DCAF12L1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DCAF12L1
Entrez Gene ID	139170
Full Name	DDB1 and CUL4 associated factor 12 like 1
Synonyms	KIAA1892L,WDR40B
General protein information	Preferred Names DDB1 and CUL4 associated factor 12 like 1 Names DDB1- and CUL4-associated factor 12-like protein 1 WD repeat domain 40B WD repeat-containing protein 40B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq25
Summary	This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_178470.5	NP_848565.2	DDB1- and CUL4-associated factor 12-like protein 1
NM_178470.4	NP_848565.2	DDB1- and CUL4-associated factor 12-like protein 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	DCAF12L1	XP_003317718.1
	LOC700674	XP_001089015.2
Homo sapiens (human)	DCAF12L1	NP_848565.2

Gene Ontology
Bibliography

Related articles in PubMed

Phospho-tyrosine dependent protein-protein interaction network.
Grossmann A, Benlasfer N, Birth P, Hegele A, Wachsmuth F, Apelt L, Stelzl U
Molecular systems biology11(3)794(2015 Mar)

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.
Jin J, Arias EE, Chen J, Harper JW, Walter JC
Molecular cell23(5)709-21(2006 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Functionally characterizes other DDB1- and CUL4-associated factors, including the DCAF12 factor which most closely resembles the product of this gene.
Title: A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.

The following DCAF12L1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DCAF12L1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18856	NM_178470.5 Latest version!	Homo sapiens DDB1 and CUL4 associated factor 12 like 1 (DCAF12L1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
View Old Accession Versions >>
OHu18856	NM_178470.4	Homo sapiens DDB1 and CUL4 associated factor 12 like 1 (DCAF12L1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DCAF12L1 ( NM_178470.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_848565.2 Homo sapiens DDB1 and CUL4 associated factor 12 like 1 (DCAF12L1), mRNA.

Price & Availability↑

CloneID	OHu18856
Clone ID Related Accession (Same CDS sequence)	NM_178470.5 , NM_178470.4
Accession Version	NM_178470.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1392bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	DDB1- and CUL4-associated factor 12-like protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM563914.1, DN999337.1, BC035674.1 and AI139786.1. This sequence is a reference standard in the RefSeqGene project. On Nov 24, 2018 this sequence version replaced NM_178470.4. ##Evidence-Data-START## Transcript exon combination :: BC035674.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000371126.3/ ENSP00000360167.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCCAGC AGCAAACAGG TAGCAGGAAA CGGAAAGCGC CCGCGGTCGA GGCGGACGCC 
GAGAGCTCGC CGTCGCAGGG CTTGGCGGCA GCGGACGGTG AGGGGCCGCT GCTACTCAAG 
AGGCAGAGGC GGCCGGCGAC GTATCGCTCG ATGGCGCACT ATCTGAAGGT TCGGGAGGTA 
GGCGGGTGGG GCCCCGCCAG GCTCCAGGGC TTCGATGGCG AGCTGCGGGG CTACGCGGTA 
CAGAGGCTGC CCGAGCTGCT GACGGAGCGC CAACTGGAGC TGGGCACGGT CAACAAGGTG 
TTCGCGTCAC AGTGGCTGAA CTCCAGGCAG GTGGTGTGCG GCACCAAGTG TAACACGCTT 
TTCGTGGTGG ACGTGGAGTC AGGCCACATC GCGCGCATTC CCCTCTTGCG GGACAGTGAG 
GCCAGGCTGG CCCAGGACCA ACAGGGCTGC GGCATCCATG CCATCGAGCT GAATCCCTCC 
AAGACGCTTC TGGCCACCGG CGGCGAAAAC CCCAACAGCC TGGCCATCTA CCAGCTGCCC 
TCCCTGGATC CCCTGTGCCT GGGCGACCGC CATGGCCACA AGGACTGGAT CTTCGCCGTC 
GCCTGGCTGA GTGACACCGT AGCCGTGAGC GGCTCCCGCG ACGGCACTGT GGCGCTGTGG 
CGGATGGACC CGGACAAGTT CGATGACACT GTTGCCTGGC ATAGCGAGGT GGGTCTCCCC 
GTATATGCCC ACATCCGTCC GAGGGATGTG GAGGCCATCC CCAGGGCCAT CATCAACCCC 
AGTAACCGCA AGGTGCGGGC CCTGGCCTGC GGCGGCAAGA ACCAGGAACT GGGAGCGGTG 
TCCTTGGACG GCTACTTCCA CCTGTGGAAA GCCGGGAGCG CACTATCCAG GCTGCTGTCC 
ATCAGGCTGC CCTACTTCCG GGATAATGTG TGCCTGACCT ACTGTGATGA TATGTCTGTG 
TACGCCGTGG GCTCCCATTC CCACGTCTCT TTCCTGGATC TGCGCCAGGA CCAGCAGAAC 
ATCCGGCCCC TGTGTTCTCG AGAGGGTGGC ACAGGCGTGC GGTCGCTGAG CTTCTACCGC 
CACATCATCA CTGTGGGCAC CGGTCAGGGC TCCCTGCTCT TCTATGACGT CCGGGCCCAG 
AAATTCCTGG AGGAAAGAGC CTCCGCCACC CTGGAGTCCT CTTCGGGACC TGCAAGGAGG 
AAGCTCAGGC TTGCCTGTGG CAGAGGCTGG CTCAACCACA ATGATTTCTG GGTGAATTAC 
TTTGGTGGCA TGGAAGTGTT TCCCAATGCG CTCTACACCC ACTGCTACAA CTGGCCTGAG 
ATGAAGCTCT TTGTGGCTGG GGGGCCTCTC CCTGCAGGCC TCCATGGGAA CTATGCAGGC 
CTCTGGAGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_848565.2
CDS	207..1598
Translation	MAQQQTGSRKRKAPAVEADAESSPSQGLAAADGEGPLLLKRQRRPATYRSMAHYLKVREVGGWGPARLQGFDGELRGYAVQRLPELLTERQLELGTVNKVFASQWLNSRQVVCGTKCNTLFVVDVESGHIARIPLLRDSEARLAQDQQGCGIHAIELNPSKTLLATGGENPNSLAIYQLPSLDPLCLGDRHGHKDWIFAVAWLSDTVAVSGSRDGTVALWRMDPDKFDDTVAWHSEVGLPVYAHIRPRDVEAIPRAIINPSNRKVRALACGGKNQELGAVSLDGYFHLWKAGSALSRLLSIRLPYFRDNVCLTYCDDMSVYAVGSHSHVSFLDLRQDQQNIRPLCSREGGTGVRSLSFYRHIITVGTGQGSLLFYDVRAQKFLEERASATLESSSGPARRKLRLACGRGWLNHNDFWVNYFGGMEVFPNALYTHCYNWPEMKLFVAGGPLPAGLHGNYAGLWS

Target ORF information:

RefSeq Version	NM_178470.5
Organism	Homo sapiens(human)
Definition	Homo sapiens DDB1 and CUL4 associated factor 12 like 1 (DCAF12L1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178470.5

ORF Insert Sequence:

ATGGCCCAGC AGCAAACAGG TAGCAGGAAA CGGAAAGCGC CCGCGGTCGA GGCGGACGCC 
GAGAGCTCGC CGTCGCAGGG CTTGGCGGCA GCGGACGGTG AGGGGCCGCT GCTACTCAAG 
AGGCAGAGGC GGCCGGCGAC GTATCGCTCG ATGGCGCACT ATCTGAAGGT TCGGGAGGTA 
GGCGGGTGGG GCCCCGCCAG GCTCCAGGGC TTCGATGGCG AGCTGCGGGG CTACGCGGTA 
CAGAGGCTGC CCGAGCTGCT GACGGAGCGC CAACTGGAGC TGGGCACGGT CAACAAGGTG 
TTCGCGTCAC AGTGGCTGAA CTCCAGGCAG GTGGTGTGCG GCACCAAGTG TAACACGCTT 
TTCGTGGTGG ACGTGGAGTC AGGCCACATC GCGCGCATTC CCCTCTTGCG GGACAGTGAG 
GCCAGGCTGG CCCAGGACCA ACAGGGCTGC GGCATCCATG CCATCGAGCT GAATCCCTCC 
AAGACGCTTC TGGCCACCGG CGGCGAAAAC CCCAACAGCC TGGCCATCTA CCAGCTGCCC 
TCCCTGGATC CCCTGTGCCT GGGCGACCGC CATGGCCACA AGGACTGGAT CTTCGCCGTC 
GCCTGGCTGA GTGACACCGT AGCCGTGAGC GGCTCCCGCG ACGGCACTGT GGCGCTGTGG 
CGGATGGACC CGGACAAGTT CGATGACACT GTTGCCTGGC ATAGCGAGGT GGGTCTCCCC 
GTATATGCCC ACATCCGTCC GAGGGATGTG GAGGCCATCC CCAGGGCCAT CATCAACCCC 
AGTAACCGCA AGGTGCGGGC CCTGGCCTGC GGCGGCAAGA ACCAGGAACT GGGAGCGGTG 
TCCTTGGACG GCTACTTCCA CCTGTGGAAA GCCGGGAGCG CACTATCCAG GCTGCTGTCC 
ATCAGGCTGC CCTACTTCCG GGATAATGTG TGCCTGACCT ACTGTGATGA TATGTCTGTG 
TACGCCGTGG GCTCCCATTC CCACGTCTCT TTCCTGGATC TGCGCCAGGA CCAGCAGAAC 
ATCCGGCCCC TGTGTTCTCG AGAGGGTGGC ACAGGCGTGC GGTCGCTGAG CTTCTACCGC 
CACATCATCA CTGTGGGCAC CGGTCAGGGC TCCCTGCTCT TCTATGACGT CCGGGCCCAG 
AAATTCCTGG AGGAAAGAGC CTCCGCCACC CTGGAGTCCT CTTCGGGACC TGCAAGGAGG 
AAGCTCAGGC TTGCCTGTGG CAGAGGCTGG CTCAACCACA ATGATTTCTG GGTGAATTAC 
TTTGGTGGCA TGGAAGTGTT TCCCAATGCG CTCTACACCC ACTGCTACAA CTGGCCTGAG 
ATGAAGCTCT TTGTGGCTGG GGGGCCTCTC CCTGCAGGCC TCCATGGGAA CTATGCAGGC 
CTCTGGAGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DCAF12L1 ( NM_178470.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_848565.2 Homo sapiens DDB1 and CUL4 associated factor 12 like 1 (DCAF12L1), mRNA.

Price & Availability↑

CloneID	OHu18856
Clone ID Related Accession (Same CDS sequence)	NM_178470.5 , NM_178470.4
Accession Version	NM_178470.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1392bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	DDB1- and CUL4-associated factor 12-like protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM563914.1, DN999337.1, BC035674.1 and AI139786.1. This sequence is a reference standard in the RefSeqGene project. On Jul 22, 2009 this sequence version replaced NM_178470.3. ##Evidence-Data-START## Transcript exon combination :: BC035674.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCCAGC AGCAAACAGG TAGCAGGAAA CGGAAAGCGC CCGCGGTCGA GGCGGACGCC 
GAGAGCTCGC CGTCGCAGGG CTTGGCGGCA GCGGACGGTG AGGGGCCGCT GCTACTCAAG 
AGGCAGAGGC GGCCGGCGAC GTATCGCTCG ATGGCGCACT ATCTGAAGGT TCGGGAGGTA 
GGCGGGTGGG GCCCCGCCAG GCTCCAGGGC TTCGATGGCG AGCTGCGGGG CTACGCGGTA 
CAGAGGCTGC CCGAGCTGCT GACGGAGCGC CAACTGGAGC TGGGCACGGT CAACAAGGTG 
TTCGCGTCAC AGTGGCTGAA CTCCAGGCAG GTGGTGTGCG GCACCAAGTG TAACACGCTT 
TTCGTGGTGG ACGTGGAGTC AGGCCACATC GCGCGCATTC CCCTCTTGCG GGACAGTGAG 
GCCAGGCTGG CCCAGGACCA ACAGGGCTGC GGCATCCATG CCATCGAGCT GAATCCCTCC 
AAGACGCTTC TGGCCACCGG CGGCGAAAAC CCCAACAGCC TGGCCATCTA CCAGCTGCCC 
TCCCTGGATC CCCTGTGCCT GGGCGACCGC CATGGCCACA AGGACTGGAT CTTCGCCGTC 
GCCTGGCTGA GTGACACCGT AGCCGTGAGC GGCTCCCGCG ACGGCACTGT GGCGCTGTGG 
CGGATGGACC CGGACAAGTT CGATGACACT GTTGCCTGGC ATAGCGAGGT GGGTCTCCCC 
GTATATGCCC ACATCCGTCC GAGGGATGTG GAGGCCATCC CCAGGGCCAT CATCAACCCC 
AGTAACCGCA AGGTGCGGGC CCTGGCCTGC GGCGGCAAGA ACCAGGAACT GGGAGCGGTG 
TCCTTGGACG GCTACTTCCA CCTGTGGAAA GCCGGGAGCG CACTATCCAG GCTGCTGTCC 
ATCAGGCTGC CCTACTTCCG GGATAATGTG TGCCTGACCT ACTGTGATGA TATGTCTGTG 
TACGCCGTGG GCTCCCATTC CCACGTCTCT TTCCTGGATC TGCGCCAGGA CCAGCAGAAC 
ATCCGGCCCC TGTGTTCTCG AGAGGGTGGC ACAGGCGTGC GGTCGCTGAG CTTCTACCGC 
CACATCATCA CTGTGGGCAC CGGTCAGGGC TCCCTGCTCT TCTATGACGT CCGGGCCCAG 
AAATTCCTGG AGGAAAGAGC CTCCGCCACC CTGGAGTCCT CTTCGGGACC TGCAAGGAGG 
AAGCTCAGGC TTGCCTGTGG CAGAGGCTGG CTCAACCACA ATGATTTCTG GGTGAATTAC 
TTTGGTGGCA TGGAAGTGTT TCCCAATGCG CTCTACACCC ACTGCTACAA CTGGCCTGAG 
ATGAAGCTCT TTGTGGCTGG GGGGCCTCTC CCTGCAGGCC TCCATGGGAA CTATGCAGGC 
CTCTGGAGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_848565.2
CDS	252..1643
Translation	MAQQQTGSRKRKAPAVEADAESSPSQGLAAADGEGPLLLKRQRRPATYRSMAHYLKVREVGGWGPARLQGFDGELRGYAVQRLPELLTERQLELGTVNKVFASQWLNSRQVVCGTKCNTLFVVDVESGHIARIPLLRDSEARLAQDQQGCGIHAIELNPSKTLLATGGENPNSLAIYQLPSLDPLCLGDRHGHKDWIFAVAWLSDTVAVSGSRDGTVALWRMDPDKFDDTVAWHSEVGLPVYAHIRPRDVEAIPRAIINPSNRKVRALACGGKNQELGAVSLDGYFHLWKAGSALSRLLSIRLPYFRDNVCLTYCDDMSVYAVGSHSHVSFLDLRQDQQNIRPLCSREGGTGVRSLSFYRHIITVGTGQGSLLFYDVRAQKFLEERASATLESSSGPARRKLRLACGRGWLNHNDFWVNYFGGMEVFPNALYTHCYNWPEMKLFVAGGPLPAGLHGNYAGLWS

Target ORF information:

RefSeq Version	NM_178470.4
Organism	Homo sapiens(human)
Definition	Homo sapiens DDB1 and CUL4 associated factor 12 like 1 (DCAF12L1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178470.4

ORF Insert Sequence:

ATGGCCCAGC AGCAAACAGG TAGCAGGAAA CGGAAAGCGC CCGCGGTCGA GGCGGACGCC 
GAGAGCTCGC CGTCGCAGGG CTTGGCGGCA GCGGACGGTG AGGGGCCGCT GCTACTCAAG 
AGGCAGAGGC GGCCGGCGAC GTATCGCTCG ATGGCGCACT ATCTGAAGGT TCGGGAGGTA 
GGCGGGTGGG GCCCCGCCAG GCTCCAGGGC TTCGATGGCG AGCTGCGGGG CTACGCGGTA 
CAGAGGCTGC CCGAGCTGCT GACGGAGCGC CAACTGGAGC TGGGCACGGT CAACAAGGTG 
TTCGCGTCAC AGTGGCTGAA CTCCAGGCAG GTGGTGTGCG GCACCAAGTG TAACACGCTT 
TTCGTGGTGG ACGTGGAGTC AGGCCACATC GCGCGCATTC CCCTCTTGCG GGACAGTGAG 
GCCAGGCTGG CCCAGGACCA ACAGGGCTGC GGCATCCATG CCATCGAGCT GAATCCCTCC 
AAGACGCTTC TGGCCACCGG CGGCGAAAAC CCCAACAGCC TGGCCATCTA CCAGCTGCCC 
TCCCTGGATC CCCTGTGCCT GGGCGACCGC CATGGCCACA AGGACTGGAT CTTCGCCGTC 
GCCTGGCTGA GTGACACCGT AGCCGTGAGC GGCTCCCGCG ACGGCACTGT GGCGCTGTGG 
CGGATGGACC CGGACAAGTT CGATGACACT GTTGCCTGGC ATAGCGAGGT GGGTCTCCCC 
GTATATGCCC ACATCCGTCC GAGGGATGTG GAGGCCATCC CCAGGGCCAT CATCAACCCC 
AGTAACCGCA AGGTGCGGGC CCTGGCCTGC GGCGGCAAGA ACCAGGAACT GGGAGCGGTG 
TCCTTGGACG GCTACTTCCA CCTGTGGAAA GCCGGGAGCG CACTATCCAG GCTGCTGTCC 
ATCAGGCTGC CCTACTTCCG GGATAATGTG TGCCTGACCT ACTGTGATGA TATGTCTGTG 
TACGCCGTGG GCTCCCATTC CCACGTCTCT TTCCTGGATC TGCGCCAGGA CCAGCAGAAC 
ATCCGGCCCC TGTGTTCTCG AGAGGGTGGC ACAGGCGTGC GGTCGCTGAG CTTCTACCGC 
CACATCATCA CTGTGGGCAC CGGTCAGGGC TCCCTGCTCT TCTATGACGT CCGGGCCCAG 
AAATTCCTGG AGGAAAGAGC CTCCGCCACC CTGGAGTCCT CTTCGGGACC TGCAAGGAGG 
AAGCTCAGGC TTGCCTGTGG CAGAGGCTGG CTCAACCACA ATGATTTCTG GGTGAATTAC 
TTTGGTGGCA TGGAAGTGTT TCCCAATGCG CTCTACACCC ACTGCTACAA CTGGCCTGAG 
ATGAAGCTCT TTGTGGCTGG GGGGCCTCTC CCTGCAGGCC TCCATGGGAA CTATGCAGGC 
CTCTGGAGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Phospho-tyrosine dependent protein-protein interaction network.
Molecular systems biology11(3)794(2015 Mar)
Grossmann A,Benlasfer N,Birth P,Hegele A,Wachsmuth F,Apelt L,Stelzl U

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.
Molecular cell23(5)709-21(2006 Sep)
Jin J,Arias EE,Chen J,Harper JW,Walter JC