RFLNA cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RFLNA
Entrez Gene ID	144347
Full Name	refilin A
Synonyms	CFM2,FAM101A
General protein information	Preferred Names refilin A Names refilin-A family with sequence similarity 101, member A filamin-interacting protein FAM101A protein FAM101A refilinA regulator of filamin protein A
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q24.31
Disorder MIM:	615927

mRNA and Protein(s)

mRNA	Protein	Name
NM_001365156.1	NP_001352085.1	refilin-A isoform 1
NM_181709.4	NP_859060.3	refilin-A isoform 2

Pathways from BioSystems

Homologies

	FAM101A	XP_001102298.1
Homo sapiens (human)	FAM101A	NP_859060.3
Homo sapiens (human)	ZNF664-FAM101A	NP_001191228.1
Pan troglodytes (chimpanzee)	FAM101A	XP_001134722.1
Canis lupus familiaris (dog)	FAM101A	XP_853093.3
Mus musculus (house mouse)	Fam101a	NP_082719.1
Rattus norvegicus (Norway rat)	Fam101a	NP_001103017.1
Bos taurus (cattle)	FAM101A	NP_001192546.1

Gene Ontology
Bibliography

Related articles in PubMed

Filamin-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeletal elements.
Mizuhashi K, Kanamoto T, Moriishi T, Muranishi Y, Miyazaki T, Terada K, Omori Y, Ito M, Komori T, Furukawa T
Human molecular genetics23(11)2953-67(2014 Jun)

Novel single-nucleotide polymorphism markers predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients.
Kim JC, Ha YJ, Roh SA, Cho DH, Choi EY, Kim TW, Kim JH, Kang TW, Kim SY, Kim YS
International journal of radiation oncology, biology, physics86(2)350-7(2013 Jun)

RefilinB (FAM101B) targets filamin A to organize perinuclear actin networks and regulates nuclear shape.
Gay O, Gilquin B, Nakamura F, Jenkins ZA, McCartney R, Krakow D, Deshiere A, Assard N, Hartwig JH, Robertson SP, Baudier J
Proceedings of the National Academy of Sciences of the United States of America108(28)11464-9(2011 Jul)

The finished DNA sequence of human chromosome 12.
Scherer SE, Muzny DM, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Montgomery KT, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Lovering RC, Wheeler DA, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clerc-Blankenburg KP, Davis C, Delgado O, Dinh HH, Draper H, Gonzalez-Garay ML, Havlak P, Jackson LR, Jacob LS, Kelly SH, Li L, Li Z, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Pasternak S, Perez LM, Plopper FJ, Santibanez J, Shen H, Tabor PE, Verduzco D, Waldron L, Wang Q, Williams GA, Zhang J, Zhou J, Allen CC, Amin AG, Anyalebechi V, Bailey M, Barbaria JA, Bimage KE, Bryant NP, Burch PE, Burkett CE, Burrell KL, Calderon E, Cardenas V, Carter K, Casias K, Cavazos I, Cavazos SR, Ceasar H, Chacko J, Chan SN, Chavez D, Christopoulos C, Chu J, Cockrell R, Cox CD, Dang M, Dathorne SR, David R, Davis CM, Davy-Carroll L, Deshazo DR, Donlin JE, D'Souza L, Eaves KA, Egan A, Emery-Cohen AJ, Escotto M, Flagg N, Forbes LD, Gabisi AM, Garza M, Hamilton C, Henderson N, Hernandez O, Hines S, Hogues ME, Huang M, Idlebird DG, Johnson R, Jolivet A, Jones S, Kagan R, King LM, Leal B, Lebow H, Lee S, LeVan JM, Lewis LC, London P, Lorensuhewa LM, Loulseged H, Lovett DA, Lucier A, Lucier RL, Ma J, Madu RC, Mapua P, Martindale AD, Martinez E, Massey E, Mawhiney S, Meador MG, Mendez S, Mercado C, Mercado IC, Merritt CE, Miner ZL, Minja E, Mitchell T, Mohabbat F, Mohabbat K, Montgomery B, Moore N, Morris S, Munidasa M, Ngo RN, Nguyen NB, Nickerson E, Nwaokelemeh OO, Nwokenkwo S, Obregon M, Oguh M, Oragunye N, Oviedo RJ, Parish BJ, Parker DN, Parrish J, Parks KL, Paul HA, Payton BA, Perez A, Perrin W, Pickens A, Primus EL, Pu LL, Puazo M, Quiles MM, Quiroz JB, Rabata D, Reeves K, Ruiz SJ, Shao H, Sisson I, Sonaike T, Sorelle RP, Sutton AE, Svatek AF, Svetz LA, Tamerisa KS, Taylor TR, Teague B, Thomas N, Thorn RD, Trejos ZY, Trevino BK, Ukegbu ON, Urban JB, Vasquez LI, Vera VA, Villasana DM, Wang L, Ward-Moore S, Warren JT, Wei X, White F, Williamson AL, Wleczyk R, Wooden HS, Wooden SH, Yen J, Yoon L, Yoon V, Zorrilla SE, Nelson D, Kucherlapati R, Weinstock G, Gibbs RA,
Nature440(7082)346-51(2006 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The candidate marker CORO2A rs1985859 and the putative marker FAM101A rs7955740 may be of value for the prediction of radiosensitivity to preoperative colorectal tumors.
Title: Novel single-nucleotide polymorphism markers predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients.

The following RFLNA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RFLNA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu21238	NM_181709.4 Latest version!	Homo sapiens refilin A (RFLNA), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu107057	NM_001365156.1 Latest version!	Homo sapiens refilin A (RFLNA), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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30% OFF

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RFLNA ( NM_181709.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_859060.3 Homo sapiens refilin A (RFLNA), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu21238
Clone ID Related Accession (Same CDS sequence)	NM_181709.4
Accession Version	NM_181709.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 408bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-22
Organism	Homo sapiens(human)
Product	refilin-A isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK126577.1, BC141805.1 and BC026875.1. On Feb 24, 2011 this sequence version replaced NM_181709.3. ##Evidence-Data-START## Transcript exon combination :: AK126577.1, DA063778.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGCCCC GGATGCTGCC AGTGTTCTTT GGGGAGAGCA TCAAGGTGAA CCCGGAACCC 
ACGCATGAGA TCCGCTGCAA CTCTGAGGTC AAGTACGCCT CGGAGAAGCA TTTCCAGGAC 
AAGGTCTTCT ATGCGCCCGT ACCCACCGTC ACGGCCTACA GCGAGACCAT CGTGGCAGCA 
CCCAACTGCA CGTGGCGCAA CTACCGCAGC CAGCTGACCC TGGAGCCACG CCCGCGCGCC 
CTGCGCTTCC GCAGCACCAC CATCATCTTC CCCAAGCATG CCAGGAGCAC TTTCCGGACC 
ACCCTGCACT GCAGCCTGGG CCGGCCCAGC CGCTGGTTCA CCGCCAGCGT GCAGCTGCAG 
CTTTGCCAGG ACCCTGCCCC CAGCCTCCTG GGCCCTGCCA CGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_859060.3
CDS	244..651
Translation	MRPRMLPVFFGESIKVNPEPTHEIRCNSEVKYASEKHFQDKVFYAPVPTVTAYSETIVAAPNCTWRNYRSQLTLEPRPRALRFRSTTIIFPKHARSTFRTTLHCSLGRPSRWFTASVQLQLCQDPAPSLLGPATL

Target ORF information:

RefSeq Version	NM_181709.4
Organism	Homo sapiens(human)
Definition	Homo sapiens refilin A (RFLNA), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181709.4

ORF Insert Sequence:

ATGAGGCCCC GGATGCTGCC AGTGTTCTTT GGGGAGAGCA TCAAGGTGAA CCCGGAACCC 
ACGCATGAGA TCCGCTGCAA CTCTGAGGTC AAGTACGCCT CGGAGAAGCA TTTCCAGGAC 
AAGGTCTTCT ATGCGCCCGT ACCCACCGTC ACGGCCTACA GCGAGACCAT CGTGGCAGCA 
CCCAACTGCA CGTGGCGCAA CTACCGCAGC CAGCTGACCC TGGAGCCACG CCCGCGCGCC 
CTGCGCTTCC GCAGCACCAC CATCATCTTC CCCAAGCATG CCAGGAGCAC TTTCCGGACC 
ACCCTGCACT GCAGCCTGGG CCGGCCCAGC CGCTGGTTCA CCGCCAGCGT GCAGCTGCAG 
CTTTGCCAGG ACCCTGCCCC CAGCCTCCTG GGCCCTGCCA CGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RFLNA ( NM_001365156.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001352085.1 Homo sapiens refilin A (RFLNA), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu107057
Clone ID Related Accession (Same CDS sequence)	NM_001365156.1
Accession Version	NM_001365156.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 651bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-22
Organism	Homo sapiens(human)
Product	refilin-A isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC073916.41, BC042102.1, AK126577.1 and BC026875.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC042102.1, SRR3476690.987446.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000546355.4/ ENSP00000444080.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTGGGCC ACCTGCATCT GCAGGGCATG GAGGACAGCC TGAAGGAGCA GGGCCGGGAG 
GGCTTGCTGG ACAGCCCCGA CTCCGGGCTG CCCCCCAGCC CCAGCCCCAG CCCGCCCTTC 
TACTCCCTGG CGCCCGGCAT CCTCGACGCG CGCGCGGGGG GCGCCGGCGC CTCCTCGGAG 
CCCCCGGGAC CCAGCGAGGC CAGAGCGCCC CCCTCCCAAC TCCCAAATCC CCCGGCGTCG 
GAGATGAGGC CCCGGATGCT GCCAGTGTTC TTTGGGGAGA GCATCAAGGT GAACCCGGAA 
CCCACGCATG AGATCCGCTG CAACTCTGAG GTCAAGTACG CCTCGGAGAA GCATTTCCAG 
GACAAGGTCT TCTATGCGCC CGTACCCACC GTCACGGCCT ACAGCGAGAC CATCGTGGCA 
GCACCCAACT GCACGTGGCG CAACTACCGC AGCCAGCTGA CCCTGGAGCC ACGCCCGCGC 
GCCCTGCGCT TCCGCAGCAC CACCATCATC TTCCCCAAGC ATGCCAGGAG CACTTTCCGG 
ACCACCCTGC ACTGCAGCCT GGGCCGGCCC AGCCGCTGGT TCACCGCCAG CGTGCAGCTG 
CAGCTTTGCC AGGACCCTGC CCCCAGCCTC CTGGGCCCTG CCACGCTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001352085.1
CDS	338..988
Translation	MVGHLHLQGMEDSLKEQGREGLLDSPDSGLPPSPSPSPPFYSLAPGILDARAGGAGASSEPPGPSEARAPPSQLPNPPASEMRPRMLPVFFGESIKVNPEPTHEIRCNSEVKYASEKHFQDKVFYAPVPTVTAYSETIVAAPNCTWRNYRSQLTLEPRPRALRFRSTTIIFPKHARSTFRTTLHCSLGRPSRWFTASVQLQLCQDPAPSLLGPATL

Target ORF information:

RefSeq Version	NM_001365156.1
Organism	Homo sapiens(human)
Definition	Homo sapiens refilin A (RFLNA), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001365156.1

ORF Insert Sequence:

ATGGTGGGCC ACCTGCATCT GCAGGGCATG GAGGACAGCC TGAAGGAGCA GGGCCGGGAG 
GGCTTGCTGG ACAGCCCCGA CTCCGGGCTG CCCCCCAGCC CCAGCCCCAG CCCGCCCTTC 
TACTCCCTGG CGCCCGGCAT CCTCGACGCG CGCGCGGGGG GCGCCGGCGC CTCCTCGGAG 
CCCCCGGGAC CCAGCGAGGC CAGAGCGCCC CCCTCCCAAC TCCCAAATCC CCCGGCGTCG 
GAGATGAGGC CCCGGATGCT GCCAGTGTTC TTTGGGGAGA GCATCAAGGT GAACCCGGAA 
CCCACGCATG AGATCCGCTG CAACTCTGAG GTCAAGTACG CCTCGGAGAA GCATTTCCAG 
GACAAGGTCT TCTATGCGCC CGTACCCACC GTCACGGCCT ACAGCGAGAC CATCGTGGCA 
GCACCCAACT GCACGTGGCG CAACTACCGC AGCCAGCTGA CCCTGGAGCC ACGCCCGCGC 
GCCCTGCGCT TCCGCAGCAC CACCATCATC TTCCCCAAGC ATGCCAGGAG CACTTTCCGG 
ACCACCCTGC ACTGCAGCCT GGGCCGGCCC AGCCGCTGGT TCACCGCCAG CGTGCAGCTG 
CAGCTTTGCC AGGACCCTGC CCCCAGCCTC CTGGGCCCTG CCACGCTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Filamin-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeletal elements.
Human molecular genetics23(11)2953-67(2014 Jun)
Mizuhashi K,Kanamoto T,Moriishi T,Muranishi Y,Miyazaki T,Terada K,Omori Y,Ito M,Komori T,Furukawa T

Novel single-nucleotide polymorphism markers predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients.
International journal of radiation oncology, biology, physics86(2)350-7(2013 Jun)
Kim JC,Ha YJ,Roh SA,Cho DH,Choi EY,Kim TW,Kim JH,Kang TW,Kim SY,Kim YS

RefilinB (FAM101B) targets filamin A to organize perinuclear actin networks and regulates nuclear shape.
Proceedings of the National Academy of Sciences of the United States of America108(28)11464-9(2011 Jul)
Gay O,Gilquin B,Nakamura F,Jenkins ZA,McCartney R,Krakow D,Deshiere A,Assard N,Hartwig JH,Robertson SP,Baudier J

The finished DNA sequence of human chromosome 12.
Nature440(7082)346-51(2006 Mar)
Scherer SE,Muzny DM,Buhay CJ,Chen R,Cree A,Ding Y,Dugan-Rocha S,Gill R,Gunaratne P,Harris RA,Hawes AC,Hernandez J,Hodgson AV,Hume J,Jackson A,Khan ZM,Kovar-Smith C,Lewis LR,Lozado RJ,Metzker ML,Milosavljevic A,Miner GR,Montgomery KT,Morgan MB,Nazareth LV,Scott G,Sodergren E,Song XZ,Steffen D,Lovering RC,Wheeler DA,Worley KC,Yuan Y,Zhang Z,Adams CQ,Ansari-Lari MA,Ayele M,Brown MJ,Chen G,Chen Z,Clerc-Blankenburg KP,Davis C,Delgado O,Dinh HH,Draper H,Gonzalez-Garay ML,Havlak P,Jackson LR,Jacob LS,Kelly SH,Li L,Li Z,Liu J,Liu W,Lu J,Maheshwari M,Nguyen BV,Okwuonu GO,Pasternak S,Perez LM,Plopper FJ,Santibanez J,Shen H,Tabor PE,Verduzco D,Waldron L,Wang Q,Williams GA,Zhang J,Zhou J,Allen CC,Amin AG,Anyalebechi V,Bailey M,Barbaria JA,Bimage KE,Bryant NP,Burch PE,Burkett CE,Burrell KL,Calderon E,Cardenas V,Carter K,Casias K,Cavazos I,Cavazos SR,Ceasar H,Chacko J,Chan SN,Chavez D,Christopoulos C,Chu J,Cockrell R,Cox CD,Dang M,Dathorne SR,David R,Davis CM,Davy-Carroll L,Deshazo DR,Donlin JE,D'Souza L,Eaves KA,Egan A,Emery-Cohen AJ,Escotto M,Flagg N,Forbes LD,Gabisi AM,Garza M,Hamilton C,Henderson N,Hernandez O,Hines S,Hogues ME,Huang M,Idlebird DG,Johnson R,Jolivet A,Jones S,Kagan R,King LM,Leal B,Lebow H,Lee S,LeVan JM,Lewis LC,London P,Lorensuhewa LM,Loulseged H,Lovett DA,Lucier A,Lucier RL,Ma J,Madu RC,Mapua P,Martindale AD,Martinez E,Massey E,Mawhiney S,Meador MG,Mendez S,Mercado C,Mercado IC,Merritt CE,Miner ZL,Minja E,Mitchell T,Mohabbat F,Mohabbat K,Montgomery B,Moore N,Morris S,Munidasa M,Ngo RN,Nguyen NB,Nickerson E,Nwaokelemeh OO,Nwokenkwo S,Obregon M,Oguh M,Oragunye N,Oviedo RJ,Parish BJ,Parker DN,Parrish J,Parks KL,Paul HA,Payton BA,Perez A,Perrin W,Pickens A,Primus EL,Pu LL,Puazo M,Quiles MM,Quiroz JB,Rabata D,Reeves K,Ruiz SJ,Shao H,Sisson I,Sonaike T,Sorelle RP,Sutton AE,Svatek AF,Svetz LA,Tamerisa KS,Taylor TR,Teague B,Thomas N,Thorn RD,Trejos ZY,Trevino BK,Ukegbu ON,Urban JB,Vasquez LI,Vera VA,Villasana DM,Wang L,Ward-Moore S,Warren JT,Wei X,White F,Williamson AL,Wleczyk R,Wooden HS,Wooden SH,Yen J,Yoon L,Yoon V,Zorrilla SE,Nelson D,Kucherlapati R,Weinstock G,Gibbs RA,

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RFLNA cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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