CASC4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CASC4
Entrez Gene ID	113201
Full Name	cancer susceptibility 4
Synonyms	H63
General protein information	Preferred Names cancer susceptibility 4 Names protein CASC4 cancer susceptibility candidate 4 cancer susceptibility candidate gene 4 protein gene associated with HER-2/neu overexpression
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q15.3
Summary	The increased expression level of this gene is associated with HER-2/neu proto-oncogene overexpression. Amplification and resulting overexpression of this proto-oncogene are found in approximately 30% of human breast and 20% of human ovarian cancers. Alternatively spliced variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Dec 2010].

mRNA and Protein(s)

mRNA	Protein	Name
NM_138423.3	NP_612432.2	protein CASC4 isoform a
XM_017021880.2	XP_016877369.1	protein CASC4 isoform X1
NM_177974.3	NP_816929.1	protein CASC4 isoform b
XM_017021880.1	XP_016877369.1	protein CASC4 isoform X1
NM_138423.4	NP_612432.2	protein CASC4 isoform a
NM_177974.2	NP_816929.1	protein CASC4 isoform b

Pathways from BioSystems

Homologies

Bos taurus (cattle)	CASC4	NP_001075206.1
Rattus norvegicus (Norway rat)	Casc4	NP_001258212.1
Homo sapiens (human)	CASC4	NP_612432.2
Pan troglodytes (chimpanzee)	CASC4	XP_509554.2
Gallus gallus (chicken)	CASC4	NP_001025727.1
Canis lupus familiaris (dog)	CASC4	XP_850044.2
Xenopus tropicalis (tropical clawed frog)	casc4	NP_001016088.1
	CASC4	XP_002804796.1
Mus musculus (house mouse)	Casc4	NP_001192298.1
Danio rerio (zebrafish)	casc4	XP_005168998.1

Gene Ontology
Bibliography

Related articles in PubMed

SRSF1-Regulated Alternative Splicing in Breast Cancer.
Anczuk?w O, Akerman M, Cl?ry A, Wu J, Shen C, Shirole NH, Raimer A, Sun S, Jensen MA, Hua Y, Allain FH, Krainer AR
Molecular cell60(1)105-17(2015 Oct)

Expression of HER2/neu does not correlate with survival in soft tissue sarcoma.
Sato T, Peiper M, Heinecke A, Zurakowski D, Eisenberger CF, Hosch S, Knoefel WT, Izbicki JR
Onkologie26(3)268-71(2003 Jun)

[Evaluation of her-2/neu amplification/overexpression in OSCC with fluorescence in situ hybridization (FISH) and immunohistochemistry].
Scheer M, Prange W, Petmecky K, Schirmacher P, Z?ller JE, K?bler AC
Mund-, Kiefer- und Gesichtschirurgie : MKG7(3)138-45(2003 May)

Identification of differentially expressed genes associated with HER-2/neu overexpression in human breast cancer cells.
Oh JJ, Grosshans DR, Wong SG, Slamon DJ
Nucleic acids research27(20)4008-17(1999 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Of 62 analyzed specimens, 43 tumors were HER2/neu negative compared to 19 HER2/neu positive tumors. Kaplan-Meier analysis indicated no difference in survival according to HER2/neu expression (p = 0.31, log-rank test = 1.10
Title: Expression of HER2/neu does not correlate with survival in soft tissue sarcoma.

In spite of missing correlation between survival and her-2/ neu overexpression in our study, the predictive value of the her-2/ neu protooncogene in adjuvant therapy in OSCC needs further investigation.
Title: [Evaluation of her-2/neu amplification/overexpression in OSCC with fluorescence in situ hybridization (FISH) and immunohistochemistry].

The following CASC4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CASC4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu32269	NM_138423.4 Latest version!	Homo sapiens cancer susceptibility 4 (CASC4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu10599	NM_177974.3 Latest version!	Homo sapiens cancer susceptibility 4 (CASC4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu85234	XM_017021880.2 Latest version!	Homo sapiens cancer susceptibility 4 (CASC4), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu85234	XM_017021880.1	Homo sapiens cancer susceptibility candidate 4 (CASC4), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu32269	NM_138423.3	Homo sapiens cancer susceptibility 4 (CASC4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00
OHu10599	NM_177974.2	Homo sapiens cancer susceptibility 4 (CASC4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CASC4 ( NM_138423.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_612432.2 Homo sapiens cancer susceptibility 4 (CASC4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu32269
Clone ID Related Accession (Same CDS sequence)	NM_138423.3 , NM_138423.4
Accession Version	NM_138423.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1311bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Homo sapiens(human)
Product	protein CASC4 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB229269.1, BC012124.1, AL832840.1 and BI467176.1. On Nov 22, 2018 this sequence version replaced NM_138423.3. Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (a). ##Evidence-Data-START## Transcript exon combination :: SRR1803617.32507.1, SRR1803611.134875.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000299957.11/ ENSP00000299957.6 RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTGGGTT TCGGGGCCAA CCGGCGGGCT GGCCGCCTGC CCTCTCTCGT GCTGGTGGTG 
CTGCTGGTGG TGATCGTCGT CCTCGCCTTC AACTACTGGA GCATCTCCTC CCGCCACGTC 
CTGCTTCAGG AGGAGGTGGC CGAGCTGCAG GGCCAGGTCC AGCGCACCGA AGTGGCCCGC 
GGGCGGCTGG AAAAGCGCAA TTCGGACCTC TTGCTGTTGG TGGACACGCA CAAGAAACAG 
ATCGACCAGA AGGAGGCCGA CTACGGCCGC CTCAGCAGCC GGCTGCAGGC CAGAGAGGGC 
CTCGGGAAGA GATGCGAGGA TGACAAGGTT AAACTACAGA ACAACATATC GTATCAGATG 
GCAGACATAC ATCATTTAAA GGAGCAACTT GCTGAGCTTC GTCAGGAATT TCTTCGACAA 
GAAGACCAGC TTCAGGACTA TAGGAAGAAC AATACTTACC TTGTGAAGAG GTTAGAATAT 
GAAAGTTTTC AGTGTGGACA GCAGATGAAG GAATTGAGAG CACAGCATGA AGAAAATATT 
AAAAAGTTAG CAGACCAGTT TTTAGAGGAA CAAAAGCAAG AGACCCAAAA GATTCAATCA 
AATGATGGAA AGGAATTGGA TATAAACAAT CAAGTAGTAC CTAAAAATAT TCCAAAAGTA 
GCTGAGAATG TTGCAGATAA GAATGAAGAA CCCTCAAGCA ATCATATTCC ACATGGGAAA 
GAACAAATCA AAAGAGGTGG TGATGCAGGG ATGCCTGGAA TAGAAGAGAA TGACCTAGCA 
AAAGTTGATG ATCTTCCCCC TGCTTTAAGG AAGCCTCCTA TTTCAGTTTC TCAACATGAA 
AGTCATCAAG CAATCTCCCA TCTTCCAACT GGACAACCTC TCTCCCCAAA TATGCCTCCA 
GATTCACACA TAAACCACAA TGGAAACCCC GGTACTTCAA AACAGAATCC TTCCAGTCCT 
CTTCAGCGTT TAATTCCAGG CTCAAACTTG GACAGTGAAC CCAGAATTCA AACAGATATA 
CTAAAGCAGG CTACCAAGGA CAGAGTCAGT GATTTCCATA AATTGAAGCA AAGCCGATTC 
TTTGATGAAA ATGAATCCCC TGTTGATCCG CAGCATGGCT CTAAACTGGC GGATTATAAT 
GGGGATGATG GTAACGTAGG TGAGTATGAG GCAGACAAGC AGGCTGAGCT GGCTTACAAT 
GAGGAAGAAG ATGGTGATGG TGGAGAGGAA GACGTCCAAG ATGATGAAGA ACGAGAGCTT 
CAAATGGATC CTGCAGACTA TGGAAAGCAA CATTTCAATG ATGTCCTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_612432.2
CDS	312..1622
Translation	MVGFGANRRAGRLPSLVLVVLLVVIVVLAFNYWSISSRHVLLQEEVAELQGQVQRTEVARGRLEKRNSDLLLLVDTHKKQIDQKEADYGRLSSRLQAREGLGKRCEDDKVKLQNNISYQMADIHHLKEQLAELRQEFLRQEDQLQDYRKNNTYLVKRLEYESFQCGQQMKELRAQHEENIKKLADQFLEEQKQETQKIQSNDGKELDINNQVVPKNIPKVAENVADKNEEPSSNHIPHGKEQIKRGGDAGMPGIEENDLAKVDDLPPALRKPPISVSQHESHQAISHLPTGQPLSPNMPPDSHINHNGNPGTSKQNPSSPLQRLIPGSNLDSEPRIQTDILKQATKDRVSDFHKLKQSRFFDENESPVDPQHGSKLADYNGDDGNVGEYEADKQAELAYNEEEDGDGGEEDVQDDEERELQMDPADYGKQHFNDVL

Target ORF information:

RefSeq Version	NM_138423.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cancer susceptibility 4 (CASC4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138423.4

ORF Insert Sequence:

ATGGTGGGTT TCGGGGCCAA CCGGCGGGCT GGCCGCCTGC CCTCTCTCGT GCTGGTGGTG 
CTGCTGGTGG TGATCGTCGT CCTCGCCTTC AACTACTGGA GCATCTCCTC CCGCCACGTC 
CTGCTTCAGG AGGAGGTGGC CGAGCTGCAG GGCCAGGTCC AGCGCACCGA AGTGGCCCGC 
GGGCGGCTGG AAAAGCGCAA TTCGGACCTC TTGCTGTTGG TGGACACGCA CAAGAAACAG 
ATCGACCAGA AGGAGGCCGA CTACGGCCGC CTCAGCAGCC GGCTGCAGGC CAGAGAGGGC 
CTCGGGAAGA GATGCGAGGA TGACAAGGTT AAACTACAGA ACAACATATC GTATCAGATG 
GCAGACATAC ATCATTTAAA GGAGCAACTT GCTGAGCTTC GTCAGGAATT TCTTCGACAA 
GAAGACCAGC TTCAGGACTA TAGGAAGAAC AATACTTACC TTGTGAAGAG GTTAGAATAT 
GAAAGTTTTC AGTGTGGACA GCAGATGAAG GAATTGAGAG CACAGCATGA AGAAAATATT 
AAAAAGTTAG CAGACCAGTT TTTAGAGGAA CAAAAGCAAG AGACCCAAAA GATTCAATCA 
AATGATGGAA AGGAATTGGA TATAAACAAT CAAGTAGTAC CTAAAAATAT TCCAAAAGTA 
GCTGAGAATG TTGCAGATAA GAATGAAGAA CCCTCAAGCA ATCATATTCC ACATGGGAAA 
GAACAAATCA AAAGAGGTGG TGATGCAGGG ATGCCTGGAA TAGAAGAGAA TGACCTAGCA 
AAAGTTGATG ATCTTCCCCC TGCTTTAAGG AAGCCTCCTA TTTCAGTTTC TCAACATGAA 
AGTCATCAAG CAATCTCCCA TCTTCCAACT GGACAACCTC TCTCCCCAAA TATGCCTCCA 
GATTCACACA TAAACCACAA TGGAAACCCC GGTACTTCAA AACAGAATCC TTCCAGTCCT 
CTTCAGCGTT TAATTCCAGG CTCAAACTTG GACAGTGAAC CCAGAATTCA AACAGATATA 
CTAAAGCAGG CTACCAAGGA CAGAGTCAGT GATTTCCATA AATTGAAGCA AAGCCGATTC 
TTTGATGAAA ATGAATCCCC TGTTGATCCG CAGCATGGCT CTAAACTGGC GGATTATAAT 
GGGGATGATG GTAACGTAGG TGAGTATGAG GCAGACAAGC AGGCTGAGCT GGCTTACAAT 
GAGGAAGAAG ATGGTGATGG TGGAGAGGAA GACGTCCAAG ATGATGAAGA ACGAGAGCTT 
CAAATGGATC CTGCAGACTA TGGAAAGCAA CATTTCAATG ATGTCCTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CASC4 ( NM_177974.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_816929.1 Homo sapiens cancer susceptibility 4 (CASC4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu10599
Clone ID Related Accession (Same CDS sequence)	NM_177974.3 , NM_177974.2
Accession Version	NM_177974.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1143bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-30
Organism	Homo sapiens(human)
Product	protein CASC4 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB229269.1, BC012124.1, AY358086.1, AC025043.7 and BI467176.1. On May 31, 2019 this sequence version replaced NM_177974.2. Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (b), that is missing an internal segment compared to isoform a. ##Evidence-Data-START## Transcript exon combination :: SRR7346977.1440213.1, SRR1660809.51856.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGGGTT TCGGGGCCAA CCGGCGGGCT GGCCGCCTGC CCTCTCTCGT GCTGGTGGTG 
CTGCTGGTGG TGATCGTCGT CCTCGCCTTC AACTACTGGA GCATCTCCTC CCGCCACGTC 
CTGCTTCAGG AGGAGGTGGC CGAGCTGCAG GGCCAGGTCC AGCGCACCGA AGTGGCCCGC 
GGGCGGCTGG AAAAGCGCAA TTCGGACCTC TTGCTGTTGG TGGACACGCA CAAGAAACAG 
ATCGACCAGA AGGAGGCCGA CTACGGCCGC CTCAGCAGCC GGCTGCAGGC CAGAGAGGGC 
CTCGGGAAGA GATGCGAGGA TGACAAGGTT AAACTACAGA ACAACATATC GTATCAGATG 
GCAGACATAC ATCATTTAAA GGAGCAACTT GCTGAGCTTC GTCAGGAATT TCTTCGACAA 
GAAGACCAGC TTCAGGACTA TAGGAAGAAC AATACTTACC TTGTGAAGAG GTTAGAATAT 
GAAAGTTTTC AGTGTGGACA GCAGATGAAG GAATTGAGAG CACAGCATGA AGAAAATATT 
AAAAAGTTAG CAGACCAGTT TTTAGAGGAA CAAAAGCAAG AGACCCAAAA GATTCAATCA 
AATGATGGAA AGGAATTGGA TATAAACAAT CAAGTAGTAC CTAAAAATAT TCCAAAAGTA 
GCTGAGAATG TTGCAGATAA GAATGAAGAA CCCTCAAGCA ATCATATTCC ACATGGGAAA 
GAACAAATCA AAAGAGGTGG TGATGCAGGG ATGCCTGGAA TAGAAGAGAA TGACCTAGCA 
AAAGTTGATG ATCTTCCCCC TGCTTTAAGG AAGCCTCCTA TTTCAGTTTC TCAACATGAA 
AGTCATCAAG CAATCTCCCA TCTTCCAACT GGACAACCTC TCTCCCCAAA TATGCCTCCA 
GATTCACACA TAAACCACAA TGGAAACCCC GGTACTTCAA AACAGAATCC TTCCAGTCCT 
CTTCAGCGTT TAATTCCAGG CTCAAACTTG GACAGTGAAC CCAGAATTCA AACAGATATA 
CTAAAGCAGG CTACCAAGGA CAGAGTCAGT GATTTCCATA AATTGAAGCA AAATGATGAA 
GAACGAGAGC TTCAAATGGA TCCTGCAGAC TATGGAAAGC AACATTTCAA TGATGTCCTT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_816929.1
CDS	312..1454
Translation	MVGFGANRRAGRLPSLVLVVLLVVIVVLAFNYWSISSRHVLLQEEVAELQGQVQRTEVARGRLEKRNSDLLLLVDTHKKQIDQKEADYGRLSSRLQAREGLGKRCEDDKVKLQNNISYQMADIHHLKEQLAELRQEFLRQEDQLQDYRKNNTYLVKRLEYESFQCGQQMKELRAQHEENIKKLADQFLEEQKQETQKIQSNDGKELDINNQVVPKNIPKVAENVADKNEEPSSNHIPHGKEQIKRGGDAGMPGIEENDLAKVDDLPPALRKPPISVSQHESHQAISHLPTGQPLSPNMPPDSHINHNGNPGTSKQNPSSPLQRLIPGSNLDSEPRIQTDILKQATKDRVSDFHKLKQNDEERELQMDPADYGKQHFNDVL

Target ORF information:

RefSeq Version	NM_177974.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cancer susceptibility 4 (CASC4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177974.3

ORF Insert Sequence:

ATGGTGGGTT TCGGGGCCAA CCGGCGGGCT GGCCGCCTGC CCTCTCTCGT GCTGGTGGTG 
CTGCTGGTGG TGATCGTCGT CCTCGCCTTC AACTACTGGA GCATCTCCTC CCGCCACGTC 
CTGCTTCAGG AGGAGGTGGC CGAGCTGCAG GGCCAGGTCC AGCGCACCGA AGTGGCCCGC 
GGGCGGCTGG AAAAGCGCAA TTCGGACCTC TTGCTGTTGG TGGACACGCA CAAGAAACAG 
ATCGACCAGA AGGAGGCCGA CTACGGCCGC CTCAGCAGCC GGCTGCAGGC CAGAGAGGGC 
CTCGGGAAGA GATGCGAGGA TGACAAGGTT AAACTACAGA ACAACATATC GTATCAGATG 
GCAGACATAC ATCATTTAAA GGAGCAACTT GCTGAGCTTC GTCAGGAATT TCTTCGACAA 
GAAGACCAGC TTCAGGACTA TAGGAAGAAC AATACTTACC TTGTGAAGAG GTTAGAATAT 
GAAAGTTTTC AGTGTGGACA GCAGATGAAG GAATTGAGAG CACAGCATGA AGAAAATATT 
AAAAAGTTAG CAGACCAGTT TTTAGAGGAA CAAAAGCAAG AGACCCAAAA GATTCAATCA 
AATGATGGAA AGGAATTGGA TATAAACAAT CAAGTAGTAC CTAAAAATAT TCCAAAAGTA 
GCTGAGAATG TTGCAGATAA GAATGAAGAA CCCTCAAGCA ATCATATTCC ACATGGGAAA 
GAACAAATCA AAAGAGGTGG TGATGCAGGG ATGCCTGGAA TAGAAGAGAA TGACCTAGCA 
AAAGTTGATG ATCTTCCCCC TGCTTTAAGG AAGCCTCCTA TTTCAGTTTC TCAACATGAA 
AGTCATCAAG CAATCTCCCA TCTTCCAACT GGACAACCTC TCTCCCCAAA TATGCCTCCA 
GATTCACACA TAAACCACAA TGGAAACCCC GGTACTTCAA AACAGAATCC TTCCAGTCCT 
CTTCAGCGTT TAATTCCAGG CTCAAACTTG GACAGTGAAC CCAGAATTCA AACAGATATA 
CTAAAGCAGG CTACCAAGGA CAGAGTCAGT GATTTCCATA AATTGAAGCA AAATGATGAA 
GAACGAGAGC TTCAAATGGA TCCTGCAGAC TATGGAAAGC AACATTTCAA TGATGTCCTT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CASC4 ( NM_177974.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_816929.1 Homo sapiens cancer susceptibility 4 (CASC4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu10599
Clone ID Related Accession (Same CDS sequence)	NM_177974.3 , NM_177974.2
Accession Version	NM_177974.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1143bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-24
Organism	Homo sapiens(human)
Product	protein CASC4 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB229269.1, BC012124.1, AY358086.1, AC025043.7 and BI467176.1. On Dec 9, 2010 this sequence version replaced NM_177974.1. Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (b), that is missing an internal segment compared to isoform a. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.220893.1, SRR1660809.153259.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGGGTT TCGGGGCCAA CCGGCGGGCT GGCCGCCTGC CCTCTCTCGT GCTGGTGGTG 
CTGCTGGTGG TGATCGTCGT CCTCGCCTTC AACTACTGGA GCATCTCCTC CCGCCACGTC 
CTGCTTCAGG AGGAGGTGGC CGAGCTGCAG GGCCAGGTCC AGCGCACCGA AGTGGCCCGC 
GGGCGGCTGG AAAAGCGCAA TTCGGACCTC TTGCTGTTGG TGGACACGCA CAAGAAACAG 
ATCGACCAGA AGGAGGCCGA CTACGGCCGC CTCAGCAGCC GGCTGCAGGC CAGAGAGGGC 
CTCGGGAAGA GATGCGAGGA TGACAAGGTT AAACTACAGA ACAACATATC GTATCAGATG 
GCAGACATAC ATCATTTAAA GGAGCAACTT GCTGAGCTTC GTCAGGAATT TCTTCGACAA 
GAAGACCAGC TTCAGGACTA TAGGAAGAAC AATACTTACC TTGTGAAGAG GTTAGAATAT 
GAAAGTTTTC AGTGTGGACA GCAGATGAAG GAATTGAGAG CACAGCATGA AGAAAATATT 
AAAAAGTTAG CAGACCAGTT TTTAGAGGAA CAAAAGCAAG AGACCCAAAA GATTCAATCA 
AATGATGGAA AGGAATTGGA TATAAACAAT CAAGTAGTAC CTAAAAATAT TCCAAAAGTA 
GCTGAGAATG TTGCAGATAA GAATGAAGAA CCCTCAAGCA ATCATATTCC ACATGGGAAA 
GAACAAATCA AAAGAGGTGG TGATGCAGGG ATGCCTGGAA TAGAAGAGAA TGACCTAGCA 
AAAGTTGATG ATCTTCCCCC TGCTTTAAGG AAGCCTCCTA TTTCAGTTTC TCAACATGAA 
AGTCATCAAG CAATCTCCCA TCTTCCAACT GGACAACCTC TCTCCCCAAA TATGCCTCCA 
GATTCACACA TAAACCACAA TGGAAACCCC GGTACTTCAA AACAGAATCC TTCCAGTCCT 
CTTCAGCGTT TAATTCCAGG CTCAAACTTG GACAGTGAAC CCAGAATTCA AACAGATATA 
CTAAAGCAGG CTACCAAGGA CAGAGTCAGT GATTTCCATA AATTGAAGCA AAATGATGAA 
GAACGAGAGC TTCAAATGGA TCCTGCAGAC TATGGAAAGC AACATTTCAA TGATGTCCTT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_816929.1
CDS	320..1462
Translation	MVGFGANRRAGRLPSLVLVVLLVVIVVLAFNYWSISSRHVLLQEEVAELQGQVQRTEVARGRLEKRNSDLLLLVDTHKKQIDQKEADYGRLSSRLQAREGLGKRCEDDKVKLQNNISYQMADIHHLKEQLAELRQEFLRQEDQLQDYRKNNTYLVKRLEYESFQCGQQMKELRAQHEENIKKLADQFLEEQKQETQKIQSNDGKELDINNQVVPKNIPKVAENVADKNEEPSSNHIPHGKEQIKRGGDAGMPGIEENDLAKVDDLPPALRKPPISVSQHESHQAISHLPTGQPLSPNMPPDSHINHNGNPGTSKQNPSSPLQRLIPGSNLDSEPRIQTDILKQATKDRVSDFHKLKQNDEERELQMDPADYGKQHFNDVL

Target ORF information:

RefSeq Version	NM_177974.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cancer susceptibility 4 (CASC4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177974.2

ORF Insert Sequence:

ATGGTGGGTT TCGGGGCCAA CCGGCGGGCT GGCCGCCTGC CCTCTCTCGT GCTGGTGGTG 
CTGCTGGTGG TGATCGTCGT CCTCGCCTTC AACTACTGGA GCATCTCCTC CCGCCACGTC 
CTGCTTCAGG AGGAGGTGGC CGAGCTGCAG GGCCAGGTCC AGCGCACCGA AGTGGCCCGC 
GGGCGGCTGG AAAAGCGCAA TTCGGACCTC TTGCTGTTGG TGGACACGCA CAAGAAACAG 
ATCGACCAGA AGGAGGCCGA CTACGGCCGC CTCAGCAGCC GGCTGCAGGC CAGAGAGGGC 
CTCGGGAAGA GATGCGAGGA TGACAAGGTT AAACTACAGA ACAACATATC GTATCAGATG 
GCAGACATAC ATCATTTAAA GGAGCAACTT GCTGAGCTTC GTCAGGAATT TCTTCGACAA 
GAAGACCAGC TTCAGGACTA TAGGAAGAAC AATACTTACC TTGTGAAGAG GTTAGAATAT 
GAAAGTTTTC AGTGTGGACA GCAGATGAAG GAATTGAGAG CACAGCATGA AGAAAATATT 
AAAAAGTTAG CAGACCAGTT TTTAGAGGAA CAAAAGCAAG AGACCCAAAA GATTCAATCA 
AATGATGGAA AGGAATTGGA TATAAACAAT CAAGTAGTAC CTAAAAATAT TCCAAAAGTA 
GCTGAGAATG TTGCAGATAA GAATGAAGAA CCCTCAAGCA ATCATATTCC ACATGGGAAA 
GAACAAATCA AAAGAGGTGG TGATGCAGGG ATGCCTGGAA TAGAAGAGAA TGACCTAGCA 
AAAGTTGATG ATCTTCCCCC TGCTTTAAGG AAGCCTCCTA TTTCAGTTTC TCAACATGAA 
AGTCATCAAG CAATCTCCCA TCTTCCAACT GGACAACCTC TCTCCCCAAA TATGCCTCCA 
GATTCACACA TAAACCACAA TGGAAACCCC GGTACTTCAA AACAGAATCC TTCCAGTCCT 
CTTCAGCGTT TAATTCCAGG CTCAAACTTG GACAGTGAAC CCAGAATTCA AACAGATATA 
CTAAAGCAGG CTACCAAGGA CAGAGTCAGT GATTTCCATA AATTGAAGCA AAATGATGAA 
GAACGAGAGC TTCAAATGGA TCCTGCAGAC TATGGAAAGC AACATTTCAA TGATGTCCTT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CASC4 ( NM_138423.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_612432.2 Homo sapiens cancer susceptibility 4 (CASC4), transcript variant 1, mRNA.

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CloneID	OHu32269
Clone ID Related Accession (Same CDS sequence)	NM_138423.3 , NM_138423.4
Accession Version	NM_138423.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1311bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	protein CASC4 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB229269.1, BC012124.1, AL832840.1 and BI467176.1. On Dec 9, 2010 this sequence version replaced NM_138423.2. Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (a). ##Evidence-Data-START## Transcript exon combination :: SRR1803611.134875.1, SRR1660807.47397.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGGGTT TCGGGGCCAA CCGGCGGGCT GGCCGCCTGC CCTCTCTCGT GCTGGTGGTG 
CTGCTGGTGG TGATCGTCGT CCTCGCCTTC AACTACTGGA GCATCTCCTC CCGCCACGTC 
CTGCTTCAGG AGGAGGTGGC CGAGCTGCAG GGCCAGGTCC AGCGCACCGA AGTGGCCCGC 
GGGCGGCTGG AAAAGCGCAA TTCGGACCTC TTGCTGTTGG TGGACACGCA CAAGAAACAG 
ATCGACCAGA AGGAGGCCGA CTACGGCCGC CTCAGCAGCC GGCTGCAGGC CAGAGAGGGC 
CTCGGGAAGA GATGCGAGGA TGACAAGGTT AAACTACAGA ACAACATATC GTATCAGATG 
GCAGACATAC ATCATTTAAA GGAGCAACTT GCTGAGCTTC GTCAGGAATT TCTTCGACAA 
GAAGACCAGC TTCAGGACTA TAGGAAGAAC AATACTTACC TTGTGAAGAG GTTAGAATAT 
GAAAGTTTTC AGTGTGGACA GCAGATGAAG GAATTGAGAG CACAGCATGA AGAAAATATT 
AAAAAGTTAG CAGACCAGTT TTTAGAGGAA CAAAAGCAAG AGACCCAAAA GATTCAATCA 
AATGATGGAA AGGAATTGGA TATAAACAAT CAAGTAGTAC CTAAAAATAT TCCAAAAGTA 
GCTGAGAATG TTGCAGATAA GAATGAAGAA CCCTCAAGCA ATCATATTCC ACATGGGAAA 
GAACAAATCA AAAGAGGTGG TGATGCAGGG ATGCCTGGAA TAGAAGAGAA TGACCTAGCA 
AAAGTTGATG ATCTTCCCCC TGCTTTAAGG AAGCCTCCTA TTTCAGTTTC TCAACATGAA 
AGTCATCAAG CAATCTCCCA TCTTCCAACT GGACAACCTC TCTCCCCAAA TATGCCTCCA 
GATTCACACA TAAACCACAA TGGAAACCCC GGTACTTCAA AACAGAATCC TTCCAGTCCT 
CTTCAGCGTT TAATTCCAGG CTCAAACTTG GACAGTGAAC CCAGAATTCA AACAGATATA 
CTAAAGCAGG CTACCAAGGA CAGAGTCAGT GATTTCCATA AATTGAAGCA AAGCCGATTC 
TTTGATGAAA ATGAATCCCC TGTTGATCCG CAGCATGGCT CTAAACTGGC GGATTATAAT 
GGGGATGATG GTAACGTAGG TGAGTATGAG GCAGACAAGC AGGCTGAGCT GGCTTACAAT 
GAGGAAGAAG ATGGTGATGG TGGAGAGGAA GACGTCCAAG ATGATGAAGA ACGAGAGCTT 
CAAATGGATC CTGCAGACTA TGGAAAGCAA CATTTCAATG ATGTCCTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_612432.2
CDS	320..1630
Translation	MVGFGANRRAGRLPSLVLVVLLVVIVVLAFNYWSISSRHVLLQEEVAELQGQVQRTEVARGRLEKRNSDLLLLVDTHKKQIDQKEADYGRLSSRLQAREGLGKRCEDDKVKLQNNISYQMADIHHLKEQLAELRQEFLRQEDQLQDYRKNNTYLVKRLEYESFQCGQQMKELRAQHEENIKKLADQFLEEQKQETQKIQSNDGKELDINNQVVPKNIPKVAENVADKNEEPSSNHIPHGKEQIKRGGDAGMPGIEENDLAKVDDLPPALRKPPISVSQHESHQAISHLPTGQPLSPNMPPDSHINHNGNPGTSKQNPSSPLQRLIPGSNLDSEPRIQTDILKQATKDRVSDFHKLKQSRFFDENESPVDPQHGSKLADYNGDDGNVGEYEADKQAELAYNEEEDGDGGEEDVQDDEERELQMDPADYGKQHFNDVL

Target ORF information:

RefSeq Version	NM_138423.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cancer susceptibility 4 (CASC4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138423.3

ORF Insert Sequence:

ATGGTGGGTT TCGGGGCCAA CCGGCGGGCT GGCCGCCTGC CCTCTCTCGT GCTGGTGGTG 
CTGCTGGTGG TGATCGTCGT CCTCGCCTTC AACTACTGGA GCATCTCCTC CCGCCACGTC 
CTGCTTCAGG AGGAGGTGGC CGAGCTGCAG GGCCAGGTCC AGCGCACCGA AGTGGCCCGC 
GGGCGGCTGG AAAAGCGCAA TTCGGACCTC TTGCTGTTGG TGGACACGCA CAAGAAACAG 
ATCGACCAGA AGGAGGCCGA CTACGGCCGC CTCAGCAGCC GGCTGCAGGC CAGAGAGGGC 
CTCGGGAAGA GATGCGAGGA TGACAAGGTT AAACTACAGA ACAACATATC GTATCAGATG 
GCAGACATAC ATCATTTAAA GGAGCAACTT GCTGAGCTTC GTCAGGAATT TCTTCGACAA 
GAAGACCAGC TTCAGGACTA TAGGAAGAAC AATACTTACC TTGTGAAGAG GTTAGAATAT 
GAAAGTTTTC AGTGTGGACA GCAGATGAAG GAATTGAGAG CACAGCATGA AGAAAATATT 
AAAAAGTTAG CAGACCAGTT TTTAGAGGAA CAAAAGCAAG AGACCCAAAA GATTCAATCA 
AATGATGGAA AGGAATTGGA TATAAACAAT CAAGTAGTAC CTAAAAATAT TCCAAAAGTA 
GCTGAGAATG TTGCAGATAA GAATGAAGAA CCCTCAAGCA ATCATATTCC ACATGGGAAA 
GAACAAATCA AAAGAGGTGG TGATGCAGGG ATGCCTGGAA TAGAAGAGAA TGACCTAGCA 
AAAGTTGATG ATCTTCCCCC TGCTTTAAGG AAGCCTCCTA TTTCAGTTTC TCAACATGAA 
AGTCATCAAG CAATCTCCCA TCTTCCAACT GGACAACCTC TCTCCCCAAA TATGCCTCCA 
GATTCACACA TAAACCACAA TGGAAACCCC GGTACTTCAA AACAGAATCC TTCCAGTCCT 
CTTCAGCGTT TAATTCCAGG CTCAAACTTG GACAGTGAAC CCAGAATTCA AACAGATATA 
CTAAAGCAGG CTACCAAGGA CAGAGTCAGT GATTTCCATA AATTGAAGCA AAGCCGATTC 
TTTGATGAAA ATGAATCCCC TGTTGATCCG CAGCATGGCT CTAAACTGGC GGATTATAAT 
GGGGATGATG GTAACGTAGG TGAGTATGAG GCAGACAAGC AGGCTGAGCT GGCTTACAAT 
GAGGAAGAAG ATGGTGATGG TGGAGAGGAA GACGTCCAAG ATGATGAAGA ACGAGAGCTT 
CAAATGGATC CTGCAGACTA TGGAAAGCAA CATTTCAATG ATGTCCTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CASC4 ( XM_017021880.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016877369.1 Homo sapiens cancer susceptibility 4 (CASC4), transcript variant X2, mRNA.

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CloneID	OHu85234
Clone ID Related Accession (Same CDS sequence)	XM_017021880.2 , XM_017021880.1
Accession Version	XM_017021880.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	protein CASC4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017021880.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGGGTT TCGGGGCCAA CCGGCGGGCT GGCCGCCTGC CCTCTCTCGT GCTGGTGGTG 
CTGCTGGTGG TGATCGTCGT CCTCGCCTTC AACTACTGGA GCATCTCCTC CCGCCACGTC 
CTGCTTCAGG AGGAGGTGGC CGAGCTGCAG GGCCAGGTCC AGCGCACCGA AGTGGCCCGC 
GGGCGGCTGG AAAAGCGCAA TTCGGACCTC TTGCTGTTGG TGGACACGCA CAAGAAACAG 
ATCGACCAGA AGGAGGCCGA CTACGGCCGC CTCAGCAGCC GGCTGCAGGC CAGAGAGGGC 
CTCGGGAAGA GATGCGAGGA TGACAAGGTT AAACTACAGA ACAACATATC GTATCAGATG 
GCAGACATAC ATCATTTAAA GGAGCAACTT GCTGAGCTTC GTCAGGAATT TCTTCGACAA 
GAAGACCAGC TTCAGGACTA TAGGAAGAAC AATACTTACC TTGTGAAGAG GTTAGAATAT 
GAAAGTTTTC AGTGTGGACA GCAGATGAAG GAATTGAGAG CACAGCATGA AGAAAATATT 
AAAAAGTTAG CAGACCAGTT TTTAGAGGAA CAAAAGCAAG AGACCCAAAA GATTCAATCA 
AATGATGGAA AGGAATTGGA TATAAACAAT CAAGTAGTAC CTAAAAATAT TCCAAAAGTA 
GCTGAGAATG TTGCAGATAA GAATGAAGAA CCCTCAAGCA ATCATATTCC ACATGGGAAA 
GAACAAATCA AAAGAGGTGG TGATGCAGGG ATGCCTGGAA TAGAAGAGAA TGACCTAGCA 
AAAGTTGATG ATCTTCCCCC TGGCTGGAGT GCGGTGGCGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016877369.1
CDS	322..1143
Translation	MVGFGANRRAGRLPSLVLVVLLVVIVVLAFNYWSISSRHVLLQEEVAELQGQVQRTEVARGRLEKRNSDLLLLVDTHKKQIDQKEADYGRLSSRLQAREGLGKRCEDDKVKLQNNISYQMADIHHLKEQLAELRQEFLRQEDQLQDYRKNNTYLVKRLEYESFQCGQQMKELRAQHEENIKKLADQFLEEQKQETQKIQSNDGKELDINNQVVPKNIPKVAENVADKNEEPSSNHIPHGKEQIKRGGDAGMPGIEENDLAKVDDLPPGWSAVA

Target ORF information:

RefSeq Version	XM_017021880.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cancer susceptibility 4 (CASC4), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017021880.2

ORF Insert Sequence:

ATGGTGGGTT TCGGGGCCAA CCGGCGGGCT GGCCGCCTGC CCTCTCTCGT GCTGGTGGTG 
CTGCTGGTGG TGATCGTCGT CCTCGCCTTC AACTACTGGA GCATCTCCTC CCGCCACGTC 
CTGCTTCAGG AGGAGGTGGC CGAGCTGCAG GGCCAGGTCC AGCGCACCGA AGTGGCCCGC 
GGGCGGCTGG AAAAGCGCAA TTCGGACCTC TTGCTGTTGG TGGACACGCA CAAGAAACAG 
ATCGACCAGA AGGAGGCCGA CTACGGCCGC CTCAGCAGCC GGCTGCAGGC CAGAGAGGGC 
CTCGGGAAGA GATGCGAGGA TGACAAGGTT AAACTACAGA ACAACATATC GTATCAGATG 
GCAGACATAC ATCATTTAAA GGAGCAACTT GCTGAGCTTC GTCAGGAATT TCTTCGACAA 
GAAGACCAGC TTCAGGACTA TAGGAAGAAC AATACTTACC TTGTGAAGAG GTTAGAATAT 
GAAAGTTTTC AGTGTGGACA GCAGATGAAG GAATTGAGAG CACAGCATGA AGAAAATATT 
AAAAAGTTAG CAGACCAGTT TTTAGAGGAA CAAAAGCAAG AGACCCAAAA GATTCAATCA 
AATGATGGAA AGGAATTGGA TATAAACAAT CAAGTAGTAC CTAAAAATAT TCCAAAAGTA 
GCTGAGAATG TTGCAGATAA GAATGAAGAA CCCTCAAGCA ATCATATTCC ACATGGGAAA 
GAACAAATCA AAAGAGGTGG TGATGCAGGG ATGCCTGGAA TAGAAGAGAA TGACCTAGCA 
AAAGTTGATG ATCTTCCCCC TGGCTGGAGT GCGGTGGCGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CASC4 ( XM_017021880.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016877369.1 Homo sapiens cancer susceptibility candidate 4 (CASC4), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu85234
Clone ID Related Accession (Same CDS sequence)	XM_017021880.2 , XM_017021880.1
Accession Version	XM_017021880.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	protein CASC4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGGGTT TCGGGGCCAA CCGGCGGGCT GGCCGCCTGC CCTCTCTCGT GCTGGTGGTG 
CTGCTGGTGG TGATCGTCGT CCTCGCCTTC AACTACTGGA GCATCTCCTC CCGCCACGTC 
CTGCTTCAGG AGGAGGTGGC CGAGCTGCAG GGCCAGGTCC AGCGCACCGA AGTGGCCCGC 
GGGCGGCTGG AAAAGCGCAA TTCGGACCTC TTGCTGTTGG TGGACACGCA CAAGAAACAG 
ATCGACCAGA AGGAGGCCGA CTACGGCCGC CTCAGCAGCC GGCTGCAGGC CAGAGAGGGC 
CTCGGGAAGA GATGCGAGGA TGACAAGGTT AAACTACAGA ACAACATATC GTATCAGATG 
GCAGACATAC ATCATTTAAA GGAGCAACTT GCTGAGCTTC GTCAGGAATT TCTTCGACAA 
GAAGACCAGC TTCAGGACTA TAGGAAGAAC AATACTTACC TTGTGAAGAG GTTAGAATAT 
GAAAGTTTTC AGTGTGGACA GCAGATGAAG GAATTGAGAG CACAGCATGA AGAAAATATT 
AAAAAGTTAG CAGACCAGTT TTTAGAGGAA CAAAAGCAAG AGACCCAAAA GATTCAATCA 
AATGATGGAA AGGAATTGGA TATAAACAAT CAAGTAGTAC CTAAAAATAT TCCAAAAGTA 
GCTGAGAATG TTGCAGATAA GAATGAAGAA CCCTCAAGCA ATCATATTCC ACATGGGAAA 
GAACAAATCA AAAGAGGTGG TGATGCAGGG ATGCCTGGAA TAGAAGAGAA TGACCTAGCA 
AAAGTTGATG ATCTTCCCCC TGGCTGGAGT GCGGTGGCGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016877369.1
CDS	415..1236
Translation	MVGFGANRRAGRLPSLVLVVLLVVIVVLAFNYWSISSRHVLLQEEVAELQGQVQRTEVARGRLEKRNSDLLLLVDTHKKQIDQKEADYGRLSSRLQAREGLGKRCEDDKVKLQNNISYQMADIHHLKEQLAELRQEFLRQEDQLQDYRKNNTYLVKRLEYESFQCGQQMKELRAQHEENIKKLADQFLEEQKQETQKIQSNDGKELDINNQVVPKNIPKVAENVADKNEEPSSNHIPHGKEQIKRGGDAGMPGIEENDLAKVDDLPPGWSAVA

Target ORF information:

RefSeq Version	XM_017021880.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cancer susceptibility candidate 4 (CASC4), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017021880.1

ORF Insert Sequence:

ATGGTGGGTT TCGGGGCCAA CCGGCGGGCT GGCCGCCTGC CCTCTCTCGT GCTGGTGGTG 
CTGCTGGTGG TGATCGTCGT CCTCGCCTTC AACTACTGGA GCATCTCCTC CCGCCACGTC 
CTGCTTCAGG AGGAGGTGGC CGAGCTGCAG GGCCAGGTCC AGCGCACCGA AGTGGCCCGC 
GGGCGGCTGG AAAAGCGCAA TTCGGACCTC TTGCTGTTGG TGGACACGCA CAAGAAACAG 
ATCGACCAGA AGGAGGCCGA CTACGGCCGC CTCAGCAGCC GGCTGCAGGC CAGAGAGGGC 
CTCGGGAAGA GATGCGAGGA TGACAAGGTT AAACTACAGA ACAACATATC GTATCAGATG 
GCAGACATAC ATCATTTAAA GGAGCAACTT GCTGAGCTTC GTCAGGAATT TCTTCGACAA 
GAAGACCAGC TTCAGGACTA TAGGAAGAAC AATACTTACC TTGTGAAGAG GTTAGAATAT 
GAAAGTTTTC AGTGTGGACA GCAGATGAAG GAATTGAGAG CACAGCATGA AGAAAATATT 
AAAAAGTTAG CAGACCAGTT TTTAGAGGAA CAAAAGCAAG AGACCCAAAA GATTCAATCA 
AATGATGGAA AGGAATTGGA TATAAACAAT CAAGTAGTAC CTAAAAATAT TCCAAAAGTA 
GCTGAGAATG TTGCAGATAA GAATGAAGAA CCCTCAAGCA ATCATATTCC ACATGGGAAA 
GAACAAATCA AAAGAGGTGG TGATGCAGGG ATGCCTGGAA TAGAAGAGAA TGACCTAGCA 
AAAGTTGATG ATCTTCCCCC TGGCTGGAGT GCGGTGGCGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SRSF1-Regulated Alternative Splicing in Breast Cancer.
Molecular cell60(1)105-17(2015 Oct)
Anczuk?w O,Akerman M,Cl?ry A,Wu J,Shen C,Shirole NH,Raimer A,Sun S,Jensen MA,Hua Y,Allain FH,Krainer AR

Expression of HER2/neu does not correlate with survival in soft tissue sarcoma.
Onkologie26(3)268-71(2003 Jun)
Sato T,Peiper M,Heinecke A,Zurakowski D,Eisenberger CF,Hosch S,Knoefel WT,Izbicki JR

[Evaluation of her-2/neu amplification/overexpression in OSCC with fluorescence in situ hybridization (FISH) and immunohistochemistry].
Mund-, Kiefer- und Gesichtschirurgie : MKG7(3)138-45(2003 May)
Scheer M,Prange W,Petmecky K,Schirmacher P,Z?ller JE,K?bler AC

Identification of differentially expressed genes associated with HER-2/neu overexpression in human breast cancer cells.
Nucleic acids research27(20)4008-17(1999 Oct)
Oh JJ,Grosshans DR,Wong SG,Slamon DJ

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CASC4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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FAX

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