UROC1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	UROC1
Entrez Gene ID	131669
Full Name	urocanate hydratase 1
Synonyms	HMFN0320,UROCD
General protein information	Preferred Names urocanate hydratase 1 Names urocanate hydratase imidazolonepropionate hydrolase urocanase 1 urocanase domain containing 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q21.3
Summary	This gene encodes an enzyme involved in histidine catabolism, metabolizing urocanic acid to formiminoglutamic acid. The gene product is known to protect the skin from ultra violet rays and is contained in human sweat. Deficiency of this gene product in the liver is an apparent cause of cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009].
Disorder MIM:	613012
Disorder Html:	?Urocanase deficiency, 276880 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001165974.2	NP_001159446.1	urocanate hydratase isoform 2
NM_144639.2	NP_653240.1	urocanate hydratase isoform 1
NM_001165974.1	NP_001159446.1	urocanate hydratase isoform 2
NM_144639.3	NP_653240.1	urocanate hydratase isoform 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	UROC1	NP_653240.1
Gallus gallus (chicken)	UROC1	XP_414375.1
Danio rerio (zebrafish)	uroc1	NP_001128601.1
	UROC1	XP_001114316.1
Canis lupus familiaris (dog)	UROC1	XP_533714.3
Caenorhabditis elegans (roundworm)	CELE_Y51H4A.7	NP_502964.2
Xenopus tropicalis (tropical clawed frog)	uroc1	NP_001025644.1
Bos taurus (cattle)	UROC1	XP_002697206.1
Mus musculus (house mouse)	Uroc1	NP_659189.2
Rattus norvegicus (Norway rat)	Uroc1	XP_001066120.2

Gene Ontology
Bibliography

Related articles in PubMed

Mutations in the urocanase gene UROC1 are associated with urocanic aciduria.
Espin?s C, Pineda M, Mart?nez-Rubio D, Lupo V, Ormazabal A, Vilaseca MA, Spaapen LJ, Palau F, Artuch R
Journal of medical genetics46(6)407-11(2009 Jun)

Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas.
Yamada S, Ohira M, Horie H, Ando K, Takayasu H, Suzuki Y, Sugano S, Hirata T, Goto T, Matsunaga T, Hiyama E, Hayashi Y, Ando H, Suita S, Kaneko M, Sasaki F, Hashizume K, Ohnuma N, Nakagawara A
Oncogene23(35)5901-11(2004 Aug)

The urocanase story: a novel role of NAD+ as electrophile.
R?tey J
Archives of biochemistry and biophysics314(1)1-16(1994 Oct)

A liver urocanase deficiency.
Kalafatic Z, Lipovac K, Jezerinac Z, Juretic D, Dumic M, Zurga B, Res L
Metabolism: clinical and experimental29(11)1013-9(1980 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following UROC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UROC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu01665	NM_144639.3 Latest version!	Homo sapiens urocanate hydratase 1 (UROC1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
OHu20967	NM_001165974.2 Latest version!	Homo sapiens urocanate hydratase 1 (UROC1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$517.30 $739.00
View Old Accession Versions >>
OHu20967	NM_001165974.1	Homo sapiens urocanate hydratase 1 (UROC1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$517.30 $739.00
OHu01665	NM_144639.2	Homo sapiens urocanate hydratase 1 (UROC1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

UROC1 ( NM_144639.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_653240.1 Homo sapiens urocanate hydratase 1 (UROC1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu01665
Clone ID Related Accession (Same CDS sequence)	NM_144639.2 , NM_144639.3
Accession Version	NM_144639.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2031bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	urocanate hydratase isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA638082.1, BC115405.1, AK055862.1, AC024558.21 and BX108463.1. On Oct 2, 2009 this sequence version replaced NM_144639.1. Transcript Variant: This variant (1) encodes the predominant isoform (1). ##Evidence-Data-START## Transcript exon combination :: AK055862.1, BC115405.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTAGCC TCCAGGCGCT GTGCTCTGGC CTGCCCCTGC GGCCCCTCCC AGAGAACCGG 
GGACGCCAGG CTGGGGTGCC CCATGCCCCT GTCAGGACCC CCAGCCTCAG CCCTGTGGAG 
AAACAGCTGG CGCTGAGGAA CGCCCTGCGC TACTTCCCCC CGGATGTCCA GGAGCTGCTG 
GCCCCAGAGT TTGCCCAGGA GCTGCAACTG TACGGACACA TCTACATGTA CCGGTTTTGC 
CCCGACATTG AAATGAGGGC CTACCCGATT GAGCAGTACC CCTGCCAGAC GAAAGTGGCT 
GCCGCCATCA TGCACATGAT TATGAACAAC CTGGATCCTG CCGTGGCCCA GTTTCCCCAG 
GAGCTGGTGA CCTATGGAGG AAATGGGCAG GTGTTCAGCA ACTGGGCTCA GTTCTGGCTG 
ACCATGTTCT ACTTGTCGAA GATGACAGAG GAGCAGACTT TGGTCATGTA CAGTGGGCAC 
CCACTTGGCC TCTTTCCCAG CAGCCGCAGT GCCCCACGGC TCGTCATCAC CAATGGGATG 
GTCATTCCCA ACTACTCCTC CCGGACGGAG TATGAGAAGC TCTTTGCCTT GGGGGTTACA 
ATGTACGGCC AGATGACAGC AGGTAGCTAC TGCTACATCG GTCCCCAGGG AATCGTTCAT 
GGCACTGTGC TCACCGTGTT GAATGCTGCA CGTCGGTACC TGGGCATCGA GGACTTGGCT 
GGGAAGGTCT TTGTCACCTC TGGGCTCGGC GGAATGAGTG GGGCTCAGGC CAAGGCCGCA 
GTCATCGTGG GGTGCATCGG TGTGATAGCA GAGGTGGATA AAGCAGCCCT TGAGAAACGC 
CACAGGCAGG GCTGGCTGAT GGAAGTGACT GACAGCTTGG ACCGCTGCAT CCAGAGGCTC 
AGGGAAGCAA GGAAAAAAAA GGAGGTGCTC AGCCTTGGTT ACCATGGCAA CGTGGTGGCT 
CTTTGGGAGC GCCTGGTCCA CGAATTGGAC ACGACGGGGG AGTGCTTGGT GGACCTGGGG 
TCAGATCAGA CATCCTGCCA CAACCCGTTC AATGGCGGCT ACTACCCTGT GCAGCTCAGC 
TTCACGGAGG CCCAGAGCCT CATGGCCTCC AACCCTGCTG TGTTCAAGGA CCTGGTCCAG 
GAAAGCCTGA GGAGGCAAGT CTCAGCCATC AACAGGTTGG CCGAGGAGAA GTTCTTCTTC 
TGGGACTACG GCAATGCCTT CCTCTTGGAG GCCCAGAGAG CAGGAGCGGA TGTGGAGAAG 
AAAGGTGCTG GCAGGACAGA GTTCCGCTAC CCTTCCTATG TGCAGCACAT CATGGGGGAC 
ATATTCTCCC AGGGATTTGG GCCTTTCCGC TGGGTGTGCA CATCGGGGGA CCCCCAGGAC 
CTGGCGGTCA CAGACGAACT GGCCACATCT GTGCTGGAGG AAGCCATTGC TGATGGAGTG 
AAGGTGTCTG TGAAGCTGCA GTACATGGAC AACATCCGCT GGATCCGGGA GGCCGCCAGG 
CACCGGCTGG TGGTGGGCTC CCAGGCAAGG ATCCTGTACT CAGACCAGAA GGGCCGCGTG 
GCCATCGCTG TGGCCATTAA CCAGGCCATC GCCTGCAGGA GGATCAAGGC GCCGGTGGTC 
CTGAGCCGAG ATCACCATGA CGTGAGCGGC ACCGACAGCC CCTTTAGGGA GACCTCCAAC 
ATTTACGACG GCTCTGCCTT CTGTGCAGAC ATGGCTGTGC AGAACTTCGT GGGAGATGCC 
TGTCGCGGAG CCACCTGGGT CGCCCTTCAC AACGGAGGGG GCGTGGGCTG GGGTGAGGTG 
ATCAACGGGG GATTCGGCCT CGTGCTGGAC GGTACCCCGG AGGCCGAGGG GAGAGCCAGG 
CTGATGCTCA GCTGGGATGT CTCCAATGGT GTGGCCCGGC GCTGCTGGTC AGGGAACCAG 
AAGGCCTATG AGATCATCTG CCAGACCATG CAGGAGAACA GCACCTTGGT GGTGACACTG 
CCTCACAAGG TGGAGGACGA GCGGGTGCTC CAGCAGGCCC TGCAGCTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_653240.1
CDS	55..2085
Translation	MSSLQALCSGLPLRPLPENRGRQAGVPHAPVRTPSLSPVEKQLALRNALRYFPPDVQELLAPEFAQELQLYGHIYMYRFCPDIEMRAYPIEQYPCQTKVAAAIMHMIMNNLDPAVAQFPQELVTYGGNGQVFSNWAQFWLTMFYLSKMTEEQTLVMYSGHPLGLFPSSRSAPRLVITNGMVIPNYSSRTEYEKLFALGVTMYGQMTAGSYCYIGPQGIVHGTVLTVLNAARRYLGIEDLAGKVFVTSGLGGMSGAQAKAAVIVGCIGVIAEVDKAALEKRHRQGWLMEVTDSLDRCIQRLREARKKKEVLSLGYHGNVVALWERLVHELDTTGECLVDLGSDQTSCHNPFNGGYYPVQLSFTEAQSLMASNPAVFKDLVQESLRRQVSAINRLAEEKFFFWDYGNAFLLEAQRAGADVEKKGAGRTEFRYPSYVQHIMGDIFSQGFGPFRWVCTSGDPQDLAVTDELATSVLEEAIADGVKVSVKLQYMDNIRWIREAARHRLVVGSQARILYSDQKGRVAIAVAINQAIACRRIKAPVVLSRDHHDVSGTDSPFRETSNIYDGSAFCADMAVQNFVGDACRGATWVALHNGGGVGWGEVINGGFGLVLDGTPEAEGRARLMLSWDVSNGVARRCWSGNQKAYEIICQTMQENSTLVVTLPHKVEDERVLQQALQL

Target ORF information:

RefSeq Version	NM_144639.2
Organism	Homo sapiens(human)
Definition	Homo sapiens urocanate hydratase 1 (UROC1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_144639.2

ORF Insert Sequence:

ATGTCTAGCC TCCAGGCGCT GTGCTCTGGC CTGCCCCTGC GGCCCCTCCC AGAGAACCGG 
GGACGCCAGG CTGGGGTGCC CCATGCCCCT GTCAGGACCC CCAGCCTCAG CCCTGTGGAG 
AAACAGCTGG CGCTGAGGAA CGCCCTGCGC TACTTCCCCC CGGATGTCCA GGAGCTGCTG 
GCCCCAGAGT TTGCCCAGGA GCTGCAACTG TACGGACACA TCTACATGTA CCGGTTTTGC 
CCCGACATTG AAATGAGGGC CTACCCGATT GAGCAGTACC CCTGCCAGAC GAAAGTGGCT 
GCCGCCATCA TGCACATGAT TATGAACAAC CTGGATCCTG CCGTGGCCCA GTTTCCCCAG 
GAGCTGGTGA CCTATGGAGG AAATGGGCAG GTGTTCAGCA ACTGGGCTCA GTTCTGGCTG 
ACCATGTTCT ACTTGTCGAA GATGACAGAG GAGCAGACTT TGGTCATGTA CAGTGGGCAC 
CCACTTGGCC TCTTTCCCAG CAGCCGCAGT GCCCCACGGC TCGTCATCAC CAATGGGATG 
GTCATTCCCA ACTACTCCTC CCGGACGGAG TATGAGAAGC TCTTTGCCTT GGGGGTTACA 
ATGTACGGCC AGATGACAGC AGGTAGCTAC TGCTACATCG GTCCCCAGGG AATCGTTCAT 
GGCACTGTGC TCACCGTGTT GAATGCTGCA CGTCGGTACC TGGGCATCGA GGACTTGGCT 
GGGAAGGTCT TTGTCACCTC TGGGCTCGGC GGAATGAGTG GGGCTCAGGC CAAGGCCGCA 
GTCATCGTGG GGTGCATCGG TGTGATAGCA GAGGTGGATA AAGCAGCCCT TGAGAAACGC 
CACAGGCAGG GCTGGCTGAT GGAAGTGACT GACAGCTTGG ACCGCTGCAT CCAGAGGCTC 
AGGGAAGCAA GGAAAAAAAA GGAGGTGCTC AGCCTTGGTT ACCATGGCAA CGTGGTGGCT 
CTTTGGGAGC GCCTGGTCCA CGAATTGGAC ACGACGGGGG AGTGCTTGGT GGACCTGGGG 
TCAGATCAGA CATCCTGCCA CAACCCGTTC AATGGCGGCT ACTACCCTGT GCAGCTCAGC 
TTCACGGAGG CCCAGAGCCT CATGGCCTCC AACCCTGCTG TGTTCAAGGA CCTGGTCCAG 
GAAAGCCTGA GGAGGCAAGT CTCAGCCATC AACAGGTTGG CCGAGGAGAA GTTCTTCTTC 
TGGGACTACG GCAATGCCTT CCTCTTGGAG GCCCAGAGAG CAGGAGCGGA TGTGGAGAAG 
AAAGGTGCTG GCAGGACAGA GTTCCGCTAC CCTTCCTATG TGCAGCACAT CATGGGGGAC 
ATATTCTCCC AGGGATTTGG GCCTTTCCGC TGGGTGTGCA CATCGGGGGA CCCCCAGGAC 
CTGGCGGTCA CAGACGAACT GGCCACATCT GTGCTGGAGG AAGCCATTGC TGATGGAGTG 
AAGGTGTCTG TGAAGCTGCA GTACATGGAC AACATCCGCT GGATCCGGGA GGCCGCCAGG 
CACCGGCTGG TGGTGGGCTC CCAGGCAAGG ATCCTGTACT CAGACCAGAA GGGCCGCGTG 
GCCATCGCTG TGGCCATTAA CCAGGCCATC GCCTGCAGGA GGATCAAGGC GCCGGTGGTC 
CTGAGCCGAG ATCACCATGA CGTGAGCGGC ACCGACAGCC CCTTTAGGGA GACCTCCAAC 
ATTTACGACG GCTCTGCCTT CTGTGCAGAC ATGGCTGTGC AGAACTTCGT GGGAGATGCC 
TGTCGCGGAG CCACCTGGGT CGCCCTTCAC AACGGAGGGG GCGTGGGCTG GGGTGAGGTG 
ATCAACGGGG GATTCGGCCT CGTGCTGGAC GGTACCCCGG AGGCCGAGGG GAGAGCCAGG 
CTGATGCTCA GCTGGGATGT CTCCAATGGT GTGGCCCGGC GCTGCTGGTC AGGGAACCAG 
AAGGCCTATG AGATCATCTG CCAGACCATG CAGGAGAACA GCACCTTGGT GGTGACACTG 
CCTCACAAGG TGGAGGACGA GCGGGTGCTC CAGCAGGCCC TGCAGCTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UROC1 ( NM_144639.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_653240.1 Homo sapiens urocanate hydratase 1 (UROC1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu01665
Clone ID Related Accession (Same CDS sequence)	NM_144639.2 , NM_144639.3
Accession Version	NM_144639.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2031bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-01
Organism	Homo sapiens(human)
Product	urocanate hydratase isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA638082.1, BC115405.1, AK055862.1, AC024558.21 and BX108463.1. On Nov 23, 2018 this sequence version replaced NM_144639.2. Transcript Variant: This variant (1) encodes the predominant isoform (1). ##Evidence-Data-START## Transcript exon combination :: AK055862.1, BC115405.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968968 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000290868.7/ ENSP00000290868.2 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCTAGCC TCCAGGCGCT GTGCTCTGGC CTGCCCCTGC GGCCCCTCCC AGAGAACCGG 
GGACGCCAGG CTGGGGTGCC CCATGCCCCT GTCAGGACCC CCAGCCTCAG CCCTGTGGAG 
AAACAGCTGG CGCTGAGGAA CGCCCTGCGC TACTTCCCCC CGGATGTCCA GGAGCTGCTG 
GCCCCAGAGT TTGCCCAGGA GCTGCAACTG TACGGACACA TCTACATGTA CCGGTTTTGC 
CCCGACATTG AAATGAGGGC CTACCCGATT GAGCAGTACC CCTGCCAGAC GAAAGTGGCT 
GCCGCCATCA TGCACATGAT TATGAACAAC CTGGATCCTG CCGTGGCCCA GTTTCCCCAG 
GAGCTGGTGA CCTATGGAGG AAATGGGCAG GTGTTCAGCA ACTGGGCTCA GTTCTGGCTG 
ACCATGTTCT ACTTGTCGAA GATGACAGAG GAGCAGACTT TGGTCATGTA CAGTGGGCAC 
CCACTTGGCC TCTTTCCCAG CAGCCGCAGT GCCCCACGGC TCGTCATCAC CAATGGGATG 
GTCATTCCCA ACTACTCCTC CCGGACGGAG TATGAGAAGC TCTTTGCCTT GGGGGTTACA 
ATGTACGGCC AGATGACAGC AGGTAGCTAC TGCTACATCG GTCCCCAGGG AATCGTTCAT 
GGCACTGTGC TCACCGTGTT GAATGCTGCA CGTCGGTACC TGGGCATCGA GGACTTGGCT 
GGGAAGGTCT TTGTCACCTC TGGGCTCGGC GGAATGAGTG GGGCTCAGGC CAAGGCCGCA 
GTCATCGTGG GGTGCATCGG TGTGATAGCA GAGGTGGATA AAGCAGCCCT TGAGAAACGC 
CACAGGCAGG GCTGGCTGAT GGAAGTGACT GACAGCTTGG ACCGCTGCAT CCAGAGGCTC 
AGGGAAGCAA GGAAAAAAAA GGAGGTGCTC AGCCTTGGTT ACCATGGCAA CGTGGTGGCT 
CTTTGGGAGC GCCTGGTCCA CGAATTGGAC ACGACGGGGG AGTGCTTGGT GGACCTGGGG 
TCAGATCAGA CATCCTGCCA CAACCCGTTC AATGGCGGCT ACTACCCTGT GCAGCTCAGC 
TTCACGGAGG CCCAGAGCCT CATGGCCTCC AACCCTGCTG TGTTCAAGGA CCTGGTCCAG 
GAAAGCCTGA GGAGGCAAGT CTCAGCCATC AACAGGTTGG CCGAGGAGAA GTTCTTCTTC 
TGGGACTACG GCAATGCCTT CCTCTTGGAG GCCCAGAGAG CAGGAGCGGA TGTGGAGAAG 
AAAGGTGCTG GCAGGACAGA GTTCCGCTAC CCTTCCTATG TGCAGCACAT CATGGGGGAC 
ATATTCTCCC AGGGATTTGG GCCTTTCCGC TGGGTGTGCA CATCGGGGGA CCCCCAGGAC 
CTGGCGGTCA CAGACGAACT GGCCACATCT GTGCTGGAGG AAGCCATTGC TGATGGAGTG 
AAGGTGTCTG TGAAGCTGCA GTACATGGAC AACATCCGCT GGATCCGGGA GGCCGCCAGG 
CACCGGCTGG TGGTGGGCTC CCAGGCAAGG ATCCTGTACT CAGACCAGAA GGGCCGCGTG 
GCCATCGCTG TGGCCATTAA CCAGGCCATC GCCTGCAGGA GGATCAAGGC GCCGGTGGTC 
CTGAGCCGAG ATCACCATGA CGTGAGCGGC ACCGACAGCC CCTTTAGGGA GACCTCCAAC 
ATTTACGACG GCTCTGCCTT CTGTGCAGAC ATGGCTGTGC AGAACTTCGT GGGAGATGCC 
TGTCGCGGAG CCACCTGGGT CGCCCTTCAC AACGGAGGGG GCGTGGGCTG GGGTGAGGTG 
ATCAACGGGG GATTCGGCCT CGTGCTGGAC GGTACCCCGG AGGCCGAGGG GAGAGCCAGG 
CTGATGCTCA GCTGGGATGT CTCCAATGGT GTGGCCCGGC GCTGCTGGTC AGGGAACCAG 
AAGGCCTATG AGATCATCTG CCAGACCATG CAGGAGAACA GCACCTTGGT GGTGACACTG 
CCTCACAAGG TGGAGGACGA GCGGGTGCTC CAGCAGGCCC TGCAGCTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_653240.1
CDS	55..2085
Translation	MSSLQALCSGLPLRPLPENRGRQAGVPHAPVRTPSLSPVEKQLALRNALRYFPPDVQELLAPEFAQELQLYGHIYMYRFCPDIEMRAYPIEQYPCQTKVAAAIMHMIMNNLDPAVAQFPQELVTYGGNGQVFSNWAQFWLTMFYLSKMTEEQTLVMYSGHPLGLFPSSRSAPRLVITNGMVIPNYSSRTEYEKLFALGVTMYGQMTAGSYCYIGPQGIVHGTVLTVLNAARRYLGIEDLAGKVFVTSGLGGMSGAQAKAAVIVGCIGVIAEVDKAALEKRHRQGWLMEVTDSLDRCIQRLREARKKKEVLSLGYHGNVVALWERLVHELDTTGECLVDLGSDQTSCHNPFNGGYYPVQLSFTEAQSLMASNPAVFKDLVQESLRRQVSAINRLAEEKFFFWDYGNAFLLEAQRAGADVEKKGAGRTEFRYPSYVQHIMGDIFSQGFGPFRWVCTSGDPQDLAVTDELATSVLEEAIADGVKVSVKLQYMDNIRWIREAARHRLVVGSQARILYSDQKGRVAIAVAINQAIACRRIKAPVVLSRDHHDVSGTDSPFRETSNIYDGSAFCADMAVQNFVGDACRGATWVALHNGGGVGWGEVINGGFGLVLDGTPEAEGRARLMLSWDVSNGVARRCWSGNQKAYEIICQTMQENSTLVVTLPHKVEDERVLQQALQL

Target ORF information:

RefSeq Version	NM_144639.3
Organism	Homo sapiens(human)
Definition	Homo sapiens urocanate hydratase 1 (UROC1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_144639.3

ORF Insert Sequence:

ATGTCTAGCC TCCAGGCGCT GTGCTCTGGC CTGCCCCTGC GGCCCCTCCC AGAGAACCGG 
GGACGCCAGG CTGGGGTGCC CCATGCCCCT GTCAGGACCC CCAGCCTCAG CCCTGTGGAG 
AAACAGCTGG CGCTGAGGAA CGCCCTGCGC TACTTCCCCC CGGATGTCCA GGAGCTGCTG 
GCCCCAGAGT TTGCCCAGGA GCTGCAACTG TACGGACACA TCTACATGTA CCGGTTTTGC 
CCCGACATTG AAATGAGGGC CTACCCGATT GAGCAGTACC CCTGCCAGAC GAAAGTGGCT 
GCCGCCATCA TGCACATGAT TATGAACAAC CTGGATCCTG CCGTGGCCCA GTTTCCCCAG 
GAGCTGGTGA CCTATGGAGG AAATGGGCAG GTGTTCAGCA ACTGGGCTCA GTTCTGGCTG 
ACCATGTTCT ACTTGTCGAA GATGACAGAG GAGCAGACTT TGGTCATGTA CAGTGGGCAC 
CCACTTGGCC TCTTTCCCAG CAGCCGCAGT GCCCCACGGC TCGTCATCAC CAATGGGATG 
GTCATTCCCA ACTACTCCTC CCGGACGGAG TATGAGAAGC TCTTTGCCTT GGGGGTTACA 
ATGTACGGCC AGATGACAGC AGGTAGCTAC TGCTACATCG GTCCCCAGGG AATCGTTCAT 
GGCACTGTGC TCACCGTGTT GAATGCTGCA CGTCGGTACC TGGGCATCGA GGACTTGGCT 
GGGAAGGTCT TTGTCACCTC TGGGCTCGGC GGAATGAGTG GGGCTCAGGC CAAGGCCGCA 
GTCATCGTGG GGTGCATCGG TGTGATAGCA GAGGTGGATA AAGCAGCCCT TGAGAAACGC 
CACAGGCAGG GCTGGCTGAT GGAAGTGACT GACAGCTTGG ACCGCTGCAT CCAGAGGCTC 
AGGGAAGCAA GGAAAAAAAA GGAGGTGCTC AGCCTTGGTT ACCATGGCAA CGTGGTGGCT 
CTTTGGGAGC GCCTGGTCCA CGAATTGGAC ACGACGGGGG AGTGCTTGGT GGACCTGGGG 
TCAGATCAGA CATCCTGCCA CAACCCGTTC AATGGCGGCT ACTACCCTGT GCAGCTCAGC 
TTCACGGAGG CCCAGAGCCT CATGGCCTCC AACCCTGCTG TGTTCAAGGA CCTGGTCCAG 
GAAAGCCTGA GGAGGCAAGT CTCAGCCATC AACAGGTTGG CCGAGGAGAA GTTCTTCTTC 
TGGGACTACG GCAATGCCTT CCTCTTGGAG GCCCAGAGAG CAGGAGCGGA TGTGGAGAAG 
AAAGGTGCTG GCAGGACAGA GTTCCGCTAC CCTTCCTATG TGCAGCACAT CATGGGGGAC 
ATATTCTCCC AGGGATTTGG GCCTTTCCGC TGGGTGTGCA CATCGGGGGA CCCCCAGGAC 
CTGGCGGTCA CAGACGAACT GGCCACATCT GTGCTGGAGG AAGCCATTGC TGATGGAGTG 
AAGGTGTCTG TGAAGCTGCA GTACATGGAC AACATCCGCT GGATCCGGGA GGCCGCCAGG 
CACCGGCTGG TGGTGGGCTC CCAGGCAAGG ATCCTGTACT CAGACCAGAA GGGCCGCGTG 
GCCATCGCTG TGGCCATTAA CCAGGCCATC GCCTGCAGGA GGATCAAGGC GCCGGTGGTC 
CTGAGCCGAG ATCACCATGA CGTGAGCGGC ACCGACAGCC CCTTTAGGGA GACCTCCAAC 
ATTTACGACG GCTCTGCCTT CTGTGCAGAC ATGGCTGTGC AGAACTTCGT GGGAGATGCC 
TGTCGCGGAG CCACCTGGGT CGCCCTTCAC AACGGAGGGG GCGTGGGCTG GGGTGAGGTG 
ATCAACGGGG GATTCGGCCT CGTGCTGGAC GGTACCCCGG AGGCCGAGGG GAGAGCCAGG 
CTGATGCTCA GCTGGGATGT CTCCAATGGT GTGGCCCGGC GCTGCTGGTC AGGGAACCAG 
AAGGCCTATG AGATCATCTG CCAGACCATG CAGGAGAACA GCACCTTGGT GGTGACACTG 
CCTCACAAGG TGGAGGACGA GCGGGTGCTC CAGCAGGCCC TGCAGCTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UROC1 ( NM_001165974.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001159446.1 Homo sapiens urocanate hydratase 1 (UROC1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu20967
Clone ID Related Accession (Same CDS sequence)	NM_001165974.2 , NM_001165974.1
Accession Version	NM_001165974.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2211bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	urocanate hydratase isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA638082.1, AB075869.1, AC024558.21, AK055862.1 and BX108463.1. This sequence is a reference standard in the RefSeqGene project. On May 31, 2019 this sequence version replaced NM_001165974.1. Transcript Variant: This variant (2) has an alternate in-frame exon and uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a longer protein (isoform 2) compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AB075869.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2162895 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTAGCC TCCAGGCGCT GTGCTCTGGC CTGCCCCTGC GGCCCCTCCC AGAGAACCGG 
GGACGCCAGG CTGGGGTGCC CCATGCCCCT GTCAGGACCC CCAGCCTCAG CCCTGTGGAG 
AAACAGCTGG CGCTGAGGAA CGCCCTGCGC TACTTCCCCC CGGATGTCCA GGAGCTGCTG 
GCCCCAGAGT TTGCCCAGGA GCTGCAACTG TACGGACACA TCTACATGTA CCGGTTTTGC 
CCCGACATTG AAATGAGGGC CTACCCGATT GAGCAGTACC CCTGCCAGAC GAAAGTGGCT 
GCCGCCATCA TGCACATGAT TATGAACAAC CTGGATCCTG CCGTGGCCCA GTTTCCCCAG 
GAGCTGGTGA CCTATGGAGG AAATGGGCAG GTGTTCAGCA ACTGGGCTCA GTTCTGGCTG 
ACCATGTTCT ACTTGTCGAA GATGACAGAG GAGCAGACTT TGGTCATGTA CAGTGGGCAC 
CCACTTGGCC TCTTTCCCAG CAGCCGCAGT GCCCCACGGC TCGTCATCAC CAATGGGATG 
GTCATTCCCA ACTACTCCTC CCGGACGGAG TATGAGAAGC TCTTTGCCTT GGGGGTTACA 
ATGTACGGCC AGATGACAGC AGGTAGCTAC TGCTACATCG GTCCCCAGGG AATCGTTCAT 
GGCACTGTGC TCACCGTGTT GAATGCTGCA CGTCGGTACC TGGGCATCGA GGACTTGGCT 
GGGAAGGTCT TTGTCACCTC TGGGCTCGGC GGAATGAGTG GGGCTCAGGC CAAGGCCGCA 
GTCATCGTGG GGTGCATCGG TGTGATAGCA GAGGTGGATA AAGCAGCCCT TGAGAAACGC 
CACAGGCAGG GCTGGCTGAT GGAAGTGACT GACAGCTTGG ACCGCTGCAT CCAGAGGCTC 
AGGGTCCTTC AGCTGGGATT GCAACAAGCC CTGGGCTGGG CCGGCCTCCC TGCTGCCCTG 
GGACTGTGTG TCCTTTCCTG CTTTGTCAAC CTTGCACCCC TGGGGGAGGG GAGGTGCCTG 
GCTCCCTCGG GCTTCTCCAG GCCACTCCTG GGGGCACCTG TTCTGCTTTT GTGTCCTTCC 
AGGGAAGCAA GGAAAAAAAA GGAGGTGCTC AGCCTTGGTT ACCATGGCAA CGTGGTGGCT 
CTTTGGGAGC GCCTGGTCCA CGAATTGGAC ACGACGGGGG AGTGCTTGGT GGACCTGGGG 
TCAGATCAGA CATCCTGCCA CAACCCGTTC AATGGCGGCT ACTACCCTGT GCAGCTCAGC 
TTCACGGAGG CCCAGAGCCT CATGGCCTCC AACCCTGCTG TGTTCAAGGA CCTGGTCCAG 
GAAAGCCTGA GGAGGCAAGT CTCAGCCATC AACAGGTTGG CCGAGGAGAA GTTCTTCTTC 
TGGGACTACG GCAATGCCTT CCTCTTGGAG GCCCAGAGAG CAGGAGCGGA TGTGGAGAAG 
AAAGGTGCTG GCAGGACAGA GTTCCGCTAC CCTTCCTATG TGCAGCACAT CATGGGGGAC 
ATATTCTCCC AGGGATTTGG GCCTTTCCGC TGGGTGTGCA CATCGGGGGA CCCCCAGGAC 
CTGGCGGTCA CAGACGAACT GGCCACATCT GTGCTGGAGG AAGCCATTGC TGATGGAGTG 
AAGGTGTCTG TGAAGCTGCA GTACATGGAC AACATCCGCT GGATCCGGGA GGCCGCCAGG 
CACCGGCTGG TGGTGGGCTC CCAGGCAAGG ATCCTGTACT CAGACCAGAA GGGCCGCGTG 
GCCATCGCTG TGGCCATTAA CCAGGCCATC GCCTGCAGGA GGATCAAGGC GCCGGTGGTC 
CTGAGCCGAG ATCACCATGA CGTGAGCGGC ACCGACAGCC CCTTTAGGGA GACCTCCAAC 
ATTTACGACG GCTCTGCCTT CTGTGCAGAC ATGGCTGTGC AGAACTTCGT GGGAGATGCC 
TGTCGCGGAG CCACCTGGGT CGCCCTTCAC AACGGAGGGG GCGTGGGCTG GGGTGAGGTG 
ATCAACGGGG GATTCGGCCT CGTGCTGGAC GGTACCCCGG AGGCCGAGGG GAGAGCCAGG 
CTGATGCTCA GCTGGGATGT CTCCAATGGT GTGGCCCGGC GCTGCTGGTC AGGGAACCAG 
AAGGCCTATG AGATCATCTG CCAGACCATG CAGGAGAACA GCACCTTGGT GGTGACACTG 
CCTCACAAGG TGGAGGACGA GCGGGTGCTC CAGCAGGCCC TGCAGCTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001159446.1
CDS	55..2265
Translation	MSSLQALCSGLPLRPLPENRGRQAGVPHAPVRTPSLSPVEKQLALRNALRYFPPDVQELLAPEFAQELQLYGHIYMYRFCPDIEMRAYPIEQYPCQTKVAAAIMHMIMNNLDPAVAQFPQELVTYGGNGQVFSNWAQFWLTMFYLSKMTEEQTLVMYSGHPLGLFPSSRSAPRLVITNGMVIPNYSSRTEYEKLFALGVTMYGQMTAGSYCYIGPQGIVHGTVLTVLNAARRYLGIEDLAGKVFVTSGLGGMSGAQAKAAVIVGCIGVIAEVDKAALEKRHRQGWLMEVTDSLDRCIQRLRVLQLGLQQALGWAGLPAALGLCVLSCFVNLAPLGEGRCLAPSGFSRPLLGAPVLLLCPSREARKKKEVLSLGYHGNVVALWERLVHELDTTGECLVDLGSDQTSCHNPFNGGYYPVQLSFTEAQSLMASNPAVFKDLVQESLRRQVSAINRLAEEKFFFWDYGNAFLLEAQRAGADVEKKGAGRTEFRYPSYVQHIMGDIFSQGFGPFRWVCTSGDPQDLAVTDELATSVLEEAIADGVKVSVKLQYMDNIRWIREAARHRLVVGSQARILYSDQKGRVAIAVAINQAIACRRIKAPVVLSRDHHDVSGTDSPFRETSNIYDGSAFCADMAVQNFVGDACRGATWVALHNGGGVGWGEVINGGFGLVLDGTPEAEGRARLMLSWDVSNGVARRCWSGNQKAYEIICQTMQENSTLVVTLPHKVEDERVLQQALQL

Target ORF information:

RefSeq Version	NM_001165974.2
Organism	Homo sapiens(human)
Definition	Homo sapiens urocanate hydratase 1 (UROC1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001165974.2

ORF Insert Sequence:

ATGTCTAGCC TCCAGGCGCT GTGCTCTGGC CTGCCCCTGC GGCCCCTCCC AGAGAACCGG 
GGACGCCAGG CTGGGGTGCC CCATGCCCCT GTCAGGACCC CCAGCCTCAG CCCTGTGGAG 
AAACAGCTGG CGCTGAGGAA CGCCCTGCGC TACTTCCCCC CGGATGTCCA GGAGCTGCTG 
GCCCCAGAGT TTGCCCAGGA GCTGCAACTG TACGGACACA TCTACATGTA CCGGTTTTGC 
CCCGACATTG AAATGAGGGC CTACCCGATT GAGCAGTACC CCTGCCAGAC GAAAGTGGCT 
GCCGCCATCA TGCACATGAT TATGAACAAC CTGGATCCTG CCGTGGCCCA GTTTCCCCAG 
GAGCTGGTGA CCTATGGAGG AAATGGGCAG GTGTTCAGCA ACTGGGCTCA GTTCTGGCTG 
ACCATGTTCT ACTTGTCGAA GATGACAGAG GAGCAGACTT TGGTCATGTA CAGTGGGCAC 
CCACTTGGCC TCTTTCCCAG CAGCCGCAGT GCCCCACGGC TCGTCATCAC CAATGGGATG 
GTCATTCCCA ACTACTCCTC CCGGACGGAG TATGAGAAGC TCTTTGCCTT GGGGGTTACA 
ATGTACGGCC AGATGACAGC AGGTAGCTAC TGCTACATCG GTCCCCAGGG AATCGTTCAT 
GGCACTGTGC TCACCGTGTT GAATGCTGCA CGTCGGTACC TGGGCATCGA GGACTTGGCT 
GGGAAGGTCT TTGTCACCTC TGGGCTCGGC GGAATGAGTG GGGCTCAGGC CAAGGCCGCA 
GTCATCGTGG GGTGCATCGG TGTGATAGCA GAGGTGGATA AAGCAGCCCT TGAGAAACGC 
CACAGGCAGG GCTGGCTGAT GGAAGTGACT GACAGCTTGG ACCGCTGCAT CCAGAGGCTC 
AGGGTCCTTC AGCTGGGATT GCAACAAGCC CTGGGCTGGG CCGGCCTCCC TGCTGCCCTG 
GGACTGTGTG TCCTTTCCTG CTTTGTCAAC CTTGCACCCC TGGGGGAGGG GAGGTGCCTG 
GCTCCCTCGG GCTTCTCCAG GCCACTCCTG GGGGCACCTG TTCTGCTTTT GTGTCCTTCC 
AGGGAAGCAA GGAAAAAAAA GGAGGTGCTC AGCCTTGGTT ACCATGGCAA CGTGGTGGCT 
CTTTGGGAGC GCCTGGTCCA CGAATTGGAC ACGACGGGGG AGTGCTTGGT GGACCTGGGG 
TCAGATCAGA CATCCTGCCA CAACCCGTTC AATGGCGGCT ACTACCCTGT GCAGCTCAGC 
TTCACGGAGG CCCAGAGCCT CATGGCCTCC AACCCTGCTG TGTTCAAGGA CCTGGTCCAG 
GAAAGCCTGA GGAGGCAAGT CTCAGCCATC AACAGGTTGG CCGAGGAGAA GTTCTTCTTC 
TGGGACTACG GCAATGCCTT CCTCTTGGAG GCCCAGAGAG CAGGAGCGGA TGTGGAGAAG 
AAAGGTGCTG GCAGGACAGA GTTCCGCTAC CCTTCCTATG TGCAGCACAT CATGGGGGAC 
ATATTCTCCC AGGGATTTGG GCCTTTCCGC TGGGTGTGCA CATCGGGGGA CCCCCAGGAC 
CTGGCGGTCA CAGACGAACT GGCCACATCT GTGCTGGAGG AAGCCATTGC TGATGGAGTG 
AAGGTGTCTG TGAAGCTGCA GTACATGGAC AACATCCGCT GGATCCGGGA GGCCGCCAGG 
CACCGGCTGG TGGTGGGCTC CCAGGCAAGG ATCCTGTACT CAGACCAGAA GGGCCGCGTG 
GCCATCGCTG TGGCCATTAA CCAGGCCATC GCCTGCAGGA GGATCAAGGC GCCGGTGGTC 
CTGAGCCGAG ATCACCATGA CGTGAGCGGC ACCGACAGCC CCTTTAGGGA GACCTCCAAC 
ATTTACGACG GCTCTGCCTT CTGTGCAGAC ATGGCTGTGC AGAACTTCGT GGGAGATGCC 
TGTCGCGGAG CCACCTGGGT CGCCCTTCAC AACGGAGGGG GCGTGGGCTG GGGTGAGGTG 
ATCAACGGGG GATTCGGCCT CGTGCTGGAC GGTACCCCGG AGGCCGAGGG GAGAGCCAGG 
CTGATGCTCA GCTGGGATGT CTCCAATGGT GTGGCCCGGC GCTGCTGGTC AGGGAACCAG 
AAGGCCTATG AGATCATCTG CCAGACCATG CAGGAGAACA GCACCTTGGT GGTGACACTG 
CCTCACAAGG TGGAGGACGA GCGGGTGCTC CAGCAGGCCC TGCAGCTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UROC1 ( NM_001165974.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001159446.1 Homo sapiens urocanate hydratase 1 (UROC1), transcript variant 2, mRNA.

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CloneID	OHu20967
Clone ID Related Accession (Same CDS sequence)	NM_001165974.2 , NM_001165974.1
Accession Version	NM_001165974.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2211bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-21
Organism	Homo sapiens(human)
Product	urocanate hydratase isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA638082.1, AB075869.1, AC024558.21, AK055862.1 and BX108463.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (2) has an alternate in-frame exon and uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a longer protein (isoform 2) compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AB075869.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2162895 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTAGCC TCCAGGCGCT GTGCTCTGGC CTGCCCCTGC GGCCCCTCCC AGAGAACCGG 
GGACGCCAGG CTGGGGTGCC CCATGCCCCT GTCAGGACCC CCAGCCTCAG CCCTGTGGAG 
AAACAGCTGG CGCTGAGGAA CGCCCTGCGC TACTTCCCCC CGGATGTCCA GGAGCTGCTG 
GCCCCAGAGT TTGCCCAGGA GCTGCAACTG TACGGACACA TCTACATGTA CCGGTTTTGC 
CCCGACATTG AAATGAGGGC CTACCCGATT GAGCAGTACC CCTGCCAGAC GAAAGTGGCT 
GCCGCCATCA TGCACATGAT TATGAACAAC CTGGATCCTG CCGTGGCCCA GTTTCCCCAG 
GAGCTGGTGA CCTATGGAGG AAATGGGCAG GTGTTCAGCA ACTGGGCTCA GTTCTGGCTG 
ACCATGTTCT ACTTGTCGAA GATGACAGAG GAGCAGACTT TGGTCATGTA CAGTGGGCAC 
CCACTTGGCC TCTTTCCCAG CAGCCGCAGT GCCCCACGGC TCGTCATCAC CAATGGGATG 
GTCATTCCCA ACTACTCCTC CCGGACGGAG TATGAGAAGC TCTTTGCCTT GGGGGTTACA 
ATGTACGGCC AGATGACAGC AGGTAGCTAC TGCTACATCG GTCCCCAGGG AATCGTTCAT 
GGCACTGTGC TCACCGTGTT GAATGCTGCA CGTCGGTACC TGGGCATCGA GGACTTGGCT 
GGGAAGGTCT TTGTCACCTC TGGGCTCGGC GGAATGAGTG GGGCTCAGGC CAAGGCCGCA 
GTCATCGTGG GGTGCATCGG TGTGATAGCA GAGGTGGATA AAGCAGCCCT TGAGAAACGC 
CACAGGCAGG GCTGGCTGAT GGAAGTGACT GACAGCTTGG ACCGCTGCAT CCAGAGGCTC 
AGGGTCCTTC AGCTGGGATT GCAACAAGCC CTGGGCTGGG CCGGCCTCCC TGCTGCCCTG 
GGACTGTGTG TCCTTTCCTG CTTTGTCAAC CTTGCACCCC TGGGGGAGGG GAGGTGCCTG 
GCTCCCTCGG GCTTCTCCAG GCCACTCCTG GGGGCACCTG TTCTGCTTTT GTGTCCTTCC 
AGGGAAGCAA GGAAAAAAAA GGAGGTGCTC AGCCTTGGTT ACCATGGCAA CGTGGTGGCT 
CTTTGGGAGC GCCTGGTCCA CGAATTGGAC ACGACGGGGG AGTGCTTGGT GGACCTGGGG 
TCAGATCAGA CATCCTGCCA CAACCCGTTC AATGGCGGCT ACTACCCTGT GCAGCTCAGC 
TTCACGGAGG CCCAGAGCCT CATGGCCTCC AACCCTGCTG TGTTCAAGGA CCTGGTCCAG 
GAAAGCCTGA GGAGGCAAGT CTCAGCCATC AACAGGTTGG CCGAGGAGAA GTTCTTCTTC 
TGGGACTACG GCAATGCCTT CCTCTTGGAG GCCCAGAGAG CAGGAGCGGA TGTGGAGAAG 
AAAGGTGCTG GCAGGACAGA GTTCCGCTAC CCTTCCTATG TGCAGCACAT CATGGGGGAC 
ATATTCTCCC AGGGATTTGG GCCTTTCCGC TGGGTGTGCA CATCGGGGGA CCCCCAGGAC 
CTGGCGGTCA CAGACGAACT GGCCACATCT GTGCTGGAGG AAGCCATTGC TGATGGAGTG 
AAGGTGTCTG TGAAGCTGCA GTACATGGAC AACATCCGCT GGATCCGGGA GGCCGCCAGG 
CACCGGCTGG TGGTGGGCTC CCAGGCAAGG ATCCTGTACT CAGACCAGAA GGGCCGCGTG 
GCCATCGCTG TGGCCATTAA CCAGGCCATC GCCTGCAGGA GGATCAAGGC GCCGGTGGTC 
CTGAGCCGAG ATCACCATGA CGTGAGCGGC ACCGACAGCC CCTTTAGGGA GACCTCCAAC 
ATTTACGACG GCTCTGCCTT CTGTGCAGAC ATGGCTGTGC AGAACTTCGT GGGAGATGCC 
TGTCGCGGAG CCACCTGGGT CGCCCTTCAC AACGGAGGGG GCGTGGGCTG GGGTGAGGTG 
ATCAACGGGG GATTCGGCCT CGTGCTGGAC GGTACCCCGG AGGCCGAGGG GAGAGCCAGG 
CTGATGCTCA GCTGGGATGT CTCCAATGGT GTGGCCCGGC GCTGCTGGTC AGGGAACCAG 
AAGGCCTATG AGATCATCTG CCAGACCATG CAGGAGAACA GCACCTTGGT GGTGACACTG 
CCTCACAAGG TGGAGGACGA GCGGGTGCTC CAGCAGGCCC TGCAGCTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001159446.1
CDS	55..2265
Translation	MSSLQALCSGLPLRPLPENRGRQAGVPHAPVRTPSLSPVEKQLALRNALRYFPPDVQELLAPEFAQELQLYGHIYMYRFCPDIEMRAYPIEQYPCQTKVAAAIMHMIMNNLDPAVAQFPQELVTYGGNGQVFSNWAQFWLTMFYLSKMTEEQTLVMYSGHPLGLFPSSRSAPRLVITNGMVIPNYSSRTEYEKLFALGVTMYGQMTAGSYCYIGPQGIVHGTVLTVLNAARRYLGIEDLAGKVFVTSGLGGMSGAQAKAAVIVGCIGVIAEVDKAALEKRHRQGWLMEVTDSLDRCIQRLRVLQLGLQQALGWAGLPAALGLCVLSCFVNLAPLGEGRCLAPSGFSRPLLGAPVLLLCPSREARKKKEVLSLGYHGNVVALWERLVHELDTTGECLVDLGSDQTSCHNPFNGGYYPVQLSFTEAQSLMASNPAVFKDLVQESLRRQVSAINRLAEEKFFFWDYGNAFLLEAQRAGADVEKKGAGRTEFRYPSYVQHIMGDIFSQGFGPFRWVCTSGDPQDLAVTDELATSVLEEAIADGVKVSVKLQYMDNIRWIREAARHRLVVGSQARILYSDQKGRVAIAVAINQAIACRRIKAPVVLSRDHHDVSGTDSPFRETSNIYDGSAFCADMAVQNFVGDACRGATWVALHNGGGVGWGEVINGGFGLVLDGTPEAEGRARLMLSWDVSNGVARRCWSGNQKAYEIICQTMQENSTLVVTLPHKVEDERVLQQALQL

Target ORF information:

RefSeq Version	NM_001165974.1
Organism	Homo sapiens(human)
Definition	Homo sapiens urocanate hydratase 1 (UROC1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001165974.1

ORF Insert Sequence:

ATGTCTAGCC TCCAGGCGCT GTGCTCTGGC CTGCCCCTGC GGCCCCTCCC AGAGAACCGG 
GGACGCCAGG CTGGGGTGCC CCATGCCCCT GTCAGGACCC CCAGCCTCAG CCCTGTGGAG 
AAACAGCTGG CGCTGAGGAA CGCCCTGCGC TACTTCCCCC CGGATGTCCA GGAGCTGCTG 
GCCCCAGAGT TTGCCCAGGA GCTGCAACTG TACGGACACA TCTACATGTA CCGGTTTTGC 
CCCGACATTG AAATGAGGGC CTACCCGATT GAGCAGTACC CCTGCCAGAC GAAAGTGGCT 
GCCGCCATCA TGCACATGAT TATGAACAAC CTGGATCCTG CCGTGGCCCA GTTTCCCCAG 
GAGCTGGTGA CCTATGGAGG AAATGGGCAG GTGTTCAGCA ACTGGGCTCA GTTCTGGCTG 
ACCATGTTCT ACTTGTCGAA GATGACAGAG GAGCAGACTT TGGTCATGTA CAGTGGGCAC 
CCACTTGGCC TCTTTCCCAG CAGCCGCAGT GCCCCACGGC TCGTCATCAC CAATGGGATG 
GTCATTCCCA ACTACTCCTC CCGGACGGAG TATGAGAAGC TCTTTGCCTT GGGGGTTACA 
ATGTACGGCC AGATGACAGC AGGTAGCTAC TGCTACATCG GTCCCCAGGG AATCGTTCAT 
GGCACTGTGC TCACCGTGTT GAATGCTGCA CGTCGGTACC TGGGCATCGA GGACTTGGCT 
GGGAAGGTCT TTGTCACCTC TGGGCTCGGC GGAATGAGTG GGGCTCAGGC CAAGGCCGCA 
GTCATCGTGG GGTGCATCGG TGTGATAGCA GAGGTGGATA AAGCAGCCCT TGAGAAACGC 
CACAGGCAGG GCTGGCTGAT GGAAGTGACT GACAGCTTGG ACCGCTGCAT CCAGAGGCTC 
AGGGTCCTTC AGCTGGGATT GCAACAAGCC CTGGGCTGGG CCGGCCTCCC TGCTGCCCTG 
GGACTGTGTG TCCTTTCCTG CTTTGTCAAC CTTGCACCCC TGGGGGAGGG GAGGTGCCTG 
GCTCCCTCGG GCTTCTCCAG GCCACTCCTG GGGGCACCTG TTCTGCTTTT GTGTCCTTCC 
AGGGAAGCAA GGAAAAAAAA GGAGGTGCTC AGCCTTGGTT ACCATGGCAA CGTGGTGGCT 
CTTTGGGAGC GCCTGGTCCA CGAATTGGAC ACGACGGGGG AGTGCTTGGT GGACCTGGGG 
TCAGATCAGA CATCCTGCCA CAACCCGTTC AATGGCGGCT ACTACCCTGT GCAGCTCAGC 
TTCACGGAGG CCCAGAGCCT CATGGCCTCC AACCCTGCTG TGTTCAAGGA CCTGGTCCAG 
GAAAGCCTGA GGAGGCAAGT CTCAGCCATC AACAGGTTGG CCGAGGAGAA GTTCTTCTTC 
TGGGACTACG GCAATGCCTT CCTCTTGGAG GCCCAGAGAG CAGGAGCGGA TGTGGAGAAG 
AAAGGTGCTG GCAGGACAGA GTTCCGCTAC CCTTCCTATG TGCAGCACAT CATGGGGGAC 
ATATTCTCCC AGGGATTTGG GCCTTTCCGC TGGGTGTGCA CATCGGGGGA CCCCCAGGAC 
CTGGCGGTCA CAGACGAACT GGCCACATCT GTGCTGGAGG AAGCCATTGC TGATGGAGTG 
AAGGTGTCTG TGAAGCTGCA GTACATGGAC AACATCCGCT GGATCCGGGA GGCCGCCAGG 
CACCGGCTGG TGGTGGGCTC CCAGGCAAGG ATCCTGTACT CAGACCAGAA GGGCCGCGTG 
GCCATCGCTG TGGCCATTAA CCAGGCCATC GCCTGCAGGA GGATCAAGGC GCCGGTGGTC 
CTGAGCCGAG ATCACCATGA CGTGAGCGGC ACCGACAGCC CCTTTAGGGA GACCTCCAAC 
ATTTACGACG GCTCTGCCTT CTGTGCAGAC ATGGCTGTGC AGAACTTCGT GGGAGATGCC 
TGTCGCGGAG CCACCTGGGT CGCCCTTCAC AACGGAGGGG GCGTGGGCTG GGGTGAGGTG 
ATCAACGGGG GATTCGGCCT CGTGCTGGAC GGTACCCCGG AGGCCGAGGG GAGAGCCAGG 
CTGATGCTCA GCTGGGATGT CTCCAATGGT GTGGCCCGGC GCTGCTGGTC AGGGAACCAG 
AAGGCCTATG AGATCATCTG CCAGACCATG CAGGAGAACA GCACCTTGGT GGTGACACTG 
CCTCACAAGG TGGAGGACGA GCGGGTGCTC CAGCAGGCCC TGCAGCTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutations in the urocanase gene UROC1 are associated with urocanic aciduria.
Journal of medical genetics46(6)407-11(2009 Jun)
Espin?s C,Pineda M,Mart?nez-Rubio D,Lupo V,Ormazabal A,Vilaseca MA,Spaapen LJ,Palau F,Artuch R

Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas.
Oncogene23(35)5901-11(2004 Aug)
Yamada S,Ohira M,Horie H,Ando K,Takayasu H,Suzuki Y,Sugano S,Hirata T,Goto T,Matsunaga T,Hiyama E,Hayashi Y,Ando H,Suita S,Kaneko M,Sasaki F,Hashizume K,Ohnuma N,Nakagawara A

The urocanase story: a novel role of NAD+ as electrophile.
Archives of biochemistry and biophysics314(1)1-16(1994 Oct)
R?tey J

A liver urocanase deficiency.
Metabolism: clinical and experimental29(11)1013-9(1980 Oct)
Kalafatic Z,Lipovac K,Jezerinac Z,Juretic D,Dumic M,Zurga B,Res L

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UROC1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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