STARD10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	STARD10
Entrez Gene ID	10809
Full Name	StAR related lipid transfer domain containing 10
Synonyms	CGI-52,NY-CO-28,PCTP2,SDCCAG28
General protein information	Preferred Names StAR related lipid transfer domain containing 10 Names START domain-containing protein 10 PCTP-L PCTP-like protein START domain containing 10 StAR-related lipid transfer (START) domain containing 10 antigen NY-CO-28 serologically defined colon cancer antigen 28 stAR-related lipid transfer protein 10
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q13.4
Disorder MIM:	617382

mRNA and Protein(s)

mRNA	Protein	Name
NM_006645.2	NP_006636.2	START domain-containing protein 10

Pathways from BioSystems

Homologies

	STARD10	XP_001115167.1
Bos taurus (cattle)	STARD10	NP_001179308.1
Mus musculus (house mouse)	Stard10	NP_064374.1
Caenorhabditis elegans (roundworm)	T28D6.7	NP_499460.1
Xenopus tropicalis (tropical clawed frog)	stard10	NP_001120059.1
Canis lupus familiaris (dog)	STARD10	XP_005633605.1
Gallus gallus (chicken)	STARD10	XP_425187.3
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008308	XP_317158.4
Homo sapiens (human)	STARD10	NP_006636.2
Pan troglodytes (chimpanzee)	STARD10	XP_003313243.1
Danio rerio (zebrafish)	zgc:77147	NP_991209.1
Rattus norvegicus (Norway rat)	Stard10	NP_001013087.1

Gene Ontology
Bibliography

Related articles in PubMed

Potentiation of docetaxel sensitivity by miR-638 via regulation of STARD10 pathway in human breast cancer cells.
Zhao G, Li Y, Wang T
Biochemical and biophysical research communications487(2)255-261(2017 May)

Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice.
Carrat GR, Hu M, Nguyen-Tu MS, Chabosseau P, Gaulton KJ, van de Bunt M, Siddiq A, Falchi M, Thurner M, Canouil M, Pattou F, Leclerc I, Pullen TJ, Cane MC, Prabhala P, Greenwald W, Schulte A, Marchetti P, Ibberson M, MacDonald PE, Manning Fox JE, Gloyn AL, Froguel P, Solimena M, McCarthy MI, Rutter GA
American journal of human genetics100(2)238-256(2017 Feb)

Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations.
Yang SK, Hong M, Zhao W, Jung Y, Baek J, Tayebi N, Kim KM, Ye BD, Kim KJ, Park SH, Lee I, Lee EJ, Kim WH, Cheon JH, Kim YH, Jang BI, Kim HS, Choi JH, Koo JS, Lee JH, Jung SA, Lee YJ, Jang JY, Shin HD, Kang D, Youn HS, Liu J, Song K
Gut63(1)80-7(2014 Jan)

Exome sequencing identifies titin mutations causing hereditary myopathy with early respiratory failure (HMERF) in families of diverse ethnic origins.
Toro C, Oliv? M, Dalakas MC, Sivakumar K, Bilbao JM, Tyndel F, Vidal N, Farrero E, Sambuughin N, Goldfarb LG
BMC neurology1329(2013 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Hence, we provide a molecular explanation for acquired resistance to DTX that is caused by the miR-638 deficiency and subsequent STARD10 upregulation. In consequence, alteration of miR-638/STARD10 cascade may represent an attractive strategy in future adjuvant therapy along with DTX chemotherapy.
Title: Potentiation of docetaxel sensitivity by miR-638 via regulation of STARD10 pathway in human breast cancer cells.

StarD10 is required for normal insulin secretion, though its deletion enhances proinsulin processing.
Title: Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

A nonpredicted link between SNAI1-triggered EMT and the down-regulation of Nectin-1 and StarD10 through the up-regulation of miR-661, which may contribute to the invasion of breast cancer cells and poor disease outcome.
Title: miR-661 expression in SNAI1-induced epithelial to mesenchymal transition contributes to breast cancer cell invasion by targeting Nectin-1 and StarD10 messengers.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

The following STARD10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the STARD10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu05618	NM_006645.2 Latest version!	Homo sapiens StAR related lipid transfer domain containing 10 (STARD10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

STARD10 ( NM_006645.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006636.2 Homo sapiens StAR related lipid transfer domain containing 10 (STARD10), mRNA.

Price & Availability↑

CloneID	OHu05618
Clone ID Related Accession (Same CDS sequence)	NM_006645.2
Accession Version	NM_006645.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 876bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Homo sapiens(human)
Product	START domain-containing protein 10
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AP002381.3 and AP003065.2. On Oct 28, 2006 this sequence version replaced NM_006645.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.62279.1, SRR1163658.422931.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGAGAAGC TGGCGGCCTC TACAGAGCCC CAAGGGCCTC GGCCGGTCCT GGGCCGTGAG 
AGTGTCCAGG TGCCCGATGA CCAAGACTTT CGCAGCTTCC GGTCAGAGTG TGAGGCTGAG 
GTGGGCTGGA ACCTGACCTA TAGCAGGGCT GGGGTGTCTG TCTGGGTGCA GGCTGTGGAG 
ATGGATCGGA CGCTGCACAA GATCAAGTGC CGGATGGAGT GCTGTGATGT GCCAGCCGAG 
ACACTCTACG ACGTCCTACA CGACATTGAG TACCGCAAGA AATGGGACAG CAACGTCATT 
GAGACTTTTG ACATCGCCCG CTTGACAGTC AACGCTGACG TGGGCTATTA CTCCTGGAGG 
TGTCCCAAGC CCCTGAAGAA CCGTGATGTC ATCACCCTCC GCTCCTGGCT CCCCATGGGC 
GCTGATTACA TCATTATGAA CTACTCAGTC AAACATCCCA AATACCCACC TCGGAAAGAC 
TTGGTCCGAG CTGTGTCCAT CCAGACGGGC TACCTCATCC AGAGCACAGG GCCCAAGAGC 
TGCGTCATCA CCTACCTGGC CCAGGTGGAC CCCAAAGGCT CCTTACCCAA GTGGGTGGTG 
AATAAATCTT CTCAGTTCCT GGCTCCCAAG GCCATGAAGA AGATGTACAA GGCGTGCCTC 
AAGTACCCCG AGTGGAAACA GAAGCACCTG CCTCACTTCA AGCCGTGGCT GCACCCGGAG 
CAGAGCCCGT TGCCGAGCCT GGCGCTGTCG GAGCTGTCGG TGCAGCATGC GGACTCACTG 
GAGAACATCG ACGAGAGCGC GGTGGCCGAG AGCAGAGAGG AGCGGATGGG CGGCGCGGGC 
GGCGAGGGCA GCGACGACGA CACCTCGCTC ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006636.2
CDS	945..1820
Translation	MEKLAASTEPQGPRPVLGRESVQVPDDQDFRSFRSECEAEVGWNLTYSRAGVSVWVQAVEMDRTLHKIKCRMECCDVPAETLYDVLHDIEYRKKWDSNVIETFDIARLTVNADVGYYSWRCPKPLKNRDVITLRSWLPMGADYIIMNYSVKHPKYPPRKDLVRAVSIQTGYLIQSTGPKSCVITYLAQVDPKGSLPKWVVNKSSQFLAPKAMKKMYKACLKYPEWKQKHLPHFKPWLHPEQSPLPSLALSELSVQHADSLENIDESAVAESREERMGGAGGEGSDDDTSLT

Target ORF information:

RefSeq Version	NM_006645.2
Organism	Homo sapiens(human)
Definition	Homo sapiens StAR related lipid transfer domain containing 10 (STARD10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006645.2

ORF Insert Sequence:

ATGGAGAAGC TGGCGGCCTC TACAGAGCCC CAAGGGCCTC GGCCGGTCCT GGGCCGTGAG 
AGTGTCCAGG TGCCCGATGA CCAAGACTTT CGCAGCTTCC GGTCAGAGTG TGAGGCTGAG 
GTGGGCTGGA ACCTGACCTA TAGCAGGGCT GGGGTGTCTG TCTGGGTGCA GGCTGTGGAG 
ATGGATCGGA CGCTGCACAA GATCAAGTGC CGGATGGAGT GCTGTGATGT GCCAGCCGAG 
ACACTCTACG ACGTCCTACA CGACATTGAG TACCGCAAGA AATGGGACAG CAACGTCATT 
GAGACTTTTG ACATCGCCCG CTTGACAGTC AACGCTGACG TGGGCTATTA CTCCTGGAGG 
TGTCCCAAGC CCCTGAAGAA CCGTGATGTC ATCACCCTCC GCTCCTGGCT CCCCATGGGC 
GCTGATTACA TCATTATGAA CTACTCAGTC AAACATCCCA AATACCCACC TCGGAAAGAC 
TTGGTCCGAG CTGTGTCCAT CCAGACGGGC TACCTCATCC AGAGCACAGG GCCCAAGAGC 
TGCGTCATCA CCTACCTGGC CCAGGTGGAC CCCAAAGGCT CCTTACCCAA GTGGGTGGTG 
AATAAATCTT CTCAGTTCCT GGCTCCCAAG GCCATGAAGA AGATGTACAA GGCGTGCCTC 
AAGTACCCCG AGTGGAAACA GAAGCACCTG CCTCACTTCA AGCCGTGGCT GCACCCGGAG 
CAGAGCCCGT TGCCGAGCCT GGCGCTGTCG GAGCTGTCGG TGCAGCATGC GGACTCACTG 
GAGAACATCG ACGAGAGCGC GGTGGCCGAG AGCAGAGAGG AGCGGATGGG CGGCGCGGGC 
GGCGAGGGCA GCGACGACGA CACCTCGCTC ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Potentiation of docetaxel sensitivity by miR-638 via regulation of STARD10 pathway in human breast cancer cells.
Biochemical and biophysical research communications487(2)255-261(2017 May)
Zhao G,Li Y,Wang T

Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice.
American journal of human genetics100(2)238-256(2017 Feb)
Carrat GR,Hu M,Nguyen-Tu MS,Chabosseau P,Gaulton KJ,van de Bunt M,Siddiq A,Falchi M,Thurner M,Canouil M,Pattou F,Leclerc I,Pullen TJ,Cane MC,Prabhala P,Greenwald W,Schulte A,Marchetti P,Ibberson M,MacDonald PE,Manning Fox JE,Gloyn AL,Froguel P,Solimena M,McCarthy MI,Rutter GA

Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations.
Gut63(1)80-7(2014 Jan)
Yang SK,Hong M,Zhao W,Jung Y,Baek J,Tayebi N,Kim KM,Ye BD,Kim KJ,Park SH,Lee I,Lee EJ,Kim WH,Cheon JH,Kim YH,Jang BI,Kim HS,Choi JH,Koo JS,Lee JH,Jung SA,Lee YJ,Jang JY,Shin HD,Kang D,Youn HS,Liu J,Song K

Exome sequencing identifies titin mutations causing hereditary myopathy with early respiratory failure (HMERF) in families of diverse ethnic origins.
BMC neurology1329(2013 Mar)
Toro C,Oliv? M,Dalakas MC,Sivakumar K,Bilbao JM,Tyndel F,Vidal N,Farrero E,Sambuughin N,Goldfarb LG