RBBP9 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RBBP9
Entrez Gene ID	10741
Full Name	RB binding protein 9, serine hydrolase
Synonyms	BOG,RBBP10
General protein information	Preferred Names RB binding protein 9, serine hydrolase Names putative hydrolase RBBP9 B5T overexpressed gene protein RBBP-10 RBBP-9 retinoblastoma-binding protein 10 retinoblastoma-binding protein 9 retinoma-binding protein 9
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20p11.23
Summary	The protein encoded by this gene is a retinoblastoma binding protein that may play a role in the regulation of cell proliferation and differentiation. Two alternatively spliced transcript variants of this gene with identical predicted protein products have been reported, one of which is a nonsense-mediated decay candidate. [provided by RefSeq, Jul 2008].
Disorder MIM:	602908

mRNA and Protein(s)

mRNA	Protein	Name
NM_006606.3	NP_006597.2	serine hydrolase RBBP9
NM_006606.2	NP_006597.2	putative hydrolase RBBP9
XM_005260652.2	XP_005260709.1	serine hydrolase RBBP9 isoform X1

Pathways from BioSystems

Homologies

	RBBP9	XP_001090408.1
Rattus norvegicus (Norway rat)	Rbbp9	NP_062092.2
Danio rerio (zebrafish)	rbbp9	NP_001036213.1
Pan troglodytes (chimpanzee)	RBBP9	XP_514534.2
Bos taurus (cattle)	RBBP9	NP_001076893.1
Mus musculus (house mouse)	Rbbp9	NP_056569.2
Canis lupus familiaris (dog)	RBBP9	XP_849723.2
Xenopus tropicalis (tropical clawed frog)	LOC100491567	XP_002940143.1
Homo sapiens (human)	RBBP9	NP_006597.2

Gene Ontology
Bibliography

Related articles in PubMed

Human retinoblastoma binding protein 9, a serine hydrolase implicated in pancreatic cancers.
Vorobiev SM, Huang YJ, Seetharaman J, Xiao R, Acton TB, Montelione GT, Tong L
Protein and peptide letters19(2)194-7(2012 Feb)

Two potential biomarkers identified in mesenchymal stem cells and leukocytes of patients with sporadic amyotrophic lateral sclerosis.
Nachmany H, Wald S, Abekasis M, Bulvik S, Weil M
Disease markers32(4)211-20(2012)

Retinoblastoma-binding proteins 4 and 9 are important for human pluripotent stem cell maintenance.
O'Connor MD, Wederell E, Robertson G, Delaney A, Morozova O, Poon SS, Yap D, Fee J, Zhao Y, McDonald H, Zeng T, Hirst M, Marra MA, Aparicio SA, Eaves CJ
Experimental hematology39(8)866-79.e1(2011 Aug)

Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
Lee OH, Kim H, He Q, Baek HJ, Yang D, Chen LY, Liang J, Chae HK, Safari A, Liu D, Songyang Z
Molecular & cellular proteomics : MCP10(2)M110.001628(2011 Feb)

RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia.
Shields DJ, Niessen S, Murphy EA, Mielgo A, Desgrosellier JS, Lau SK, Barnes LA, Lesperance J, Bouvet M, Tarin D, Cravatt BF, Cheresh DA
Proceedings of the National Academy of Sciences of the United States of America107(5)2189-94(2010 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Structure- function studies of RBBP9 suggest possible routes for novel cancer drug discovery programs.
Title: Human retinoblastoma binding protein 9, a serine hydrolase implicated in pancreatic cancers.

blood samples of lateral sclerosis patients were found to have significantly different levels of expression of CyFIP2 and RbBP9 compared to the levels of expression in control subjects.
Title: Two potential biomarkers identified in mesenchymal stem cells and leukocytes of patients with sporadic amyotrophic lateral sclerosis.

Data identified RBBP4 and RBBP9 as required for maintenance of multiple PS cell types, and both RBBPs were bound to RB in PS cells.
Title: Retinoblastoma-binding proteins 4 and 9 are important for human pluripotent stem cell maintenance.

identify RBBP9 as a tumor-associated serine hydrolase that displays elevated activity in pancreatic carcinomas. RBBP9 promotes pancreatic carcinogenesis.
Title: RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia.

The crystal structure of human RBBP9 has been determined at 1.72 A resolution by the seleno-methionyl single-wavelength anomalous diffraction method.
Title: Crystal structure of human retinoblastoma binding protein 9.

The following RBBP9 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RBBP9 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05655	NM_006606.3 Latest version!	Homo sapiens RB binding protein 9, serine hydrolase (RBBP9), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu52661	XM_005260652.2 Latest version!	Homo sapiens RB binding protein 9, serine hydrolase (RBBP9), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OHu05655	NM_006606.2	Homo sapiens RB binding protein 9, serine hydrolase (RBBP9), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RBBP9 ( NM_006606.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006597.2 Homo sapiens RB binding protein 9, serine hydrolase (RBBP9), mRNA.

Price & Availability↑

CloneID	OHu05655
Clone ID Related Accession (Same CDS sequence)	NM_006606.3 , NM_006606.2
Accession Version	NM_006606.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-28
Organism	Homo sapiens(human)
Product	serine hydrolase RBBP9
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL121893.21. On Nov 26, 2018 this sequence version replaced NM_006606.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC015938.1, SRR1660807.49110.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267769 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000337227.9/ ENSP00000336866.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTTCTC CTAGCAAGGC AGTGATTGTT CCCGGGAACG GAGGCGGGGA TGTGACCACC 
CACGGCTGGT ATGGCTGGGT GAAAAAGGAG CTGGAGAAGA TACCTGGTTT CCAGTGTTTG 
GCTAAAAACA TGCCCGACCC AATTACAGCA CGAGAGAGCA TCTGGCTGCC CTTCATGGAG 
ACAGAGCTGC ACTGTGATGA GAAGACTATC ATCATTGGCC ACAGTTCTGG GGCCATCGCG 
GCCATGAGGT ATGCAGAAAC ACATCGAGTA TATGCTATTG TATTAGTGTC TGCGTACACA 
TCAGACTTGG GGGATGAAAA TGAGCGTGCA AGTGGATACT TCACCCGCCC CTGGCAGTGG 
GAGAAGATCA AGGCCAACTG CCCTTACATT GTGCAGTTTG GCTCTACTGA CGACCCGTTC 
CTTCCCTGGA AGGAACAACA AGAAGTGGCC GATAGGTTGG AAACCAAATT GCACAAATTC 
ACTGACTGTG GCCACTTTCA GAACACAGAG TTTCATGAAC TGATTACTGT TGTAAAGTCT 
TTGCTGAAAG TACCAGCATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006597.2
CDS	59..619
Translation	MASPSKAVIVPGNGGGDVTTHGWYGWVKKELEKIPGFQCLAKNMPDPITARESIWLPFMETELHCDEKTIIIGHSSGAIAAMRYAETHRVYAIVLVSAYTSDLGDENERASGYFTRPWQWEKIKANCPYIVQFGSTDDPFLPWKEQQEVADRLETKLHKFTDCGHFQNTEFHELITVVKSLLKVPA

Target ORF information:

RefSeq Version	NM_006606.3
Organism	Homo sapiens(human)
Definition	Homo sapiens RB binding protein 9, serine hydrolase (RBBP9), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006606.3

ORF Insert Sequence:

ATGGCTTCTC CTAGCAAGGC AGTGATTGTT CCCGGGAACG GAGGCGGGGA TGTGACCACC 
CACGGCTGGT ATGGCTGGGT GAAAAAGGAG CTGGAGAAGA TACCTGGTTT CCAGTGTTTG 
GCTAAAAACA TGCCCGACCC AATTACAGCA CGAGAGAGCA TCTGGCTGCC CTTCATGGAG 
ACAGAGCTGC ACTGTGATGA GAAGACTATC ATCATTGGCC ACAGTTCTGG GGCCATCGCG 
GCCATGAGGT ATGCAGAAAC ACATCGAGTA TATGCTATTG TATTAGTGTC TGCGTACACA 
TCAGACTTGG GGGATGAAAA TGAGCGTGCA AGTGGATACT TCACCCGCCC CTGGCAGTGG 
GAGAAGATCA AGGCCAACTG CCCTTACATT GTGCAGTTTG GCTCTACTGA CGACCCGTTC 
CTTCCCTGGA AGGAACAACA AGAAGTGGCC GATAGGTTGG AAACCAAATT GCACAAATTC 
ACTGACTGTG GCCACTTTCA GAACACAGAG TTTCATGAAC TGATTACTGT TGTAAAGTCT 
TTGCTGAAAG TACCAGCATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RBBP9 ( NM_006606.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006597.2 Homo sapiens RB binding protein 9, serine hydrolase (RBBP9), mRNA.

Price & Availability↑

CloneID	OHu05655
Clone ID Related Accession (Same CDS sequence)	NM_006606.3 , NM_006606.2
Accession Version	NM_006606.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	putative hydrolase RBBP9
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC015938.1. On Oct 18, 2002 this sequence version replaced NM_006606.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC015938.1, SRR1660807.49110.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267769 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTTCTC CTAGCAAGGC AGTGATTGTT CCCGGGAACG GAGGCGGGGA TGTGACCACC 
CACGGCTGGT ATGGCTGGGT GAAAAAGGAG CTGGAGAAGA TACCTGGTTT CCAGTGTTTG 
GCTAAAAACA TGCCCGACCC AATTACAGCA CGAGAGAGCA TCTGGCTGCC CTTCATGGAG 
ACAGAGCTGC ACTGTGATGA GAAGACTATC ATCATTGGCC ACAGTTCTGG GGCCATCGCG 
GCCATGAGGT ATGCAGAAAC ACATCGAGTA TATGCTATTG TATTAGTGTC TGCGTACACA 
TCAGACTTGG GGGATGAAAA TGAGCGTGCA AGTGGATACT TCACCCGCCC CTGGCAGTGG 
GAGAAGATCA AGGCCAACTG CCCTTACATT GTGCAGTTTG GCTCTACTGA CGACCCGTTC 
CTTCCCTGGA AGGAACAACA AGAAGTGGCC GATAGGTTGG AAACCAAATT GCACAAATTC 
ACTGACTGTG GCCACTTTCA GAACACAGAG TTTCATGAAC TGATTACTGT TGTAAAGTCT 
TTGCTGAAAG TACCAGCATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006597.2
CDS	77..637
Translation	MASPSKAVIVPGNGGGDVTTHGWYGWVKKELEKIPGFQCLAKNMPDPITARESIWLPFMETELHCDEKTIIIGHSSGAIAAMRYAETHRVYAIVLVSAYTSDLGDENERASGYFTRPWQWEKIKANCPYIVQFGSTDDPFLPWKEQQEVADRLETKLHKFTDCGHFQNTEFHELITVVKSLLKVPA

Target ORF information:

RefSeq Version	NM_006606.2
Organism	Homo sapiens(human)
Definition	Homo sapiens RB binding protein 9, serine hydrolase (RBBP9), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006606.2

ORF Insert Sequence:

ATGGCTTCTC CTAGCAAGGC AGTGATTGTT CCCGGGAACG GAGGCGGGGA TGTGACCACC 
CACGGCTGGT ATGGCTGGGT GAAAAAGGAG CTGGAGAAGA TACCTGGTTT CCAGTGTTTG 
GCTAAAAACA TGCCCGACCC AATTACAGCA CGAGAGAGCA TCTGGCTGCC CTTCATGGAG 
ACAGAGCTGC ACTGTGATGA GAAGACTATC ATCATTGGCC ACAGTTCTGG GGCCATCGCG 
GCCATGAGGT ATGCAGAAAC ACATCGAGTA TATGCTATTG TATTAGTGTC TGCGTACACA 
TCAGACTTGG GGGATGAAAA TGAGCGTGCA AGTGGATACT TCACCCGCCC CTGGCAGTGG 
GAGAAGATCA AGGCCAACTG CCCTTACATT GTGCAGTTTG GCTCTACTGA CGACCCGTTC 
CTTCCCTGGA AGGAACAACA AGAAGTGGCC GATAGGTTGG AAACCAAATT GCACAAATTC 
ACTGACTGTG GCCACTTTCA GAACACAGAG TTTCATGAAC TGATTACTGT TGTAAAGTCT 
TTGCTGAAAG TACCAGCATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RBBP9 ( XM_005260652.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005260709.1 Homo sapiens RB binding protein 9, serine hydrolase (RBBP9), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu52661
Clone ID Related Accession (Same CDS sequence)	XM_005260652.2
Accession Version	XM_005260652.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	serine hydrolase RBBP9 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005260652.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGACAG AGCTGCACTG TGATGAGAAG ACTATCATCA TTGGCCACAG TTCTGGGGCC 
ATCGCGGCCA TGAGGTATGC AGAAACACAT CGAGTATATG CTATTGTATT AGTGTCTGCG 
TACACATCAG ACTTGGGGGA TGAAAATGAG CGTGCAAGTG GATACTTCAC CCGCCCCTGG 
CAGTGGGAGA AGATCAAGGC CAACTGCCCT TACATTGTGC AGTTTGGCTC TACTGACGAC 
CCGTTCCTTC CCTGGAAGGA ACAACAAGAA GTGGCCGATA GGTTGGAAAC CAAATTGCAC 
AAATTCACTG ACTGTGGCCA CTTTCAGAAC ACAGAGTTTC ATGAACTGAT TACTGTTGTA 
AAGTCTTTGC TGAAAGTACC AGCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005260709.1
CDS	215..601
Translation	METELHCDEKTIIIGHSSGAIAAMRYAETHRVYAIVLVSAYTSDLGDENERASGYFTRPWQWEKIKANCPYIVQFGSTDDPFLPWKEQQEVADRLETKLHKFTDCGHFQNTEFHELITVVKSLLKVPA

Target ORF information:

RefSeq Version	XM_005260652.2
Organism	Homo sapiens(human)
Definition	Homo sapiens RB binding protein 9, serine hydrolase (RBBP9), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005260652.2

ORF Insert Sequence:

ATGGAGACAG AGCTGCACTG TGATGAGAAG ACTATCATCA TTGGCCACAG TTCTGGGGCC 
ATCGCGGCCA TGAGGTATGC AGAAACACAT CGAGTATATG CTATTGTATT AGTGTCTGCG 
TACACATCAG ACTTGGGGGA TGAAAATGAG CGTGCAAGTG GATACTTCAC CCGCCCCTGG 
CAGTGGGAGA AGATCAAGGC CAACTGCCCT TACATTGTGC AGTTTGGCTC TACTGACGAC 
CCGTTCCTTC CCTGGAAGGA ACAACAAGAA GTGGCCGATA GGTTGGAAAC CAAATTGCAC 
AAATTCACTG ACTGTGGCCA CTTTCAGAAC ACAGAGTTTC ATGAACTGAT TACTGTTGTA 
AAGTCTTTGC TGAAAGTACC AGCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human retinoblastoma binding protein 9, a serine hydrolase implicated in pancreatic cancers.
Protein and peptide letters19(2)194-7(2012 Feb)
Vorobiev SM,Huang YJ,Seetharaman J,Xiao R,Acton TB,Montelione GT,Tong L

Two potential biomarkers identified in mesenchymal stem cells and leukocytes of patients with sporadic amyotrophic lateral sclerosis.
Disease markers32(4)211-20(2012)
Nachmany H,Wald S,Abekasis M,Bulvik S,Weil M

Retinoblastoma-binding proteins 4 and 9 are important for human pluripotent stem cell maintenance.
Experimental hematology39(8)866-79.e1(2011 Aug)
O'Connor MD,Wederell E,Robertson G,Delaney A,Morozova O,Poon SS,Yap D,Fee J,Zhao Y,McDonald H,Zeng T,Hirst M,Marra MA,Aparicio SA,Eaves CJ

Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
Molecular & cellular proteomics : MCP10(2)M110.001628(2011 Feb)
Lee OH,Kim H,He Q,Baek HJ,Yang D,Chen LY,Liang J,Chae HK,Safari A,Liu D,Songyang Z

RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia.
Proceedings of the National Academy of Sciences of the United States of America107(5)2189-94(2010 Feb)
Shields DJ,Niessen S,Murphy EA,Mielgo A,Desgrosellier JS,Lau SK,Barnes LA,Lesperance J,Bouvet M,Tarin D,Cravatt BF,Cheresh DA

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RBBP9 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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見積依頼

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FAX

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