ZNRF4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ZNRF4
Entrez Gene ID	148066
Full Name	zinc and ring finger 4
Synonyms	RNF204,SPERIZIN,Ssrzf1,spzn
General protein information	Preferred Names zinc and ring finger 4 Names E3 ubiquitin-protein ligase ZNRF4 RING finger protein 204 RING-type E3 ubiquitin transferase ZNRF4 nixin zinc/RING finger protein 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.3
Disorder MIM:	612063

mRNA and Protein(s)

mRNA	Protein	Name
NM_181710.3	NP_859061.3	E3 ubiquitin-protein ligase ZNRF4 precursor
NM_181710.4	NP_859061.3	E3 ubiquitin-protein ligase ZNRF4 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	ZNRF4	NP_859061.3
Pan troglodytes (chimpanzee)	ZNRF4	XP_524065.2
	ZNRF4	XP_001083609.1
Bos taurus (cattle)	ZNRF4	XP_002688963.2
Mus musculus (house mouse)	Znrf4	NP_035613.2
Canis lupus familiaris (dog)	ZNRF4	XP_005633071.1
Rattus norvegicus (Norway rat)	Znrf4	NP_001020049.1

Gene Ontology
Bibliography

Related articles in PubMed

E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP.
Bist P, Cheong WS, Ng A, Dikshit N, Kim BH, Pulloor NK, Khameneh HJ, Hedl M, Shenoy AR, Balamuralidhar V, Malik NBA, Hong M, Neutzner A, Chin KC, Kobayashi KS, Bertoletti A, Mortellaro A, Abraham C, MacMicking JD, Xavier RJ, Sukumaran B
Nature communications815865(2017 Jun)

A systematic search for endoplasmic reticulum (ER) membrane-associated RING finger proteins identifies Nixin/ZNRF4 as a regulator of calnexin stability and ER homeostasis.
Neutzner A, Neutzner M, Benischke AS, Ryu SW, Frank S, Youle RJ, Karbowski M
The Journal of biological chemistry286(10)8633-43(2011 Mar)

The DNA sequence and biology of human chromosome 19.
Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O, Tran-Gyamfi M, Aerts A, Altherr M, Ashworth L, Bajorek E, Black S, Branscomb E, Caenepeel S, Carrano A, Caoile C, Chan YM, Christensen M, Cleland CA, Copeland A, Dalin E, Dehal P, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Garcia C, Georgescu AM, Glavina T, Gomez M, Gonzales E, Groza M, Hammon N, Hawkins T, Haydu L, Ho I, Huang W, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Larionov V, Leem SH, Lopez F, Lou Y, Lowry S, Malfatti S, Martinez D, McCready P, Medina C, Morgan J, Nelson K, Nolan M, Ovcharenko I, Pitluck S, Pollard M, Popkie AP, Predki P, Quan G, Ramirez L, Rash S, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, She X, Smith D, Slezak T, Solovyev V, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wagner M, Wheeler J, Wu K, Xie G, Yang J, Dubchak I, Furey TS, DeJong P, Dickson M, Gordon D, Eichler EE, Pennacchio LA, Richardson P, Stubbs L, Rokhsar DS, Myers RM, Rubin EM, Lucas SM
Nature428(6982)529-35(2004 Apr)

Sperizin is a murine RING zinc-finger protein specifically expressed in Haploid germ cells.
Fujii T, Tamura K, Copeland NG, Gilbert DJ, Jenkins NA, Yomogida K, Tanaka H, Nishimune Y, Nojima H, Abiko Y
Genomics57(1)94-101(1999 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Nixin/ZNRF4 to be central for the regulation of calnexin turnover.
Title: A systematic search for endoplasmic reticulum (ER) membrane-associated RING finger proteins identifies Nixin/ZNRF4 as a regulator of calnexin stability and ER homeostasis.

Characterization and study of mouse homolog.
Title: Sperizin is a murine RING zinc-finger protein specifically expressed in Haploid germ cells.

The following ZNRF4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ZNRF4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24262	NM_181710.4 Latest version!	Homo sapiens zinc and ring finger 4 (ZNRF4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
View Old Accession Versions >>
OHu24262	NM_181710.3	Homo sapiens zinc and ring finger 4 (ZNRF4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ZNRF4 ( NM_181710.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_859061.3 Homo sapiens zinc and ring finger 4 (ZNRF4), mRNA.

Price & Availability↑

CloneID	OHu24262
Clone ID Related Accession (Same CDS sequence)	NM_181710.3 , NM_181710.4
Accession Version	NM_181710.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1290bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-20
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase ZNRF4 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC005764.1. On Jun 30, 2007 this sequence version replaced NM_181710.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.

ATGCCGCTCT GCCGTCCGGA GCACTTAATG CCTAGAGCCA GCAGGGTCCC AGTGGCCGCG 
TCACTGCCTC TGAGCCACGC GGTCATTCCA ACTCAACTGC CCTCGCGTCC TGGCCACAGG 
CCCCCTGGGA GACCCCGGAG ATGCCCAAAG GCCTCATGCC TGCCGCCTCC AGTGGGACCT 
AGCAGCACAC AGACAGCGAA GCGGGTGACC ATGGGGTGGC CACGGCCGGG CCGAGCCCTC 
GTGGCAGTCA AAGCCTTGCT GGTCTTGTCG CTGCTCCAGG TGCCCGCGCA GGCAGTGGTA 
CGGGCCGTGC TGGAAGACAA CTCGAGCTCG GTGGACTTTG CGGATCTGCC GGCGCTGTTC 
GGCGTCCCCC TGGCCCCCGA GGGCATACGG GGCTACCTGA TGGAGGTCAA GCCAGCCAAC 
GCGTGCCATC CCATCGAGGC CCCGCGACTG GGCAACCGCT CTCTGGGCGC CATCGTGCTG 
ATCCGCCGCT ACGACTGCAC CTTCGACCTC AAGGTGCTGA ACGCCCAGCG CGCCGGCTTC 
GAGGCGGCCA TCGTGCACAA CGTCCACTCC GACGACCTCG TGAGCATGAC CCACGTCTAC 
GAGGACTTGA GGGGCCAGAT CGCCATCCCC TCAGTGTTCG TGAGCGAGGC CGCCTCGCAG 
GACCTGCGGG TCATCCTGGG CTGCAACAAG TCGGCCCACG CGCTGCTCCT GCCCGACGAC 
CCACCGTGCC ACGACCTGGG CTGTCACCCC GTGCTGACCG TGTCCTGGGT GCTGGGCTGT 
ACCCTGGCCC TGGTCGTATC AGCCTTCTTT GTCCTGAACC ACCTGTGGCT CTGGGCCCAG 
GCCTGCTGCA GCCACAGACG GCCGGTGAAG ACGTCTACCT GCCAGAAGGC CCAGGTCCGC 
ACCTTCACGT GGCACAACGA CCTGTGTGCC ATCTGCCTGG ATGAGTATGA GGAGGGCGAC 
CAACTCAAGA TCCTGCCCTG CTCCCACACC TACCACTGCA AATGCATTGA CCCCTGGTTC 
TCCCAAGCCC CCCGGCGCTC CTGCCCCGTG TGCAAACAGT CGGTGGCCGC CACAGAAGAC 
AGCTTTGACT CCACCACCTA CAGCTTCAGG GACGAGGACC CCTCCCTACC GGGCCACCGG 
CCCCCCATCT GGGCCATTCA AGTCCAGCTA CGCTCCCGGA GGCTGGAGCT GCTGGGCCGC 
GCCAGTCCCC ACTGCCACTG CAGCACCACG TCCCTGGAGG CAGAGTATAC CACTGTCTCC 
TCAGCCCCTC CTGAGGCCCC TGGTCAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_859061.3
CDS	78..1367
Translation	MPLCRPEHLMPRASRVPVAASLPLSHAVIPTQLPSRPGHRPPGRPRRCPKASCLPPPVGPSSTQTAKRVTMGWPRPGRALVAVKALLVLSLLQVPAQAVVRAVLEDNSSSVDFADLPALFGVPLAPEGIRGYLMEVKPANACHPIEAPRLGNRSLGAIVLIRRYDCTFDLKVLNAQRAGFEAAIVHNVHSDDLVSMTHVYEDLRGQIAIPSVFVSEAASQDLRVILGCNKSAHALLLPDDPPCHDLGCHPVLTVSWVLGCTLALVVSAFFVLNHLWLWAQACCSHRRPVKTSTCQKAQVRTFTWHNDLCAICLDEYEEGDQLKILPCSHTYHCKCIDPWFSQAPRRSCPVCKQSVAATEDSFDSTTYSFRDEDPSLPGHRPPIWAIQVQLRSRRLELLGRASPHCHCSTTSLEAEYTTVSSAPPEAPGQ

Target ORF information:

RefSeq Version	NM_181710.3
Organism	Homo sapiens(human)
Definition	Homo sapiens zinc and ring finger 4 (ZNRF4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181710.3

ORF Insert Sequence:

ATGCCGCTCT GCCGTCCGGA GCACTTAATG CCTAGAGCCA GCAGGGTCCC AGTGGCCGCG 
TCACTGCCTC TGAGCCACGC GGTCATTCCA ACTCAACTGC CCTCGCGTCC TGGCCACAGG 
CCCCCTGGGA GACCCCGGAG ATGCCCAAAG GCCTCATGCC TGCCGCCTCC AGTGGGACCT 
AGCAGCACAC AGACAGCGAA GCGGGTGACC ATGGGGTGGC CACGGCCGGG CCGAGCCCTC 
GTGGCAGTCA AAGCCTTGCT GGTCTTGTCG CTGCTCCAGG TGCCCGCGCA GGCAGTGGTA 
CGGGCCGTGC TGGAAGACAA CTCGAGCTCG GTGGACTTTG CGGATCTGCC GGCGCTGTTC 
GGCGTCCCCC TGGCCCCCGA GGGCATACGG GGCTACCTGA TGGAGGTCAA GCCAGCCAAC 
GCGTGCCATC CCATCGAGGC CCCGCGACTG GGCAACCGCT CTCTGGGCGC CATCGTGCTG 
ATCCGCCGCT ACGACTGCAC CTTCGACCTC AAGGTGCTGA ACGCCCAGCG CGCCGGCTTC 
GAGGCGGCCA TCGTGCACAA CGTCCACTCC GACGACCTCG TGAGCATGAC CCACGTCTAC 
GAGGACTTGA GGGGCCAGAT CGCCATCCCC TCAGTGTTCG TGAGCGAGGC CGCCTCGCAG 
GACCTGCGGG TCATCCTGGG CTGCAACAAG TCGGCCCACG CGCTGCTCCT GCCCGACGAC 
CCACCGTGCC ACGACCTGGG CTGTCACCCC GTGCTGACCG TGTCCTGGGT GCTGGGCTGT 
ACCCTGGCCC TGGTCGTATC AGCCTTCTTT GTCCTGAACC ACCTGTGGCT CTGGGCCCAG 
GCCTGCTGCA GCCACAGACG GCCGGTGAAG ACGTCTACCT GCCAGAAGGC CCAGGTCCGC 
ACCTTCACGT GGCACAACGA CCTGTGTGCC ATCTGCCTGG ATGAGTATGA GGAGGGCGAC 
CAACTCAAGA TCCTGCCCTG CTCCCACACC TACCACTGCA AATGCATTGA CCCCTGGTTC 
TCCCAAGCCC CCCGGCGCTC CTGCCCCGTG TGCAAACAGT CGGTGGCCGC CACAGAAGAC 
AGCTTTGACT CCACCACCTA CAGCTTCAGG GACGAGGACC CCTCCCTACC GGGCCACCGG 
CCCCCCATCT GGGCCATTCA AGTCCAGCTA CGCTCCCGGA GGCTGGAGCT GCTGGGCCGC 
GCCAGTCCCC ACTGCCACTG CAGCACCACG TCCCTGGAGG CAGAGTATAC CACTGTCTCC 
TCAGCCCCTC CTGAGGCCCC TGGTCAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ZNRF4 ( NM_181710.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_859061.3 Homo sapiens zinc and ring finger 4 (ZNRF4), mRNA.

Price & Availability↑

CloneID	OHu24262
Clone ID Related Accession (Same CDS sequence)	NM_181710.3 , NM_181710.4
Accession Version	NM_181710.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1290bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase ZNRF4 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC005764.1. On May 17, 2019 this sequence version replaced NM_181710.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript is intronless :: BC017592.2, AK292251.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000222033.6/ ENSP00000222033.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCCGCTCT GCCGTCCGGA GCACTTAATG CCTAGAGCCA GCAGGGTCCC AGTGGCCGCG 
TCACTGCCTC TGAGCCACGC GGTCATTCCA ACTCAACTGC CCTCGCGTCC TGGCCACAGG 
CCCCCTGGGA GACCCCGGAG ATGCCCAAAG GCCTCATGCC TGCCGCCTCC AGTGGGACCT 
AGCAGCACAC AGACAGCGAA GCGGGTGACC ATGGGGTGGC CACGGCCGGG CCGAGCCCTC 
GTGGCAGTCA AAGCCTTGCT GGTCTTGTCG CTGCTCCAGG TGCCCGCGCA GGCAGTGGTA 
CGGGCCGTGC TGGAAGACAA CTCGAGCTCG GTGGACTTTG CGGATCTGCC GGCGCTGTTC 
GGCGTCCCCC TGGCCCCCGA GGGCATACGG GGCTACCTGA TGGAGGTCAA GCCAGCCAAC 
GCGTGCCATC CCATCGAGGC CCCGCGACTG GGCAACCGCT CTCTGGGCGC CATCGTGCTG 
ATCCGCCGCT ACGACTGCAC CTTCGACCTC AAGGTGCTGA ACGCCCAGCG CGCCGGCTTC 
GAGGCGGCCA TCGTGCACAA CGTCCACTCC GACGACCTCG TGAGCATGAC CCACGTCTAC 
GAGGACTTGA GGGGCCAGAT CGCCATCCCC TCAGTGTTCG TGAGCGAGGC CGCCTCGCAG 
GACCTGCGGG TCATCCTGGG CTGCAACAAG TCGGCCCACG CGCTGCTCCT GCCCGACGAC 
CCACCGTGCC ACGACCTGGG CTGTCACCCC GTGCTGACCG TGTCCTGGGT GCTGGGCTGT 
ACCCTGGCCC TGGTCGTATC AGCCTTCTTT GTCCTGAACC ACCTGTGGCT CTGGGCCCAG 
GCCTGCTGCA GCCACAGACG GCCGGTGAAG ACGTCTACCT GCCAGAAGGC CCAGGTCCGC 
ACCTTCACGT GGCACAACGA CCTGTGTGCC ATCTGCCTGG ATGAGTATGA GGAGGGCGAC 
CAACTCAAGA TCCTGCCCTG CTCCCACACC TACCACTGCA AATGCATTGA CCCCTGGTTC 
TCCCAAGCCC CCCGGCGCTC CTGCCCCGTG TGCAAACAGT CGGTGGCCGC CACAGAAGAC 
AGCTTTGACT CCACCACCTA CAGCTTCAGG GACGAGGACC CCTCCCTACC GGGCCACCGG 
CCCCCCATCT GGGCCATTCA AGTCCAGCTA CGCTCCCGGA GGCTGGAGCT GCTGGGCCGC 
GCCAGTCCCC ACTGCCACTG CAGCACCACG TCCCTGGAGG CAGAGTATAC CACTGTCTCC 
TCAGCCCCTC CTGAGGCCCC TGGTCAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_859061.3
CDS	76..1365
Translation	MPLCRPEHLMPRASRVPVAASLPLSHAVIPTQLPSRPGHRPPGRPRRCPKASCLPPPVGPSSTQTAKRVTMGWPRPGRALVAVKALLVLSLLQVPAQAVVRAVLEDNSSSVDFADLPALFGVPLAPEGIRGYLMEVKPANACHPIEAPRLGNRSLGAIVLIRRYDCTFDLKVLNAQRAGFEAAIVHNVHSDDLVSMTHVYEDLRGQIAIPSVFVSEAASQDLRVILGCNKSAHALLLPDDPPCHDLGCHPVLTVSWVLGCTLALVVSAFFVLNHLWLWAQACCSHRRPVKTSTCQKAQVRTFTWHNDLCAICLDEYEEGDQLKILPCSHTYHCKCIDPWFSQAPRRSCPVCKQSVAATEDSFDSTTYSFRDEDPSLPGHRPPIWAIQVQLRSRRLELLGRASPHCHCSTTSLEAEYTTVSSAPPEAPGQ

Target ORF information:

RefSeq Version	NM_181710.4
Organism	Homo sapiens(human)
Definition	Homo sapiens zinc and ring finger 4 (ZNRF4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181710.4

ORF Insert Sequence:

ATGCCGCTCT GCCGTCCGGA GCACTTAATG CCTAGAGCCA GCAGGGTCCC AGTGGCCGCG 
TCACTGCCTC TGAGCCACGC GGTCATTCCA ACTCAACTGC CCTCGCGTCC TGGCCACAGG 
CCCCCTGGGA GACCCCGGAG ATGCCCAAAG GCCTCATGCC TGCCGCCTCC AGTGGGACCT 
AGCAGCACAC AGACAGCGAA GCGGGTGACC ATGGGGTGGC CACGGCCGGG CCGAGCCCTC 
GTGGCAGTCA AAGCCTTGCT GGTCTTGTCG CTGCTCCAGG TGCCCGCGCA GGCAGTGGTA 
CGGGCCGTGC TGGAAGACAA CTCGAGCTCG GTGGACTTTG CGGATCTGCC GGCGCTGTTC 
GGCGTCCCCC TGGCCCCCGA GGGCATACGG GGCTACCTGA TGGAGGTCAA GCCAGCCAAC 
GCGTGCCATC CCATCGAGGC CCCGCGACTG GGCAACCGCT CTCTGGGCGC CATCGTGCTG 
ATCCGCCGCT ACGACTGCAC CTTCGACCTC AAGGTGCTGA ACGCCCAGCG CGCCGGCTTC 
GAGGCGGCCA TCGTGCACAA CGTCCACTCC GACGACCTCG TGAGCATGAC CCACGTCTAC 
GAGGACTTGA GGGGCCAGAT CGCCATCCCC TCAGTGTTCG TGAGCGAGGC CGCCTCGCAG 
GACCTGCGGG TCATCCTGGG CTGCAACAAG TCGGCCCACG CGCTGCTCCT GCCCGACGAC 
CCACCGTGCC ACGACCTGGG CTGTCACCCC GTGCTGACCG TGTCCTGGGT GCTGGGCTGT 
ACCCTGGCCC TGGTCGTATC AGCCTTCTTT GTCCTGAACC ACCTGTGGCT CTGGGCCCAG 
GCCTGCTGCA GCCACAGACG GCCGGTGAAG ACGTCTACCT GCCAGAAGGC CCAGGTCCGC 
ACCTTCACGT GGCACAACGA CCTGTGTGCC ATCTGCCTGG ATGAGTATGA GGAGGGCGAC 
CAACTCAAGA TCCTGCCCTG CTCCCACACC TACCACTGCA AATGCATTGA CCCCTGGTTC 
TCCCAAGCCC CCCGGCGCTC CTGCCCCGTG TGCAAACAGT CGGTGGCCGC CACAGAAGAC 
AGCTTTGACT CCACCACCTA CAGCTTCAGG GACGAGGACC CCTCCCTACC GGGCCACCGG 
CCCCCCATCT GGGCCATTCA AGTCCAGCTA CGCTCCCGGA GGCTGGAGCT GCTGGGCCGC 
GCCAGTCCCC ACTGCCACTG CAGCACCACG TCCCTGGAGG CAGAGTATAC CACTGTCTCC 
TCAGCCCCTC CTGAGGCCCC TGGTCAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP.
Nature communications815865(2017 Jun)
Bist P,Cheong WS,Ng A,Dikshit N,Kim BH,Pulloor NK,Khameneh HJ,Hedl M,Shenoy AR,Balamuralidhar V,Malik NBA,Hong M,Neutzner A,Chin KC,Kobayashi KS,Bertoletti A,Mortellaro A,Abraham C,MacMicking JD,Xavier RJ,Sukumaran B

A systematic search for endoplasmic reticulum (ER) membrane-associated RING finger proteins identifies Nixin/ZNRF4 as a regulator of calnexin stability and ER homeostasis.
The Journal of biological chemistry286(10)8633-43(2011 Mar)
Neutzner A,Neutzner M,Benischke AS,Ryu SW,Frank S,Youle RJ,Karbowski M

The DNA sequence and biology of human chromosome 19.
Nature428(6982)529-35(2004 Apr)
Grimwood J,Gordon LA,Olsen A,Terry A,Schmutz J,Lamerdin J,Hellsten U,Goodstein D,Couronne O,Tran-Gyamfi M,Aerts A,Altherr M,Ashworth L,Bajorek E,Black S,Branscomb E,Caenepeel S,Carrano A,Caoile C,Chan YM,Christensen M,Cleland CA,Copeland A,Dalin E,Dehal P,Denys M,Detter JC,Escobar J,Flowers D,Fotopulos D,Garcia C,Georgescu AM,Glavina T,Gomez M,Gonzales E,Groza M,Hammon N,Hawkins T,Haydu L,Ho I,Huang W,Israni S,Jett J,Kadner K,Kimball H,Kobayashi A,Larionov V,Leem SH,Lopez F,Lou Y,Lowry S,Malfatti S,Martinez D,McCready P,Medina C,Morgan J,Nelson K,Nolan M,Ovcharenko I,Pitluck S,Pollard M,Popkie AP,Predki P,Quan G,Ramirez L,Rash S,Retterer J,Rodriguez A,Rogers S,Salamov A,Salazar A,She X,Smith D,Slezak T,Solovyev V,Thayer N,Tice H,Tsai M,Ustaszewska A,Vo N,Wagner M,Wheeler J,Wu K,Xie G,Yang J,Dubchak I,Furey TS,DeJong P,Dickson M,Gordon D,Eichler EE,Pennacchio LA,Richardson P,Stubbs L,Rokhsar DS,Myers RM,Rubin EM,Lucas SM

Sperizin is a murine RING zinc-finger protein specifically expressed in Haploid germ cells.
Genomics57(1)94-101(1999 Apr)
Fujii T,Tamura K,Copeland NG,Gilbert DJ,Jenkins NA,Yomogida K,Tanaka H,Nishimune Y,Nojima H,Abiko Y

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ZNRF4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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