ADIRF cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ADIRF
Entrez Gene ID	10974
Full Name	adipogenesis regulatory factor
Synonyms	AFRO,APM2,C10orf116,apM-2
General protein information	Preferred Names adipogenesis regulatory factor Names adipogenesis regulatory factor adipogenesis factor rich in obesity adipose most abundant gene transcript 2 protein adipose specific 2 adipose-specific protein 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q23.2
Summary	APM2 gene is exclusively expressed in adipose tissue. Its function is currently unknown. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_006829.2	NP_006820.1	adipogenesis regulatory factor
NM_006829.3	NP_006820.1	adipogenesis regulatory factor

Pathways from BioSystems

Homologies

Homo sapiens (human)	ADIRF	NP_006820.1
Canis lupus familiaris (dog)	C4H10orf116	XP_005619173.1
Pan troglodytes (chimpanzee)	C10H10orf116	XP_001136008.2
Bos taurus (cattle)	C28H10orf116	NP_001107985.1

Gene Ontology
Bibliography

Related articles in PubMed

C10orf116 Gene Copy Number Loss in Prostate Cancer: Clinicopathological Correlations and Prognostic Significance.
Meng J, Wang LH, Zou CL, Dai SM, Zhang J, Lu Y
Medical science monitor : international medical journal of experimental and clinical research235176-5183(2017 Oct)

A Novel pro-adipogenesis factor abundant in adipose tissues and over-expressed in obesity acts upstream of PPAR? and C/EBP?.
Ni Y, Ji C, Wang B, Qiu J, Wang J, Guo X
Journal of bioenergetics and biomembranes45(3)219-28(2013 Jun)

Overexpression of C10orf116 promotes proliferation, inhibits apoptosis and enhances glucose transport in 3T3-L1 adipocytes.
Chen L, Zhou XG, Zhou XY, Zhu C, Ji CB, Shi CM, Qiu J, Guo XR
Molecular medicine reports7(5)1477-81(2013 May)

Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.
Chapuis J, Hot D, Hansmannel F, Kerdraon O, Ferreira S, Hubans C, Maurage CA, Huot L, Bensemain F, Laumet G, Ayral AM, Fievet N, Hauw JJ, DeKosky ST, Lemoine Y, Iwatsubo T, Wavrant-Devri?ze F, Dartigues JF, Tzourio C, Bu?e L, Pasquier F, Berr C, Mann D, Lendon C, Alp?rovitch A, Kamboh MI, Amouyel P, Lambert JC
Molecular psychiatry14(11)1004-16(2009 Nov)

APM2 is a novel mediator of cisplatin resistance in a variety of cancer cell types regardless of p53 or MMR status.
Scott BJ, Qutob S, Liu QY, Ng CE
International journal of cancer125(5)1193-204(2009 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Over-expressed in omental tissues from obese patients, C10orf16 manifested the characteristics of an adipocyte lineage-specific nuclear factor that can modulate the master adipogenesis transcription factors early during differentiation.
Title: A Novel pro-adipogenesis factor abundant in adipose tissues and over-expressed in obesity acts upstream of PPAR? and C/EBP?.

Observational study of gene-disease association. (HuGE Navigator)
Title: Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.

Overexpression of APM2 promote cisplatin resistance in cancer.
Title: APM2 is a novel mediator of cisplatin resistance in a variety of cancer cell types regardless of p53 or MMR status.

The following ADIRF gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ADIRF cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13029	NM_006829.3 Latest version!	Homo sapiens adipogenesis regulatory factor (ADIRF), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu13029	NM_006829.2	Homo sapiens adipogenesis regulatory factor (ADIRF), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ADIRF ( NM_006829.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006820.1 Homo sapiens adipogenesis regulatory factor (ADIRF), mRNA.

Price & Availability↑

CloneID	OHu13029
Clone ID Related Accession (Same CDS sequence)	NM_006829.2 , NM_006829.3
Accession Version	NM_006829.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 231bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-07-28
Organism	Homo sapiens(human)
Product	adipogenesis regulatory factor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM789611.1, AI401530.1, BM850559.1 and CD722742.1. On May 7, 2004 this sequence version replaced NM_006829.1. ##Evidence-Data-START## Transcript exon combination :: CD109960.1, DB290291.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAAGCA AGGGCTTGCA GGACCTGAAG CAACAGGTGG AGGGGACCGC CCAGGAAGCC 
GTGTCAGCGG CCGGAGCGGC AGCTCAGCAA GTGGTGGACC AGGCCACAGA GGCGGGGCAG 
AAAGCCATGG ACCAGCTGGC CAAGACCACC CAGGAAACCA TCGACAAGAC TGCTAACCAG 
GCCTCTGACA CCTTCTCTGG GATTGGGAAA AAATTCGGCC TCCTGAAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006820.1
CDS	115..345
Translation	MASKGLQDLKQQVEGTAQEAVSAAGAAAQQVVDQATEAGQKAMDQLAKTTQETIDKTANQASDTFSGIGKKFGLLK

Target ORF information:

RefSeq Version	NM_006829.2
Organism	Homo sapiens(human)
Definition	Homo sapiens adipogenesis regulatory factor (ADIRF), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006829.2

ORF Insert Sequence:

ATGGCAAGCA AGGGCTTGCA GGACCTGAAG CAACAGGTGG AGGGGACCGC CCAGGAAGCC 
GTGTCAGCGG CCGGAGCGGC AGCTCAGCAA GTGGTGGACC AGGCCACAGA GGCGGGGCAG 
AAAGCCATGG ACCAGCTGGC CAAGACCACC CAGGAAACCA TCGACAAGAC TGCTAACCAG 
GCCTCTGACA CCTTCTCTGG GATTGGGAAA AAATTCGGCC TCCTGAAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ADIRF ( NM_006829.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006820.1 Homo sapiens adipogenesis regulatory factor (ADIRF), mRNA.

Price & Availability↑

CloneID	OHu13029
Clone ID Related Accession (Same CDS sequence)	NM_006829.2 , NM_006829.3
Accession Version	NM_006829.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 231bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Homo sapiens(human)
Product	adipogenesis regulatory factor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM789611.1, AI401530.1, BM850559.1, CD722742.1 and AL136982.11. On May 17, 2019 this sequence version replaced NM_006829.2. ##Evidence-Data-START## Transcript exon combination :: DB290291.1, DA559348.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000372013.8/ ENSP00000361083.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCAAGCA AGGGCTTGCA GGACCTGAAG CAACAGGTGG AGGGGACCGC CCAGGAAGCC 
GTGTCAGCGG CCGGAGCGGC AGCTCAGCAA GTGGTGGACC AGGCCACAGA GGCGGGGCAG 
AAAGCCATGG ACCAGCTGGC CAAGACCACC CAGGAAACCA TCGACAAGAC TGCTAACCAG 
GCCTCTGACA CCTTCTCTGG GATTGGGAAA AAATTCGGCC TCCTGAAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006820.1
CDS	64..294
Translation	MASKGLQDLKQQVEGTAQEAVSAAGAAAQQVVDQATEAGQKAMDQLAKTTQETIDKTANQASDTFSGIGKKFGLLK

Target ORF information:

RefSeq Version	NM_006829.3
Organism	Homo sapiens(human)
Definition	Homo sapiens adipogenesis regulatory factor (ADIRF), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006829.3

ORF Insert Sequence:

ATGGCAAGCA AGGGCTTGCA GGACCTGAAG CAACAGGTGG AGGGGACCGC CCAGGAAGCC 
GTGTCAGCGG CCGGAGCGGC AGCTCAGCAA GTGGTGGACC AGGCCACAGA GGCGGGGCAG 
AAAGCCATGG ACCAGCTGGC CAAGACCACC CAGGAAACCA TCGACAAGAC TGCTAACCAG 
GCCTCTGACA CCTTCTCTGG GATTGGGAAA AAATTCGGCC TCCTGAAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

C10orf116 Gene Copy Number Loss in Prostate Cancer: Clinicopathological Correlations and Prognostic Significance.
Medical science monitor : international medical journal of experimental and clinical research235176-5183(2017 Oct)
Meng J,Wang LH,Zou CL,Dai SM,Zhang J,Lu Y

A Novel pro-adipogenesis factor abundant in adipose tissues and over-expressed in obesity acts upstream of PPAR? and C/EBP?.
Journal of bioenergetics and biomembranes45(3)219-28(2013 Jun)
Ni Y,Ji C,Wang B,Qiu J,Wang J,Guo X

Overexpression of C10orf116 promotes proliferation, inhibits apoptosis and enhances glucose transport in 3T3-L1 adipocytes.
Molecular medicine reports7(5)1477-81(2013 May)
Chen L,Zhou XG,Zhou XY,Zhu C,Ji CB,Shi CM,Qiu J,Guo XR

Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.
Molecular psychiatry14(11)1004-16(2009 Nov)
Chapuis J,Hot D,Hansmannel F,Kerdraon O,Ferreira S,Hubans C,Maurage CA,Huot L,Bensemain F,Laumet G,Ayral AM,Fievet N,Hauw JJ,DeKosky ST,Lemoine Y,Iwatsubo T,Wavrant-Devri?ze F,Dartigues JF,Tzourio C,Bu?e L,Pasquier F,Berr C,Mann D,Lendon C,Alp?rovitch A,Kamboh MI,Amouyel P,Lambert JC

APM2 is a novel mediator of cisplatin resistance in a variety of cancer cell types regardless of p53 or MMR status.
International journal of cancer125(5)1193-204(2009 Sep)
Scott BJ,Qutob S,Liu QY,Ng CE