DCUN1D3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DCUN1D3
Entrez Gene ID	123879
Full Name	defective in cullin neddylation 1 domain containing 3
Synonyms	44M2.4,SCCRO3
General protein information	Preferred Names defective in cullin neddylation 1 domain containing 3 Names DCN1-like protein 3 DCN1, defective in cullin neddylation 1, domain containing 3 DCUN1 domain-containing protein 3 defective in cullin neddylation protein 1-like protein 3 squamous cell carcinoma-related oncogene 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p12.3
Disorder MIM:	616167

mRNA and Protein(s)

mRNA	Protein	Name
NM_173475.3	NP_775746.1	DCN1-like protein 3
NM_173475.2	NP_775746.1	DCN1-like protein 3
NM_173475.4	NP_775746.1	DCN1-like protein 3

Pathways from BioSystems

Homologies

Homo sapiens (human)	DCUN1D3	NP_775746.1
Pan troglodytes (chimpanzee)	DCUN1D3	XP_003952857.1
	DCUN1D3	XP_001090443.1
Mus musculus (house mouse)	Dcun1d3	NP_775584.1
Drosophila melanogaster (fruit fly)	CG13322	NP_610828.2
Xenopus tropicalis (tropical clawed frog)	dcun1d3	NP_001096288.1
Danio rerio (zebrafish)	zgc:154015	NP_001096582.1
Rattus norvegicus (Norway rat)	Dcun1d3	NP_001020057.1
Canis lupus familiaris (dog)	DCUN1D3	XP_005621510.1
Bos taurus (cattle)	DCUN1D3	NP_001015518.1
Gallus gallus (chicken)	DCUN1D3	XP_004945523.1

Gene Ontology
Bibliography

Related articles in PubMed

DCUN1D3 activates SCFSKP2 ubiquitin E3 ligase activity and cell cycle progression under UV damage.
Zhang S, Huang J, Shi T, Hu F, Zhang L, Zhou PK, Ma D, Ma T, Qiu X
Oncotarget7(36)58483-58491(2016 Sep)

SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1).
Huang G, Stock C, Bommelj? CC, Weeda VB, Shah K, Bains S, Buss E, Shaha M, Rechler W, Ramanathan SY, Singh B
The Journal of biological chemistry289(50)34728-42(2014 Dec)

The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes.
Meyer-Schaller N, Chou YC, Sumara I, Martin DD, Kurz T, Katheder N, Hofmann K, Berthiaume LG, Sicheri F, Peter M
Proceedings of the National Academy of Sciences of the United States of America106(30)12365-70(2009 Jul)

DCUN1D3, a novel UVC-responsive gene that is involved in cell cycle progression and cell growth.
Ma T, Shi T, Huang J, Wu L, Hu F, He P, Deng W, Gao P, Zhang Y, Song Q, Ma D, Qiu X
Cancer science99(11)2128-35(2008 Nov)

The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae.
Kurz T, Ozl? N, Rudolf F, O'Rourke SM, Luke B, Hofmann K, Hyman AA, Bowerman B, Peter M
Nature435(7046)1257-61(2005 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SCCRO3 functions as a tumor suppressor by antagonizing the neddylation activity of SCCRO
Title: SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1).

DCUN1D3 is a novel UVC-response gene involved in cell cycle regulation and cell survival.
Title: DCUN1D3, a novel UVC-responsive gene that is involved in cell cycle progression and cell growth.

The following DCUN1D3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DCUN1D3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu07251	NM_173475.4 Latest version!	Homo sapiens defective in cullin neddylation 1 domain containing 3 (DCUN1D3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu07251	NM_173475.2	Homo sapiens DCN1, defective in cullin neddylation 1, domain containing 3 (DCUN1D3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu07251	NM_173475.3	Homo sapiens defective in cullin neddylation 1 domain containing 3 (DCUN1D3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DCUN1D3 ( NM_173475.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_775746.1 Homo sapiens defective in cullin neddylation 1 domain containing 3 (DCUN1D3), mRNA.

Price & Availability↑

CloneID	OHu07251
Clone ID Related Accession (Same CDS sequence)	NM_173475.3 , NM_173475.2 , NM_173475.4
Accession Version	NM_173475.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 915bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	DCN1-like protein 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA545688.1, BC040442.1, AC002394.1, AC004381.1 and AK027199.1. On Apr 12, 2016 this sequence version replaced NM_173475.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.13472.1, SRR1803611.205494.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGGCCAGT GTGTCACCAA GTGTAAGAAT CCCTCATCGA CCCTGGGCAG CAAAAATGGA 
GACCGTGAGC CCAGCAACAA GTCACATAGC AGGAGGGGTG CAGGCCACCG TGAGGAGCAG 
GTACCACCCT GTGGCAAGCC AGGTGGAGAT ATCCTCGTCA ACGGGACCAA GAAGGCCGAG 
GCTGCCACTG AGGCCTGCCA GCTGCCAACG TCCTCGGGAG ATGCTGGGAG GGAGTCCAAG 
TCCAATGCCG AGGAGTCTTC CTTGCAAAGA TTGGAAGAAC TGTTCAGGCG CTACAAGGAT 
GAGCGGGAAG ATGCAATTTT GGAGGAAGGC ATGGAGCGCT TTTGCAATGA CCTGTGTGTT 
GACCCCACAG AATTTCGAGT GCTGCTCTTG GCTTGGAAGT TCCAGGCTGC AACCATGTGC 
AAATTCACCA GGAAGGAGTT TTTTGATGGC TGCAAAGCAA TAAGTGCAGA CAGCATTGAC 
GGAATCTGTG CACGGTTCCC TAGCCTCTTA ACAGAAGCCA AACAAGAGGA TAAATTCAAG 
GATCTCTACC GGTTTACATT TCAGTTTGGC CTGGACTCTG AAGAAGGGCA GCGGTCACTG 
CATCGGGAAA TAGCCATTGC CCTGTGGAAA CTAGTCTTTA CCCAGAACAA TCCTCCGGTA 
TTGGACCAAT GGCTAAACTT CCTAACAGAG AACCCCTCGG GGATCAAGGG CATCTCCCGG 
GACACTTGGA ACATGTTCCT TAACTTCACT CAGGTGATTG GCCCTGACCT CAGCAACTAC 
AGTGAAGATG AGGCCTGGCC AAGTCTCTTT GACACCTTTG TGGAGTGGGA AATGGAGCGA 
AGGAAAAGAG AAGGGGAAGG GAGAGGTGCA CTCAGCTCAG GGCCTGAGGG CTTGTGTCCC 
GAGGAGCAGA CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_775746.1
CDS	261..1175
Translation	MGQCVTKCKNPSSTLGSKNGDREPSNKSHSRRGAGHREEQVPPCGKPGGDILVNGTKKAEAATEACQLPTSSGDAGRESKSNAEESSLQRLEELFRRYKDEREDAILEEGMERFCNDLCVDPTEFRVLLLAWKFQAATMCKFTRKEFFDGCKAISADSIDGICARFPSLLTEAKQEDKFKDLYRFTFQFGLDSEEGQRSLHREIAIALWKLVFTQNNPPVLDQWLNFLTENPSGIKGISRDTWNMFLNFTQVIGPDLSNYSEDEAWPSLFDTFVEWEMERRKREGEGRGALSSGPEGLCPEEQT

Target ORF information:

RefSeq Version	NM_173475.3
Organism	Homo sapiens(human)
Definition	Homo sapiens defective in cullin neddylation 1 domain containing 3 (DCUN1D3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173475.3

ORF Insert Sequence:

ATGGGCCAGT GTGTCACCAA GTGTAAGAAT CCCTCATCGA CCCTGGGCAG CAAAAATGGA 
GACCGTGAGC CCAGCAACAA GTCACATAGC AGGAGGGGTG CAGGCCACCG TGAGGAGCAG 
GTACCACCCT GTGGCAAGCC AGGTGGAGAT ATCCTCGTCA ACGGGACCAA GAAGGCCGAG 
GCTGCCACTG AGGCCTGCCA GCTGCCAACG TCCTCGGGAG ATGCTGGGAG GGAGTCCAAG 
TCCAATGCCG AGGAGTCTTC CTTGCAAAGA TTGGAAGAAC TGTTCAGGCG CTACAAGGAT 
GAGCGGGAAG ATGCAATTTT GGAGGAAGGC ATGGAGCGCT TTTGCAATGA CCTGTGTGTT 
GACCCCACAG AATTTCGAGT GCTGCTCTTG GCTTGGAAGT TCCAGGCTGC AACCATGTGC 
AAATTCACCA GGAAGGAGTT TTTTGATGGC TGCAAAGCAA TAAGTGCAGA CAGCATTGAC 
GGAATCTGTG CACGGTTCCC TAGCCTCTTA ACAGAAGCCA AACAAGAGGA TAAATTCAAG 
GATCTCTACC GGTTTACATT TCAGTTTGGC CTGGACTCTG AAGAAGGGCA GCGGTCACTG 
CATCGGGAAA TAGCCATTGC CCTGTGGAAA CTAGTCTTTA CCCAGAACAA TCCTCCGGTA 
TTGGACCAAT GGCTAAACTT CCTAACAGAG AACCCCTCGG GGATCAAGGG CATCTCCCGG 
GACACTTGGA ACATGTTCCT TAACTTCACT CAGGTGATTG GCCCTGACCT CAGCAACTAC 
AGTGAAGATG AGGCCTGGCC AAGTCTCTTT GACACCTTTG TGGAGTGGGA AATGGAGCGA 
AGGAAAAGAG AAGGGGAAGG GAGAGGTGCA CTCAGCTCAG GGCCTGAGGG CTTGTGTCCC 
GAGGAGCAGA CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DCUN1D3 ( NM_173475.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_775746.1 Homo sapiens DCN1, defective in cullin neddylation 1, domain containing 3 (DCUN1D3), mRNA.

Price & Availability↑

CloneID	OHu07251
Clone ID Related Accession (Same CDS sequence)	NM_173475.3 , NM_173475.2 , NM_173475.4
Accession Version	NM_173475.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 915bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-05-04
Organism	Homo sapiens(Human)
Product	DCN1-like protein 3
Comment

ATGGGCCAGT GTGTCACCAA GTGTAAGAAT CCCTCATCGA CCCTGGGCAG CAAAAATGGA 
GACCGTGAGC CCAGCAACAA GTCACATAGC AGGAGGGGTG CAGGCCACCG TGAGGAGCAG 
GTACCACCCT GTGGCAAGCC AGGTGGAGAT ATCCTCGTCA ACGGGACCAA GAAGGCCGAG 
GCTGCCACTG AGGCCTGCCA GCTGCCAACG TCCTCGGGAG ATGCTGGGAG GGAGTCCAAG 
TCCAATGCCG AGGAGTCTTC CTTGCAAAGA TTGGAAGAAC TGTTCAGGCG CTACAAGGAT 
GAGCGGGAAG ATGCAATTTT GGAGGAAGGC ATGGAGCGCT TTTGCAATGA CCTGTGTGTT 
GACCCCACAG AATTTCGAGT GCTGCTCTTG GCTTGGAAGT TCCAGGCTGC AACCATGTGC 
AAATTCACCA GGAAGGAGTT TTTTGATGGC TGCAAAGCAA TAAGTGCAGA CAGCATTGAC 
GGAATCTGTG CACGGTTCCC TAGCCTCTTA ACAGAAGCCA AACAAGAGGA TAAATTCAAG 
GATCTCTACC GGTTTACATT TCAGTTTGGC CTGGACTCTG AAGAAGGGCA GCGGTCACTG 
CATCGGGAAA TAGCCATTGC CCTGTGGAAA CTAGTCTTTA CCCAGAACAA TCCTCCGGTA 
TTGGACCAAT GGCTAAACTT CCTAACAGAG AACCCCTCGG GGATCAAGGG CATCTCCCGG 
GACACTTGGA ACATGTTCCT TAACTTCACT CAGGTGATTG GCCCTGACCT CAGCAACTAC 
AGTGAAGATG AGGCCTGGCC AAGTCTCTTT GACACCTTTG TGGAGTGGGA AATGGAGCGA 
AGGAAAAGAG AAGGGGAAGG GAGAGGTGCA CTCAGCTCAG GGCCTGAGGG CTTGTGTCCC 
GAGGAGCAGA CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_775746.1
Translation	MGQCVTKCKNPSSTLGSKNGDREPSNKSHSRRGAGHREEQVPPCGKPGGDILVNGTKKAEAATEACQLPTSSGDAGRESKSNAEESSLQRLEELFRRYKDEREDAILEEGMERFCNDLCVDPTEFRVLLLAWKFQAATMCKFTRKEFFDGCKAISADSIDGICARFPSLLTEAKQEDKFKDLYRFTFQFGLDSEEGQRSLHREIAIALWKLVFTQNNPPVLDQWLNFLTENPSGIKGISRDTWNMFLNFTQVIGPDLSNYSEDEAWPSLFDTFVEWEMERRKREGEGRGALSSGPEGLCPEEQT

Target ORF information:

RefSeq Version	NM_173475.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens DCN1, defective in cullin neddylation 1, domain containing 3 (DCUN1D3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173475.2

ORF Insert Sequence:

ATGGGCCAGT GTGTCACCAA GTGTAAGAAT CCCTCATCGA CCCTGGGCAG CAAAAATGGA 
GACCGTGAGC CCAGCAACAA GTCACATAGC AGGAGGGGTG CAGGCCACCG TGAGGAGCAG 
GTACCACCCT GTGGCAAGCC AGGTGGAGAT ATCCTCGTCA ACGGGACCAA GAAGGCCGAG 
GCTGCCACTG AGGCCTGCCA GCTGCCAACG TCCTCGGGAG ATGCTGGGAG GGAGTCCAAG 
TCCAATGCCG AGGAGTCTTC CTTGCAAAGA TTGGAAGAAC TGTTCAGGCG CTACAAGGAT 
GAGCGGGAAG ATGCAATTTT GGAGGAAGGC ATGGAGCGCT TTTGCAATGA CCTGTGTGTT 
GACCCCACAG AATTTCGAGT GCTGCTCTTG GCTTGGAAGT TCCAGGCTGC AACCATGTGC 
AAATTCACCA GGAAGGAGTT TTTTGATGGC TGCAAAGCAA TAAGTGCAGA CAGCATTGAC 
GGAATCTGTG CACGGTTCCC TAGCCTCTTA ACAGAAGCCA AACAAGAGGA TAAATTCAAG 
GATCTCTACC GGTTTACATT TCAGTTTGGC CTGGACTCTG AAGAAGGGCA GCGGTCACTG 
CATCGGGAAA TAGCCATTGC CCTGTGGAAA CTAGTCTTTA CCCAGAACAA TCCTCCGGTA 
TTGGACCAAT GGCTAAACTT CCTAACAGAG AACCCCTCGG GGATCAAGGG CATCTCCCGG 
GACACTTGGA ACATGTTCCT TAACTTCACT CAGGTGATTG GCCCTGACCT CAGCAACTAC 
AGTGAAGATG AGGCCTGGCC AAGTCTCTTT GACACCTTTG TGGAGTGGGA AATGGAGCGA 
AGGAAAAGAG AAGGGGAAGG GAGAGGTGCA CTCAGCTCAG GGCCTGAGGG CTTGTGTCCC 
GAGGAGCAGA CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DCUN1D3 ( NM_173475.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_775746.1 Homo sapiens defective in cullin neddylation 1 domain containing 3 (DCUN1D3), mRNA.

Price & Availability↑

CloneID	OHu07251
Clone ID Related Accession (Same CDS sequence)	NM_173475.3 , NM_173475.2 , NM_173475.4
Accession Version	NM_173475.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 915bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	DCN1-like protein 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA545688.1, BC040442.1, AC002394.1, AC004381.1 and AK027199.1. On Nov 23, 2018 this sequence version replaced NM_173475.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.13472.1, BC040442.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000324344.9/ ENSP00000319482.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCCAGT GTGTCACCAA GTGTAAGAAT CCCTCATCGA CCCTGGGCAG CAAAAATGGA 
GACCGTGAGC CCAGCAACAA GTCACATAGC AGGAGGGGTG CAGGCCACCG TGAGGAGCAG 
GTACCACCCT GTGGCAAGCC AGGTGGAGAT ATCCTCGTCA ACGGGACCAA GAAGGCCGAG 
GCTGCCACTG AGGCCTGCCA GCTGCCAACG TCCTCGGGAG ATGCTGGGAG GGAGTCCAAG 
TCCAATGCCG AGGAGTCTTC CTTGCAAAGA TTGGAAGAAC TGTTCAGGCG CTACAAGGAT 
GAGCGGGAAG ATGCAATTTT GGAGGAAGGC ATGGAGCGCT TTTGCAATGA CCTGTGTGTT 
GACCCCACAG AATTTCGAGT GCTGCTCTTG GCTTGGAAGT TCCAGGCTGC AACCATGTGC 
AAATTCACCA GGAAGGAGTT TTTTGATGGC TGCAAAGCAA TAAGTGCAGA CAGCATTGAC 
GGAATCTGTG CACGGTTCCC TAGCCTCTTA ACAGAAGCCA AACAAGAGGA TAAATTCAAG 
GATCTCTACC GGTTTACATT TCAGTTTGGC CTGGACTCTG AAGAAGGGCA GCGGTCACTG 
CATCGGGAAA TAGCCATTGC CCTGTGGAAA CTAGTCTTTA CCCAGAACAA TCCTCCGGTA 
TTGGACCAAT GGCTAAACTT CCTAACAGAG AACCCCTCGG GGATCAAGGG CATCTCCCGG 
GACACTTGGA ACATGTTCCT TAACTTCACT CAGGTGATTG GCCCTGACCT CAGCAACTAC 
AGTGAAGATG AGGCCTGGCC AAGTCTCTTT GACACCTTTG TGGAGTGGGA AATGGAGCGA 
AGGAAAAGAG AAGGGGAAGG GAGAGGTGCA CTCAGCTCAG GGCCTGAGGG CTTGTGTCCC 
GAGGAGCAGA CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_775746.1
CDS	261..1175
Translation	MGQCVTKCKNPSSTLGSKNGDREPSNKSHSRRGAGHREEQVPPCGKPGGDILVNGTKKAEAATEACQLPTSSGDAGRESKSNAEESSLQRLEELFRRYKDEREDAILEEGMERFCNDLCVDPTEFRVLLLAWKFQAATMCKFTRKEFFDGCKAISADSIDGICARFPSLLTEAKQEDKFKDLYRFTFQFGLDSEEGQRSLHREIAIALWKLVFTQNNPPVLDQWLNFLTENPSGIKGISRDTWNMFLNFTQVIGPDLSNYSEDEAWPSLFDTFVEWEMERRKREGEGRGALSSGPEGLCPEEQT

Target ORF information:

RefSeq Version	NM_173475.4
Organism	Homo sapiens(human)
Definition	Homo sapiens defective in cullin neddylation 1 domain containing 3 (DCUN1D3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173475.4

ORF Insert Sequence:

ATGGGCCAGT GTGTCACCAA GTGTAAGAAT CCCTCATCGA CCCTGGGCAG CAAAAATGGA 
GACCGTGAGC CCAGCAACAA GTCACATAGC AGGAGGGGTG CAGGCCACCG TGAGGAGCAG 
GTACCACCCT GTGGCAAGCC AGGTGGAGAT ATCCTCGTCA ACGGGACCAA GAAGGCCGAG 
GCTGCCACTG AGGCCTGCCA GCTGCCAACG TCCTCGGGAG ATGCTGGGAG GGAGTCCAAG 
TCCAATGCCG AGGAGTCTTC CTTGCAAAGA TTGGAAGAAC TGTTCAGGCG CTACAAGGAT 
GAGCGGGAAG ATGCAATTTT GGAGGAAGGC ATGGAGCGCT TTTGCAATGA CCTGTGTGTT 
GACCCCACAG AATTTCGAGT GCTGCTCTTG GCTTGGAAGT TCCAGGCTGC AACCATGTGC 
AAATTCACCA GGAAGGAGTT TTTTGATGGC TGCAAAGCAA TAAGTGCAGA CAGCATTGAC 
GGAATCTGTG CACGGTTCCC TAGCCTCTTA ACAGAAGCCA AACAAGAGGA TAAATTCAAG 
GATCTCTACC GGTTTACATT TCAGTTTGGC CTGGACTCTG AAGAAGGGCA GCGGTCACTG 
CATCGGGAAA TAGCCATTGC CCTGTGGAAA CTAGTCTTTA CCCAGAACAA TCCTCCGGTA 
TTGGACCAAT GGCTAAACTT CCTAACAGAG AACCCCTCGG GGATCAAGGG CATCTCCCGG 
GACACTTGGA ACATGTTCCT TAACTTCACT CAGGTGATTG GCCCTGACCT CAGCAACTAC 
AGTGAAGATG AGGCCTGGCC AAGTCTCTTT GACACCTTTG TGGAGTGGGA AATGGAGCGA 
AGGAAAAGAG AAGGGGAAGG GAGAGGTGCA CTCAGCTCAG GGCCTGAGGG CTTGTGTCCC 
GAGGAGCAGA CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

DCUN1D3 activates SCFSKP2 ubiquitin E3 ligase activity and cell cycle progression under UV damage.
Oncotarget7(36)58483-58491(2016 Sep)
Zhang S,Huang J,Shi T,Hu F,Zhang L,Zhou PK,Ma D,Ma T,Qiu X

SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1).
The Journal of biological chemistry289(50)34728-42(2014 Dec)
Huang G,Stock C,Bommelj? CC,Weeda VB,Shah K,Bains S,Buss E,Shaha M,Rechler W,Ramanathan SY,Singh B

The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes.
Proceedings of the National Academy of Sciences of the United States of America106(30)12365-70(2009 Jul)
Meyer-Schaller N,Chou YC,Sumara I,Martin DD,Kurz T,Katheder N,Hofmann K,Berthiaume LG,Sicheri F,Peter M

DCUN1D3, a novel UVC-responsive gene that is involved in cell cycle progression and cell growth.
Cancer science99(11)2128-35(2008 Nov)
Ma T,Shi T,Huang J,Wu L,Hu F,He P,Deng W,Gao P,Zhang Y,Song Q,Ma D,Qiu X

The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae.
Nature435(7046)1257-61(2005 Jun)
Kurz T,Ozl? N,Rudolf F,O'Rourke SM,Luke B,Hofmann K,Hyman AA,Bowerman B,Peter M

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DCUN1D3 cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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