolinate phosphoribosyltransferase (QPRT), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17075
Clone ID Related Accession (Same CDS sequence)	NM_014298.4 , NM_014298.3 , NM_014298.5
Accession Version	NM_014298.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 894bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	nicotinate-nucleotide pyrophosphorylase [carboxylating] isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC010033.2, BX508036.1, AL563955.3 and BG576832.1. On Nov 22, 2018 this sequence version replaced NM_014298.4. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.425502.1, SRR3476690.69397.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGACGCTG AAGGCCTGGC GCTGCTGCTG CCGCCCGTCA CCCTGGCAGC CCTGGTGGAC 
AGCTGGCTCC GAGAGGACTG CCCAGGGCTC AACTACGCAG CCTTGGTCAG CGGGGCAGGC 
CCCTCGCAGG CGGCGCTGTG GGCCAAATCC CCTGGGGTAC TGGCAGGGCA GCCTTTCTTC 
GATGCCATAT TTACCCAACT CAACTGCCAA GTCTCCTGGT TCCTCCCCGA GGGATCGAAG 
CTGGTGCCGG TGGCCAGAGT GGCCGAGGTC CGGGGCCCTG CCCACTGCCT GCTGCTGGGG 
GAACGGGTGG CCCTCAACAC GCTGGCCCGC TGCAGTGGCA TTGCCAGTGC TGCCGCCGCT 
GCAGTGGAGG CCGCCAGGGG GGCCGGCTGG ACTGGGCACG TGGCAGGCAC GAGGAAGACC 
ACGCCAGGCT TCCGGCTGGT GGAGAAGTAT GGGCTCCTGG TGGGCGGGGC CGCCTCGCAC 
CGCTACGACC TGGGAGGGCT GGTGATGGTG AAGGATAACC ATGTGGTGGC CGCCGGTGGC 
GTGGAGAAGG CGGTGCGGGC GGCCAGACAG GCGGCTGACT TCGCTCTGAA GGTGGAAGTG 
GAATGCAGCA GCCTGCAGGA GGCCGTGCAG GCAGCTGAGG CTGGTGCCGA CCTTGTCCTG 
CTGGACAACT TCAAGCCAGA GGAGCTGCAC CCCACGGCCA CCGTGCTGAA GGCCCAGTTC 
CCGAGTGTGG CTGTGGAAGC CAGTGGGGGC ATCACCCTGG ACAACCTCCC CCAGTTCTGC 
GGGCCGCACA TAGACGTCAT CTCCATGGGG ATGCTGACCC AGGCGGCCCC AGCCCTTGAT 
TTCTCCCTCA AGCTGTTTGC CAAAGAGGTG GCTCCAGTGC CCAAAATCCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055113.2
CDS	19..912
Translation	MDAEGLALLLPPVTLAALVDSWLREDCPGLNYAALVSGAGPSQAALWAKSPGVLAGQPFFDAIFTQLNCQVSWFLPEGSKLVPVARVAEVRGPAHCLLLGERVALNTLARCSGIASAAAAAVEAARGAGWTGHVAGTRKTTPGFRLVEKYGLLVGGAASHRYDLGGLVMVKDNHVVAAGGVEKAVRAARQAADFALKVEVECSSLQEAVQAAEAGADLVLLDNFKPEELHPTATVLKAQFPSVAVEASGGITLDNLPQFCGPHIDVISMGMLTQAAPALDFSLKLFAKEVAPVPKIH

Target ORF information:

RefSeq Version	NM_014298.5
Organism	Homo sapiens(human)
Definition	Homo sapiens quinolinate phosphoribosyltransferase (QPRT), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014298.5

ORF Insert Sequence:

ATGGACGCTG AAGGCCTGGC GCTGCTGCTG CCGCCCGTCA CCCTGGCAGC CCTGGTGGAC 
AGCTGGCTCC GAGAGGACTG CCCAGGGCTC AACTACGCAG CCTTGGTCAG CGGGGCAGGC 
CCCTCGCAGG CGGCGCTGTG GGCCAAATCC CCTGGGGTAC TGGCAGGGCA GCCTTTCTTC 
GATGCCATAT TTACCCAACT CAACTGCCAA GTCTCCTGGT TCCTCCCCGA GGGATCGAAG 
CTGGTGCCGG TGGCCAGAGT GGCCGAGGTC CGGGGCCCTG CCCACTGCCT GCTGCTGGGG 
GAACGGGTGG CCCTCAACAC GCTGGCCCGC TGCAGTGGCA TTGCCAGTGC TGCCGCCGCT 
GCAGTGGAGG CCGCCAGGGG GGCCGGCTGG ACTGGGCACG TGGCAGGCAC GAGGAAGACC 
ACGCCAGGCT TCCGGCTGGT GGAGAAGTAT GGGCTCCTGG TGGGCGGGGC CGCCTCGCAC 
CGCTACGACC TGGGAGGGCT GGTGATGGTG AAGGATAACC ATGTGGTGGC CGCCGGTGGC 
GTGGAGAAGG CGGTGCGGGC GGCCAGACAG GCGGCTGACT TCGCTCTGAA GGTGGAAGTG 
GAATGCAGCA GCCTGCAGGA GGCCGTGCAG GCAGCTGAGG CTGGTGCCGA CCTTGTCCTG 
CTGGACAACT TCAAGCCAGA GGAGCTGCAC CCCACGGCCA CCGTGCTGAA GGCCCAGTTC 
CCGAGTGTGG CTGTGGAAGC CAGTGGGGGC ATCACCCTGG ACAACCTCCC CCAGTTCTGC 
GGGCCGCACA TAGACGTCAT CTCCATGGGG ATGCTGACCC AGGCGGCCCC AGCCCTTGAT 
TTCTCCCTCA AGCTGTTTGC CAAAGAGGTG GCTCCAGTGC CCAAAATCCA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

QPRT ( XM_005255223.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005255280.2 Homo sapiens quinolinate phosphoribosyltransferase (QPRT), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu66212
Clone ID Related Accession (Same CDS sequence)	XM_005255223.3
Accession Version	XM_005255223.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1143bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	nicotinate-nucleotide pyrophosphorylase [carboxylating] isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005255223.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACTTTGG AAAATACCAG CAATATAATG TTAAGTGGGG AAAAAAGCAA GTTACTCCTC 
TGTAATACAT ATGATTTTAG TTTTGTAATA AAAATTCCCA ACCATATATG CACTTATAGG 
GAAACAAAGG ACCCATCGCA AATGTTTTCC ATGCTGATCT CCAAAGTGTC CCACCCCCAG 
CCTGGGGCCT CTGGGAGCCT TGGTCCTGAG CAGCCAACAC ACCAGCCCAG ACAGCTGCAA 
GTCACCATGG ACGCTGAAGG CCTGGCGCTG CTGCTGCCGC CCGTCACCCT GGCAGCCCTG 
GTGGACAGCT GGCTCCGAGA GGACTGCCCA GGGCTCAACT ACGCAGCCTT GGTCAGCGGG 
GCAGGCCCCT CGCAGGCGGC GCTGTGGGCC AAATCCCCTG GGGTACTGGC AGGGCAGCCT 
TTCTTCGATG CCATATTTAC CCAACTCAAC TGCCAAGTCT CCTGGTTCCT CCCCGAGGGA 
TCGAAGCTGG TGCCGGTGGC CAGAGTGGCC GAGGTCCGGG GCCCTGCCCA CTGCCTGCTG 
CTGGGGGAAC GGGTGGCCCT CAACACGCTG GCCCGCTGCA GTGGCATTGC CAGTGCTGCC 
GCCGCTGCAG TGGAGGCCGC CAGGGGGGCC GGCTGGACTG GGCACGTGGC AGGCACGAGG 
AAGACCACGC CAGGCTTCCG GCTGGTGGAG AAGTATGGGC TCCTGGTGGG CGGGGCCGCC 
TCGCACCGCT ACGACCTGGG AGGGCTGGTG ATGGTGAAGG ATAACCATGT GGTGGCCGCC 
GGTGGCGTGG AGAAGCAGGC GGTGCGGGCG GCCAGACAGG CGGCTGACTT CACTCTGAAG 
GTGGAAGTGG AATGCAGCAG CCTGCAGGAG GCCGTGCAGG CAGCTGAGGC TGGTGCCGAC 
CTTGTCCTGC TGGACAACTT CAAGCCAGAG GAGCTGCACC CCACGGCCAC CGTGCTGAAG 
GCCCAGTTCC CGAGTGTGGC TGTGGAAGCC AGTGGGGGCA TCACCCTGGA CAACCTCCCC 
CAGTTCTGCG GGCCGCACAT AGACGTCATC TCCATGGGGA TGCTGACCCA GGCGGCCCCA 
GCCCTTGATT TCTCCCTCAA GCTGTTTGCC AAAGAGGTGG CTCCAGTGCC CAAAATCCAC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005255280.2
CDS	28..1170
Translation	MTLENTSNIMLSGEKSKLLLCNTYDFSFVIKIPNHICTYRETKDPSQMFSMLISKVSHPQPGASGSLGPEQPTHQPRQLQVTMDAEGLALLLPPVTLAALVDSWLREDCPGLNYAALVSGAGPSQAALWAKSPGVLAGQPFFDAIFTQLNCQVSWFLPEGSKLVPVARVAEVRGPAHCLLLGERVALNTLARCSGIASAAAAAVEAARGAGWTGHVAGTRKTTPGFRLVEKYGLLVGGAASHRYDLGGLVMVKDNHVVAAGGVEKQAVRAARQAADFTLKVEVECSSLQEAVQAAEAGADLVLLDNFKPEELHPTATVLKAQFPSVAVEASGGITLDNLPQFCGPHIDVISMGMLTQAAPALDFSLKLFAKEVAPVPKIH

Target ORF information:

RefSeq Version	XM_005255223.3
Organism	Homo sapiens(human)
Definition	Homo sapiens quinolinate phosphoribosyltransferase (QPRT), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005255223.3

ORF Insert Sequence:

ATGACTTTGG AAAATACCAG CAATATAATG TTAAGTGGGG AAAAAAGCAA GTTACTCCTC 
TGTAATACAT ATGATTTTAG TTTTGTAATA AAAATTCCCA ACCATATATG CACTTATAGG 
GAAACAAAGG ACCCATCGCA AATGTTTTCC ATGCTGATCT CCAAAGTGTC CCACCCCCAG 
CCTGGGGCCT CTGGGAGCCT TGGTCCTGAG CAGCCAACAC ACCAGCCCAG ACAGCTGCAA 
GTCACCATGG ACGCTGAAGG CCTGGCGCTG CTGCTGCCGC CCGTCACCCT GGCAGCCCTG 
GTGGACAGCT GGCTCCGAGA GGACTGCCCA GGGCTCAACT ACGCAGCCTT GGTCAGCGGG 
GCAGGCCCCT CGCAGGCGGC GCTGTGGGCC AAATCCCCTG GGGTACTGGC AGGGCAGCCT 
TTCTTCGATG CCATATTTAC CCAACTCAAC TGCCAAGTCT CCTGGTTCCT CCCCGAGGGA 
TCGAAGCTGG TGCCGGTGGC CAGAGTGGCC GAGGTCCGGG GCCCTGCCCA CTGCCTGCTG 
CTGGGGGAAC GGGTGGCCCT CAACACGCTG GCCCGCTGCA GTGGCATTGC CAGTGCTGCC 
GCCGCTGCAG TGGAGGCCGC CAGGGGGGCC GGCTGGACTG GGCACGTGGC AGGCACGAGG 
AAGACCACGC CAGGCTTCCG GCTGGTGGAG AAGTATGGGC TCCTGGTGGG CGGGGCCGCC 
TCGCACCGCT ACGACCTGGG AGGGCTGGTG ATGGTGAAGG ATAACCATGT GGTGGCCGCC 
GGTGGCGTGG AGAAGCAGGC GGTGCGGGCG GCCAGACAGG CGGCTGACTT CACTCTGAAG 
GTGGAAGTGG AATGCAGCAG CCTGCAGGAG GCCGTGCAGG CAGCTGAGGC TGGTGCCGAC 
CTTGTCCTGC TGGACAACTT CAAGCCAGAG GAGCTGCACC CCACGGCCAC CGTGCTGAAG 
GCCCAGTTCC CGAGTGTGGC TGTGGAAGCC AGTGGGGGCA TCACCCTGGA CAACCTCCCC 
CAGTTCTGCG GGCCGCACAT AGACGTCATC TCCATGGGGA TGCTGACCCA GGCGGCCCCA 
GCCCTTGATT TCTCCCTCAA GCTGTTTGCC AAAGAGGTGG CTCCAGTGCC CAAAATCCAC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

QPRT ( NM_001318250.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001305179.1 Homo sapiens quinolinate phosphoribosyltransferase (QPRT), transcript variant 3, mRNA.

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CloneID	OHu100457
Clone ID Related Accession (Same CDS sequence)	NM_001318250.1
Accession Version	NM_001318250.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 450bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Homo sapiens(human)
Product	nicotinate-nucleotide pyrophosphorylase [carboxylating] isoform 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK293195.1, BP314322.1, BC005060.1, BX508036.1, AL563955.3 and BG576832.1. Transcript Variant: This variant (3) contains an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 3, which lacks an internal in-frame segment, and is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP314322.1, DA476206.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACGCTG AAGGCCTGGC GCTGCTGCTG CCGCCCGTCA CCCTGGCAGC CCTGGTGGAC 
AGCTGGCTCC GAGAGGACTG CCCAGGGCTC AACTACGCAG CCTTGGCGGT GCGGGCGGCC 
AGACAGGCGG CTGACTTCGC TCTGAAGGTG GAAGTGGAAT GCAGCAGCCT GCAGGAGGCC 
GTGCAGGCAG CTGAGGCTGG TGCCGACCTT GTCCTGCTGG ACAACTTCAA GCCAGAGGAG 
CTGCACCCCA CGGCCACCGT GCTGAAGGCC CAGTTCCCGA GTGTGGCTGT GGAAGCCAGT 
GGGGGCATCA CCCTGGACAA CCTCCCCCAG TTCTGCGGGC CGCACATAGA CGTCATCTCC 
ATGGGGATGC TGACCCAGGC GGCCCCAGCC CTTGATTTCT CCCTCAAGCT GTTTGCCAAA 
GAGGTGGCTC CAGTGCCCAA AATCCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001305179.1
CDS	191..640
Translation	MDAEGLALLLPPVTLAALVDSWLREDCPGLNYAALAVRAARQAADFALKVEVECSSLQEAVQAAEAGADLVLLDNFKPEELHPTATVLKAQFPSVAVEASGGITLDNLPQFCGPHIDVISMGMLTQAAPALDFSLKLFAKEVAPVPKIH

Target ORF information:

RefSeq Version	NM_001318250.1
Organism	Homo sapiens(human)
Definition	Homo sapiens quinolinate phosphoribosyltransferase (QPRT), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001318250.1

ORF Insert Sequence:

ATGGACGCTG AAGGCCTGGC GCTGCTGCTG CCGCCCGTCA CCCTGGCAGC CCTGGTGGAC 
AGCTGGCTCC GAGAGGACTG CCCAGGGCTC AACTACGCAG CCTTGGCGGT GCGGGCGGCC 
AGACAGGCGG CTGACTTCGC TCTGAAGGTG GAAGTGGAAT GCAGCAGCCT GCAGGAGGCC 
GTGCAGGCAG CTGAGGCTGG TGCCGACCTT GTCCTGCTGG ACAACTTCAA GCCAGAGGAG 
CTGCACCCCA CGGCCACCGT GCTGAAGGCC CAGTTCCCGA GTGTGGCTGT GGAAGCCAGT 
GGGGGCATCA CCCTGGACAA CCTCCCCCAG TTCTGCGGGC CGCACATAGA CGTCATCTCC 
ATGGGGATGC TGACCCAGGC GGCCCCAGCC CTTGATTTCT CCCTCAAGCT GTTTGCCAAA 
GAGGTGGCTC CAGTGCCCAA AATCCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

QPRT ( NM_001318249.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001305178.1 Homo sapiens quinolinate phosphoribosyltransferase (QPRT), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu82785
Clone ID Related Accession (Same CDS sequence)	NM_001318249.1
Accession Version	NM_001318249.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	nicotinate-nucleotide pyrophosphorylase [carboxylating] isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK293195.1, BC005060.1, BX508036.1, AL563955.3 and BG576832.1. Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, lacks an exon in the CDS and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK293195.1, SRR1163657.307808.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCCCTC CCTCCCTCCA CAGTCCCACC CCCAGCCTGG GGCCTCTGGG AGCCTTGGTC 
CTGAGCAGCC AACACACCAG CCCAGACAGC TGCAAGTCAC CATGGACGCT GAAGGCGGTG 
CGGGCGGCCA GACAGGCGGC TGACTTCGCT CTGAAGGTGG AAGTGGAATG CAGCAGCCTG 
CAGGAGGCCG TGCAGGCAGC TGAGGCTGGT GCCGACCTTG TCCTGCTGGA CAACTTCAAG 
CCAGAGGAGC TGCACCCCAC GGCCACCGTG CTGAAGGCCC AGTTCCCGAG TGTGGCTGTG 
GAAGCCAGTG GGGGCATCAC CCTGGACAAC CTCCCCCAGT TCTGCGGGCC GCACATAGAC 
GTCATCTCCA TGGGGATGCT GACCCAGGCG GCCCCAGCCC TTGATTTCTC CCTCAAGCTG 
TTTGCCAAAG AGGTGGCTCC AGTGCCCAAA ATCCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001305178.1
CDS	90..548
Translation	MGPPSLHSPTPSLGPLGALVLSSQHTSPDSCKSPWTLKAVRAARQAADFALKVEVECSSLQEAVQAAEAGADLVLLDNFKPEELHPTATVLKAQFPSVAVEASGGITLDNLPQFCGPHIDVISMGMLTQAAPALDFSLKLFAKEVAPVPKIH

Target ORF information:

RefSeq Version	NM_001318249.1
Organism	Homo sapiens(human)
Definition	Homo sapiens quinolinate phosphoribosyltransferase (QPRT), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001318249.1

ORF Insert Sequence:

ATGGGCCCTC CCTCCCTCCA CAGTCCCACC CCCAGCCTGG GGCCTCTGGG AGCCTTGGTC 
CTGAGCAGCC AACACACCAG CCCAGACAGC TGCAAGTCAC CATGGACGCT GAAGGCGGTG 
CGGGCGGCCA GACAGGCGGC TGACTTCGCT CTGAAGGTGG AAGTGGAATG CAGCAGCCTG 
CAGGAGGCCG TGCAGGCAGC TGAGGCTGGT GCCGACCTTG TCCTGCTGGA CAACTTCAAG 
CCAGAGGAGC TGCACCCCAC GGCCACCGTG CTGAAGGCCC AGTTCCCGAG TGTGGCTGTG 
GAAGCCAGTG GGGGCATCAC CCTGGACAAC CTCCCCCAGT TCTGCGGGCC GCACATAGAC 
GTCATCTCCA TGGGGATGCT GACCCAGGCG GCCCCAGCCC TTGATTTCTC CCTCAAGCTG 
TTTGCCAAAG AGGTGGCTCC AGTGCCCAAA ATCCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

QPRT ( XM_017023101.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016878590.1 Homo sapiens quinolinate phosphoribosyltransferase (QPRT), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu85950
Clone ID Related Accession (Same CDS sequence)	XM_017023101.1
Accession Version	XM_017023101.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1140bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	nicotinate-nucleotide pyrophosphorylase [carboxylating] isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACTTTGG AAAATACCAG CAATATAATG TTAAGTGGGG AAAAAAGCAA GTTACTCCTC 
TGTAATACAT ATGATTTTAG TTTTGTAATA AAAATTCCCA ACCATATATG CACTTATAGG 
GAAACAAAGG ACCCATCGCA AATGTTTTCC ATGCTGATCT CCAAAGTGTC CCACCCCCAG 
CCTGGGGCCT CTGGGAGCCT TGGTCCTGAG CAGCCAACAC ACCAGCCCAG ACAGCTGCAA 
GTCACCATGG ACGCTGAAGG CCTGGCGCTG CTGCTGCCGC CCGTCACCCT GGCAGCCCTG 
GTGGACAGCT GGCTCCGAGA GGACTGCCCA GGGCTCAACT ACGCAGCCTT GGTCAGCGGG 
GCAGGCCCCT CGCAGGCGGC GCTGTGGGCC AAATCCCCTG GGGTACTGGC AGGGCAGCCT 
TTCTTCGATG CCATATTTAC CCAACTCAAC TGCCAAGTCT CCTGGTTCCT CCCCGAGGGA 
TCGAAGCTGG TGCCGGTGGC CAGAGTGGCC GAGGTCCGGG GCCCTGCCCA CTGCCTGCTG 
CTGGGGGAAC GGGTGGCCCT CAACACGCTG GCCCGCTGCA GTGGCATTGC CAGTGCTGCC 
GCCGCTGCAG TGGAGGCCGC CAGGGGGGCC GGCTGGACTG GGCACGTGGC AGGCACGAGG 
AAGACCACGC CAGGCTTCCG GCTGGTGGAG AAGTATGGGC TCCTGGTGGG CGGGGCCGCC 
TCGCACCGCT ACGACCTGGG AGGGCTGGTG ATGGTGAAGG ATAACCATGT GGTGGCCGCC 
GGTGGCGTGG AGAAGGCGGT GCGGGCGGCC AGACAGGCGG CTGACTTCAC TCTGAAGGTG 
GAAGTGGAAT GCAGCAGCCT GCAGGAGGCC GTGCAGGCAG CTGAGGCTGG TGCCGACCTT 
GTCCTGCTGG ACAACTTCAA GCCAGAGGAG CTGCACCCCA CGGCCACCGT GCTGAAGGCC 
CAGTTCCCGA GTGTGGCTGT GGAAGCCAGT GGGGGCATCA CCCTGGACAA CCTCCCCCAG 
TTCTGCGGGC CGCACATAGA CGTCATCTCC ATGGGGATGC TGACCCAGGC GGCCCCAGCC 
CTTGATTTCT CCCTCAAGCT GTTTGCCAAA GAGGTGGCTC CAGTGCCCAA AATCCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016878590.1
CDS	28..1167
Translation	MTLENTSNIMLSGEKSKLLLCNTYDFSFVIKIPNHICTYRETKDPSQMFSMLISKVSHPQPGASGSLGPEQPTHQPRQLQVTMDAEGLALLLPPVTLAALVDSWLREDCPGLNYAALVSGAGPSQAALWAKSPGVLAGQPFFDAIFTQLNCQVSWFLPEGSKLVPVARVAEVRGPAHCLLLGERVALNTLARCSGIASAAAAAVEAARGAGWTGHVAGTRKTTPGFRLVEKYGLLVGGAASHRYDLGGLVMVKDNHVVAAGGVEKAVRAARQAADFTLKVEVECSSLQEAVQAAEAGADLVLLDNFKPEELHPTATVLKAQFPSVAVEASGGITLDNLPQFCGPHIDVISMGMLTQAAPALDFSLKLFAKEVAPVPKIH

Target ORF information:

RefSeq Version	XM_017023101.1
Organism	Homo sapiens(human)
Definition	Homo sapiens quinolinate phosphoribosyltransferase (QPRT), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017023101.1

ORF Insert Sequence:

ATGACTTTGG AAAATACCAG CAATATAATG TTAAGTGGGG AAAAAAGCAA GTTACTCCTC 
TGTAATACAT ATGATTTTAG TTTTGTAATA AAAATTCCCA ACCATATATG CACTTATAGG 
GAAACAAAGG ACCCATCGCA AATGTTTTCC ATGCTGATCT CCAAAGTGTC CCACCCCCAG 
CCTGGGGCCT CTGGGAGCCT TGGTCCTGAG CAGCCAACAC ACCAGCCCAG ACAGCTGCAA 
GTCACCATGG ACGCTGAAGG CCTGGCGCTG CTGCTGCCGC CCGTCACCCT GGCAGCCCTG 
GTGGACAGCT GGCTCCGAGA GGACTGCCCA GGGCTCAACT ACGCAGCCTT GGTCAGCGGG 
GCAGGCCCCT CGCAGGCGGC GCTGTGGGCC AAATCCCCTG GGGTACTGGC AGGGCAGCCT 
TTCTTCGATG CCATATTTAC CCAACTCAAC TGCCAAGTCT CCTGGTTCCT CCCCGAGGGA 
TCGAAGCTGG TGCCGGTGGC CAGAGTGGCC GAGGTCCGGG GCCCTGCCCA CTGCCTGCTG 
CTGGGGGAAC GGGTGGCCCT CAACACGCTG GCCCGCTGCA GTGGCATTGC CAGTGCTGCC 
GCCGCTGCAG TGGAGGCCGC CAGGGGGGCC GGCTGGACTG GGCACGTGGC AGGCACGAGG 
AAGACCACGC CAGGCTTCCG GCTGGTGGAG AAGTATGGGC TCCTGGTGGG CGGGGCCGCC 
TCGCACCGCT ACGACCTGGG AGGGCTGGTG ATGGTGAAGG ATAACCATGT GGTGGCCGCC 
GGTGGCGTGG AGAAGGCGGT GCGGGCGGCC AGACAGGCGG CTGACTTCAC TCTGAAGGTG 
GAAGTGGAAT GCAGCAGCCT GCAGGAGGCC GTGCAGGCAG CTGAGGCTGG TGCCGACCTT 
GTCCTGCTGG ACAACTTCAA GCCAGAGGAG CTGCACCCCA CGGCCACCGT GCTGAAGGCC 
CAGTTCCCGA GTGTGGCTGT GGAAGCCAGT GGGGGCATCA CCCTGGACAA CCTCCCCCAG 
TTCTGCGGGC CGCACATAGA CGTCATCTCC ATGGGGATGC TGACCCAGGC GGCCCCAGCC 
CTTGATTTCT CCCTCAAGCT GTTTGCCAAA GAGGTGGCTC CAGTGCCCAA AATCCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Quinolinate Phosphoribosyltransferase is an Antiviral Host Factor Against Hepatitis C Virus Infection.
Scientific reports7(1)5876(2017 Jul)
Wang Z,Gao Y,Zhang C,Hu H,Guo D,Xu Y,Xu Q,Zhang W,Deng S,Lv P,Yang Y,Ding Y,Li Q,Weng C,Chen X,Gong S,Chen H,Niu J,Tang H

Anti-apoptotic quinolinate phosphoribosyltransferase (QPRT) is a target gene of Wilms' tumor gene 1 (WT1) protein in leukemic cells.
Biochemical and biophysical research communications482(4)802-807(2017 Jan)
Ullmark T,Montano G,J?rvstr?t L,Jernmark Nilsson H,H?kansson E,Drott K,Nilsson B,Vidovic K,Gullberg U

Structural Insights into the Quaternary Catalytic Mechanism of Hexameric Human Quinolinate Phosphoribosyltransferase, a Key Enzyme in de novo NAD Biosynthesis.
Scientific reports619681(2016 Jan)
Youn HS,Kim TG,Kim MK,Kang GB,Kang JY,Lee JG,An JY,Park KR,Lee Y,Im YJ,Lee JH,Eom SH

Expression of the Kynurenine Pathway in Human Peripheral Blood Mononuclear Cells: Implications for Inflammatory and Neurodegenerative Disease.
PloS one10(6)e0131389(2015)
Jones SP,Franco NF,Varney B,Sundaram G,Brown DA,de Bie J,Lim CK,Guillemin GJ,Brew BJ

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QPRT cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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