AASS cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	AASS
Entrez Gene ID	10157
Full Name	aminoadipate-semialdehyde synthase
Synonyms	LKR/SDH,LKRSDH,LORSDH
General protein information	Preferred Names aminoadipate-semialdehyde synthase Names alpha-aminoadipic semialdehyde synthase, mitochondrial alpha-aminoadipate semialdehyde synthase aminoadipic semialdehyde synthase lysine-2-oxoglutarate reductase lysine-ketoglutarate reductase /saccharopine dehydrogenase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q31.32
Summary	This gene encodes a bifunctional enzyme that catalyzes the first two steps in the mammalian lysine degradation pathway. The N-terminal and the C-terminal portions of this enzyme contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively, resulting in the conversion of lysine to alpha-aminoadipic semialdehyde. Mutations in this gene are associated with familial hyperlysinemia. [provided by RefSeq, Jul 2008].
Disorder MIM:	605113
Disorder Html:	Hyperlysinemia, 238700 (3); Saccharopinuria, 268700 (1)

mRNA and Protein(s)

mRNA	Protein	Name
NM_005763.3	NP_005754.2	alpha-aminoadipic semialdehyde synthase, mitochondrial
XM_011515725.2	XP_011514027.1	alpha-aminoadipic semialdehyde synthase, mitochondrial isoform X1
NM_005763.4	NP_005754.2	alpha-aminoadipic semialdehyde synthase, mitochondrial

Pathways from BioSystems

Homologies

	AASS	XP_002803495.1
Canis lupus familiaris (dog)	AASS	XP_005628825.1
Bos taurus (cattle)	AASS	NP_001103267.1
Rattus norvegicus (Norway rat)	Aass	NP_001094433.1
Magnaporthe oryzae (rice blast fungus)	MGG_17041	XP_003716085.1
Arabidopsis thaliana (thale cress)	AT4G33150	NP_567914.1
Homo sapiens (human)	AASS	NP_005754.2
Gallus gallus (chicken)	AASS	XP_416001.2
Schizosaccharomyces pombe (fission yeast)	SPBC3B8.03	NP_596411.1
Oryza sativa (rice)	Os02g0783700	NP_001048324.1
Pan troglodytes (chimpanzee)	AASS	XP_001145257.1
Caenorhabditis elegans (roundworm)	CELE_R02D3.1	NP_499884.1
Neurospora crassa	NCU03748	XP_961095.2
Xenopus tropicalis (tropical clawed frog)	aass	NP_001011437.1
Mus musculus (house mouse)	Aass	NP_038958.2
Danio rerio (zebrafish)	aass	NP_001167456.1
Drosophila melanogaster (fruit fly)	LKR	NP_609150.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008632	XP_314728.3
Saccharomyces cerevisiae (baker's yeast)	LYS9	NP_014448.1
Kluyveromyces lactis	KLLA0C18744g	XP_453035.1

Gene Ontology
Bibliography

Related articles in PubMed

Response Element Composition Governs Correlations between Binding Site Affinity and Transcription in Glucocorticoid Receptor Feed-forward Loops.
Sasse SK, Zuo Z, Kadiyala V, Zhang L, Pufall MA, Jain MK, Phang TL, Stormo GD, Gerber AN
The Journal of biological chemistry290(32)19756-69(2015 Aug)

Mitochondrial NADP(H) deficiency due to a mutation in NADK2 causes dienoyl-CoA reductase deficiency with hyperlysinemia.
Houten SM, Denis S, Te Brinke H, Jongejan A, van Kampen AH, Bradley EJ, Baas F, Hennekam RC, Millington DS, Young SP, Frazier DM, Gucsavas-Calikoglu M, Wanders RJ
Human molecular genetics23(18)5009-16(2014 Sep)

Genetic basis of hyperlysinemia.
Houten SM, Te Brinke H, Denis S, Ruiter JP, Knegt AC, de Klerk JB, Augoustides-Savvopoulou P, H?berle J, Baumgartner MR, Co?kun T, Zschocke J, Sass JO, Poll-The BT, Wanders RJ, Duran M
Orphanet journal of rare diseases857(2013 Apr)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

Identification of the alpha-aminoadipic semialdehyde synthase gene, which is defective in familial hyperlysinemia.
Sacksteder KA, Biery BJ, Morrell JC, Goodman BK, Geisbrecht BV, Cox RP, Gould SJ, Geraghty MT
American journal of human genetics66(6)1736-43(2000 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

GR and KLF15 physically interact via low affinity GR binding sites within glucocorticoid response elements (GREs) for PRODH and AASS that contribute to combinatorial regulation with KLF15.
Title: Response Element Composition Governs Correlations between Binding Site Affinity and Transcription in Glucocorticoid Receptor Feed-forward Loops.

Mitochondrial NADPH is crucial for AASS function
Title: Mitochondrial NADP(H) deficiency due to a mutation in NADK2 causes dienoyl-CoA reductase deficiency with hyperlysinemia.

Hyperlysinemia is caused by mutations in AASS
Title: Genetic basis of hyperlysinemia.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Isolation and characterization of the mouse ortholog.
Title: Lysine degradation through the saccharopine pathway in mammals: involvement of both bifunctional and monofunctional lysine-degrading enzymes in mouse.

The following AASS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AASS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17831	NM_005763.4 Latest version!	Homo sapiens aminoadipate-semialdehyde synthase (AASS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$657.30 $939.00
OHu63737	XM_011515725.2 Latest version!	Homo sapiens aminoadipate-semialdehyde synthase (AASS), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
View Old Accession Versions >>
OHu17831	NM_005763.3	Homo sapiens aminoadipate-semialdehyde synthase (AASS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$657.30 $939.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

AASS ( NM_005763.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005754.2 Homo sapiens aminoadipate-semialdehyde synthase (AASS), mRNA.

Price & Availability↑

CloneID	OHu17831
Clone ID Related Accession (Same CDS sequence)	NM_005763.3 , NM_005763.4
Accession Version	NM_005763.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2781bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-27
Organism	Homo sapiens(human)
Product	alpha-aminoadipic semialdehyde synthase, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA995180.1, AF229180.1, AC006020.2 and BM669241.1. This sequence is a reference standard in the RefSeqGene project. On Sep 4, 2008 this sequence version replaced NM_005763.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.21373.1, SRR1660809.102574.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGCAAG TACATAGGAC TGGACTGGGC AGGCTGGGGG TCAGCCTCTC CAAGGGTCTT 
CACCACAAAG CTGTGTTGGC CGTCCGGAGG GAGGATGTGA ACGCCTGGGA GAGAAGGGCC 
CCGCTAGCTC CCAAGCACAT CAAAGGCATC ACCAATCTGG GATACAAGGT CTTGATACAG 
CCTTCGAATC GGCGGGCCAT TCATGATAAG GACTATGTCA AAGCTGGTGG CATTCTTCAG 
GAGGATATTT CTGAAGCTTG TCTAATTTTA GGAGTTAAAA GACCTCCAGA GGAAAAATTA 
ATGTCCAGGA AGACTTATGC ATTTTTCTCC CACACAATAA AAGCTCAGGA GGCCAATATG 
GGCTTGTTGG ATGAGATTCT AAAACAGGAA ATTCGCCTTA TTGATTATGA GAAAATGGTG 
GATCATAGAG GAGTACGGGT AGTGGCATTT GGACAGTGGG CTGGTGTGGC AGGAATGATC 
AACATTTTAC ATGGAATGGG TTTAAGGCTC CTTGCTTTGG GACATCACAC ACCTTTTATG 
CACATTGGCA TGGCTCATAA CTACAGGAAT AGCAGTCAGG CTGTGCAAGC TGTCCGTGAT 
GCTGGCTATG AAATATCTTT GGGTTTGATG CCTAAGTCAA TAGGACCCTT AACATTTGTG 
TTCACAGGAA CTGGTAATGT TTCTAAGGGA GCCCAAGCAA TCTTTAATGA GCTACCTTGT 
GAATATGTGG AGCCCCATGA ATTAAAAGAA GTTTCCCAAA CTGGAGACCT CAGAAAAGTG 
TATGGGACGG TGTTAAGTCG TCATCATCAT CTTGTCAGGA AAACAGATGC TGTGTATGAT 
CCTGCAGAGT ATGACAAACA TCCGGAGCGC TACATAAGTC GTTTTAATAC TGATATTGCA 
CCCTATACAA CTTGCTTAAT TAATGGAATC TACTGGGAAC AAAACACTCC TCGCCTCCTA 
ACCCGCCAAG ATGCTCAGAG TCTCCTGGCT CCGGGCAAGT TCTCACCTGC TGGTGTGGAA 
GGCTGCCCTG CATTACCACA CAAACTCGTG GCAATATGTG ACATTTCAGC TGACACAGGA 
GGGTCTATAG AGTTTATGAC TGAGTGTACA ACAATAGAGC ATCCCTTTTG CATGTATGAT 
GCAGACCAGC ATATTATTCA TGACAGTGTT GAAGGCTCGG GGATCCTGAT GTGTTCCATT 
GACAATTTGC CGGCACAGCT CCCAATTGAA GCTACAGAAT GCTTTGGAGA CATGCTTTAC 
CCTTATGTTG AAGAAATGAT ATTATCAGAC GCGACACAGC CTCTTGAAAG TCAGAATTTT 
TCTCCTGTGG TGAGAGATGC AGTGATTACA TCCAACGGTA CATTACCTGA TAAATATAAA 
TATATCCAGA CACTCCGGGA GAGCAGGGAA CGTGCTCAGT CACTTTCAAT GGGCACCAGG 
AGAAAGGTTT TGGTTCTTGG ATCTGGCTAC ATATCTGAGC CTGTATTAGA ATATTTATCA 
AGAGATGGCA ATATAGAAAT AACAGTAGGA TCTGACATGA AGAATCAAAT TGAACAGTTA 
GGCAAGAAAT ATAATATTAA TCCTGTTAGC ATGGACATTT GTAAACAAGA AGAGAAGCTG 
GGCTTCTTGG TGGCAAAACA GGATCTTGTC ATCAGCTTGT TGCCTTATGT ATTGCACCCT 
CTTGTGGCCA AGGCCTGCAT CACAAACAAA GTTAACATGG TCACTGCAAG CTACATCACA 
CCAGCACTAA AAGAATTGGA AAAGAGTGTG GAAGATGCTG GCATCACAAT CATTGGTGAA 
TTGGGATTGG ACCCTGGTCT GGATCACATG TTAGCAATGG AAACAATAGA TAAAGCCAAG 
GAAGTGGGAG CCACGATTGA ATCATATATT TCCTACTGTG GTGGGCTTCC AGCCCCTGAA 
CATTCAAACA ATCCATTGAG ATATAAATTT AGCTGGAGTC CAGTGGGAGT TTTGATGAAT 
GTAATGCAGT CTGCCACCTA TCTGCTCGAT GGAAAGGTTG TGAATGTTGC AGGAGGCATC 
TCCTTTCTTG ATGCCGTTAC GTCCATGGAT TTTTTTCCAG GATTAAATTT GGAAGGCTAT 
CCTAACAGAG ACAGTACGAA ATATGCTGAG ATTTATGGCA TTTCTTCTGC TCACACTTTG 
TTGCGGGGGA CACTGAGATA TAAGGGATAT ATGAAAGCTT TGAATGGATT TGTAAAATTA 
GGTCTTATAA ACAGAGAAGC GCTTCCTGCC TTTAGACCTG AGGCCAACCC TCTCACCTGG 
AAACAACTCC TCTGTGACCT AGTTGGGATT TCACCCTCCT CTGAGCATGA TGTGTTGAAG 
GAAGCTGTTC TTAAGAAACT AGGAGGAGAC AATACCCAGT TGGAGGCTGC TGAATGGTTG 
GGCTTACTTG GGGATGAACA AGTTCCTCAG GCAGAGTCCA TTCTGGATGC CCTCTCCAAG 
CATTTGGTCA TGAAGCTTTC CTATGGTCCT GAAGAAAAAG ATATGATTGT GATGAGAGAC 
AGCTTTGGAA TCAGACATCC TTCTGGACAT TTAGAACATA AAACGATTGA TCTTGTGGCT 
TATGGGGACA TCAATGGCTT TTCAGCCATG GCTAAAACCG TGGGGTTACC CACCGCCATG 
GCAGCCAAAA TGTTGCTTGA TGGTGAAATT GGAGCCAAAG GCCTAATGGG GCCCTTTTCA 
AAGGAGATCT ATGGACCAAT ATTGGAGCGA ATTAAAGCAG AAGGCATTAT ATATACTACA 
CAGAGTACAA TTAAACCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005754.2
CDS	146..2926
Translation	MLQVHRTGLGRLGVSLSKGLHHKAVLAVRREDVNAWERRAPLAPKHIKGITNLGYKVLIQPSNRRAIHDKDYVKAGGILQEDISEACLILGVKRPPEEKLMSRKTYAFFSHTIKAQEANMGLLDEILKQEIRLIDYEKMVDHRGVRVVAFGQWAGVAGMINILHGMGLRLLALGHHTPFMHIGMAHNYRNSSQAVQAVRDAGYEISLGLMPKSIGPLTFVFTGTGNVSKGAQAIFNELPCEYVEPHELKEVSQTGDLRKVYGTVLSRHHHLVRKTDAVYDPAEYDKHPERYISRFNTDIAPYTTCLINGIYWEQNTPRLLTRQDAQSLLAPGKFSPAGVEGCPALPHKLVAICDISADTGGSIEFMTECTTIEHPFCMYDADQHIIHDSVEGSGILMCSIDNLPAQLPIEATECFGDMLYPYVEEMILSDATQPLESQNFSPVVRDAVITSNGTLPDKYKYIQTLRESRERAQSLSMGTRRKVLVLGSGYISEPVLEYLSRDGNIEITVGSDMKNQIEQLGKKYNINPVSMDICKQEEKLGFLVAKQDLVISLLPYVLHPLVAKACITNKVNMVTASYITPALKELEKSVEDAGITIIGELGLDPGLDHMLAMETIDKAKEVGATIESYISYCGGLPAPEHSNNPLRYKFSWSPVGVLMNVMQSATYLLDGKVVNVAGGISFLDAVTSMDFFPGLNLEGYPNRDSTKYAEIYGISSAHTLLRGTLRYKGYMKALNGFVKLGLINREALPAFRPEANPLTWKQLLCDLVGISPSSEHDVLKEAVLKKLGGDNTQLEAAEWLGLLGDEQVPQAESILDALSKHLVMKLSYGPEEKDMIVMRDSFGIRHPSGHLEHKTIDLVAYGDINGFSAMAKTVGLPTAMAAKMLLDGEIGAKGLMGPFSKEIYGPILERIKAEGIIYTTQSTIKP

Target ORF information:

RefSeq Version	NM_005763.3
Organism	Homo sapiens(human)
Definition	Homo sapiens aminoadipate-semialdehyde synthase (AASS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005763.3

ORF Insert Sequence:

ATGCTGCAAG TACATAGGAC TGGACTGGGC AGGCTGGGGG TCAGCCTCTC CAAGGGTCTT 
CACCACAAAG CTGTGTTGGC CGTCCGGAGG GAGGATGTGA ACGCCTGGGA GAGAAGGGCC 
CCGCTAGCTC CCAAGCACAT CAAAGGCATC ACCAATCTGG GATACAAGGT CTTGATACAG 
CCTTCGAATC GGCGGGCCAT TCATGATAAG GACTATGTCA AAGCTGGTGG CATTCTTCAG 
GAGGATATTT CTGAAGCTTG TCTAATTTTA GGAGTTAAAA GACCTCCAGA GGAAAAATTA 
ATGTCCAGGA AGACTTATGC ATTTTTCTCC CACACAATAA AAGCTCAGGA GGCCAATATG 
GGCTTGTTGG ATGAGATTCT AAAACAGGAA ATTCGCCTTA TTGATTATGA GAAAATGGTG 
GATCATAGAG GAGTACGGGT AGTGGCATTT GGACAGTGGG CTGGTGTGGC AGGAATGATC 
AACATTTTAC ATGGAATGGG TTTAAGGCTC CTTGCTTTGG GACATCACAC ACCTTTTATG 
CACATTGGCA TGGCTCATAA CTACAGGAAT AGCAGTCAGG CTGTGCAAGC TGTCCGTGAT 
GCTGGCTATG AAATATCTTT GGGTTTGATG CCTAAGTCAA TAGGACCCTT AACATTTGTG 
TTCACAGGAA CTGGTAATGT TTCTAAGGGA GCCCAAGCAA TCTTTAATGA GCTACCTTGT 
GAATATGTGG AGCCCCATGA ATTAAAAGAA GTTTCCCAAA CTGGAGACCT CAGAAAAGTG 
TATGGGACGG TGTTAAGTCG TCATCATCAT CTTGTCAGGA AAACAGATGC TGTGTATGAT 
CCTGCAGAGT ATGACAAACA TCCGGAGCGC TACATAAGTC GTTTTAATAC TGATATTGCA 
CCCTATACAA CTTGCTTAAT TAATGGAATC TACTGGGAAC AAAACACTCC TCGCCTCCTA 
ACCCGCCAAG ATGCTCAGAG TCTCCTGGCT CCGGGCAAGT TCTCACCTGC TGGTGTGGAA 
GGCTGCCCTG CATTACCACA CAAACTCGTG GCAATATGTG ACATTTCAGC TGACACAGGA 
GGGTCTATAG AGTTTATGAC TGAGTGTACA ACAATAGAGC ATCCCTTTTG CATGTATGAT 
GCAGACCAGC ATATTATTCA TGACAGTGTT GAAGGCTCGG GGATCCTGAT GTGTTCCATT 
GACAATTTGC CGGCACAGCT CCCAATTGAA GCTACAGAAT GCTTTGGAGA CATGCTTTAC 
CCTTATGTTG AAGAAATGAT ATTATCAGAC GCGACACAGC CTCTTGAAAG TCAGAATTTT 
TCTCCTGTGG TGAGAGATGC AGTGATTACA TCCAACGGTA CATTACCTGA TAAATATAAA 
TATATCCAGA CACTCCGGGA GAGCAGGGAA CGTGCTCAGT CACTTTCAAT GGGCACCAGG 
AGAAAGGTTT TGGTTCTTGG ATCTGGCTAC ATATCTGAGC CTGTATTAGA ATATTTATCA 
AGAGATGGCA ATATAGAAAT AACAGTAGGA TCTGACATGA AGAATCAAAT TGAACAGTTA 
GGCAAGAAAT ATAATATTAA TCCTGTTAGC ATGGACATTT GTAAACAAGA AGAGAAGCTG 
GGCTTCTTGG TGGCAAAACA GGATCTTGTC ATCAGCTTGT TGCCTTATGT ATTGCACCCT 
CTTGTGGCCA AGGCCTGCAT CACAAACAAA GTTAACATGG TCACTGCAAG CTACATCACA 
CCAGCACTAA AAGAATTGGA AAAGAGTGTG GAAGATGCTG GCATCACAAT CATTGGTGAA 
TTGGGATTGG ACCCTGGTCT GGATCACATG TTAGCAATGG AAACAATAGA TAAAGCCAAG 
GAAGTGGGAG CCACGATTGA ATCATATATT TCCTACTGTG GTGGGCTTCC AGCCCCTGAA 
CATTCAAACA ATCCATTGAG ATATAAATTT AGCTGGAGTC CAGTGGGAGT TTTGATGAAT 
GTAATGCAGT CTGCCACCTA TCTGCTCGAT GGAAAGGTTG TGAATGTTGC AGGAGGCATC 
TCCTTTCTTG ATGCCGTTAC GTCCATGGAT TTTTTTCCAG GATTAAATTT GGAAGGCTAT 
CCTAACAGAG ACAGTACGAA ATATGCTGAG ATTTATGGCA TTTCTTCTGC TCACACTTTG 
TTGCGGGGGA CACTGAGATA TAAGGGATAT ATGAAAGCTT TGAATGGATT TGTAAAATTA 
GGTCTTATAA ACAGAGAAGC GCTTCCTGCC TTTAGACCTG AGGCCAACCC TCTCACCTGG 
AAACAACTCC TCTGTGACCT AGTTGGGATT TCACCCTCCT CTGAGCATGA TGTGTTGAAG 
GAAGCTGTTC TTAAGAAACT AGGAGGAGAC AATACCCAGT TGGAGGCTGC TGAATGGTTG 
GGCTTACTTG GGGATGAACA AGTTCCTCAG GCAGAGTCCA TTCTGGATGC CCTCTCCAAG 
CATTTGGTCA TGAAGCTTTC CTATGGTCCT GAAGAAAAAG ATATGATTGT GATGAGAGAC 
AGCTTTGGAA TCAGACATCC TTCTGGACAT TTAGAACATA AAACGATTGA TCTTGTGGCT 
TATGGGGACA TCAATGGCTT TTCAGCCATG GCTAAAACCG TGGGGTTACC CACCGCCATG 
GCAGCCAAAA TGTTGCTTGA TGGTGAAATT GGAGCCAAAG GCCTAATGGG GCCCTTTTCA 
AAGGAGATCT ATGGACCAAT ATTGGAGCGA ATTAAAGCAG AAGGCATTAT ATATACTACA 
CAGAGTACAA TTAAACCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AASS ( NM_005763.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005754.2 Homo sapiens aminoadipate-semialdehyde synthase (AASS), mRNA.

Price & Availability↑

CloneID	OHu17831
Clone ID Related Accession (Same CDS sequence)	NM_005763.3 , NM_005763.4
Accession Version	NM_005763.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2781bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	alpha-aminoadipic semialdehyde synthase, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA995180.1, AF229180.1, AC006020.2 and BM669241.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_005763.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.21373.1, SRR1660809.102574.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000417368.7/ ENSP00000403768.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGCAAG TACATAGGAC TGGACTGGGC AGGCTGGGGG TCAGCCTCTC CAAGGGTCTT 
CACCACAAAG CTGTGTTGGC CGTCCGGAGG GAGGATGTGA ACGCCTGGGA GAGAAGGGCC 
CCGCTAGCTC CCAAGCACAT CAAAGGCATC ACCAATCTGG GATACAAGGT CTTGATACAG 
CCTTCGAATC GGCGGGCCAT TCATGATAAG GACTATGTCA AAGCTGGTGG CATTCTTCAG 
GAGGATATTT CTGAAGCTTG TCTAATTTTA GGAGTTAAAA GACCTCCAGA GGAAAAATTA 
ATGTCCAGGA AGACTTATGC ATTTTTCTCC CACACAATAA AAGCTCAGGA GGCCAATATG 
GGCTTGTTGG ATGAGATTCT AAAACAGGAA ATTCGCCTTA TTGATTATGA GAAAATGGTG 
GATCATAGAG GAGTACGGGT AGTGGCATTT GGACAGTGGG CTGGTGTGGC AGGAATGATC 
AACATTTTAC ATGGAATGGG TTTAAGGCTC CTTGCTTTGG GACATCACAC ACCTTTTATG 
CACATTGGCA TGGCTCATAA CTACAGGAAT AGCAGTCAGG CTGTGCAAGC TGTCCGTGAT 
GCTGGCTATG AAATATCTTT GGGTTTGATG CCTAAGTCAA TAGGACCCTT AACATTTGTG 
TTCACAGGAA CTGGTAATGT TTCTAAGGGA GCCCAAGCAA TCTTTAATGA GCTACCTTGT 
GAATATGTGG AGCCCCATGA ATTAAAAGAA GTTTCCCAAA CTGGAGACCT CAGAAAAGTG 
TATGGGACGG TGTTAAGTCG TCATCATCAT CTTGTCAGGA AAACAGATGC TGTGTATGAT 
CCTGCAGAGT ATGACAAACA TCCGGAGCGC TACATAAGTC GTTTTAATAC TGATATTGCA 
CCCTATACAA CTTGCTTAAT TAATGGAATC TACTGGGAAC AAAACACTCC TCGCCTCCTA 
ACCCGCCAAG ATGCTCAGAG TCTCCTGGCT CCGGGCAAGT TCTCACCTGC TGGTGTGGAA 
GGCTGCCCTG CATTACCACA CAAACTCGTG GCAATATGTG ACATTTCAGC TGACACAGGA 
GGGTCTATAG AGTTTATGAC TGAGTGTACA ACAATAGAGC ATCCCTTTTG CATGTATGAT 
GCAGACCAGC ATATTATTCA TGACAGTGTT GAAGGCTCGG GGATCCTGAT GTGTTCCATT 
GACAATTTGC CGGCACAGCT CCCAATTGAA GCTACAGAAT GCTTTGGAGA CATGCTTTAC 
CCTTATGTTG AAGAAATGAT ATTATCAGAC GCGACACAGC CTCTTGAAAG TCAGAATTTT 
TCTCCTGTGG TGAGAGATGC AGTGATTACA TCCAACGGTA CATTACCTGA TAAATATAAA 
TATATCCAGA CACTCCGGGA GAGCAGGGAA CGTGCTCAGT CACTTTCAAT GGGCACCAGG 
AGAAAGGTTT TGGTTCTTGG ATCTGGCTAC ATATCTGAGC CTGTATTAGA ATATTTATCA 
AGAGATGGCA ATATAGAAAT AACAGTAGGA TCTGACATGA AGAATCAAAT TGAACAGTTA 
GGCAAGAAAT ATAATATTAA TCCTGTTAGC ATGGACATTT GTAAACAAGA AGAGAAGCTG 
GGCTTCTTGG TGGCAAAACA GGATCTTGTC ATCAGCTTGT TGCCTTATGT ATTGCACCCT 
CTTGTGGCCA AGGCCTGCAT CACAAACAAA GTTAACATGG TCACTGCAAG CTACATCACA 
CCAGCACTAA AAGAATTGGA AAAGAGTGTG GAAGATGCTG GCATCACAAT CATTGGTGAA 
TTGGGATTGG ACCCTGGTCT GGATCACATG TTAGCAATGG AAACAATAGA TAAAGCCAAG 
GAAGTGGGAG CCACGATTGA ATCATATATT TCCTACTGTG GTGGGCTTCC AGCCCCTGAA 
CATTCAAACA ATCCATTGAG ATATAAATTT AGCTGGAGTC CAGTGGGAGT TTTGATGAAT 
GTAATGCAGT CTGCCACCTA TCTGCTCGAT GGAAAGGTTG TGAATGTTGC AGGAGGCATC 
TCCTTTCTTG ATGCCGTTAC GTCCATGGAT TTTTTTCCAG GATTAAATTT GGAAGGCTAT 
CCTAACAGAG ACAGTACGAA ATATGCTGAG ATTTATGGCA TTTCTTCTGC TCACACTTTG 
TTGCGGGGGA CACTGAGATA TAAGGGATAT ATGAAAGCTT TGAATGGATT TGTAAAATTA 
GGTCTTATAA ACAGAGAAGC GCTTCCTGCC TTTAGACCTG AGGCCAACCC TCTCACCTGG 
AAACAACTCC TCTGTGACCT AGTTGGGATT TCACCCTCCT CTGAGCATGA TGTGTTGAAG 
GAAGCTGTTC TTAAGAAACT AGGAGGAGAC AATACCCAGT TGGAGGCTGC TGAATGGTTG 
GGCTTACTTG GGGATGAACA AGTTCCTCAG GCAGAGTCCA TTCTGGATGC CCTCTCCAAG 
CATTTGGTCA TGAAGCTTTC CTATGGTCCT GAAGAAAAAG ATATGATTGT GATGAGAGAC 
AGCTTTGGAA TCAGACATCC TTCTGGACAT TTAGAACATA AAACGATTGA TCTTGTGGCT 
TATGGGGACA TCAATGGCTT TTCAGCCATG GCTAAAACCG TGGGGTTACC CACCGCCATG 
GCAGCCAAAA TGTTGCTTGA TGGTGAAATT GGAGCCAAAG GCCTAATGGG GCCCTTTTCA 
AAGGAGATCT ATGGACCAAT ATTGGAGCGA ATTAAAGCAG AAGGCATTAT ATATACTACA 
CAGAGTACAA TTAAACCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005754.2
CDS	105..2885
Translation	MLQVHRTGLGRLGVSLSKGLHHKAVLAVRREDVNAWERRAPLAPKHIKGITNLGYKVLIQPSNRRAIHDKDYVKAGGILQEDISEACLILGVKRPPEEKLMSRKTYAFFSHTIKAQEANMGLLDEILKQEIRLIDYEKMVDHRGVRVVAFGQWAGVAGMINILHGMGLRLLALGHHTPFMHIGMAHNYRNSSQAVQAVRDAGYEISLGLMPKSIGPLTFVFTGTGNVSKGAQAIFNELPCEYVEPHELKEVSQTGDLRKVYGTVLSRHHHLVRKTDAVYDPAEYDKHPERYISRFNTDIAPYTTCLINGIYWEQNTPRLLTRQDAQSLLAPGKFSPAGVEGCPALPHKLVAICDISADTGGSIEFMTECTTIEHPFCMYDADQHIIHDSVEGSGILMCSIDNLPAQLPIEATECFGDMLYPYVEEMILSDATQPLESQNFSPVVRDAVITSNGTLPDKYKYIQTLRESRERAQSLSMGTRRKVLVLGSGYISEPVLEYLSRDGNIEITVGSDMKNQIEQLGKKYNINPVSMDICKQEEKLGFLVAKQDLVISLLPYVLHPLVAKACITNKVNMVTASYITPALKELEKSVEDAGITIIGELGLDPGLDHMLAMETIDKAKEVGATIESYISYCGGLPAPEHSNNPLRYKFSWSPVGVLMNVMQSATYLLDGKVVNVAGGISFLDAVTSMDFFPGLNLEGYPNRDSTKYAEIYGISSAHTLLRGTLRYKGYMKALNGFVKLGLINREALPAFRPEANPLTWKQLLCDLVGISPSSEHDVLKEAVLKKLGGDNTQLEAAEWLGLLGDEQVPQAESILDALSKHLVMKLSYGPEEKDMIVMRDSFGIRHPSGHLEHKTIDLVAYGDINGFSAMAKTVGLPTAMAAKMLLDGEIGAKGLMGPFSKEIYGPILERIKAEGIIYTTQSTIKP

Target ORF information:

RefSeq Version	NM_005763.4
Organism	Homo sapiens(human)
Definition	Homo sapiens aminoadipate-semialdehyde synthase (AASS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005763.4

ORF Insert Sequence:

ATGCTGCAAG TACATAGGAC TGGACTGGGC AGGCTGGGGG TCAGCCTCTC CAAGGGTCTT 
CACCACAAAG CTGTGTTGGC CGTCCGGAGG GAGGATGTGA ACGCCTGGGA GAGAAGGGCC 
CCGCTAGCTC CCAAGCACAT CAAAGGCATC ACCAATCTGG GATACAAGGT CTTGATACAG 
CCTTCGAATC GGCGGGCCAT TCATGATAAG GACTATGTCA AAGCTGGTGG CATTCTTCAG 
GAGGATATTT CTGAAGCTTG TCTAATTTTA GGAGTTAAAA GACCTCCAGA GGAAAAATTA 
ATGTCCAGGA AGACTTATGC ATTTTTCTCC CACACAATAA AAGCTCAGGA GGCCAATATG 
GGCTTGTTGG ATGAGATTCT AAAACAGGAA ATTCGCCTTA TTGATTATGA GAAAATGGTG 
GATCATAGAG GAGTACGGGT AGTGGCATTT GGACAGTGGG CTGGTGTGGC AGGAATGATC 
AACATTTTAC ATGGAATGGG TTTAAGGCTC CTTGCTTTGG GACATCACAC ACCTTTTATG 
CACATTGGCA TGGCTCATAA CTACAGGAAT AGCAGTCAGG CTGTGCAAGC TGTCCGTGAT 
GCTGGCTATG AAATATCTTT GGGTTTGATG CCTAAGTCAA TAGGACCCTT AACATTTGTG 
TTCACAGGAA CTGGTAATGT TTCTAAGGGA GCCCAAGCAA TCTTTAATGA GCTACCTTGT 
GAATATGTGG AGCCCCATGA ATTAAAAGAA GTTTCCCAAA CTGGAGACCT CAGAAAAGTG 
TATGGGACGG TGTTAAGTCG TCATCATCAT CTTGTCAGGA AAACAGATGC TGTGTATGAT 
CCTGCAGAGT ATGACAAACA TCCGGAGCGC TACATAAGTC GTTTTAATAC TGATATTGCA 
CCCTATACAA CTTGCTTAAT TAATGGAATC TACTGGGAAC AAAACACTCC TCGCCTCCTA 
ACCCGCCAAG ATGCTCAGAG TCTCCTGGCT CCGGGCAAGT TCTCACCTGC TGGTGTGGAA 
GGCTGCCCTG CATTACCACA CAAACTCGTG GCAATATGTG ACATTTCAGC TGACACAGGA 
GGGTCTATAG AGTTTATGAC TGAGTGTACA ACAATAGAGC ATCCCTTTTG CATGTATGAT 
GCAGACCAGC ATATTATTCA TGACAGTGTT GAAGGCTCGG GGATCCTGAT GTGTTCCATT 
GACAATTTGC CGGCACAGCT CCCAATTGAA GCTACAGAAT GCTTTGGAGA CATGCTTTAC 
CCTTATGTTG AAGAAATGAT ATTATCAGAC GCGACACAGC CTCTTGAAAG TCAGAATTTT 
TCTCCTGTGG TGAGAGATGC AGTGATTACA TCCAACGGTA CATTACCTGA TAAATATAAA 
TATATCCAGA CACTCCGGGA GAGCAGGGAA CGTGCTCAGT CACTTTCAAT GGGCACCAGG 
AGAAAGGTTT TGGTTCTTGG ATCTGGCTAC ATATCTGAGC CTGTATTAGA ATATTTATCA 
AGAGATGGCA ATATAGAAAT AACAGTAGGA TCTGACATGA AGAATCAAAT TGAACAGTTA 
GGCAAGAAAT ATAATATTAA TCCTGTTAGC ATGGACATTT GTAAACAAGA AGAGAAGCTG 
GGCTTCTTGG TGGCAAAACA GGATCTTGTC ATCAGCTTGT TGCCTTATGT ATTGCACCCT 
CTTGTGGCCA AGGCCTGCAT CACAAACAAA GTTAACATGG TCACTGCAAG CTACATCACA 
CCAGCACTAA AAGAATTGGA AAAGAGTGTG GAAGATGCTG GCATCACAAT CATTGGTGAA 
TTGGGATTGG ACCCTGGTCT GGATCACATG TTAGCAATGG AAACAATAGA TAAAGCCAAG 
GAAGTGGGAG CCACGATTGA ATCATATATT TCCTACTGTG GTGGGCTTCC AGCCCCTGAA 
CATTCAAACA ATCCATTGAG ATATAAATTT AGCTGGAGTC CAGTGGGAGT TTTGATGAAT 
GTAATGCAGT CTGCCACCTA TCTGCTCGAT GGAAAGGTTG TGAATGTTGC AGGAGGCATC 
TCCTTTCTTG ATGCCGTTAC GTCCATGGAT TTTTTTCCAG GATTAAATTT GGAAGGCTAT 
CCTAACAGAG ACAGTACGAA ATATGCTGAG ATTTATGGCA TTTCTTCTGC TCACACTTTG 
TTGCGGGGGA CACTGAGATA TAAGGGATAT ATGAAAGCTT TGAATGGATT TGTAAAATTA 
GGTCTTATAA ACAGAGAAGC GCTTCCTGCC TTTAGACCTG AGGCCAACCC TCTCACCTGG 
AAACAACTCC TCTGTGACCT AGTTGGGATT TCACCCTCCT CTGAGCATGA TGTGTTGAAG 
GAAGCTGTTC TTAAGAAACT AGGAGGAGAC AATACCCAGT TGGAGGCTGC TGAATGGTTG 
GGCTTACTTG GGGATGAACA AGTTCCTCAG GCAGAGTCCA TTCTGGATGC CCTCTCCAAG 
CATTTGGTCA TGAAGCTTTC CTATGGTCCT GAAGAAAAAG ATATGATTGT GATGAGAGAC 
AGCTTTGGAA TCAGACATCC TTCTGGACAT TTAGAACATA AAACGATTGA TCTTGTGGCT 
TATGGGGACA TCAATGGCTT TTCAGCCATG GCTAAAACCG TGGGGTTACC CACCGCCATG 
GCAGCCAAAA TGTTGCTTGA TGGTGAAATT GGAGCCAAAG GCCTAATGGG GCCCTTTTCA 
AAGGAGATCT ATGGACCAAT ATTGGAGCGA ATTAAAGCAG AAGGCATTAT ATATACTACA 
CAGAGTACAA TTAAACCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AASS ( XM_011515725.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011514027.1 Homo sapiens aminoadipate-semialdehyde synthase (AASS), transcript variant X1, mRNA.

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CloneID	OHu63737
Clone ID Related Accession (Same CDS sequence)	XM_011515725.2
Accession Version	XM_011515725.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2685bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	alpha-aminoadipic semialdehyde synthase, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011515725.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGCAAG TACATAGGAC TGGACTGGGC AGGCTGGGGG TCAGCCTCTC CAAGGGTCTT 
CACCACAAAG CTGTGTTGGC CGTCCGGAGG GAGGATGTGA ACGCCTGGGA GAGAAGGGCC 
CCGCTAGCTC CCAAGCACAT CAAAGGCATC ACCAATCTGG GATACAAGGT CTTGATACAG 
CCTTCGAATC GGCGGGCCAT TCATGATAAG GACTATGTCA AAGCTGGTGG CATTCTTCAG 
GAGGATATTT CTGAAGCTTG TCTAATTTTA GGAGTTAAAA GACCTCCAGA GGAAAAATTA 
ATGTCCAGGA AGACTTATGC ATTTTTCTCC CACACAATAA AAGCTCAGGA GGCCAATATG 
GGCTTGTTGG ATGAGATTCT AAAACAGGAA ATTCGCCTTA TTGATTATGA GAAAATGGTG 
GATCATAGAG GAGTACGGGT AGTGGCATTT GGACAGTGGG CTGGTGTGGC AGGAATGATC 
AACATTTTAC ATGGAATGGG TTTAAGGCTC CTTGCTTTGG GACATCACAC ACCTTTTATG 
CACATTGGCA TGGCTCATAA CTACAGGAAT AGCAGTCAGG CTGTGCAAGC TGTCCGTGAT 
GCTGGCTATG AAATATCTTT GGGTTTGATG CCTAAGTCAA TAGGACCCTT AACATTTGTG 
TTCACAGGAA CTGGTAATGT TTCTAAGGGA GCCCAAGCAA TCTTTAATGA GCTACCTTGT 
GAATATGTGG AGCCCCATGA ATTAAAAGAA GTTTCCCAAA CTGGAGACCT CAGAAAAGTG 
TATGGGACGG TGTTAAGTCG TCATCATCAT CTTGTCAGGA AAACAGATGC TGTGTATGAT 
CCTGCAGAGT ATGACAAACA TCCGGAGCGC TACATAAGTC GTTTTAATAC TGATATTGCA 
CCCTATACAA CTTGCTTAAT TAATGGAATC TACTGGGAAC AAAACACTCC TCGCCTCCTA 
ACCCGCCAAG ATGCTCAGAG TCTCCTGGCT CCGGGCAAGT TCTCACCTGC TGGTGTGGAA 
GGCTGCCCTG CATTACCACA CAAACTCGTG GCAATATGTG ACATTTCAGC TGACACAGGA 
GGGTCTATAG AGTTTATGAC TGAGTGTACA ACAATAGAGC ATCCCTTTTG CATGTATGAT 
GCAGACCAGC ATATTATTCA TGACAGTGTT GAAGGCTCGG GGATCCTGAT GTGTTCCATT 
GACAATTTGC CGGCACAGCT CCCAATTGAA GCTACAGAAT GCTTTGGAGA CATGCTTTAC 
CCTTATGTTG AAGAAATGAT ATTATCAGAC GCGACACAGC CTCTTGAAAG TCAGAATTTT 
TCTCCTGTGG TGAGAGATGC AGTGATTACA TCCAACGGTA CATTACCTGA TAAATATAAA 
TATATCCAGA CACTCCGGGA GAGCAGGGAA CGTGCTCAGT CACTTTCAAT GGGCACCAGG 
AGAAAGGTTT TGGTTCTTGG ATCTGGCTAC ATATCTGAGC CTGTATTAGA ATATTTATCA 
AGAGATGGCA ATATAGAAAT AACAGTAGGA TCTGACATGA AGAATCAAAT TGAACAGTTA 
GGCAAGAAAT ATAATATTAA TCCTGTTAGC ATGGACATTT GTAAACAAGA AGAGAAGCTG 
GGCTTCTTGG TGGCAAAACA GGATCTTGTC ATCAGCTTGT TGCCTTATGT ATTGCACCCT 
CTTGTGGCCA AGGCCTGCAT CACAAACAAA GTTAACATGG TCACTGCAAG CTACATCACA 
CCAGCACTAA AAGAATTGGA AAAGAGTGTG GAAGATGCTG GCATCACAAT CATTGGTGAA 
TTGGGATTGG ACCCTGGTCT GGATCACATG TTAGCAATGG AAACAATAGA TAAAGCCAAG 
GAAGTGGGAG CCACGATTGA ATCATATATT TCCTACTGTG GTGGGCTTCC AGCCCCTGAA 
CATTCAAACA ATCCATTGAG ATATAAATTT AGCTGGAGTC CAGTGGGAGT TTTGATGAAT 
GTAATGCAGT CTGCCACCTA TCTGCTCGAT GGAAAGGTTG TGAATGTTGC AGGAGGCATC 
TCCTTTCTTG ATGCCGTTAC GTCCATGGAT TTTTTTCCAG GATTAAATTT GGAAGGCTAT 
CCTAACAGAG ACAGTACGAA ATATGCTGAG ATTTATGGCA TTTCTTCTGC TCACACTTTG 
TTGCGGGGGA CACTGAGATA TAAGAAACAA CTCCTCTGTG ACCTAGTTGG GATTTCACCC 
TCCTCTGAGC ATGATGTGTT GAAGGAAGCT GTTCTTAAGA AACTAGGAGG AGACAATACC 
CAGTTGGAGG CTGCTGAATG GTTGGGCTTA CTTGGGGATG AACAAGTTCC TCAGGCAGAG 
TCCATTCTGG ATGCCCTCTC CAAGCATTTG GTCATGAAGC TTTCCTATGG TCCTGAAGAA 
AAAGATATGA TTGTGATGAG AGACAGCTTT GGAATCAGAC ATCCTTCTGG ACATTTAGAA 
CATAAAACGA TTGATCTTGT GGCTTATGGG GACATCAATG GCTTTTCAGC CATGGCTAAA 
ACCGTGGGGT TACCCACCGC CATGGCAGCC AAAATGTTGC TTGATGGTGA AATTGGAGCC 
AAAGGCCTAA TGGGGCCCTT TTCAAAGGAG ATCTATGGAC CAATATTGGA GCGAATTAAA 
GCAGAAGGCA TTATATATAC TACACAGAGT ACAATTAAAC CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011514027.1
CDS	125..2809
Translation	MLQVHRTGLGRLGVSLSKGLHHKAVLAVRREDVNAWERRAPLAPKHIKGITNLGYKVLIQPSNRRAIHDKDYVKAGGILQEDISEACLILGVKRPPEEKLMSRKTYAFFSHTIKAQEANMGLLDEILKQEIRLIDYEKMVDHRGVRVVAFGQWAGVAGMINILHGMGLRLLALGHHTPFMHIGMAHNYRNSSQAVQAVRDAGYEISLGLMPKSIGPLTFVFTGTGNVSKGAQAIFNELPCEYVEPHELKEVSQTGDLRKVYGTVLSRHHHLVRKTDAVYDPAEYDKHPERYISRFNTDIAPYTTCLINGIYWEQNTPRLLTRQDAQSLLAPGKFSPAGVEGCPALPHKLVAICDISADTGGSIEFMTECTTIEHPFCMYDADQHIIHDSVEGSGILMCSIDNLPAQLPIEATECFGDMLYPYVEEMILSDATQPLESQNFSPVVRDAVITSNGTLPDKYKYIQTLRESRERAQSLSMGTRRKVLVLGSGYISEPVLEYLSRDGNIEITVGSDMKNQIEQLGKKYNINPVSMDICKQEEKLGFLVAKQDLVISLLPYVLHPLVAKACITNKVNMVTASYITPALKELEKSVEDAGITIIGELGLDPGLDHMLAMETIDKAKEVGATIESYISYCGGLPAPEHSNNPLRYKFSWSPVGVLMNVMQSATYLLDGKVVNVAGGISFLDAVTSMDFFPGLNLEGYPNRDSTKYAEIYGISSAHTLLRGTLRYKKQLLCDLVGISPSSEHDVLKEAVLKKLGGDNTQLEAAEWLGLLGDEQVPQAESILDALSKHLVMKLSYGPEEKDMIVMRDSFGIRHPSGHLEHKTIDLVAYGDINGFSAMAKTVGLPTAMAAKMLLDGEIGAKGLMGPFSKEIYGPILERIKAEGIIYTTQSTIKP

Target ORF information:

RefSeq Version	XM_011515725.2
Organism	Homo sapiens(human)
Definition	Homo sapiens aminoadipate-semialdehyde synthase (AASS), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011515725.2

ORF Insert Sequence:

ATGCTGCAAG TACATAGGAC TGGACTGGGC AGGCTGGGGG TCAGCCTCTC CAAGGGTCTT 
CACCACAAAG CTGTGTTGGC CGTCCGGAGG GAGGATGTGA ACGCCTGGGA GAGAAGGGCC 
CCGCTAGCTC CCAAGCACAT CAAAGGCATC ACCAATCTGG GATACAAGGT CTTGATACAG 
CCTTCGAATC GGCGGGCCAT TCATGATAAG GACTATGTCA AAGCTGGTGG CATTCTTCAG 
GAGGATATTT CTGAAGCTTG TCTAATTTTA GGAGTTAAAA GACCTCCAGA GGAAAAATTA 
ATGTCCAGGA AGACTTATGC ATTTTTCTCC CACACAATAA AAGCTCAGGA GGCCAATATG 
GGCTTGTTGG ATGAGATTCT AAAACAGGAA ATTCGCCTTA TTGATTATGA GAAAATGGTG 
GATCATAGAG GAGTACGGGT AGTGGCATTT GGACAGTGGG CTGGTGTGGC AGGAATGATC 
AACATTTTAC ATGGAATGGG TTTAAGGCTC CTTGCTTTGG GACATCACAC ACCTTTTATG 
CACATTGGCA TGGCTCATAA CTACAGGAAT AGCAGTCAGG CTGTGCAAGC TGTCCGTGAT 
GCTGGCTATG AAATATCTTT GGGTTTGATG CCTAAGTCAA TAGGACCCTT AACATTTGTG 
TTCACAGGAA CTGGTAATGT TTCTAAGGGA GCCCAAGCAA TCTTTAATGA GCTACCTTGT 
GAATATGTGG AGCCCCATGA ATTAAAAGAA GTTTCCCAAA CTGGAGACCT CAGAAAAGTG 
TATGGGACGG TGTTAAGTCG TCATCATCAT CTTGTCAGGA AAACAGATGC TGTGTATGAT 
CCTGCAGAGT ATGACAAACA TCCGGAGCGC TACATAAGTC GTTTTAATAC TGATATTGCA 
CCCTATACAA CTTGCTTAAT TAATGGAATC TACTGGGAAC AAAACACTCC TCGCCTCCTA 
ACCCGCCAAG ATGCTCAGAG TCTCCTGGCT CCGGGCAAGT TCTCACCTGC TGGTGTGGAA 
GGCTGCCCTG CATTACCACA CAAACTCGTG GCAATATGTG ACATTTCAGC TGACACAGGA 
GGGTCTATAG AGTTTATGAC TGAGTGTACA ACAATAGAGC ATCCCTTTTG CATGTATGAT 
GCAGACCAGC ATATTATTCA TGACAGTGTT GAAGGCTCGG GGATCCTGAT GTGTTCCATT 
GACAATTTGC CGGCACAGCT CCCAATTGAA GCTACAGAAT GCTTTGGAGA CATGCTTTAC 
CCTTATGTTG AAGAAATGAT ATTATCAGAC GCGACACAGC CTCTTGAAAG TCAGAATTTT 
TCTCCTGTGG TGAGAGATGC AGTGATTACA TCCAACGGTA CATTACCTGA TAAATATAAA 
TATATCCAGA CACTCCGGGA GAGCAGGGAA CGTGCTCAGT CACTTTCAAT GGGCACCAGG 
AGAAAGGTTT TGGTTCTTGG ATCTGGCTAC ATATCTGAGC CTGTATTAGA ATATTTATCA 
AGAGATGGCA ATATAGAAAT AACAGTAGGA TCTGACATGA AGAATCAAAT TGAACAGTTA 
GGCAAGAAAT ATAATATTAA TCCTGTTAGC ATGGACATTT GTAAACAAGA AGAGAAGCTG 
GGCTTCTTGG TGGCAAAACA GGATCTTGTC ATCAGCTTGT TGCCTTATGT ATTGCACCCT 
CTTGTGGCCA AGGCCTGCAT CACAAACAAA GTTAACATGG TCACTGCAAG CTACATCACA 
CCAGCACTAA AAGAATTGGA AAAGAGTGTG GAAGATGCTG GCATCACAAT CATTGGTGAA 
TTGGGATTGG ACCCTGGTCT GGATCACATG TTAGCAATGG AAACAATAGA TAAAGCCAAG 
GAAGTGGGAG CCACGATTGA ATCATATATT TCCTACTGTG GTGGGCTTCC AGCCCCTGAA 
CATTCAAACA ATCCATTGAG ATATAAATTT AGCTGGAGTC CAGTGGGAGT TTTGATGAAT 
GTAATGCAGT CTGCCACCTA TCTGCTCGAT GGAAAGGTTG TGAATGTTGC AGGAGGCATC 
TCCTTTCTTG ATGCCGTTAC GTCCATGGAT TTTTTTCCAG GATTAAATTT GGAAGGCTAT 
CCTAACAGAG ACAGTACGAA ATATGCTGAG ATTTATGGCA TTTCTTCTGC TCACACTTTG 
TTGCGGGGGA CACTGAGATA TAAGAAACAA CTCCTCTGTG ACCTAGTTGG GATTTCACCC 
TCCTCTGAGC ATGATGTGTT GAAGGAAGCT GTTCTTAAGA AACTAGGAGG AGACAATACC 
CAGTTGGAGG CTGCTGAATG GTTGGGCTTA CTTGGGGATG AACAAGTTCC TCAGGCAGAG 
TCCATTCTGG ATGCCCTCTC CAAGCATTTG GTCATGAAGC TTTCCTATGG TCCTGAAGAA 
AAAGATATGA TTGTGATGAG AGACAGCTTT GGAATCAGAC ATCCTTCTGG ACATTTAGAA 
CATAAAACGA TTGATCTTGT GGCTTATGGG GACATCAATG GCTTTTCAGC CATGGCTAAA 
ACCGTGGGGT TACCCACCGC CATGGCAGCC AAAATGTTGC TTGATGGTGA AATTGGAGCC 
AAAGGCCTAA TGGGGCCCTT TTCAAAGGAG ATCTATGGAC CAATATTGGA GCGAATTAAA 
GCAGAAGGCA TTATATATAC TACACAGAGT ACAATTAAAC CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Response Element Composition Governs Correlations between Binding Site Affinity and Transcription in Glucocorticoid Receptor Feed-forward Loops.
The Journal of biological chemistry290(32)19756-69(2015 Aug)
Sasse SK,Zuo Z,Kadiyala V,Zhang L,Pufall MA,Jain MK,Phang TL,Stormo GD,Gerber AN

Mitochondrial NADP(H) deficiency due to a mutation in NADK2 causes dienoyl-CoA reductase deficiency with hyperlysinemia.
Human molecular genetics23(18)5009-16(2014 Sep)
Houten SM,Denis S,Te Brinke H,Jongejan A,van Kampen AH,Bradley EJ,Baas F,Hennekam RC,Millington DS,Young SP,Frazier DM,Gucsavas-Calikoglu M,Wanders RJ

Genetic basis of hyperlysinemia.
Orphanet journal of rare diseases857(2013 Apr)
Houten SM,Te Brinke H,Denis S,Ruiter JP,Knegt AC,de Klerk JB,Augoustides-Savvopoulou P,H?berle J,Baumgartner MR,Co?kun T,Zschocke J,Sass JO,Poll-The BT,Wanders RJ,Duran M

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

Identification of the alpha-aminoadipic semialdehyde synthase gene, which is defective in familial hyperlysinemia.
American journal of human genetics66(6)1736-43(2000 Jun)
Sacksteder KA,Biery BJ,Morrell JC,Goodman BK,Geisbrecht BV,Cox RP,Gould SJ,Geraghty MT

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AASS cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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見積依頼

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電話

FAX

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