OTUD1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	OTUD1
Entrez Gene ID	220213
Full Name	OTU deubiquitinase 1
Synonyms	DUBA7,OTDC1
General protein information	Preferred Names OTU deubiquitinase 1 Names OTU domain-containing protein 1 DUBA-7 OTU domain containing 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10p12.2
Summary	Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA7 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.[supplied by OMIM, May 2008]. COMPLETENESS: complete on the 3' end.
Disorder MIM:	612022

mRNA and Protein(s)

mRNA	Protein	Name
NM_001145373.2	NP_001138845.1	OTU domain-containing protein 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	OTUD1	NP_001138845.1
Mus musculus (house mouse)	Otud1	NP_081991.1
Pan troglodytes (chimpanzee)	OTUD1	XP_521426.3
Rattus norvegicus (Norway rat)	Otud1	XP_574086.3
Bos taurus (cattle)	OTUD1	XP_005214353.1
Gallus gallus (chicken)	OTUD1	XP_418604.4
	OTUD1	XP_001097857.1

Gene Ontology
Bibliography

Related articles in PubMed

Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7.
Zhang Z, Fan Y, Xie F, Zhou H, Jin K, Shao L, Shi W, Fang P, Yang B, van Dam H, Ten Dijke P, Zheng X, Yan X, Jia J, Zheng M, Jin J, Ding C, Ye S, Zhou F, Zhang L
Nature communications8(1)2116(2017 Dec)

Ovarian tumor domain-containing protein 1 deubiquitinates and stabilizes p53.
Piao S, Pei HZ, Huang B, Baek SH
Cellular signalling3322-29(2017 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these results suggest that OTUD1 is a novel regulator of p53 stability and activity.
Title: Ovarian tumor domain-containing protein 1 deubiquitinates and stabilizes p53.

OTU domain-containing protein 1 deubiquitinating enzyme is differentially expressed in thyroid cancer.
Title: A putative OTU domain-containing protein 1 deubiquitinating enzyme is differentially expressed in thyroid cancer and identifies less-aggressive tumours.

The following OTUD1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OTUD1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu05650	NM_001145373.2 Latest version!	Homo sapiens OTU deubiquitinase 1 (OTUD1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$286.30 $409.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OTUD1 ( NM_001145373.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001138845.1 Homo sapiens OTU deubiquitinase 1 (OTUD1), mRNA.

Price & Availability↑

CloneID	OHu05650
Clone ID Related Accession (Same CDS sequence)	NM_001145373.2
Accession Version	NM_001145373.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1446bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Homo sapiens(human)
Product	OTU domain-containing protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AB188491.1, AL512603.26, AK096389.1 and AI261652.1. On Jul 14, 2009 this sequence version replaced NM_001145373.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCAGCTCT ACAGCAGCGT CTGCACCCAC TACCCCGCCG GGGCCCCGGG TCCCACGGCC 
GCCGCCCCCG CGCCACCCGC CGCCGCTACC CCCTTCAAGG TCTCGCTGCA GCCCCCGGGA 
GCCGCCGGCG CCGCGCCCGA GCCCGAGACC GGTGAGTGCC AGCCCGCCGC GGCCGCCGAG 
CACCGGGAAG CCGCCGCTGT CCCCGCCGCC AAGATGCCCG CCTTCTCCTC CTGCTTCGAG 
GTGGTGTCCG GGGCCGCCGC GCCCGCCTCC GCCGCCGCCG GCCCGCCCGG CGCGTCCTGC 
AAGCCGCCGC TGCCGCCGCA CTACACGTCC ACCGCACAGA TCACCGTGCG GGCCCTGGGC 
GCCGACAGGC TCCTGCTGCA CGGGCCCGAT CCCGTTCCCG GCGCCGCGGG CTCCGCCGCT 
GCCCCGCGCG GCCGCTGCCT CCTGCTCGCC CCGGCGCCCG CAGCCCCGGT CCCGCCGCGG 
CGGGGCTCCT CGGCCTGGCT CCTGGAGGAG CTGCTGCGGC CCGACTGCCC CGAGCCCGCG 
GGCTTGGACG CGACACGGGA GGGGCCCGAT CGGAACTTCC GACTGAGCGA GCACCGCCAG 
GCCCTGGCCG CCGCCAAGCA CCGAGGCCCC GCGGCGACCC CGGGGAGCCC CGATCCCGGC 
CCCGGTCCGT GGGGCGAAGA GCACTTGGCG GAGAGGGGCC CCAGGGGCTG GGAGAGGGGC 
GGCGATCGCT GCGACGCGCC CGGTGGGGAC GCGGCGCGGA GGCCCGACCC AGAGGCCGAG 
GCACCCCCCG CCGGGAGCAT CGAGGCCGCC CCGAGTAGTG CGGCGGAGCC GGTGATCGTC 
TCCAGGTCGG ATCCCAGAGA CGAGAAGCTG GCCCTATACC TGGCCGAGGT GGAGAAGCAG 
GACAAGTATC TGCGGCAGAG GAATAAGTAC CGATTCCACA TCATTCCAGA CGGCAACTGC 
CTCTACCGAG CTGTCAGCAA GACGGTGTAT GGGGACCAGA GCCTGCACCG GGAGTTGAGG 
GAGCAGACGG TGCACTACAT CGCCGACCAT CTCGACCACT TCAGCCCCCT GATTGAGGGC 
GACGTGGGGG AGTTTATCAT CGCTGCTGCC CAAGACGGGG CATGGGCCGG GTACCCGGAG 
TTGCTGGCCA TGGGGCAGAT GCTGAATGTG AATATCCATT TAACTACTGG AGGGAGGCTG 
GAGAGTCCCA CGGTGTCTAC CATGATTCAT TATTTGGGCC CAGAGGATTC CCTGAGGCCT 
AGTATTTGGC TCAGTTGGCT CAGTAACGGA CACTATGATG CTGTATTTGA TCACTCCTAT 
CCTAACCCAG AGTACGACAA CTGGTGCAAA CAAACTCAAG TGCAAAGGAA ACGCGACGAA 
GAACTTGCCA AATCTATGGC CATATCCTTG TCTAAAATGT ATATTGAACA AAATGCATGC 
TCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001138845.1
CDS	190..1635
Translation	MQLYSSVCTHYPAGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAAKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQITVRALGADRLLLHGPDPVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPAGLDATREGPDRNFRLSEHRQALAAAKHRGPAATPGSPDPGPGPWGEEHLAERGPRGWERGGDRCDAPGGDAARRPDPEAEAPPAGSIEAAPSSAAEPVIVSRSDPRDEKLALYLAEVEKQDKYLRQRNKYRFHIIPDGNCLYRAVSKTVYGDQSLHRELREQTVHYIADHLDHFSPLIEGDVGEFIIAAAQDGAWAGYPELLAMGQMLNVNIHLTTGGRLESPTVSTMIHYLGPEDSLRPSIWLSWLSNGHYDAVFDHSYPNPEYDNWCKQTQVQRKRDEELAKSMAISLSKMYIEQNACS

Target ORF information:

RefSeq Version	NM_001145373.2
Organism	Homo sapiens(human)
Definition	Homo sapiens OTU deubiquitinase 1 (OTUD1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001145373.2

ORF Insert Sequence:

ATGCAGCTCT ACAGCAGCGT CTGCACCCAC TACCCCGCCG GGGCCCCGGG TCCCACGGCC 
GCCGCCCCCG CGCCACCCGC CGCCGCTACC CCCTTCAAGG TCTCGCTGCA GCCCCCGGGA 
GCCGCCGGCG CCGCGCCCGA GCCCGAGACC GGTGAGTGCC AGCCCGCCGC GGCCGCCGAG 
CACCGGGAAG CCGCCGCTGT CCCCGCCGCC AAGATGCCCG CCTTCTCCTC CTGCTTCGAG 
GTGGTGTCCG GGGCCGCCGC GCCCGCCTCC GCCGCCGCCG GCCCGCCCGG CGCGTCCTGC 
AAGCCGCCGC TGCCGCCGCA CTACACGTCC ACCGCACAGA TCACCGTGCG GGCCCTGGGC 
GCCGACAGGC TCCTGCTGCA CGGGCCCGAT CCCGTTCCCG GCGCCGCGGG CTCCGCCGCT 
GCCCCGCGCG GCCGCTGCCT CCTGCTCGCC CCGGCGCCCG CAGCCCCGGT CCCGCCGCGG 
CGGGGCTCCT CGGCCTGGCT CCTGGAGGAG CTGCTGCGGC CCGACTGCCC CGAGCCCGCG 
GGCTTGGACG CGACACGGGA GGGGCCCGAT CGGAACTTCC GACTGAGCGA GCACCGCCAG 
GCCCTGGCCG CCGCCAAGCA CCGAGGCCCC GCGGCGACCC CGGGGAGCCC CGATCCCGGC 
CCCGGTCCGT GGGGCGAAGA GCACTTGGCG GAGAGGGGCC CCAGGGGCTG GGAGAGGGGC 
GGCGATCGCT GCGACGCGCC CGGTGGGGAC GCGGCGCGGA GGCCCGACCC AGAGGCCGAG 
GCACCCCCCG CCGGGAGCAT CGAGGCCGCC CCGAGTAGTG CGGCGGAGCC GGTGATCGTC 
TCCAGGTCGG ATCCCAGAGA CGAGAAGCTG GCCCTATACC TGGCCGAGGT GGAGAAGCAG 
GACAAGTATC TGCGGCAGAG GAATAAGTAC CGATTCCACA TCATTCCAGA CGGCAACTGC 
CTCTACCGAG CTGTCAGCAA GACGGTGTAT GGGGACCAGA GCCTGCACCG GGAGTTGAGG 
GAGCAGACGG TGCACTACAT CGCCGACCAT CTCGACCACT TCAGCCCCCT GATTGAGGGC 
GACGTGGGGG AGTTTATCAT CGCTGCTGCC CAAGACGGGG CATGGGCCGG GTACCCGGAG 
TTGCTGGCCA TGGGGCAGAT GCTGAATGTG AATATCCATT TAACTACTGG AGGGAGGCTG 
GAGAGTCCCA CGGTGTCTAC CATGATTCAT TATTTGGGCC CAGAGGATTC CCTGAGGCCT 
AGTATTTGGC TCAGTTGGCT CAGTAACGGA CACTATGATG CTGTATTTGA TCACTCCTAT 
CCTAACCCAG AGTACGACAA CTGGTGCAAA CAAACTCAAG TGCAAAGGAA ACGCGACGAA 
GAACTTGCCA AATCTATGGC CATATCCTTG TCTAAAATGT ATATTGAACA AAATGCATGC 
TCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7.
Nature communications8(1)2116(2017 Dec)
Zhang Z,Fan Y,Xie F,Zhou H,Jin K,Shao L,Shi W,Fang P,Yang B,van Dam H,Ten Dijke P,Zheng X,Yan X,Jia J,Zheng M,Jin J,Ding C,Ye S,Zhou F,Zhang L

Ovarian tumor domain-containing protein 1 deubiquitinates and stabilizes p53.
Cellular signalling3322-29(2017 May)
Piao S,Pei HZ,Huang B,Baek SH