CXCL2 cDNA ORF clone, Equus caballus(horse)

Gene
Clones
gRNAs

Summary

Gene Symbol	CXCL2
Entrez Gene ID	100233237
Full Name	chemokine (C-X-C motif) ligand 2
Synonyms	MIP-2alpha
Gene Type	protein-coding
Organism	Equus caballus(horse)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001143955.1	NP_001137427.1	C-X-C motif chemokine 2 precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Annotation of the Protein Coding Regions of the Equine Genome.
Hestand MS, Kalbfleisch TS, Coleman SJ, Zeng Z, Liu J, Orlando L, MacLeod JN
PloS one10(6)e0124375(2015)

Effects of in vitro exposure to autologous blood and serum on expression of interleukin-8, interleukin-1?, and chemokine (C-X-C motif) ligand 2 in equine primary bronchial epithelial cell cultures.
Ainsworth DM, Reyner CL
American journal of veterinary research73(2)296-301(2012 Feb)

Effects of in vitro exposure to hay dust on expression of interleukin-23, -17, -8, and -1beta and chemokine (C-X-C motif) ligand 2 by pulmonary mononuclear cells from horses susceptible to recurrent airway obstruction.
Reyner CL, Wagner B, Young JC, Ainsworth DM
American journal of veterinary research70(10)1277-83(2009 Oct)

Effects of in vitro exposure to hay dust on expression of interleukin-17, -23, -8, and -1beta and chemokine (C-X-C motif) ligand 2 by pulmonary mononuclear cells isolated from horses chronically affected with recurrent airway disease.
Ainsworth DM, Wagner B, Erb HN, Young JC, Retallick DE
American journal of veterinary research68(12)1361-9(2007 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results suggested that chemokine expression by cultured equine BECs following exposure to pulmonary hemorrhage conditions may contribute to the development of inflammatory airway disease in horses.
Title: Effects of in vitro exposure to autologous blood and serum on expression of interleukin-8, interleukin-1?, and chemokine (C-X-C motif) ligand 2 in equine primary bronchial epithelial cell cultures.

The acute pulmonary neutrophilia characteristic of recurrent airway obstruction was not associated with an increase in expression of chemokines in pulmonary mononuclear cells from disease-susceptible horses.
Title: Effects of in vitro exposure to hay dust on expression of interleukin-23, -17, -8, and -1beta and chemokine (C-X-C motif) ligand 2 by pulmonary mononuclear cells from horses susceptible to recurrent airway obstruction.

This study examined effects of in vitro exposure to solutions of hay dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction.
Title: Effects of in vitro exposure to hay dust on expression of interleukin-17, -23, -8, and -1beta and chemokine (C-X-C motif) ligand 2 by pulmonary mononuclear cells isolated from horses chronically affected with recurrent airway disease.

The following CXCL2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CXCL2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHb27928	NM_001143955.1 Latest version!	Equus caballus chemokine (C-X-C motif) ligand 2 (CXCL2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$104.30 $149.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CXCL2 ( NM_001143955.1 ) cDNA ORF clone, Equus caballus(horse) -> NP_001137427.1 Equus caballus chemokine (C-X-C motif) ligand 2 (CXCL2), mRNA.

Price & Availability↑

CloneID	OHb27928
Clone ID Related Accession (Same CDS sequence)	NM_001143955.1
Accession Version	NM_001143955.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-01-28
Organism	Equus caballus(horse)
Product	C-X-C motif chemokine 2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from FJ470293.1. ##Evidence-Data-START## Transcript exon combination :: FJ470293.1, CD535249.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2452530, SAMEA2452532 [ECO:0000348] ##Evidence-Data-END##

ATGGCCCGCG CCGCCACCGC CACCGCGTCC TGCGCTCCCC GGCTCCTCCG GGCCGCGCTG 
CTGCTCCTGC TCCTGGTCGC CGCCACCCGG CGCGCGGCAG GGGCGCCCGT GGTCAGTGAA 
CTGCGCTGCC AGTGCTTGCA GACCGTGCAG GGGATTCACT TCAAGAACAT CCAGAGCGTG 
AAGGTGACGC CGGCGGGCTC CCACTGCGCC CAAACCGAAG TCATAGCCAC TCTCAAGAAT 
GGACAGGAAG TTTGTCTCAA CCCTGAAGCC CCCATGGTTA AGAAAATGAT CGAAAAGATG 
CTAAACAAGG GCAGCTCCGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001137427.1
CDS	1..324
Translation	MARAATATASCAPRLLRAALLLLLLVAATRRAAGAPVVSELRCQCLQTVQGIHFKNIQSVKVTPAGSHCAQTEVIATLKNGQEVCLNPEAPMVKKMIEKMLNKGSSD

Target ORF information:

RefSeq Version	NM_001143955.1
Organism	Equus caballus(horse)
Definition	Equus caballus chemokine (C-X-C motif) ligand 2 (CXCL2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001143955.1

ORF Insert Sequence:

ATGGCCCGCG CCGCCACCGC CACCGCGTCC TGCGCTCCCC GGCTCCTCCG GGCCGCGCTG 
CTGCTCCTGC TCCTGGTCGC CGCCACCCGG CGCGCGGCAG GGGCGCCCGT GGTCAGTGAA 
CTGCGCTGCC AGTGCTTGCA GACCGTGCAG GGGATTCACT TCAAGAACAT CCAGAGCGTG 
AAGGTGACGC CGGCGGGCTC CCACTGCGCC CAAACCGAAG TCATAGCCAC TCTCAAGAAT 
GGACAGGAAG TTTGTCTCAA CCCTGAAGCC CCCATGGTTA AGAAAATGAT CGAAAAGATG 
CTAAACAAGG GCAGCTCCGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Annotation of the Protein Coding Regions of the Equine Genome.
PloS one10(6)e0124375(2015)
Hestand MS,Kalbfleisch TS,Coleman SJ,Zeng Z,Liu J,Orlando L,MacLeod JN

Effects of in vitro exposure to autologous blood and serum on expression of interleukin-8, interleukin-1?, and chemokine (C-X-C motif) ligand 2 in equine primary bronchial epithelial cell cultures.
American journal of veterinary research73(2)296-301(2012 Feb)
Ainsworth DM,Reyner CL

Effects of in vitro exposure to hay dust on expression of interleukin-23, -17, -8, and -1beta and chemokine (C-X-C motif) ligand 2 by pulmonary mononuclear cells from horses susceptible to recurrent airway obstruction.
American journal of veterinary research70(10)1277-83(2009 Oct)
Reyner CL,Wagner B,Young JC,Ainsworth DM

Effects of in vitro exposure to hay dust on expression of interleukin-17, -23, -8, and -1beta and chemokine (C-X-C motif) ligand 2 by pulmonary mononuclear cells isolated from horses chronically affected with recurrent airway disease.
American journal of veterinary research68(12)1361-9(2007 Dec)
Ainsworth DM,Wagner B,Erb HN,Young JC,Retallick DE