TADA3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TADA3
Entrez Gene ID	10474
Full Name	transcriptional adaptor 3
Synonyms	ADA3,NGG1,STAF54,TADA3L,hADA3
General protein information	Preferred Names transcriptional adaptor 3 Names transcriptional adapter 3 ADA3 homolog ADA3-like protein alteration/deficiency in activation 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3p25.3
Summary	DNA-binding transcriptional activator proteins increase the rate of transcription by interacting with the transcriptional machinery bound to the basal promoter in conjunction with adaptor proteins, possibly by acetylation and destabilization of nucleosomes. The protein encoded by this gene is a transcriptional activator adaptor and a component of the histone acetyl transferase (HAT) coactivator complex which plays a crucial role in chromatin modulation and cell cycle progression. Along with the other components of the complex, this protein links transcriptional activators bound to specific promoters, to histone acetylation and the transcriptional machinery. The protein is also involved in the stabilization and activation of the p53 tumor suppressor protein that plays a role in the cellular response to DNA damage. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013].
Disorder MIM:	602945

mRNA and Protein(s)

mRNA	Protein	Name
NM_001278270.1	NP_001265199.1	transcriptional adapter 3 isoform a
NM_006354.3	NP_006345.1	transcriptional adapter 3 isoform a
NM_133480.2	NP_597814.1	transcriptional adapter 3 isoform b

Pathways from BioSystems

Homologies

Homo sapiens (human)	TADA3	NP_006345.1
Rattus norvegicus (Norway rat)	Tada3	NP_001020905.1
Danio rerio (zebrafish)	tada3l	NP_956220.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010459	XP_311489.4
Xenopus tropicalis (tropical clawed frog)	tada3	NP_001008040.1
Mus musculus (house mouse)	Tada3	NP_598693.1
Gallus gallus (chicken)	TADA3	XP_414389.2
Drosophila melanogaster (fruit fly)	dik	NP_001259667.1
Pan troglodytes (chimpanzee)	TADA3	XP_516264.3
Bos taurus (cattle)	TADA3	NP_001019682.1
	TADA3	XP_001095334.1
Canis lupus familiaris (dog)	TADA3	XP_533748.2

Gene Ontology
Bibliography

Related articles in PubMed

Epidermal Growth Factor Receptor activation promotes ADA3 acetylation through the AKT-p300 pathway.
Srivastava S, Mohibi S, Mirza S, Band H, Band V
Cell cycle (Georgetown, Tex.)16(16)1515-1525(2017 Aug)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Che1/AATF interacts with subunits of the histone acetyltransferase core module of SAGA complexes.
Caliskan G, Baris IC, Ayaydin F, Dobson MJ, Senarisoy M, Boros IM, Topcu Z, Zencir S
PloS one12(12)e0189193(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ADA3 overexpression enhances cell proliferation that is associated with increased expression of c-MYC. Expression patterns with respect to ADA3/c-MYC can divide patients into four significantly different subgroups, with c-MYC High and ADA3 Low status independently predicting poor survival in patients.
Title: ADA3 regulates normal and tumor mammary epithelial cell proliferation through c-MYC.

Findings demonstrate that acetylation of ADA3 by its associated histone acetyltransferases is essential for its key role in histone acetylation and cell cycle progression.
Title: Acetylation of Mammalian ADA3 Is Required for Its Functional Roles in Histone Acetylation and Cell Proliferation.

review on hADA3 with a comprehensive outlook on the molecular and functional roles of hADA3
Title: Tale of a multifaceted co-activator, hADA3: from embryogenesis to cancer and beyond.

results thus demonstrate that the catalytic activity of GCN5 is stimulated by subunits of the ADA2a- or ADA2b-containing HAT modules and is further increased by incorporation of the distinct HAT modules in the ATAC or SAGA holo-complexes
Title: Subunits of ADA-two-A-containing (ATAC) or Spt-Ada-Gcn5-acetyltrasferase (SAGA) Coactivator Complexes Enhance the Acetyltransferase Activity of GCN5.

PCAF and ADA3 regulate Bid processing via PACS2, to modulate the mitochondrial cell death pathway in response to hGrzB.
Title: A functional genomics screen identifies PCAF and ADA3 as regulators of human granzyme B-mediated apoptosis and Bid cleavage.

The following TADA3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TADA3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04390	NM_001278270.1 Latest version!	Homo sapiens transcriptional adaptor 3 (TADA3), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu04390	NM_006354.3 Latest version!	Homo sapiens transcriptional adaptor 3 (TADA3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu07670	NM_133480.2 Latest version!	Homo sapiens transcriptional adaptor 3 (TADA3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TADA3 ( NM_001278270.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001265199.1 Homo sapiens transcriptional adaptor 3 (TADA3), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu04390
Clone ID Related Accession (Same CDS sequence)	NM_001278270.1 , NM_006354.3
Accession Version	NM_001278270.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1299bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-10
Organism	Homo sapiens(human)
Product	transcriptional adapter 3 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK292264.1, BC009240.2, BC013433.1 and AA602644.1. Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK292264.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTGAGT TGAAAGACTG CCCCTTGCAG TTCCACGACT TCAAGTCTGT GGATCACCTG 
AAGGTCTGTC CCCGCTACAC GGCAGTGCTG GCACGCTCTG AGGATGATGG CATCGGCATC 
GAGGAGCTGG ACACCCTGCA GCTGGAGCTG GAGACCCTGC TGTCTTCTGC CAGCCGGCGC 
CTGCGTGTGC TTGAGGCCGA AACCCAGATC CTCACCGACT GGCAGGATAA GAAAGGTGAC 
AGACGATTCC TGAAGCTGGG TCGAGACCAT GAACTTGGAG CTCCCCCCAA ACATGGGAAG 
CCCAAGAAGC AGAAACTGGA AGGGAAGGCA GGACATGGGC CGGGCCCTGG CCCAGGACGG 
CCCAAATCCA AAAACCTTCA GCCCAAGATC CAGGAATATG AATTCACTGA TGACCCTATC 
GACGTGCCAC GGATCCCCAA AAATGATGCC CCCAACAGGT TCTGGGCTTC AGTGGAGCCC 
TACTGTGCTG ACATCACCAG CGAGGAGGTC CGCACACTTG AGGAGTTACT GAAGCCCCCA 
GAAGATGAGG CTGAGCATTA CAAGATCCCA CCCCTGGGGA AGCACTACTC CCAGCGCTGG 
GCCCAGGAGG ACCTGCTGGA GGAGCAGAAG GATGGGGCCC GGGCAGCGGC TGTGGCTGAC 
AAGAAGAAAG GCCTCATGGG GCCACTGACC GAACTGGACA CTAAAGATGT GGATGCCCTG 
CTGAAGAAGT CTGAGGCCCA GCATGAACAG CCGGAAGATG GATGCCCCTT TGGTGCCCTG 
ACGCAGCGCC TCCTGCAGGC CCTGGTGGAG GAAAATATTA TTTCCCCTAT GGAGGATTCT 
CCTATTCCTG ACATGTCTGG GAAAGAATCA GGGGCTGACG GGGCAAGCAC CTCCCCTCGC 
AATCAGAACA AGCCCTTCAG TGTGCCGCAT ACTAAGTCCC TGGAGAGCCG CATCAAGGAG 
GAGCTAATTG CCCAGGGCCT TTTGGAGTCT GAGGACCGCC CCGCAGAGGA CTCCGAGGAT 
GAGGTCCTTG CTGAGCTTCG CAAACGGCAG GCTGAGCTGA AGGCACTTAG TGCCCACAAC 
CGCACCAAGA AGCACGACCT GCTGAGGCTG GCAAAGGAGG AGGTGAGCCG GCAGGAGCTG 
AGGCAGCGGG TGCGCATGGC TGACAACGAG GTCATGGACG CCTTTCGCAA GATCATGGCT 
GCCCGGCAGA AGAAGCGGAC TCCCACCAAG AAAGAAAAGG ACCAGGCCTG GAAGACTCTG 
AAGGAGCGTG AGAGCATCCT GAAGCTGCTG GATGGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001265199.1
CDS	218..1516
Translation	MSELKDCPLQFHDFKSVDHLKVCPRYTAVLARSEDDGIGIEELDTLQLELETLLSSASRRLRVLEAETQILTDWQDKKGDRRFLKLGRDHELGAPPKHGKPKKQKLEGKAGHGPGPGPGRPKSKNLQPKIQEYEFTDDPIDVPRIPKNDAPNRFWASVEPYCADITSEEVRTLEELLKPPEDEAEHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAVADKKKGLMGPLTELDTKDVDALLKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTLKERESILKLLDG

Target ORF information:

RefSeq Version	NM_001278270.1
Organism	Homo sapiens(human)
Definition	Homo sapiens transcriptional adaptor 3 (TADA3), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001278270.1

ORF Insert Sequence:

ATGAGTGAGT TGAAAGACTG CCCCTTGCAG TTCCACGACT TCAAGTCTGT GGATCACCTG 
AAGGTCTGTC CCCGCTACAC GGCAGTGCTG GCACGCTCTG AGGATGATGG CATCGGCATC 
GAGGAGCTGG ACACCCTGCA GCTGGAGCTG GAGACCCTGC TGTCTTCTGC CAGCCGGCGC 
CTGCGTGTGC TTGAGGCCGA AACCCAGATC CTCACCGACT GGCAGGATAA GAAAGGTGAC 
AGACGATTCC TGAAGCTGGG TCGAGACCAT GAACTTGGAG CTCCCCCCAA ACATGGGAAG 
CCCAAGAAGC AGAAACTGGA AGGGAAGGCA GGACATGGGC CGGGCCCTGG CCCAGGACGG 
CCCAAATCCA AAAACCTTCA GCCCAAGATC CAGGAATATG AATTCACTGA TGACCCTATC 
GACGTGCCAC GGATCCCCAA AAATGATGCC CCCAACAGGT TCTGGGCTTC AGTGGAGCCC 
TACTGTGCTG ACATCACCAG CGAGGAGGTC CGCACACTTG AGGAGTTACT GAAGCCCCCA 
GAAGATGAGG CTGAGCATTA CAAGATCCCA CCCCTGGGGA AGCACTACTC CCAGCGCTGG 
GCCCAGGAGG ACCTGCTGGA GGAGCAGAAG GATGGGGCCC GGGCAGCGGC TGTGGCTGAC 
AAGAAGAAAG GCCTCATGGG GCCACTGACC GAACTGGACA CTAAAGATGT GGATGCCCTG 
CTGAAGAAGT CTGAGGCCCA GCATGAACAG CCGGAAGATG GATGCCCCTT TGGTGCCCTG 
ACGCAGCGCC TCCTGCAGGC CCTGGTGGAG GAAAATATTA TTTCCCCTAT GGAGGATTCT 
CCTATTCCTG ACATGTCTGG GAAAGAATCA GGGGCTGACG GGGCAAGCAC CTCCCCTCGC 
AATCAGAACA AGCCCTTCAG TGTGCCGCAT ACTAAGTCCC TGGAGAGCCG CATCAAGGAG 
GAGCTAATTG CCCAGGGCCT TTTGGAGTCT GAGGACCGCC CCGCAGAGGA CTCCGAGGAT 
GAGGTCCTTG CTGAGCTTCG CAAACGGCAG GCTGAGCTGA AGGCACTTAG TGCCCACAAC 
CGCACCAAGA AGCACGACCT GCTGAGGCTG GCAAAGGAGG AGGTGAGCCG GCAGGAGCTG 
AGGCAGCGGG TGCGCATGGC TGACAACGAG GTCATGGACG CCTTTCGCAA GATCATGGCT 
GCCCGGCAGA AGAAGCGGAC TCCCACCAAG AAAGAAAAGG ACCAGGCCTG GAAGACTCTG 
AAGGAGCGTG AGAGCATCCT GAAGCTGCTG GATGGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TADA3 ( NM_006354.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006345.1 Homo sapiens transcriptional adaptor 3 (TADA3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu04390
Clone ID Related Accession (Same CDS sequence)	NM_001278270.1 , NM_006354.3
Accession Version	NM_006354.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1299bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-10
Organism	Homo sapiens(human)
Product	transcriptional adapter 3 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK292264.1, AC022382.4, DB032623.1, BM560517.1, BC009240.2, BC013433.1 and AA602644.1. On May 25, 2013 this sequence version replaced NM_006354.2. Transcript Variant: This variant (1) encodes the longer protein. Variants 1 and 3 encode the same isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC013433.1, SRR1163657.255573.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGTGAGT TGAAAGACTG CCCCTTGCAG TTCCACGACT TCAAGTCTGT GGATCACCTG 
AAGGTCTGTC CCCGCTACAC GGCAGTGCTG GCACGCTCTG AGGATGATGG CATCGGCATC 
GAGGAGCTGG ACACCCTGCA GCTGGAGCTG GAGACCCTGC TGTCTTCTGC CAGCCGGCGC 
CTGCGTGTGC TTGAGGCCGA AACCCAGATC CTCACCGACT GGCAGGATAA GAAAGGTGAC 
AGACGATTCC TGAAGCTGGG TCGAGACCAT GAACTTGGAG CTCCCCCCAA ACATGGGAAG 
CCCAAGAAGC AGAAACTGGA AGGGAAGGCA GGACATGGGC CGGGCCCTGG CCCAGGACGG 
CCCAAATCCA AAAACCTTCA GCCCAAGATC CAGGAATATG AATTCACTGA TGACCCTATC 
GACGTGCCAC GGATCCCCAA AAATGATGCC CCCAACAGGT TCTGGGCTTC AGTGGAGCCC 
TACTGTGCTG ACATCACCAG CGAGGAGGTC CGCACACTTG AGGAGTTACT GAAGCCCCCA 
GAAGATGAGG CTGAGCATTA CAAGATCCCA CCCCTGGGGA AGCACTACTC CCAGCGCTGG 
GCCCAGGAGG ACCTGCTGGA GGAGCAGAAG GATGGGGCCC GGGCAGCGGC TGTGGCTGAC 
AAGAAGAAAG GCCTCATGGG GCCACTGACC GAACTGGACA CTAAAGATGT GGATGCCCTG 
CTGAAGAAGT CTGAGGCCCA GCATGAACAG CCGGAAGATG GATGCCCCTT TGGTGCCCTG 
ACGCAGCGCC TCCTGCAGGC CCTGGTGGAG GAAAATATTA TTTCCCCTAT GGAGGATTCT 
CCTATTCCTG ACATGTCTGG GAAAGAATCA GGGGCTGACG GGGCAAGCAC CTCCCCTCGC 
AATCAGAACA AGCCCTTCAG TGTGCCGCAT ACTAAGTCCC TGGAGAGCCG CATCAAGGAG 
GAGCTAATTG CCCAGGGCCT TTTGGAGTCT GAGGACCGCC CCGCAGAGGA CTCCGAGGAT 
GAGGTCCTTG CTGAGCTTCG CAAACGGCAG GCTGAGCTGA AGGCACTTAG TGCCCACAAC 
CGCACCAAGA AGCACGACCT GCTGAGGCTG GCAAAGGAGG AGGTGAGCCG GCAGGAGCTG 
AGGCAGCGGG TGCGCATGGC TGACAACGAG GTCATGGACG CCTTTCGCAA GATCATGGCT 
GCCCGGCAGA AGAAGCGGAC TCCCACCAAG AAAGAAAAGG ACCAGGCCTG GAAGACTCTG 
AAGGAGCGTG AGAGCATCCT GAAGCTGCTG GATGGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006345.1
CDS	824..2122
Translation	MSELKDCPLQFHDFKSVDHLKVCPRYTAVLARSEDDGIGIEELDTLQLELETLLSSASRRLRVLEAETQILTDWQDKKGDRRFLKLGRDHELGAPPKHGKPKKQKLEGKAGHGPGPGPGRPKSKNLQPKIQEYEFTDDPIDVPRIPKNDAPNRFWASVEPYCADITSEEVRTLEELLKPPEDEAEHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAVADKKKGLMGPLTELDTKDVDALLKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTLKERESILKLLDG

Target ORF information:

RefSeq Version	NM_006354.3
Organism	Homo sapiens(human)
Definition	Homo sapiens transcriptional adaptor 3 (TADA3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006354.3

ORF Insert Sequence:

ATGAGTGAGT TGAAAGACTG CCCCTTGCAG TTCCACGACT TCAAGTCTGT GGATCACCTG 
AAGGTCTGTC CCCGCTACAC GGCAGTGCTG GCACGCTCTG AGGATGATGG CATCGGCATC 
GAGGAGCTGG ACACCCTGCA GCTGGAGCTG GAGACCCTGC TGTCTTCTGC CAGCCGGCGC 
CTGCGTGTGC TTGAGGCCGA AACCCAGATC CTCACCGACT GGCAGGATAA GAAAGGTGAC 
AGACGATTCC TGAAGCTGGG TCGAGACCAT GAACTTGGAG CTCCCCCCAA ACATGGGAAG 
CCCAAGAAGC AGAAACTGGA AGGGAAGGCA GGACATGGGC CGGGCCCTGG CCCAGGACGG 
CCCAAATCCA AAAACCTTCA GCCCAAGATC CAGGAATATG AATTCACTGA TGACCCTATC 
GACGTGCCAC GGATCCCCAA AAATGATGCC CCCAACAGGT TCTGGGCTTC AGTGGAGCCC 
TACTGTGCTG ACATCACCAG CGAGGAGGTC CGCACACTTG AGGAGTTACT GAAGCCCCCA 
GAAGATGAGG CTGAGCATTA CAAGATCCCA CCCCTGGGGA AGCACTACTC CCAGCGCTGG 
GCCCAGGAGG ACCTGCTGGA GGAGCAGAAG GATGGGGCCC GGGCAGCGGC TGTGGCTGAC 
AAGAAGAAAG GCCTCATGGG GCCACTGACC GAACTGGACA CTAAAGATGT GGATGCCCTG 
CTGAAGAAGT CTGAGGCCCA GCATGAACAG CCGGAAGATG GATGCCCCTT TGGTGCCCTG 
ACGCAGCGCC TCCTGCAGGC CCTGGTGGAG GAAAATATTA TTTCCCCTAT GGAGGATTCT 
CCTATTCCTG ACATGTCTGG GAAAGAATCA GGGGCTGACG GGGCAAGCAC CTCCCCTCGC 
AATCAGAACA AGCCCTTCAG TGTGCCGCAT ACTAAGTCCC TGGAGAGCCG CATCAAGGAG 
GAGCTAATTG CCCAGGGCCT TTTGGAGTCT GAGGACCGCC CCGCAGAGGA CTCCGAGGAT 
GAGGTCCTTG CTGAGCTTCG CAAACGGCAG GCTGAGCTGA AGGCACTTAG TGCCCACAAC 
CGCACCAAGA AGCACGACCT GCTGAGGCTG GCAAAGGAGG AGGTGAGCCG GCAGGAGCTG 
AGGCAGCGGG TGCGCATGGC TGACAACGAG GTCATGGACG CCTTTCGCAA GATCATGGCT 
GCCCGGCAGA AGAAGCGGAC TCCCACCAAG AAAGAAAAGG ACCAGGCCTG GAAGACTCTG 
AAGGAGCGTG AGAGCATCCT GAAGCTGCTG GATGGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TADA3 ( NM_133480.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_597814.1 Homo sapiens transcriptional adaptor 3 (TADA3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu07670
Clone ID Related Accession (Same CDS sequence)	NM_133480.2
Accession Version	NM_133480.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1110bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-10
Organism	Homo sapiens(human)
Product	transcriptional adapter 3 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK292264.1, AC022382.4, DB032623.1, BM560517.1 and BC009240.2. On May 25, 2013 this sequence version replaced NM_133480.1. Transcript Variant: This variant (2) lacks an exon and its 3' terminal exon extends past a splice site that is used in variant 1, that results in an early stop codon and a different 3' UTR, compared to variant 1. It encodes isoform b which is shorter at the C-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC009240.2, SRR1803617.46405.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTGAGT TGAAAGACTG CCCCTTGCAG TTCCACGACT TCAAGTCTGT GGATCACCTG 
AAGGTCTGTC CCCGCTACAC GGCAGTGCTG GCACGCTCTG AGGATGATGG CATCGGCATC 
GAGGAGCTGG ACACCCTGCA GCTGGAGCTG GAGACCCTGC TGTCTTCTGC CAGCCGGCGC 
CTGCGTGTGC TTGAGGCCGA AACCCAGATC CTCACCGACT GGCAGGATAA GAAAGGTGAC 
AGACGATTCC TGAAGCTGGG TCGAGACCAT GAACTTGGAG CTCCCCCCAA ACATGGGAAG 
CCCAAGAAGC AGAAACTGGA AGGGAAGGCA GGACATGGGC CGGGCCCTGG CCCAGGACGG 
CCCAAATCCA AAAACCTTCA GCCCAAGATC CAGGAATATG AATTCACTGA TGACCCTATC 
GACGTGCCAC GGATCCCCAA AAATGATGCC CCCAACAGGT TCTGGGCTTC AGTGGAGCCC 
TACTGTGCTG ACATCACCAG CGAGGAGGTC CGCACACTTG AGGAGTTACT GAAGCCCCCA 
GAAGATGAGG CTGAGCATTA CAAGATCCCA CCCCTGGGGA AGCACTACTC CCAGCGCTGG 
GCCCAGGAGG ACCTGCTGGA GGAGCAGAAG GATGGGGCCC GGGCAGCGGC TGTGGCTGAC 
AAGAAGAAAG GCCTCATGGG GCCACTGACC GAACTGGACA CTAAAGATGT GGATGCCCTG 
CTGAAGAAGT CTGAGGCCCA GCATGAACAG CCGGAAGATG GATGCCCCTT TGGTGCCCTG 
ACGCAGCGCC TCCTGCAGGC CCTGGTGGAG GAAAATATTA TTTCCCCTAT GGAGGATTCT 
CCTATTCCTG ACATGTCTGG GAAAGAATCA GGGGCTGACG GGGCAAGCAC CTCCCCTCGC 
AATCAGAACA AGCCCTTCAG TGTGCCGCAT ACTAAGTCCC TGGAGAGCCG CATCAAGGAG 
GAGCTAATTG CCCAGGGCCT TTTGGAGTCT GAGGACCGCC CCGCAGAGGA CTCCGAGGAT 
GAGGTCCTTG CTGAGCTTCG CAAACGGCAG GCTGAGCTGA AGGCACTTAG TGCCCACAAC 
CGCACCAAGA AGCACGACCT GCTGAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_597814.1
CDS	824..1933
Translation	MSELKDCPLQFHDFKSVDHLKVCPRYTAVLARSEDDGIGIEELDTLQLELETLLSSASRRLRVLEAETQILTDWQDKKGDRRFLKLGRDHELGAPPKHGKPKKQKLEGKAGHGPGPGPGRPKSKNLQPKIQEYEFTDDPIDVPRIPKNDAPNRFWASVEPYCADITSEEVRTLEELLKPPEDEAEHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAVADKKKGLMGPLTELDTKDVDALLKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRTKKHDLLR

Target ORF information:

RefSeq Version	NM_133480.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transcriptional adaptor 3 (TADA3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133480.2

ORF Insert Sequence:

ATGAGTGAGT TGAAAGACTG CCCCTTGCAG TTCCACGACT TCAAGTCTGT GGATCACCTG 
AAGGTCTGTC CCCGCTACAC GGCAGTGCTG GCACGCTCTG AGGATGATGG CATCGGCATC 
GAGGAGCTGG ACACCCTGCA GCTGGAGCTG GAGACCCTGC TGTCTTCTGC CAGCCGGCGC 
CTGCGTGTGC TTGAGGCCGA AACCCAGATC CTCACCGACT GGCAGGATAA GAAAGGTGAC 
AGACGATTCC TGAAGCTGGG TCGAGACCAT GAACTTGGAG CTCCCCCCAA ACATGGGAAG 
CCCAAGAAGC AGAAACTGGA AGGGAAGGCA GGACATGGGC CGGGCCCTGG CCCAGGACGG 
CCCAAATCCA AAAACCTTCA GCCCAAGATC CAGGAATATG AATTCACTGA TGACCCTATC 
GACGTGCCAC GGATCCCCAA AAATGATGCC CCCAACAGGT TCTGGGCTTC AGTGGAGCCC 
TACTGTGCTG ACATCACCAG CGAGGAGGTC CGCACACTTG AGGAGTTACT GAAGCCCCCA 
GAAGATGAGG CTGAGCATTA CAAGATCCCA CCCCTGGGGA AGCACTACTC CCAGCGCTGG 
GCCCAGGAGG ACCTGCTGGA GGAGCAGAAG GATGGGGCCC GGGCAGCGGC TGTGGCTGAC 
AAGAAGAAAG GCCTCATGGG GCCACTGACC GAACTGGACA CTAAAGATGT GGATGCCCTG 
CTGAAGAAGT CTGAGGCCCA GCATGAACAG CCGGAAGATG GATGCCCCTT TGGTGCCCTG 
ACGCAGCGCC TCCTGCAGGC CCTGGTGGAG GAAAATATTA TTTCCCCTAT GGAGGATTCT 
CCTATTCCTG ACATGTCTGG GAAAGAATCA GGGGCTGACG GGGCAAGCAC CTCCCCTCGC 
AATCAGAACA AGCCCTTCAG TGTGCCGCAT ACTAAGTCCC TGGAGAGCCG CATCAAGGAG 
GAGCTAATTG CCCAGGGCCT TTTGGAGTCT GAGGACCGCC CCGCAGAGGA CTCCGAGGAT 
GAGGTCCTTG CTGAGCTTCG CAAACGGCAG GCTGAGCTGA AGGCACTTAG TGCCCACAAC 
CGCACCAAGA AGCACGACCT GCTGAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Epidermal Growth Factor Receptor activation promotes ADA3 acetylation through the AKT-p300 pathway.
Cell cycle (Georgetown, Tex.)16(16)1515-1525(2017 Aug)
Srivastava S,Mohibi S,Mirza S,Band H,Band V

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Che1/AATF interacts with subunits of the histone acetyltransferase core module of SAGA complexes.
PloS one12(12)e0189193(2017)
Caliskan G,Baris IC,Ayaydin F,Dobson MJ,Senarisoy M,Boros IM,Topcu Z,Zencir S

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TADA3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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