FOXE1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FOXE1
Entrez Gene ID	2304
Full Name	forkhead box E1
Synonyms	FKHL15,FOXE2,HFKH4,HFKL5,NMTC4,TITF2,TTF-2,TTF2
General protein information	Preferred Names forkhead box E1 Names forkhead box protein E1 HNF-3/fork head-like protein 5 forkhead box protein E2 forkhead, drosophila, homolog-like 15 forkhead-related protein FKHL15 thyroid transcription factor 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9q22.33
Summary	This intronless gene encodes a protein that belongs to the forkhead family of transcription factors. Members of this family contain a conserved 100-amino acid DNA-binding 'forkhead' domain. The encoded protein functions as a thyroid transcription factor that plays a role in thyroid morphogenesis. Mutations in this gene are associated with the Bamforth-Lazarus syndrome, and with susceptibility to nonmedullary thyroid cancer-4. [provided by RefSeq, Nov 2016].
Disorder MIM:	602617
Disorder Html:	Bamforth-Lazarus syndrome, 241850 (3); {Thyroid cancer, nonmedullary, 4}, 616534 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_004473.4	NP_004464.2	forkhead box protein E1
NM_004473.3	NP_004464.2	forkhead box protein E1

Pathways from BioSystems

Homologies

	LOC715656	XP_001114004.1
Mus musculus (house mouse)	Foxe1	NP_899121.1
Gallus gallus (chicken)	FOXE1	XP_003643136.2
Homo sapiens (human)	FOXE1	NP_004464.2
Danio rerio (zebrafish)	foxe1	XP_005159967.1
Bos taurus (cattle)	FOXE1	XP_005210253.1
Rattus norvegicus (Norway rat)	Foxe1	NP_620264.1
Xenopus tropicalis (tropical clawed frog)	foxe1	XP_002936729.1

Gene Ontology
Bibliography

Related articles in PubMed

Replication confirms the association of loci in FOXE1, PDE8B, CAPZB and PDE10A with thyroid traits: a Genetics of Diabetes Audit and Research Tayside study (GoDARTS).
Soto-Pedre E, Siddiqui MK, Doney AS, Palmer CNA, Pearson ER, Leese GP
Pharmacogenetics and genomics27(10)356-362(2017 Oct)

Age at diagnosis and gender modify the risk of 9q22 and 14q13 polymorphisms for papillary thyroid carcinoma.
Kula D, Kalemba M, Puch Z, Pola?ska J, ?wierniak M, Rusinek D, ?ebracka-Gala J, Kowalska M, Handkiewicz-Junak D, Kowal M, Tyszkiewicz T, Piasna E, Czarniecka A, Pawlaczek A, Krajewska J, Szpak-Ulczok S, Jarz?b B
Endokrynologia Polska68(3)283-289(2017)

Cloning, chromosomal localization and identification of polymorphisms in the human thyroid transcription factor 2 gene (TITF2).
Macchia PE, Mattei MG, Lapi P, Fenzi G, Di Lauro R
Biochimie81(5)433-40(1999 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We identified a FOXE1: c.532_537delGCCGCC p.(Ala178_Ala179del) variant that predisposes to thyroid ectopia. Taken together, this is the first report of mosaic 11p13 deletion in association with thyroid dysgenesis
Title: WAGR syndrome and congenital hypothyroidism in a child with a Mosaic 11p13 deletion.

In the analysis of all OFCs combined, SNPs near FOXE1 reached genome-wide significance
Title: Genome-wide meta-analyses of nonsyndromic orofacial clefts identify novel associations between FOXE1 and all orofacial clefts, and TP63 and cleft lip with or without cleft palate.

Patient-related factors modify the predisposition to papillary thyroid carcinoma by increasing the risk for rs944289 (near the NKX2-1 locus) per year of age, and by enhancing the protective effect of the FOXE1 GGT haplotype in men.
Title: Age at diagnosis and gender modify the risk of 9q22 and 14q13 polymorphisms for papillary thyroid carcinoma.

Our results implicate FOXE1 as an important locus whose polymorphic variation increases risks for all types of isolated clefts, and opens a new biological pathway to investigate in efforts to understand genetic factors underlying human clefting.
Title: Genetic variation of FOXE1 and risk for orofacial clefts in a California population.

FOXE1 was the only gene which was over-expressed in six out of eight lung cancer cell lines and human cancer tissue specimens and is an important regulator by targeting autophagy and Matrix Metalloproteinases pathways in lung cancer development.
Title: Profiling analysis of FOX gene family members identified FOXE1 as potential regulator of NSCLC development.

The following FOXE1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FOXE1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18348	NM_004473.4 Latest version!	Homo sapiens forkhead box E1 (FOXE1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu18348	NM_004473.3	Homo sapiens forkhead box E1 (FOXE1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FOXE1 ( NM_004473.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004464.2 Homo sapiens forkhead box E1 (FOXE1), mRNA.

Price & Availability↑

CloneID	OHu18348
Clone ID Related Accession (Same CDS sequence)	NM_004473.4 , NM_004473.3
Accession Version	NM_004473.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1122bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	forkhead box protein E1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL499604.9 and U89995.2. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_004473.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: U89995.2, DRR138513.469772.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000375123.5/ ENSP00000364265.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACTGCCG AGAGCGGGCC GCCGCCGCCG CAGCCGGAGG TGCTGGCTAC CGTGAAGGAA 
GAGCGCGGCG AGACGGCAGC AGGGGCCGGG GTCCCAGGGG AGGCCACGGG CCGCGGGGCG 
GGCGGGCGGC GCCGCAAGCG CCCCCTGCAG CGCGGGAAGC CGCCCTACAG CTACATCGCG 
CTCATCGCCA TGGCCATCGC GCACGCGCCC GAGCGCCGCC TCACGCTGGG CGGCATCTAC 
AAGTTCATCA CCGAGCGCTT CCCCTTCTAC CGCGACAACC CCAAAAAGTG GCAGAACAGC 
ATCCGCCACA ACCTCACACT CAACGACTGC TTCCTCAAGA TCCCGCGCGA GGCCGGCCGC 
CCGGGTAAGG GCAACTACTG GGCGCTTGAC CCCAACGCGG AGGACATGTT CGAGAGCGGC 
AGCTTCCTGC GCCGCCGCAA GCGCTTCAAG CGCTCGGACC TCTCCACCTA CCCGGCTTAC 
ATGCACGACG CGGCGGCTGC CGCAGCCGCC GCCGCCGCCG CCGCCGCCGC CGCCGCCATC 
TTCCCAGGCG CGGTGCCCGC CGCGCGCCCC CCCTACCCGG GCGCCGTCTA TGCAGGCTAC 
GCGCCGCCGT CGCTGGCCGC GCCGCCTCCA GTCTACTACC CCGCGGCGTC GCCCGGCCCT 
TGCCGCGTCT TCGGCCTGGT TCCTGAGCGG CCGCTCAGCC CAGAGCTGGG GCCCGCACCG 
TCGGGGCCCG GCGGCTCTTG CGCCTTTGCC TCCGCCGGCG CCCCCGCTAC CACCACCGGC 
TACCAGCCCG CAGGCTGCAC CGGGGCCCGG CCGGCCAACC CCTCCGCCTA TGCGGCTGCC 
TACGCGGGCC CCGACGGCGC GTACCCGCAG GGCGCCGGCA GTGCGATCTT TGCCGCTGCT 
GGCCGCCTGG CGGGACCCGC TTCGCCCCCA GCGGGCGGCA GCAGTGGCGG CGTGGAGACC 
ACGGTGGACT TCTACGGGCG CACGTCGCCC GGCCAGTTCG GAGCGCTGGG AGCCTGCTAC 
AACCCTGGCG GGCAGCTCGG AGGGGCCAGT GCAGGCGCCT ACCATGCTCG CCATGCTGCC 
GCTTATCCCG GTGGGATAGA TCGGTTCGTG TCCGCCATGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004464.2
CDS	690..1811
Translation	MTAESGPPPPQPEVLATVKEERGETAAGAGVPGEATGRGAGGRRRKRPLQRGKPPYSYIALIAMAIAHAPERRLTLGGIYKFITERFPFYRDNPKKWQNSIRHNLTLNDCFLKIPREAGRPGKGNYWALDPNAEDMFESGSFLRRRKRFKRSDLSTYPAYMHDAAAAAAAAAAAAAAAAIFPGAVPAARPPYPGAVYAGYAPPSLAAPPPVYYPAASPGPCRVFGLVPERPLSPELGPAPSGPGGSCAFASAGAPATTTGYQPAGCTGARPANPSAYAAAYAGPDGAYPQGAGSAIFAAAGRLAGPASPPAGGSSGGVETTVDFYGRTSPGQFGALGACYNPGGQLGGASAGAYHARHAAAYPGGIDRFVSAM

Target ORF information:

RefSeq Version	NM_004473.4
Organism	Homo sapiens(human)
Definition	Homo sapiens forkhead box E1 (FOXE1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004473.4

ORF Insert Sequence:

ATGACTGCCG AGAGCGGGCC GCCGCCGCCG CAGCCGGAGG TGCTGGCTAC CGTGAAGGAA 
GAGCGCGGCG AGACGGCAGC AGGGGCCGGG GTCCCAGGGG AGGCCACGGG CCGCGGGGCG 
GGCGGGCGGC GCCGCAAGCG CCCCCTGCAG CGCGGGAAGC CGCCCTACAG CTACATCGCG 
CTCATCGCCA TGGCCATCGC GCACGCGCCC GAGCGCCGCC TCACGCTGGG CGGCATCTAC 
AAGTTCATCA CCGAGCGCTT CCCCTTCTAC CGCGACAACC CCAAAAAGTG GCAGAACAGC 
ATCCGCCACA ACCTCACACT CAACGACTGC TTCCTCAAGA TCCCGCGCGA GGCCGGCCGC 
CCGGGTAAGG GCAACTACTG GGCGCTTGAC CCCAACGCGG AGGACATGTT CGAGAGCGGC 
AGCTTCCTGC GCCGCCGCAA GCGCTTCAAG CGCTCGGACC TCTCCACCTA CCCGGCTTAC 
ATGCACGACG CGGCGGCTGC CGCAGCCGCC GCCGCCGCCG CCGCCGCCGC CGCCGCCATC 
TTCCCAGGCG CGGTGCCCGC CGCGCGCCCC CCCTACCCGG GCGCCGTCTA TGCAGGCTAC 
GCGCCGCCGT CGCTGGCCGC GCCGCCTCCA GTCTACTACC CCGCGGCGTC GCCCGGCCCT 
TGCCGCGTCT TCGGCCTGGT TCCTGAGCGG CCGCTCAGCC CAGAGCTGGG GCCCGCACCG 
TCGGGGCCCG GCGGCTCTTG CGCCTTTGCC TCCGCCGGCG CCCCCGCTAC CACCACCGGC 
TACCAGCCCG CAGGCTGCAC CGGGGCCCGG CCGGCCAACC CCTCCGCCTA TGCGGCTGCC 
TACGCGGGCC CCGACGGCGC GTACCCGCAG GGCGCCGGCA GTGCGATCTT TGCCGCTGCT 
GGCCGCCTGG CGGGACCCGC TTCGCCCCCA GCGGGCGGCA GCAGTGGCGG CGTGGAGACC 
ACGGTGGACT TCTACGGGCG CACGTCGCCC GGCCAGTTCG GAGCGCTGGG AGCCTGCTAC 
AACCCTGGCG GGCAGCTCGG AGGGGCCAGT GCAGGCGCCT ACCATGCTCG CCATGCTGCC 
GCTTATCCCG GTGGGATAGA TCGGTTCGTG TCCGCCATGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FOXE1 ( NM_004473.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004464.2 Homo sapiens forkhead box E1 (FOXE1), mRNA.

Price & Availability↑

CloneID	OHu18348
Clone ID Related Accession (Same CDS sequence)	NM_004473.4 , NM_004473.3
Accession Version	NM_004473.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1122bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-03
Organism	Homo sapiens(human)
Product	forkhead box protein E1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U89995.2 and AL499604.9. This sequence is a reference standard in the RefSeqGene project. On or before Sep 3, 2004 this sequence version replaced NM_012185.1, NM_004473.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGACTGCCG AGAGCGGGCC GCCGCCGCCG CAGCCGGAGG TGCTGGCTAC CGTGAAGGAA 
GAGCGCGGCG AGACGGCAGC AGGGGCCGGG GTCCCAGGGG AGGCCACGGG CCGCGGGGCG 
GGCGGGCGGC GCCGCAAGCG CCCCCTGCAG CGCGGGAAGC CGCCCTACAG CTACATCGCG 
CTCATCGCCA TGGCCATCGC GCACGCGCCC GAGCGCCGCC TCACGCTGGG CGGCATCTAC 
AAGTTCATCA CCGAGCGCTT CCCCTTCTAC CGCGACAACC CCAAAAAGTG GCAGAACAGC 
ATCCGCCACA ACCTCACACT CAACGACTGC TTCCTCAAGA TCCCGCGCGA GGCCGGCCGC 
CCGGGTAAGG GCAACTACTG GGCGCTTGAC CCCAACGCGG AGGACATGTT CGAGAGCGGC 
AGCTTCCTGC GCCGCCGCAA GCGCTTCAAG CGCTCGGACC TCTCCACCTA CCCGGCTTAC 
ATGCACGACG CGGCGGCTGC CGCAGCCGCC GCCGCCGCCG CCGCCGCCGC CGCCGCCATC 
TTCCCAGGCG CGGTGCCCGC CGCGCGCCCC CCCTACCCGG GCGCCGTCTA TGCAGGCTAC 
GCGCCGCCGT CGCTGGCCGC GCCGCCTCCA GTCTACTACC CCGCGGCGTC GCCCGGCCCT 
TGCCGCGTCT TCGGCCTGGT TCCTGAGCGG CCGCTCAGCC CAGAGCTGGG GCCCGCACCG 
TCGGGGCCCG GCGGCTCTTG CGCCTTTGCC TCCGCCGGCG CCCCCGCTAC CACCACCGGC 
TACCAGCCCG CAGGCTGCAC CGGGGCCCGG CCGGCCAACC CCTCCGCCTA TGCGGCTGCC 
TACGCGGGCC CCGACGGCGC GTACCCGCAG GGCGCCGGCA GTGCGATCTT TGCCGCTGCT 
GGCCGCCTGG CGGGACCCGC TTCGCCCCCA GCGGGCGGCA GCAGTGGCGG CGTGGAGACC 
ACGGTGGACT TCTACGGGCG CACGTCGCCC GGCCAGTTCG GAGCGCTGGG AGCCTGCTAC 
AACCCTGGCG GGCAGCTCGG AGGGGCCAGT GCAGGCGCCT ACCATGCTCG CCATGCTGCC 
GCTTATCCCG GTGGGATAGA TCGGTTCGTG TCCGCCATGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004464.2
CDS	661..1782
Translation	MTAESGPPPPQPEVLATVKEERGETAAGAGVPGEATGRGAGGRRRKRPLQRGKPPYSYIALIAMAIAHAPERRLTLGGIYKFITERFPFYRDNPKKWQNSIRHNLTLNDCFLKIPREAGRPGKGNYWALDPNAEDMFESGSFLRRRKRFKRSDLSTYPAYMHDAAAAAAAAAAAAAAAAIFPGAVPAARPPYPGAVYAGYAPPSLAAPPPVYYPAASPGPCRVFGLVPERPLSPELGPAPSGPGGSCAFASAGAPATTTGYQPAGCTGARPANPSAYAAAYAGPDGAYPQGAGSAIFAAAGRLAGPASPPAGGSSGGVETTVDFYGRTSPGQFGALGACYNPGGQLGGASAGAYHARHAAAYPGGIDRFVSAM

Target ORF information:

RefSeq Version	NM_004473.3
Organism	Homo sapiens(human)
Definition	Homo sapiens forkhead box E1 (FOXE1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004473.3

ORF Insert Sequence:

ATGACTGCCG AGAGCGGGCC GCCGCCGCCG CAGCCGGAGG TGCTGGCTAC CGTGAAGGAA 
GAGCGCGGCG AGACGGCAGC AGGGGCCGGG GTCCCAGGGG AGGCCACGGG CCGCGGGGCG 
GGCGGGCGGC GCCGCAAGCG CCCCCTGCAG CGCGGGAAGC CGCCCTACAG CTACATCGCG 
CTCATCGCCA TGGCCATCGC GCACGCGCCC GAGCGCCGCC TCACGCTGGG CGGCATCTAC 
AAGTTCATCA CCGAGCGCTT CCCCTTCTAC CGCGACAACC CCAAAAAGTG GCAGAACAGC 
ATCCGCCACA ACCTCACACT CAACGACTGC TTCCTCAAGA TCCCGCGCGA GGCCGGCCGC 
CCGGGTAAGG GCAACTACTG GGCGCTTGAC CCCAACGCGG AGGACATGTT CGAGAGCGGC 
AGCTTCCTGC GCCGCCGCAA GCGCTTCAAG CGCTCGGACC TCTCCACCTA CCCGGCTTAC 
ATGCACGACG CGGCGGCTGC CGCAGCCGCC GCCGCCGCCG CCGCCGCCGC CGCCGCCATC 
TTCCCAGGCG CGGTGCCCGC CGCGCGCCCC CCCTACCCGG GCGCCGTCTA TGCAGGCTAC 
GCGCCGCCGT CGCTGGCCGC GCCGCCTCCA GTCTACTACC CCGCGGCGTC GCCCGGCCCT 
TGCCGCGTCT TCGGCCTGGT TCCTGAGCGG CCGCTCAGCC CAGAGCTGGG GCCCGCACCG 
TCGGGGCCCG GCGGCTCTTG CGCCTTTGCC TCCGCCGGCG CCCCCGCTAC CACCACCGGC 
TACCAGCCCG CAGGCTGCAC CGGGGCCCGG CCGGCCAACC CCTCCGCCTA TGCGGCTGCC 
TACGCGGGCC CCGACGGCGC GTACCCGCAG GGCGCCGGCA GTGCGATCTT TGCCGCTGCT 
GGCCGCCTGG CGGGACCCGC TTCGCCCCCA GCGGGCGGCA GCAGTGGCGG CGTGGAGACC 
ACGGTGGACT TCTACGGGCG CACGTCGCCC GGCCAGTTCG GAGCGCTGGG AGCCTGCTAC 
AACCCTGGCG GGCAGCTCGG AGGGGCCAGT GCAGGCGCCT ACCATGCTCG CCATGCTGCC 
GCTTATCCCG GTGGGATAGA TCGGTTCGTG TCCGCCATGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Replication confirms the association of loci in FOXE1, PDE8B, CAPZB and PDE10A with thyroid traits: a Genetics of Diabetes Audit and Research Tayside study (GoDARTS).
Pharmacogenetics and genomics27(10)356-362(2017 Oct)
Soto-Pedre E,Siddiqui MK,Doney AS,Palmer CNA,Pearson ER,Leese GP

Age at diagnosis and gender modify the risk of 9q22 and 14q13 polymorphisms for papillary thyroid carcinoma.
Endokrynologia Polska68(3)283-289(2017)
Kula D,Kalemba M,Puch Z,Pola?ska J,?wierniak M,Rusinek D,?ebracka-Gala J,Kowalska M,Handkiewicz-Junak D,Kowal M,Tyszkiewicz T,Piasna E,Czarniecka A,Pawlaczek A,Krajewska J,Szpak-Ulczok S,Jarz?b B

Cloning, chromosomal localization and identification of polymorphisms in the human thyroid transcription factor 2 gene (TITF2).
Biochimie81(5)433-40(1999 May)
Macchia PE,Mattei MG,Lapi P,Fenzi G,Di Lauro R