PRAF2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PRAF2
Entrez Gene ID	11230
Full Name	PRA1 domain family member 2
Synonyms	JM4,Yip6a
General protein information	Preferred Names PRA1 domain family member 2 Names PRA1 family protein 2 Jena-Muenchen 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp11.23
Disorder MIM:	300840

mRNA and Protein(s)

mRNA	Protein	Name
NM_007213.2	NP_009144.1	PRA1 family protein 2
NM_007213.3	NP_009144.1	PRA1 family protein 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PRAF2	XP_538032.1
Rattus norvegicus (Norway rat)	Praf2	NP_001102483.1
Homo sapiens (human)	PRAF2	NP_009144.1
Pan troglodytes (chimpanzee)	PRAF2	XP_528974.2
Danio rerio (zebrafish)	praf2	NP_001017698.1
Bos taurus (cattle)	PRAF2	NP_001039474.1
Mus musculus (house mouse)	Praf2	NP_613068.1

Gene Ontology
Bibliography

Related articles in PubMed

PRAF2 stimulates cell proliferation and migration and predicts poor prognosis in neuroblastoma.
Yco LP, Geerts D, Koster J, Bachmann AS
International journal of oncology42(4)1408-16(2013 Apr)

Praf2 is a novel Bcl-xL/Bcl-2 interacting protein with the ability to modulate survival of cancer cells.
Vento MT, Zazzu V, Loffreda A, Cross JR, Downward J, Stoppelli MP, Iaccarino I
PloS one5(12)e15636(2010 Dec)

Subcellular distribution and expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in malignant glioma: Influence on cell survival and migration.
Borsics T, Lundberg E, Geerts D, Koomoa DL, Koster J, Wester K, Bachmann AS
Cancer science101(7)1624-31(2010 Jul)

Expression profile of PRAF2 in the human brain and enrichment in synaptic vesicles.
Koomoa DL, Go RC, Wester K, Bachmann AS
Neuroscience letters436(2)171-6(2008 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PRAF2 plays an essential role in neuroblastoma tumorigenesis and metastasis.
Title: PRAF2 stimulates cell proliferation and migration and predicts poor prognosis in neuroblastoma.

Praf2 is a novel Bcl-xL/Bcl-2 interacting protein with the ability to modulate survival of cancer cells
Title: Praf2 is a novel Bcl-xL/Bcl-2 interacting protein with the ability to modulate survival of cancer cells.

PRAF2 expression is elevated in various tumors with exceptionally high expression in malignant gliomas, and may thus presents a candidate molecular target for therapeutic intervention.
Title: Subcellular distribution and expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in malignant glioma: Influence on cell survival and migration.

The expression of PRAF2 in specific regions of the brain including SVs suggest an important physiological function for this novel protein, possibly by participating in multiple aspects of SV maturation, transport, and signal transmission.
Title: Expression profile of PRAF2 in the human brain and enrichment in synaptic vesicles.

PRAF2 has a role in progression of neuroblastoma
Title: Expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in neuroblastoma: correlation with clinical features, cellular localization, and cerulenin-mediated apoptosis regulation.

The following PRAF2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PRAF2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12218	NM_007213.3 Latest version!	Homo sapiens PRA1 domain family member 2 (PRAF2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu12218	NM_007213.2	Homo sapiens PRA1 domain family member 2 (PRAF2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PRAF2 ( NM_007213.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_009144.1 Homo sapiens PRA1 domain family member 2 (PRAF2), mRNA.

Price & Availability↑

CloneID	OHu12218
Clone ID Related Accession (Same CDS sequence)	NM_007213.2 , NM_007213.3
Accession Version	NM_007213.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 537bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	PRA1 family protein 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB155577.1, AJ005896.1, AC231657.2 and AA720948.1. On Aug 21, 2013 this sequence version replaced NM_007213.1. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.243742.1, AJ005896.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGGAGG TGCGGCTGCC ACCGCTACGC GCCCTGGACG ACTTTGTTCT GGGGTCGGCG 
CGTCTGGCGG CTCCGGATCC ATGCGACCCG CAGCGATGGT GCCACCGCGT CATCAACAAC 
CTCCTCTACT ACCAAACCAA CTACCTTCTC TGCTTCGGCA TCGGCCTCGC TCTCGCCGGG 
TACGTGCGGC CACTTCATAC GCTCCTGAGC GCGCTGGTAG TGGCGGTGGC CCTCGGCGTG 
CTGGTGTGGG CAGCTGAGAC CCGCGCAGCT GTGCGCCGCT GCCGCCGCAG CCACCCTGCA 
GCCTGCCTGG CCGCAGTGCT TGCCGTCGGC CTCCTGGTGC TCTGGGTCGC GGGCGGCGCT 
TGCACCTTCC TGTTCAGCAT CGCCGGGCCG GTGCTTCTGA TCCTGGTGCA CGCCTCGTTG 
CGCCTGCGCA ACCTTAAGAA CAAGATTGAG AACAAGATCG AGAGCATTGG TCTCAAGCGG 
ACGCCAATGG GCCTGCTACT AGAGGCACTG GGACAAGAGC AGGAGGCTGG ATCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009144.1
CDS	59..595
Translation	MSEVRLPPLRALDDFVLGSARLAAPDPCDPQRWCHRVINNLLYYQTNYLLCFGIGLALAGYVRPLHTLLSALVVAVALGVLVWAAETRAAVRRCRRSHPAACLAAVLAVGLLVLWVAGGACTFLFSIAGPVLLILVHASLRLRNLKNKIENKIESIGLKRTPMGLLLEALGQEQEAGS

Target ORF information:

RefSeq Version	NM_007213.2
Organism	Homo sapiens(human)
Definition	Homo sapiens PRA1 domain family member 2 (PRAF2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007213.2

ORF Insert Sequence:

ATGTCGGAGG TGCGGCTGCC ACCGCTACGC GCCCTGGACG ACTTTGTTCT GGGGTCGGCG 
CGTCTGGCGG CTCCGGATCC ATGCGACCCG CAGCGATGGT GCCACCGCGT CATCAACAAC 
CTCCTCTACT ACCAAACCAA CTACCTTCTC TGCTTCGGCA TCGGCCTCGC TCTCGCCGGG 
TACGTGCGGC CACTTCATAC GCTCCTGAGC GCGCTGGTAG TGGCGGTGGC CCTCGGCGTG 
CTGGTGTGGG CAGCTGAGAC CCGCGCAGCT GTGCGCCGCT GCCGCCGCAG CCACCCTGCA 
GCCTGCCTGG CCGCAGTGCT TGCCGTCGGC CTCCTGGTGC TCTGGGTCGC GGGCGGCGCT 
TGCACCTTCC TGTTCAGCAT CGCCGGGCCG GTGCTTCTGA TCCTGGTGCA CGCCTCGTTG 
CGCCTGCGCA ACCTTAAGAA CAAGATTGAG AACAAGATCG AGAGCATTGG TCTCAAGCGG 
ACGCCAATGG GCCTGCTACT AGAGGCACTG GGACAAGAGC AGGAGGCTGG ATCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRAF2 ( NM_007213.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_009144.1 Homo sapiens PRA1 domain family member 2 (PRAF2), mRNA.

Price & Availability↑

CloneID	OHu12218
Clone ID Related Accession (Same CDS sequence)	NM_007213.2 , NM_007213.3
Accession Version	NM_007213.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 537bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	PRA1 family protein 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AJ005896.1 and AC231657.2. On Nov 23, 2018 this sequence version replaced NM_007213.2. ##Evidence-Data-START## Transcript exon combination :: AJ005896.1, SRR1660807.243742.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000553851.3/ ENSP00000451962.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCGGAGG TGCGGCTGCC ACCGCTACGC GCCCTGGACG ACTTTGTTCT GGGGTCGGCG 
CGTCTGGCGG CTCCGGATCC ATGCGACCCG CAGCGATGGT GCCACCGCGT CATCAACAAC 
CTCCTCTACT ACCAAACCAA CTACCTTCTC TGCTTCGGCA TCGGCCTCGC TCTCGCCGGG 
TACGTGCGGC CACTTCATAC GCTCCTGAGC GCGCTGGTAG TGGCGGTGGC CCTCGGCGTG 
CTGGTGTGGG CAGCTGAGAC CCGCGCAGCT GTGCGCCGCT GCCGCCGCAG CCACCCTGCA 
GCCTGCCTGG CCGCAGTGCT TGCCGTCGGC CTCCTGGTGC TCTGGGTCGC GGGCGGCGCT 
TGCACCTTCC TGTTCAGCAT CGCCGGGCCG GTGCTTCTGA TCCTGGTGCA CGCCTCGTTG 
CGCCTGCGCA ACCTTAAGAA CAAGATTGAG AACAAGATCG AGAGCATTGG TCTCAAGCGG 
ACGCCAATGG GCCTGCTACT AGAGGCACTG GGACAAGAGC AGGAGGCTGG ATCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009144.1
CDS	16..552
Translation	MSEVRLPPLRALDDFVLGSARLAAPDPCDPQRWCHRVINNLLYYQTNYLLCFGIGLALAGYVRPLHTLLSALVVAVALGVLVWAAETRAAVRRCRRSHPAACLAAVLAVGLLVLWVAGGACTFLFSIAGPVLLILVHASLRLRNLKNKIENKIESIGLKRTPMGLLLEALGQEQEAGS

Target ORF information:

RefSeq Version	NM_007213.3
Organism	Homo sapiens(human)
Definition	Homo sapiens PRA1 domain family member 2 (PRAF2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007213.3

ORF Insert Sequence:

ATGTCGGAGG TGCGGCTGCC ACCGCTACGC GCCCTGGACG ACTTTGTTCT GGGGTCGGCG 
CGTCTGGCGG CTCCGGATCC ATGCGACCCG CAGCGATGGT GCCACCGCGT CATCAACAAC 
CTCCTCTACT ACCAAACCAA CTACCTTCTC TGCTTCGGCA TCGGCCTCGC TCTCGCCGGG 
TACGTGCGGC CACTTCATAC GCTCCTGAGC GCGCTGGTAG TGGCGGTGGC CCTCGGCGTG 
CTGGTGTGGG CAGCTGAGAC CCGCGCAGCT GTGCGCCGCT GCCGCCGCAG CCACCCTGCA 
GCCTGCCTGG CCGCAGTGCT TGCCGTCGGC CTCCTGGTGC TCTGGGTCGC GGGCGGCGCT 
TGCACCTTCC TGTTCAGCAT CGCCGGGCCG GTGCTTCTGA TCCTGGTGCA CGCCTCGTTG 
CGCCTGCGCA ACCTTAAGAA CAAGATTGAG AACAAGATCG AGAGCATTGG TCTCAAGCGG 
ACGCCAATGG GCCTGCTACT AGAGGCACTG GGACAAGAGC AGGAGGCTGG ATCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PRAF2 stimulates cell proliferation and migration and predicts poor prognosis in neuroblastoma.
International journal of oncology42(4)1408-16(2013 Apr)
Yco LP,Geerts D,Koster J,Bachmann AS

Praf2 is a novel Bcl-xL/Bcl-2 interacting protein with the ability to modulate survival of cancer cells.
PloS one5(12)e15636(2010 Dec)
Vento MT,Zazzu V,Loffreda A,Cross JR,Downward J,Stoppelli MP,Iaccarino I

Subcellular distribution and expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in malignant glioma: Influence on cell survival and migration.
Cancer science101(7)1624-31(2010 Jul)
Borsics T,Lundberg E,Geerts D,Koomoa DL,Koster J,Wester K,Bachmann AS

Expression profile of PRAF2 in the human brain and enrichment in synaptic vesicles.
Neuroscience letters436(2)171-6(2008 May)
Koomoa DL,Go RC,Wester K,Bachmann AS