CMC4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CMC4
Entrez Gene ID	100272147
Full Name	C-X9-C motif containing 4
Synonyms	C6.1B,MTCP1,MTCP1B,MTCP1NB,p8,p8MTCP1
General protein information	Preferred Names C-X9-C motif containing 4 Names cx9C motif-containing protein 4 C-x(9)-C motif containing 4 homolog MTCP-1 type A mature T-cell proliferation 1 mature T-cell proliferation 1 neighbor protein mature T-cell proliferation-1 type A protein p8 MTCP-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq28
Summary	This gene was identified by involvement in some t(X;14) translocations associated with mature T-cell proliferations. This region has a complex gene structure, with a common promoter and 5' exon spliced to two different sets of 3' exons that encode two different proteins. This gene represents the downstream 8 kDa protein that localizes to mitochondria.[provided by RefSeq, Mar 2009].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001018024.2	NP_001018024.1	cx9C motif-containing protein 4
NM_001018024.3	NP_001018024.1	cx9C motif-containing protein 4

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CMC4	XP_005642101.1
Homo sapiens (human)	CMC4	NP_001018024.1
Bos taurus (cattle)	MTCP1NB	NP_001071619.1
Gallus gallus (chicken)	MTCP1NB	XP_004940683.1
Pan troglodytes (chimpanzee)	CMC4	XP_003954173.1
Rattus norvegicus (Norway rat)	LOC102546764	XP_006254452.1
	MTCP1NB	XP_002806504.1
Mus musculus (house mouse)	Mtcp1	NP_034969.1

Gene Ontology
Bibliography

Related articles in PubMed

Genome-wide analysis of eukaryotic twin CX9C proteins.
Cavallaro G
Molecular bioSystems6(12)2459-70(2010 Dec)

Solution structure of human p8MTCP1, a cysteine-rich protein encoded by the MTCP1 oncogene, reveals a new alpha-helical assembly motif.
Barthe P, Yang YS, Chiche L, Hoh F, Strub MP, Guignard L, Soulier J, Stern MH, van Tilbeurgh H, Lhoste JM, Roumestand C
Journal of molecular biology274(5)801-15(1997 Dec)

The 8 kD product of the putative oncogene MTCP-1 is a mitochondrial protein.
Madani A, Soulier J, Schmid M, Plichtova R, Lerm? F, Gateau-Roesch O, Garnier JP, Pla M, Sigaux F, Stern MH
Oncogene10(11)2259-62(1995 Jun)

The MTCP-1/c6.1B gene encodes for a cytoplasmic 8 kD protein overexpressed in T cell leukemia bearing a t(X;14) translocation.
Soulier J, Madani A, Cacheux V, Rosenzwajg M, Sigaux F, Stern MH
Oncogene9(12)3565-70(1994 Dec)

MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations.
Stern MH, Soulier J, Rosenzwajg M, Nakahara K, Canki-Klain N, Aurias A, Sigaux F, Kirsch IR
Oncogene8(9)2475-83(1993 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CMC4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CMC4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09219	NM_001018024.3 Latest version!	Homo sapiens C-X9-C motif containing 4 (CMC4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu09219	NM_001018024.2	Homo sapiens C-X9-C motif containing 4 (CMC4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CMC4 ( NM_001018024.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001018024.1 Homo sapiens C-X9-C motif containing 4 (CMC4), mRNA.

Price & Availability↑

CloneID	OHu09219
Clone ID Related Accession (Same CDS sequence)	NM_001018024.2 , NM_001018024.3
Accession Version	NM_001018024.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 207bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	cx9C motif-containing protein 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG707795.1 and BC002600.1. On Mar 24, 2009 this sequence version replaced NM_001018024.1. ##Evidence-Data-START## Transcript exon combination :: BC002600.1, X64644.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267752 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCGCAGA AGGATCCGTG CCAGAAGCAA GCCTGTGAGA TACAGAAATG TTTACAAGCC 
AACAGCTACA TGGAATCAAA GTGTCAGGCT GTCATCCAAG AACTGCGTAA GTGTTGTGCT 
CAGTATCCCA AGGGAAGATC TGTCGTCTGT TCAGGATTTG AAAAAGAAGA GGAAGAAAAC 
CTAACACGGA AGTCTGCATC AAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001018024.1
CDS	590..796
Translation	MPQKDPCQKQACEIQKCLQANSYMESKCQAVIQELRKCCAQYPKGRSVVCSGFEKEEEENLTRKSASK

Target ORF information:

RefSeq Version	NM_001018024.2
Organism	Homo sapiens(human)
Definition	Homo sapiens C-X9-C motif containing 4 (CMC4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001018024.2

ORF Insert Sequence:

ATGCCGCAGA AGGATCCGTG CCAGAAGCAA GCCTGTGAGA TACAGAAATG TTTACAAGCC 
AACAGCTACA TGGAATCAAA GTGTCAGGCT GTCATCCAAG AACTGCGTAA GTGTTGTGCT 
CAGTATCCCA AGGGAAGATC TGTCGTCTGT TCAGGATTTG AAAAAGAAGA GGAAGAAAAC 
CTAACACGGA AGTCTGCATC AAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CMC4 ( NM_001018024.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001018024.1 Homo sapiens C-X9-C motif containing 4 (CMC4), mRNA.

Price & Availability↑

CloneID	OHu09219
Clone ID Related Accession (Same CDS sequence)	NM_001018024.2 , NM_001018024.3
Accession Version	NM_001018024.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 207bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	cx9C motif-containing protein 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC002600.1. On Nov 23, 2018 this sequence version replaced NM_001018024.2. ##Evidence-Data-START## Transcript exon combination :: BC002600.1, SRR5189655.194343.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267752 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology MANE Ensembl match :: ENST00000369484.8/ ENSP00000358496.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCGCAGA AGGATCCGTG CCAGAAGCAA GCCTGTGAGA TACAGAAATG TTTACAAGCC 
AACAGCTACA TGGAATCAAA GTGTCAGGCT GTCATCCAAG AACTGCGTAA GTGTTGTGCT 
CAGTATCCCA AGGGAAGATC TGTCGTCTGT TCAGGATTTG AAAAAGAAGA GGAAGAAAAC 
CTAACACGGA AGTCTGCATC AAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001018024.1
CDS	454..660
Translation	MPQKDPCQKQACEIQKCLQANSYMESKCQAVIQELRKCCAQYPKGRSVVCSGFEKEEEENLTRKSASK

Target ORF information:

RefSeq Version	NM_001018024.3
Organism	Homo sapiens(human)
Definition	Homo sapiens C-X9-C motif containing 4 (CMC4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001018024.3

ORF Insert Sequence:

ATGCCGCAGA AGGATCCGTG CCAGAAGCAA GCCTGTGAGA TACAGAAATG TTTACAAGCC 
AACAGCTACA TGGAATCAAA GTGTCAGGCT GTCATCCAAG AACTGCGTAA GTGTTGTGCT 
CAGTATCCCA AGGGAAGATC TGTCGTCTGT TCAGGATTTG AAAAAGAAGA GGAAGAAAAC 
CTAACACGGA AGTCTGCATC AAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome-wide analysis of eukaryotic twin CX9C proteins.
Molecular bioSystems6(12)2459-70(2010 Dec)
Cavallaro G

Solution structure of human p8MTCP1, a cysteine-rich protein encoded by the MTCP1 oncogene, reveals a new alpha-helical assembly motif.
Journal of molecular biology274(5)801-15(1997 Dec)
Barthe P,Yang YS,Chiche L,Hoh F,Strub MP,Guignard L,Soulier J,Stern MH,van Tilbeurgh H,Lhoste JM,Roumestand C

The 8 kD product of the putative oncogene MTCP-1 is a mitochondrial protein.
Oncogene10(11)2259-62(1995 Jun)
Madani A,Soulier J,Schmid M,Plichtova R,Lerm? F,Gateau-Roesch O,Garnier JP,Pla M,Sigaux F,Stern MH

The MTCP-1/c6.1B gene encodes for a cytoplasmic 8 kD protein overexpressed in T cell leukemia bearing a t(X;14) translocation.
Oncogene9(12)3565-70(1994 Dec)
Soulier J,Madani A,Cacheux V,Rosenzwajg M,Sigaux F,Stern MH

MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations.
Oncogene8(9)2475-83(1993 Sep)
Stern MH,Soulier J,Rosenzwajg M,Nakahara K,Canki-Klain N,Aurias A,Sigaux F,Kirsch IR