RAB39B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RAB39B
Entrez Gene ID	116442
Full Name	RAB39B, member RAS oncogene family
Synonyms	BGMR,MRX72,WSMN,WSN
General protein information	Preferred Names RAB39B, member RAS oncogene family Names ras-related protein Rab-39B Waisman syndrome Waisman syndrome (basal ganglion disorder with mental retardation)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq28
Summary	This gene encodes a member of the Rab family of proteins. Rab proteins are small GTPases that are involved in vesicular trafficking. Mutations in this gene are associated with X-linked cognitive disability. [provided by RefSeq, Aug 2013].
Disorder MIM:	300774
Disorder Html:	Mental retardation, X-linked 72, 300271 (3); ?Waisman syndrome, 311510 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_171998.4	NP_741995.1	ras-related protein Rab-39B
NM_171998.3	NP_741995.1	ras-related protein Rab-39B

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	rab39b	NP_001073492.1
Danio rerio (zebrafish)	tmem230	NP_001092211.1
Caenorhabditis elegans (roundworm)	rab-39	NP_495984.2
Homo sapiens (human)	RAB39B	NP_741995.1
	RAB39B	XP_001098848.1
Bos taurus (cattle)	RAB39B	NP_001069563.1
Mus musculus (house mouse)	Rab39b	NP_780331.1
Gallus gallus (chicken)	RAB39B	XP_420326.3
Drosophila melanogaster (fruit fly)	Rab39	NP_001245568.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000433	XP_310666.5
Xenopus tropicalis (tropical clawed frog)	LOC100486510	XP_002931827.2
Canis lupus familiaris (dog)	RAB39B	XP_003435654.2
Pan troglodytes (chimpanzee)	RAB39B	XP_003317848.1

Gene Ontology
Bibliography

Related articles in PubMed

X-linked Parkinsonism with Intellectual Disability caused by novel mutations and somatic mosaicism in RAB39B gene.
Ciammola A, Carrera P, Di Fonzo A, Sassone J, Villa R, Poletti B, Ferrari M, Girotti F, Monfrini E, Buongarzone G, Silani V, Cinnante CM, Mignogna ML, D'Adamo P, Bonati MT
Parkinsonism & related disorders44142-146(2017 Nov)

Lack of RAB39B mutations in early-onset and familial Parkinson's disease in a Taiwanese cohort.
Lin HH, Wu RM, Lin HI, Chen ML, Tai CH, Lin CH
Neurobiology of aging50169.e3-169.e4(2017 Feb)

Mutations in
Woodbury-Smith M, Deneault E, Yuen RKC, Walker S, Zarrei M, Pellecchia G, Howe JL, Hoang N, Uddin M, Marshall CR, Chrysler C, Thompson A, Szatmari P, Scherer SW
Molecular autism859(2017)

A novel RAB39B gene mutation in X-linked juvenile parkinsonism with basal ganglia calcification.
Shi CH, Zhang SY, Yang ZH, Yang J, Shang DD, Mao CY, Liu H, Hou HM, Shi MM, Wu J, Xu YM
Movement disorders : official journal of the Movement Disorder Society31(12)1905-1909(2016 Dec)

RAB39B gene mutations are not linked to familial Parkinson's disease in China.
Kang JF, Luo Y, Tang BS, Wan CM, Yang Y, Li K, Liu ZH, Sun QY, Xu Q, Yan XX, Guo JF
Scientific reports634502(2016 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RAB39B mutations are not a common cause of early-onset or familial PD in our Taiwanese population.
Title: Lack of RAB39B mutations in early-onset and familial Parkinson's disease in a Taiwanese cohort.

X-linked juvenile parkinsonism could be caused by a RAB39B mutation, and basal ganglia calcification may be a novel clinical feature of RAB39B-related parkinsonism.
Title: A novel RAB39B gene mutation in X-linked juvenile parkinsonism with basal ganglia calcification.

RAB39B mutations are not a common cause of Parkinson's disease or dementia with Lewy bodies in Caucasian population
Title: RAB39B gene mutations are not a common cause of Parkinson's disease or dementia with Lewy bodies.

RAB39B mutations are a rare finding in Parkinson disease patients
Title: RAB39B mutations are a rare finding in Parkinson disease patients.

RAB39B is an essential regulator of vesicular-trafficking in clinically typical Parkinson's disease
Title: The RAB39B p.G192R mutation causes X-linked dominant Parkinson's disease.

The following RAB39B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RAB39B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21055	NM_171998.4 Latest version!	Homo sapiens RAB39B, member RAS oncogene family (RAB39B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu21055	NM_171998.3	Homo sapiens RAB39B, member RAS oncogene family (RAB39B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RAB39B ( NM_171998.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_741995.1 Homo sapiens RAB39B, member RAS oncogene family (RAB39B), mRNA.

Price & Availability↑

CloneID	OHu21055
Clone ID Related Accession (Same CDS sequence)	NM_171998.4 , NM_171998.3
Accession Version	NM_171998.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	ras-related protein Rab-39B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC009714.1, AL834460.1, BM721593.1 and H30898.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_171998.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.93953.1, SRR1803612.57940.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000369454.4/ ENSP00000358466.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGGCCA TCTGGCTGTA CCAGTTCCGG CTCATTGTCA TCGGGGATTC CACAGTGGGC 
AAGTCCTGCC TGATCCGCCG CTTCACCGAG GGTCGCTTTG CCCAGGTTTC TGACCCCACC 
GTGGGGGTGG ATTTTTTCTC CCGCTTGGTG GAGATCGAGC CAGGAAAACG CATCAAGCTC 
CAGATCTGGG ATACCGCGGG TCAAGAGAGG TTCAGATCCA TCACTCGCGC CTACTACAGG 
AACTCAGTAG GTGGTCTTCT CTTATTTGAC ATTACCAACC GCAGGTCCTT CCAGAATGTC 
CATGAGTGGT TAGAAGAGAC CAAAGTACAC GTTCAGCCCT ACCAAATTGT ATTTGTTCTG 
GTGGGTCACA AGTGTGACCT GGATACACAG AGGCAAGTGA CTCGCCACGA GGCCGAGAAA 
CTGGCTGCTG CATACGGCAT GAAGTACATT GAAACGTCAG CCCGAGATGC CATTAATGTG 
GAGAAAGCCT TCACAGACCT GACAAGAGAC ATATATGAGC TGGTTAAAAG GGGGGAGATT 
ACAATCCAGG AGGGCTGGGA AGGGGTGAAG AGTGGATTTG TACCAAATGT GGTTCACTCT 
TCAGAAGAGG TTGTCAAATC AGAGAGGAGA TGTTTGTGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_741995.1
CDS	204..845
Translation	MEAIWLYQFRLIVIGDSTVGKSCLIRRFTEGRFAQVSDPTVGVDFFSRLVEIEPGKRIKLQIWDTAGQERFRSITRAYYRNSVGGLLLFDITNRRSFQNVHEWLEETKVHVQPYQIVFVLVGHKCDLDTQRQVTRHEAEKLAAAYGMKYIETSARDAINVEKAFTDLTRDIYELVKRGEITIQEGWEGVKSGFVPNVVHSSEEVVKSERRCLC

Target ORF information:

RefSeq Version	NM_171998.4
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB39B, member RAS oncogene family (RAB39B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_171998.4

ORF Insert Sequence:

ATGGAGGCCA TCTGGCTGTA CCAGTTCCGG CTCATTGTCA TCGGGGATTC CACAGTGGGC 
AAGTCCTGCC TGATCCGCCG CTTCACCGAG GGTCGCTTTG CCCAGGTTTC TGACCCCACC 
GTGGGGGTGG ATTTTTTCTC CCGCTTGGTG GAGATCGAGC CAGGAAAACG CATCAAGCTC 
CAGATCTGGG ATACCGCGGG TCAAGAGAGG TTCAGATCCA TCACTCGCGC CTACTACAGG 
AACTCAGTAG GTGGTCTTCT CTTATTTGAC ATTACCAACC GCAGGTCCTT CCAGAATGTC 
CATGAGTGGT TAGAAGAGAC CAAAGTACAC GTTCAGCCCT ACCAAATTGT ATTTGTTCTG 
GTGGGTCACA AGTGTGACCT GGATACACAG AGGCAAGTGA CTCGCCACGA GGCCGAGAAA 
CTGGCTGCTG CATACGGCAT GAAGTACATT GAAACGTCAG CCCGAGATGC CATTAATGTG 
GAGAAAGCCT TCACAGACCT GACAAGAGAC ATATATGAGC TGGTTAAAAG GGGGGAGATT 
ACAATCCAGG AGGGCTGGGA AGGGGTGAAG AGTGGATTTG TACCAAATGT GGTTCACTCT 
TCAGAAGAGG TTGTCAAATC AGAGAGGAGA TGTTTGTGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAB39B ( NM_171998.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_741995.1 Homo sapiens RAB39B, member RAS oncogene family (RAB39B), mRNA.

Price & Availability↑

CloneID	OHu21055
Clone ID Related Accession (Same CDS sequence)	NM_171998.4 , NM_171998.3
Accession Version	NM_171998.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-31
Organism	Homo sapiens(human)
Product	ras-related protein Rab-39B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC009714.1, AL834460.1, BM721593.1 and H30898.1. This sequence is a reference standard in the RefSeqGene project. On Aug 28, 2013 this sequence version replaced NM_171998.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC009714.1, SRR1660805.48292.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGCCA TCTGGCTGTA CCAGTTCCGG CTCATTGTCA TCGGGGATTC CACAGTGGGC 
AAGTCCTGCC TGATCCGCCG CTTCACCGAG GGTCGCTTTG CCCAGGTTTC TGACCCCACC 
GTGGGGGTGG ATTTTTTCTC CCGCTTGGTG GAGATCGAGC CAGGAAAACG CATCAAGCTC 
CAGATCTGGG ATACCGCGGG TCAAGAGAGG TTCAGATCCA TCACTCGCGC CTACTACAGG 
AACTCAGTAG GTGGTCTTCT CTTATTTGAC ATTACCAACC GCAGGTCCTT CCAGAATGTC 
CATGAGTGGT TAGAAGAGAC CAAAGTACAC GTTCAGCCCT ACCAAATTGT ATTTGTTCTG 
GTGGGTCACA AGTGTGACCT GGATACACAG AGGCAAGTGA CTCGCCACGA GGCCGAGAAA 
CTGGCTGCTG CATACGGCAT GAAGTACATT GAAACGTCAG CCCGAGATGC CATTAATGTG 
GAGAAAGCCT TCACAGACCT GACAAGAGAC ATATATGAGC TGGTTAAAAG GGGGGAGATT 
ACAATCCAGG AGGGCTGGGA AGGGGTGAAG AGTGGATTTG TACCAAATGT GGTTCACTCT 
TCAGAAGAGG TTGTCAAATC AGAGAGGAGA TGTTTGTGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_741995.1
CDS	302..943
Translation	MEAIWLYQFRLIVIGDSTVGKSCLIRRFTEGRFAQVSDPTVGVDFFSRLVEIEPGKRIKLQIWDTAGQERFRSITRAYYRNSVGGLLLFDITNRRSFQNVHEWLEETKVHVQPYQIVFVLVGHKCDLDTQRQVTRHEAEKLAAAYGMKYIETSARDAINVEKAFTDLTRDIYELVKRGEITIQEGWEGVKSGFVPNVVHSSEEVVKSERRCLC

Target ORF information:

RefSeq Version	NM_171998.3
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB39B, member RAS oncogene family (RAB39B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_171998.3

ORF Insert Sequence:

ATGGAGGCCA TCTGGCTGTA CCAGTTCCGG CTCATTGTCA TCGGGGATTC CACAGTGGGC 
AAGTCCTGCC TGATCCGCCG CTTCACCGAG GGTCGCTTTG CCCAGGTTTC TGACCCCACC 
GTGGGGGTGG ATTTTTTCTC CCGCTTGGTG GAGATCGAGC CAGGAAAACG CATCAAGCTC 
CAGATCTGGG ATACCGCGGG TCAAGAGAGG TTCAGATCCA TCACTCGCGC CTACTACAGG 
AACTCAGTAG GTGGTCTTCT CTTATTTGAC ATTACCAACC GCAGGTCCTT CCAGAATGTC 
CATGAGTGGT TAGAAGAGAC CAAAGTACAC GTTCAGCCCT ACCAAATTGT ATTTGTTCTG 
GTGGGTCACA AGTGTGACCT GGATACACAG AGGCAAGTGA CTCGCCACGA GGCCGAGAAA 
CTGGCTGCTG CATACGGCAT GAAGTACATT GAAACGTCAG CCCGAGATGC CATTAATGTG 
GAGAAAGCCT TCACAGACCT GACAAGAGAC ATATATGAGC TGGTTAAAAG GGGGGAGATT 
ACAATCCAGG AGGGCTGGGA AGGGGTGAAG AGTGGATTTG TACCAAATGT GGTTCACTCT 
TCAGAAGAGG TTGTCAAATC AGAGAGGAGA TGTTTGTGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

X-linked Parkinsonism with Intellectual Disability caused by novel mutations and somatic mosaicism in RAB39B gene.
Parkinsonism & related disorders44142-146(2017 Nov)
Ciammola A,Carrera P,Di Fonzo A,Sassone J,Villa R,Poletti B,Ferrari M,Girotti F,Monfrini E,Buongarzone G,Silani V,Cinnante CM,Mignogna ML,D'Adamo P,Bonati MT

Lack of RAB39B mutations in early-onset and familial Parkinson's disease in a Taiwanese cohort.
Neurobiology of aging50169.e3-169.e4(2017 Feb)
Lin HH,Wu RM,Lin HI,Chen ML,Tai CH,Lin CH

Mutations in
Molecular autism859(2017)
Woodbury-Smith M,Deneault E,Yuen RKC,Walker S,Zarrei M,Pellecchia G,Howe JL,Hoang N,Uddin M,Marshall CR,Chrysler C,Thompson A,Szatmari P,Scherer SW

A novel RAB39B gene mutation in X-linked juvenile parkinsonism with basal ganglia calcification.
Movement disorders : official journal of the Movement Disorder Society31(12)1905-1909(2016 Dec)
Shi CH,Zhang SY,Yang ZH,Yang J,Shang DD,Mao CY,Liu H,Hou HM,Shi MM,Wu J,Xu YM

RAB39B gene mutations are not linked to familial Parkinson's disease in China.
Scientific reports634502(2016 Oct)
Kang JF,Luo Y,Tang BS,Wan CM,Yang Y,Li K,Liu ZH,Sun QY,Xu Q,Yan XX,Guo JF

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RAB39B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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Services & Products

見積依頼

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電話

FAX

オンラインフォーム