FOXL1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FOXL1
Entrez Gene ID	2300
Full Name	forkhead box L1
Synonyms	FKH6,FKHL11,FREAC7
General protein information	Preferred Names forkhead box L1 Names forkhead box protein L1 forkhead-like 11 forkhead-related protein FKHL11 forkhead-related transcription factor 7
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16q24.1
Summary	This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors are characterized by a distinct DNA-binding forkhead domain and play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis. [provided by RefSeq, Nov 2012].
Disorder MIM:	603252

mRNA and Protein(s)

mRNA	Protein	Name
NM_005250.3	NP_005241.1	forkhead box protein L1
NM_005250.2	NP_005241.1	forkhead box protein L1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	FOXL1	XP_005620647.1
Homo sapiens (human)	FOXL1	NP_005241.1
Pan troglodytes (chimpanzee)	FOXL1	XP_511154.2
Bos taurus (cattle)	FOXL1	XP_005218819.1
Mus musculus (house mouse)	Foxl1	NP_032050.2
Rattus norvegicus (Norway rat)	LOC687553	XP_006255788.1
Gallus gallus (chicken)	FOXL1	XP_001231599.2

Gene Ontology
Bibliography

Related articles in PubMed

Overexpression of Forkhead Box L1 (FOXL1) Inhibits the Proliferation and Invasion of Breast Cancer Cells.
Zhong J, Wang H, Yu J, Zhang J, Wang H
Oncology research25(6)959-965(2017 Jul)

Low level of FOXL1 indicates a worse prognosis for gastric cancer patients.
Ertao Z, Jianhui C, Chuangqi C, Changjiang Q, Sile C, Yulong H, Shirong C, Hui W
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine37(8)11331-7(2016 Aug)

Inhibitory effects of forkhead box L1 gene on osteosarcoma growth through the induction of cell cycle arrest and apoptosis.
Chen X, Deng M, Ma L, Zhou J, Xiao Y, Zhou X, Zhang C, Wu M
Oncology reports34(1)265-71(2015 Jul)

Forkhead box L1 is frequently downregulated in gallbladder cancer and inhibits cell growth through apoptosis induction by mitochondrial dysfunction.
Qin Y, Gong W, Zhang M, Wang J, Tang Z, Quan Z
PloS one9(7)e102084(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

our findings provide evidence that FOXL1 might serve as a candidate tumor suppressor and a potential prognostic biomarker for gastric cancer
Title: Low level of FOXL1 indicates a worse prognosis for gastric cancer patients.

the downregulation of FOXL1 expression was associated with osteosarcoma cell growth. Restoration of FOXL1 gene expression by gene therapy may have a therapeutic potential for patients with osteosarcoma
Title: Inhibitory effects of forkhead box L1 gene on osteosarcoma growth through the induction of cell cycle arrest and apoptosis.

dysregulated FOXL1 is involved in tumorigenesis and progression of gallbladder cancer.
Title: Forkhead box L1 is frequently downregulated in gallbladder cancer and inhibits cell growth through apoptosis induction by mitochondrial dysfunction.

results suggest that Foxl1 plays an inhibitory role in renal tumor progression.
Title: Foxl1 inhibits tumor invasion and predicts outcome in human renal cancer.

Lower FOXL1 expression is correlated with metastasis and advanced pathologic stage of pancreatic cancer.
Title: FOXL1, a novel candidate tumor suppressor, inhibits tumor aggressiveness and predicts outcome in human pancreatic cancer.

The following FOXL1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FOXL1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17903	NM_005250.3 Latest version!	Homo sapiens forkhead box L1 (FOXL1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu17903	NM_005250.2	Homo sapiens forkhead box L1 (FOXL1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FOXL1 ( NM_005250.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005241.1 Homo sapiens forkhead box L1 (FOXL1), mRNA.

Price & Availability↑

CloneID	OHu17903
Clone ID Related Accession (Same CDS sequence)	NM_005250.3 , NM_005250.2
Accession Version	NM_005250.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1038bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-29
Organism	Homo sapiens(human)
Product	forkhead box protein L1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC100027.1, AC009108.10 and BM675371.1. This sequence is a reference standard in the RefSeqGene project. On Aug 27, 2019 this sequence version replaced NM_005250.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC100027.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGTCACC TCTTCGATCC CCGGCTGCCT GCCCTGGCCG CCTCGCCCAT GCTGTATCTG 
TACGGTCCCG AGAGACCCGG CCTCCCTCTG GCCTTCGCCC CCGCGGCTGC TCTAGCTGCC 
TCGGGCCGGG CCGAGACCCC GCAGAAGCCT CCCTACAGCT ACATCGCGCT CATCGCCATG 
GCGATCCAGG ACGCGCCCGA GCAGAGGGTC ACGCTCAACG GCATCTACCA GTTCATCATG 
GACCGCTTCC CCTTCTACCA CGACAACCGG CAGGGCTGGC AGAACAGCAT CCGCCACAAC 
CTCTCGCTCA ACGACTGCTT CGTCAAGGTG CCCCGCGAGA AAGGGCGGCC GGGCAAGGGC 
AGCTACTGGA CGCTGGACCC CCGCTGCCTG GACATGTTTG AGAACGGCAA CTACCGGCGC 
CGGAAGAGGA AGCCCAAGCC GGGCCCCGGG GCCCCGGAGG CCAAGAGGCC CCGCGCCGAG 
ACGCACCAGC GCAGCGCGGA GGCGCAGCCG GAGGCGGGGA GCGGGGCAGG GGGCTCGGGC 
CCCGCAATCT CCCGCCTGCA GGCAGCGCCC GCGGGCCCCT CGCCCCTCCT GGACGGCCCC 
TCTCCGCCGG CGCCCCTCCA CTGGCCGGGG ACCGCGTCCC CGAACGAGGA CGCTGGTGAC 
GCTGCCCAGG GCGCAGCGGC CGTGGCGGTC GGCCAGGCAG CGCGCACAGG GGACGGCCCG 
GGGTCCCCTC TGCGCCCCGC CTCCCGCAGC TCTCCGAAGA GCTCCGACAA GTCCAAGAGC 
TTCAGCATAG ACAGCATCCT GGCGGGAAAG CAGGGCCAGA AGCCGCCTTC AGGGGACGAA 
CTCCTAGGGG GTGCCAAGCC TGGGCCCGGC GGCCGTCTGG GTGCCTCGCT CCTGGCCGCC 
TCCTCCAGCC TCCGTCCGCC TTTCAACGCT TCCCTGATGC TCGACCCGCA TGTCCAGGGC 
GGCTTTTACC AGCTCGGGAT CCCCTTCCTC TCTTATTTCC CCCTGCAGGT TCCCGACACG 
GTACTCCACT TCCAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005241.1
CDS	176..1213
Translation	MSHLFDPRLPALAASPMLYLYGPERPGLPLAFAPAAALAASGRAETPQKPPYSYIALIAMAIQDAPEQRVTLNGIYQFIMDRFPFYHDNRQGWQNSIRHNLSLNDCFVKVPREKGRPGKGSYWTLDPRCLDMFENGNYRRRKRKPKPGPGAPEAKRPRAETHQRSAEAQPEAGSGAGGSGPAISRLQAAPAGPSPLLDGPSPPAPLHWPGTASPNEDAGDAAQGAAAVAVGQAARTGDGPGSPLRPASRSSPKSSDKSKSFSIDSILAGKQGQKPPSGDELLGGAKPGPGGRLGASLLAASSSLRPPFNASLMLDPHVQGGFYQLGIPFLSYFPLQVPDTVLHFQ

Target ORF information:

RefSeq Version	NM_005250.3
Organism	Homo sapiens(human)
Definition	Homo sapiens forkhead box L1 (FOXL1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005250.3

ORF Insert Sequence:

ATGAGTCACC TCTTCGATCC CCGGCTGCCT GCCCTGGCCG CCTCGCCCAT GCTGTATCTG 
TACGGTCCCG AGAGACCCGG CCTCCCTCTG GCCTTCGCCC CCGCGGCTGC TCTAGCTGCC 
TCGGGCCGGG CCGAGACCCC GCAGAAGCCT CCCTACAGCT ACATCGCGCT CATCGCCATG 
GCGATCCAGG ACGCGCCCGA GCAGAGGGTC ACGCTCAACG GCATCTACCA GTTCATCATG 
GACCGCTTCC CCTTCTACCA CGACAACCGG CAGGGCTGGC AGAACAGCAT CCGCCACAAC 
CTCTCGCTCA ACGACTGCTT CGTCAAGGTG CCCCGCGAGA AAGGGCGGCC GGGCAAGGGC 
AGCTACTGGA CGCTGGACCC CCGCTGCCTG GACATGTTTG AGAACGGCAA CTACCGGCGC 
CGGAAGAGGA AGCCCAAGCC GGGCCCCGGG GCCCCGGAGG CCAAGAGGCC CCGCGCCGAG 
ACGCACCAGC GCAGCGCGGA GGCGCAGCCG GAGGCGGGGA GCGGGGCAGG GGGCTCGGGC 
CCCGCAATCT CCCGCCTGCA GGCAGCGCCC GCGGGCCCCT CGCCCCTCCT GGACGGCCCC 
TCTCCGCCGG CGCCCCTCCA CTGGCCGGGG ACCGCGTCCC CGAACGAGGA CGCTGGTGAC 
GCTGCCCAGG GCGCAGCGGC CGTGGCGGTC GGCCAGGCAG CGCGCACAGG GGACGGCCCG 
GGGTCCCCTC TGCGCCCCGC CTCCCGCAGC TCTCCGAAGA GCTCCGACAA GTCCAAGAGC 
TTCAGCATAG ACAGCATCCT GGCGGGAAAG CAGGGCCAGA AGCCGCCTTC AGGGGACGAA 
CTCCTAGGGG GTGCCAAGCC TGGGCCCGGC GGCCGTCTGG GTGCCTCGCT CCTGGCCGCC 
TCCTCCAGCC TCCGTCCGCC TTTCAACGCT TCCCTGATGC TCGACCCGCA TGTCCAGGGC 
GGCTTTTACC AGCTCGGGAT CCCCTTCCTC TCTTATTTCC CCCTGCAGGT TCCCGACACG 
GTACTCCACT TCCAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FOXL1 ( NM_005250.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005241.1 Homo sapiens forkhead box L1 (FOXL1), mRNA.

Price & Availability↑

CloneID	OHu17903
Clone ID Related Accession (Same CDS sequence)	NM_005250.3 , NM_005250.2
Accession Version	NM_005250.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1038bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	forkhead box protein L1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC100027.1, AC009108.10 and BM675371.1. This sequence is a reference standard in the RefSeqGene project. On Jun 29, 2006 this sequence version replaced NM_005250.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC100027.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGTCACC TCTTCGATCC CCGGCTGCCT GCCCTGGCCG CCTCGCCCAT GCTGTATCTG 
TACGGTCCCG AGAGACCCGG CCTCCCTCTG GCCTTCGCCC CCGCGGCTGC TCTAGCTGCC 
TCGGGCCGGG CCGAGACCCC GCAGAAGCCT CCCTACAGCT ACATCGCGCT CATCGCCATG 
GCGATCCAGG ACGCGCCCGA GCAGAGGGTC ACGCTCAACG GCATCTACCA GTTCATCATG 
GACCGCTTCC CCTTCTACCA CGACAACCGG CAGGGCTGGC AGAACAGCAT CCGCCACAAC 
CTCTCGCTCA ACGACTGCTT CGTCAAGGTG CCCCGCGAGA AAGGGCGGCC GGGCAAGGGC 
AGCTACTGGA CGCTGGACCC CCGCTGCCTG GACATGTTTG AGAACGGCAA CTACCGGCGC 
CGGAAGAGGA AGCCCAAGCC GGGCCCCGGG GCCCCGGAGG CCAAGAGGCC CCGCGCCGAG 
ACGCACCAGC GCAGCGCGGA GGCGCAGCCG GAGGCGGGGA GCGGGGCAGG GGGCTCGGGC 
CCCGCAATCT CCCGCCTGCA GGCAGCGCCC GCGGGCCCCT CGCCCCTCCT GGACGGCCCC 
TCTCCGCCGG CGCCCCTCCA CTGGCCGGGG ACCGCGTCCC CGAACGAGGA CGCTGGTGAC 
GCTGCCCAGG GCGCAGCGGC CGTGGCGGTC GGCCAGGCAG CGCGCACAGG GGACGGCCCG 
GGGTCCCCTC TGCGCCCCGC CTCCCGCAGC TCTCCGAAGA GCTCCGACAA GTCCAAGAGC 
TTCAGCATAG ACAGCATCCT GGCGGGAAAG CAGGGCCAGA AGCCGCCTTC AGGGGACGAA 
CTCCTAGGGG GTGCCAAGCC TGGGCCCGGC GGCCGTCTGG GTGCCTCGCT CCTGGCCGCC 
TCCTCCAGCC TCCGTCCGCC TTTCAACGCT TCCCTGATGC TCGACCCGCA TGTCCAGGGC 
GGCTTTTACC AGCTCGGGAT CCCCTTCCTC TCTTATTTCC CCCTGCAGGT TCCCGACACG 
GTACTCCACT TCCAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005241.1
CDS	216..1253
Translation	MSHLFDPRLPALAASPMLYLYGPERPGLPLAFAPAAALAASGRAETPQKPPYSYIALIAMAIQDAPEQRVTLNGIYQFIMDRFPFYHDNRQGWQNSIRHNLSLNDCFVKVPREKGRPGKGSYWTLDPRCLDMFENGNYRRRKRKPKPGPGAPEAKRPRAETHQRSAEAQPEAGSGAGGSGPAISRLQAAPAGPSPLLDGPSPPAPLHWPGTASPNEDAGDAAQGAAAVAVGQAARTGDGPGSPLRPASRSSPKSSDKSKSFSIDSILAGKQGQKPPSGDELLGGAKPGPGGRLGASLLAASSSLRPPFNASLMLDPHVQGGFYQLGIPFLSYFPLQVPDTVLHFQ

Target ORF information:

RefSeq Version	NM_005250.2
Organism	Homo sapiens(human)
Definition	Homo sapiens forkhead box L1 (FOXL1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005250.2

ORF Insert Sequence:

ATGAGTCACC TCTTCGATCC CCGGCTGCCT GCCCTGGCCG CCTCGCCCAT GCTGTATCTG 
TACGGTCCCG AGAGACCCGG CCTCCCTCTG GCCTTCGCCC CCGCGGCTGC TCTAGCTGCC 
TCGGGCCGGG CCGAGACCCC GCAGAAGCCT CCCTACAGCT ACATCGCGCT CATCGCCATG 
GCGATCCAGG ACGCGCCCGA GCAGAGGGTC ACGCTCAACG GCATCTACCA GTTCATCATG 
GACCGCTTCC CCTTCTACCA CGACAACCGG CAGGGCTGGC AGAACAGCAT CCGCCACAAC 
CTCTCGCTCA ACGACTGCTT CGTCAAGGTG CCCCGCGAGA AAGGGCGGCC GGGCAAGGGC 
AGCTACTGGA CGCTGGACCC CCGCTGCCTG GACATGTTTG AGAACGGCAA CTACCGGCGC 
CGGAAGAGGA AGCCCAAGCC GGGCCCCGGG GCCCCGGAGG CCAAGAGGCC CCGCGCCGAG 
ACGCACCAGC GCAGCGCGGA GGCGCAGCCG GAGGCGGGGA GCGGGGCAGG GGGCTCGGGC 
CCCGCAATCT CCCGCCTGCA GGCAGCGCCC GCGGGCCCCT CGCCCCTCCT GGACGGCCCC 
TCTCCGCCGG CGCCCCTCCA CTGGCCGGGG ACCGCGTCCC CGAACGAGGA CGCTGGTGAC 
GCTGCCCAGG GCGCAGCGGC CGTGGCGGTC GGCCAGGCAG CGCGCACAGG GGACGGCCCG 
GGGTCCCCTC TGCGCCCCGC CTCCCGCAGC TCTCCGAAGA GCTCCGACAA GTCCAAGAGC 
TTCAGCATAG ACAGCATCCT GGCGGGAAAG CAGGGCCAGA AGCCGCCTTC AGGGGACGAA 
CTCCTAGGGG GTGCCAAGCC TGGGCCCGGC GGCCGTCTGG GTGCCTCGCT CCTGGCCGCC 
TCCTCCAGCC TCCGTCCGCC TTTCAACGCT TCCCTGATGC TCGACCCGCA TGTCCAGGGC 
GGCTTTTACC AGCTCGGGAT CCCCTTCCTC TCTTATTTCC CCCTGCAGGT TCCCGACACG 
GTACTCCACT TCCAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Overexpression of Forkhead Box L1 (FOXL1) Inhibits the Proliferation and Invasion of Breast Cancer Cells.
Oncology research25(6)959-965(2017 Jul)
Zhong J,Wang H,Yu J,Zhang J,Wang H

Low level of FOXL1 indicates a worse prognosis for gastric cancer patients.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine37(8)11331-7(2016 Aug)
Ertao Z,Jianhui C,Chuangqi C,Changjiang Q,Sile C,Yulong H,Shirong C,Hui W

Inhibitory effects of forkhead box L1 gene on osteosarcoma growth through the induction of cell cycle arrest and apoptosis.
Oncology reports34(1)265-71(2015 Jul)
Chen X,Deng M,Ma L,Zhou J,Xiao Y,Zhou X,Zhang C,Wu M

Forkhead box L1 is frequently downregulated in gallbladder cancer and inhibits cell growth through apoptosis induction by mitochondrial dysfunction.
PloS one9(7)e102084(2014)
Qin Y,Gong W,Zhang M,Wang J,Tang Z,Quan Z