CXCR3.1 cDNA ORF clone, Danio rerio(Zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	CXCR3.1
Entrez Gene ID	654692
Full Name	chemokine (C-X-C motif) receptor 3, tandem duplicate 1
Synonyms	sb:eu378
General protein information	Preferred Names chemokine (C-X-C motif) receptor 3, tandem duplicate 1 Names chemokine (C-X-C motif) receptor 3.1 CXCR3ab dr-chr16-CXCR3-41.8%-EK27498 dr-chr16-CXCR3-41.8-EK27498
Gene Type	protein-coding
Organism	Danio rerio(Zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001089430.2	NP_001082899.2	chemokine (C-X-C motif) receptor 3.1
XM_005173488.3	XP_005173545.1	chemokine (C-X-C motif) receptor 3.1 isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Cxcr3	NP_034040.1
Danio rerio (zebrafish)	cxcr3.1	NP_001082899.2
Xenopus tropicalis (tropical clawed frog)	LOC100485636	XP_002938579.2
Homo sapiens (human)	CXCR3	NP_001136269.1
Canis lupus familiaris (dog)	CXCR3	NP_001011887.1
	CXCR3	NP_001138512.1
Pan troglodytes (chimpanzee)	CXCR3	XP_001137964.1
Bos taurus (cattle)	CXCR3	NP_001011673.1
Rattus norvegicus (Norway rat)	Cxcr3	NP_445867.1

Gene Ontology
Bibliography

Related articles in PubMed

Pathogen response-like recruitment and activation of neutrophils by sterile immunogenic dying cells drives neutrophil-mediated residual cell killing.
Garg AD, Vandenberk L, Fang S, Fasche T, Van Eygen S, Maes J, Van Woensel M, Koks C, Vanthillo N, Graf N, de Witte P, Van Gool S, Salven P, Agostinis P
Cell death and differentiation24(5)832-843(2017 May)

CXCR1 remodels the vascular niche to promote hematopoietic stem and progenitor cell engraftment.
Blaser BW, Moore JL, Hagedorn EJ, Li B, Riquelme R, Lichtig A, Yang S, Zhou Y, Tamplin OJ, Binder V, Zon LI
The Journal of experimental medicine214(4)1011-1027(2017 Apr)

The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection.
Torraca V, Cui C, Boland R, Bebelman JP, van der Sar AM, Smit MJ, Siderius M, Spaink HP, Meijer AH
Disease models & mechanisms8(3)253-69(2015 Mar)

First Demonstration of Antigen Induced Cytokine Expression by CD4-1+ Lymphocytes in a Poikilotherm: Studies in Zebrafish (Danio rerio).
Yoon S, Mitra S, Wyse C, Alnabulsi A, Zou J, Weerdenburg EM, van der Sar AM, Wang D, Secombes CJ, Bird S
PloS one10(6)e0126378(2015)

Selection of reliable biomarkers from PCR array analyses using relative distance computational model: methodology and proof-of-concept study.
Liu C, Xu H, Lam SH, Gong Z
PloS one8(12)e83954(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The demonstration of a conserved CXCR3-CXCL11 signaling axis in zebrafish extends the translational applicability of this model for studying diseases involving the innate immune system.
Title: The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection.

The following CXCR3.1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CXCR3.1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa01030	NM_001089430.2 Latest version!	Danio rerio chemokine (C-X-C motif) receptor 3, tandem duplicate 1 (cxcr3.1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00
ODa21151	XM_005173488.3 Latest version!	Danio rerio chemokine (C-X-C motif) receptor 3, tandem duplicate 1 (cxcr3.1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CXCR3.1 ( NM_001089430.2 ) cDNA ORF clone, Danio rerio(Zebrafish) -> NP_001082899.2 Danio rerio chemokine (C-X-C motif) receptor 3, tandem duplicate 1 (cxcr3.1), mRNA.

Price & Availability↑

CloneID	ODa01030
Clone ID Related Accession (Same CDS sequence)	NM_001089430.2
Accession Version	NM_001089430.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1104bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-03-13
Organism	Danio rerio(zebrafish)
Product	chemokine (C-X-C motif) receptor 3.1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC139525.1. On or before May 21, 2009 this sequence version replaced NM_001144788.1, NM_001089430.1. ##Evidence-Data-START## Transcript exon combination :: CK017467.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2168446, SAMEA4476799 [ECO:0000348] ##Evidence-Data-END##

ATGAATGTTG ACTCAAAAAC AACATTCAGT ATGAAGGATT TCAGTGACTA CACAGACCTT 
TACAATTACA GTGACTACAA TGACAATGAA AGCTATGGCG CAGGAGCTGT GTGCACTCAA 
GACTCCAGCA TGTACTTTGA CAGCATTTTT AAGCCAATCC TTTACTCACT GGCAGCGGTC 
GTGGGGCTGC TGGGAAACGG CTTGGTTCTG ATTGTACTGT GGAAGAAGAG AGCAGGTTTG 
AATGTTACAG ACATCTTCAT CCTCCACCTG AGCCTGGCAG ATATTTTGCT GCTGTTAACA 
CTGCCCTTCT GGGCTGTAGA GGCGGTGAAG GAGTGGATCT TTGGCACACC ACTTTGCAAA 
CTGACTGGAG CTATGTTCAG GATCAATTTC TACTGTGGCA TTTACATGCT TTCCTGCATC 
AGTCTCGACC GCTACCTGTC CATCGTCCAT GCAGTCCAAA TGTACTCCCG TAAAAAGCCC 
ATGGCGGTTC ACTGTTGCTG CATGATAGTC TGGTTCTTCT GCTTTCTGCT CTCCATTCCC 
GATTGGATAT TACTTGGTGC CAACAAGGAC TCCAGACGTC AGGATAGAAC AGAATGTGTT 
AATTCAGAAG CTCTATCTGA TTTTTGGGTT CTGGTCAATC GTCTGATCTA TCATTTTTTG 
GGTTTCATTA TTCCAGCAAT AATGATGGTC TTCTGCTACA CTAGCATTCT GCTGCGCTTA 
CTGCTCGGCT CCAAGTGCAT GCAGAAGAAG AGGGCCATCC ATGTCATTGT AGCCCTGGTA 
CTGGCCTTCT TCATCAGCTG GACGCCCTAC AACATCGCCC TCATGGCTGA CACCATACAT 
ACCAACAGGA CTGACAATAA CCAAACGTCC TGCGAGACCA GAACCACGTT GGATGTTGCG 
ATCACAGCCA CTTCAACATT TGCCTACATG CACTGCTGTG TCAACCCAAT TCTTTATGCT 
TTTGTGGGGG TGAAATTTCG TCAGCACCTG CTAGACATGC TACGACCTCT GGGCTTCAAG 
CTGAAGGGCC GCGCAGGCCT GGTTTCTCGG AAGAGCTCGG GATGGTCAGA GTCGGTGGAC 
ACTTCCCACA CATCTGCTTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001082899.2
CDS	43..1146
Translation	MNVDSKTTFSMKDFSDYTDLYNYSDYNDNESYGAGAVCTQDSSMYFDSIFKPILYSLAAVVGLLGNGLVLIVLWKKRAGLNVTDIFILHLSLADILLLLTLPFWAVEAVKEWIFGTPLCKLTGAMFRINFYCGIYMLSCISLDRYLSIVHAVQMYSRKKPMAVHCCCMIVWFFCFLLSIPDWILLGANKDSRRQDRTECVNSEALSDFWVLVNRLIYHFLGFIIPAIMMVFCYTSILLRLLLGSKCMQKKRAIHVIVALVLAFFISWTPYNIALMADTIHTNRTDNNQTSCETRTTLDVAITATSTFAYMHCCVNPILYAFVGVKFRQHLLDMLRPLGFKLKGRAGLVSRKSSGWSESVDTSHTSAF

Target ORF information:

RefSeq Version	NM_001089430.2
Organism	Danio rerio(zebrafish)
Definition	Danio rerio chemokine (C-X-C motif) receptor 3, tandem duplicate 1 (cxcr3.1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001089430.2

ORF Insert Sequence:

ATGAATGTTG ACTCAAAAAC AACATTCAGT ATGAAGGATT TCAGTGACTA CACAGACCTT 
TACAATTACA GTGACTACAA TGACAATGAA AGCTATGGCG CAGGAGCTGT GTGCACTCAA 
GACTCCAGCA TGTACTTTGA CAGCATTTTT AAGCCAATCC TTTACTCACT GGCAGCGGTC 
GTGGGGCTGC TGGGAAACGG CTTGGTTCTG ATTGTACTGT GGAAGAAGAG AGCAGGTTTG 
AATGTTACAG ACATCTTCAT CCTCCACCTG AGCCTGGCAG ATATTTTGCT GCTGTTAACA 
CTGCCCTTCT GGGCTGTAGA GGCGGTGAAG GAGTGGATCT TTGGCACACC ACTTTGCAAA 
CTGACTGGAG CTATGTTCAG GATCAATTTC TACTGTGGCA TTTACATGCT TTCCTGCATC 
AGTCTCGACC GCTACCTGTC CATCGTCCAT GCAGTCCAAA TGTACTCCCG TAAAAAGCCC 
ATGGCGGTTC ACTGTTGCTG CATGATAGTC TGGTTCTTCT GCTTTCTGCT CTCCATTCCC 
GATTGGATAT TACTTGGTGC CAACAAGGAC TCCAGACGTC AGGATAGAAC AGAATGTGTT 
AATTCAGAAG CTCTATCTGA TTTTTGGGTT CTGGTCAATC GTCTGATCTA TCATTTTTTG 
GGTTTCATTA TTCCAGCAAT AATGATGGTC TTCTGCTACA CTAGCATTCT GCTGCGCTTA 
CTGCTCGGCT CCAAGTGCAT GCAGAAGAAG AGGGCCATCC ATGTCATTGT AGCCCTGGTA 
CTGGCCTTCT TCATCAGCTG GACGCCCTAC AACATCGCCC TCATGGCTGA CACCATACAT 
ACCAACAGGA CTGACAATAA CCAAACGTCC TGCGAGACCA GAACCACGTT GGATGTTGCG 
ATCACAGCCA CTTCAACATT TGCCTACATG CACTGCTGTG TCAACCCAAT TCTTTATGCT 
TTTGTGGGGG TGAAATTTCG TCAGCACCTG CTAGACATGC TACGACCTCT GGGCTTCAAG 
CTGAAGGGCC GCGCAGGCCT GGTTTCTCGG AAGAGCTCGG GATGGTCAGA GTCGGTGGAC 
ACTTCCCACA CATCTGCTTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CXCR3.1 ( XM_005173488.3 ) cDNA ORF clone, Danio rerio(Zebrafish) -> XP_005173545.1 Danio rerio chemokine (C-X-C motif) receptor 3, tandem duplicate 1 (cxcr3.1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ODa21151
Clone ID Related Accession (Same CDS sequence)	XM_005173488.3
Accession Version	XM_005173488.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1158bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-23
Organism	Danio rerio(Zebrafish)
Product	chemokine (C-X-C motif) receptor 3.1 isoform X1
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007127.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XM_005173488.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGACAAC AGAGAACAGA CAAGCTCAGG GTTAAACAGG AGAAGTTGAA GAAAATGAAT 
GTTGACTCAA AAACAACATT CAGTATGAAG GATTTCAGTG ACTACACAGA CCTTTACAAT 
TACAGTGACT ACAATGACAA TGAAAGCTAT GGCGCAGGAG CTGTGTGCAC TCAAGACTCC 
AGCATGTACT TTGACAGCAT TTTTAAGCCA ATCCTTTACT CACTGGCAGC GGTCGTGGGG 
CTGCTGGGAA ACGGCTTGGT TCTGATTGTA CTGTGGAAGA AGAGAGCAGG TTTGAATGTT 
ACAGACATCT TCATCCTCCA CCTGAGCCTG GCAGATATTT TGCTGCTGTT AACACTGCCC 
TTCTGGGCTG TAGAGGCGGT GAAGGAGTGG ATCTTTGGCA CACCACTTTG CAAACTGACT 
GGAGCTATGT TCAGGATCAA TTTCTACTGT GGCATTTACA TGCTTTCCTG CATCAGTCTC 
GACCGCTACC TGTCCATCGT CCATGCAGTC CAAATGTACT CCCGTAAAAA GCCCATGGCG 
GTTCACTGTT GCTGCATGAT AGTCTGGTTC TTCTGCTTTC TGCTCTCCAT TCCCGATTGG 
ATATTACTTG GTGCCAACAA GGACTCCAGA CGTCAGGATA GAACAGAATG TGTTAATTCA 
GAAGCTCTAT CTGATTTTTG GGTTCTGGTC AATCGTCTGA TCTATCATTT TTTGGGTTTC 
ATTATTCCAG CAATAATGAT GGTCTTCTGC TACACTAGCA TTCTGCTGCG CTTACTGCTC 
GGCTCCAAGT GCATGCAGAA GAAGAGGGCC ATCCATGTCA TTGTAGCCCT GGTACTGGCC 
TTCTTCATCA GCTGGACGCC CTACAACATC GCCCTCATGG CTGACACCAT ACATACCAAC 
AGGACTGACA ATAACCAAAC GTCCTGCGAG ACCAGAACCA CGTTGGATGT TGCGATCACA 
GCCACTTCAA CATTTGCCTA CATGCACTGC TGTGTCAACC CAATTCTTTA TGCTTTTGTG 
GGGGTGAAAT TTCGTCAGCA CCTGCTAGAC ATGCTACGAC CTCTGGGCTT CAAGCTGAAG 
GGCCGCGCAG GCCTGGTTTC TCGGAAGAGC TCGGGATGGT CAGAGTCGGT GGACACTTCC 
CACACATCTG CTTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005173545.1
CDS	196..1353
Translation	MGQQRTDKLRVKQEKLKKMNVDSKTTFSMKDFSDYTDLYNYSDYNDNESYGAGAVCTQDSSMYFDSIFKPILYSLAAVVGLLGNGLVLIVLWKKRAGLNVTDIFILHLSLADILLLLTLPFWAVEAVKEWIFGTPLCKLTGAMFRINFYCGIYMLSCISLDRYLSIVHAVQMYSRKKPMAVHCCCMIVWFFCFLLSIPDWILLGANKDSRRQDRTECVNSEALSDFWVLVNRLIYHFLGFIIPAIMMVFCYTSILLRLLLGSKCMQKKRAIHVIVALVLAFFISWTPYNIALMADTIHTNRTDNNQTSCETRTTLDVAITATSTFAYMHCCVNPILYAFVGVKFRQHLLDMLRPLGFKLKGRAGLVSRKSSGWSESVDTSHTSAF

Target ORF information:

RefSeq Version	XM_005173488.3
Organism	Danio rerio(Zebrafish)
Definition	Danio rerio chemokine (C-X-C motif) receptor 3, tandem duplicate 1 (cxcr3.1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005173488.3

ORF Insert Sequence:

ATGGGACAAC AGAGAACAGA CAAGCTCAGG GTTAAACAGG AGAAGTTGAA GAAAATGAAT 
GTTGACTCAA AAACAACATT CAGTATGAAG GATTTCAGTG ACTACACAGA CCTTTACAAT 
TACAGTGACT ACAATGACAA TGAAAGCTAT GGCGCAGGAG CTGTGTGCAC TCAAGACTCC 
AGCATGTACT TTGACAGCAT TTTTAAGCCA ATCCTTTACT CACTGGCAGC GGTCGTGGGG 
CTGCTGGGAA ACGGCTTGGT TCTGATTGTA CTGTGGAAGA AGAGAGCAGG TTTGAATGTT 
ACAGACATCT TCATCCTCCA CCTGAGCCTG GCAGATATTT TGCTGCTGTT AACACTGCCC 
TTCTGGGCTG TAGAGGCGGT GAAGGAGTGG ATCTTTGGCA CACCACTTTG CAAACTGACT 
GGAGCTATGT TCAGGATCAA TTTCTACTGT GGCATTTACA TGCTTTCCTG CATCAGTCTC 
GACCGCTACC TGTCCATCGT CCATGCAGTC CAAATGTACT CCCGTAAAAA GCCCATGGCG 
GTTCACTGTT GCTGCATGAT AGTCTGGTTC TTCTGCTTTC TGCTCTCCAT TCCCGATTGG 
ATATTACTTG GTGCCAACAA GGACTCCAGA CGTCAGGATA GAACAGAATG TGTTAATTCA 
GAAGCTCTAT CTGATTTTTG GGTTCTGGTC AATCGTCTGA TCTATCATTT TTTGGGTTTC 
ATTATTCCAG CAATAATGAT GGTCTTCTGC TACACTAGCA TTCTGCTGCG CTTACTGCTC 
GGCTCCAAGT GCATGCAGAA GAAGAGGGCC ATCCATGTCA TTGTAGCCCT GGTACTGGCC 
TTCTTCATCA GCTGGACGCC CTACAACATC GCCCTCATGG CTGACACCAT ACATACCAAC 
AGGACTGACA ATAACCAAAC GTCCTGCGAG ACCAGAACCA CGTTGGATGT TGCGATCACA 
GCCACTTCAA CATTTGCCTA CATGCACTGC TGTGTCAACC CAATTCTTTA TGCTTTTGTG 
GGGGTGAAAT TTCGTCAGCA CCTGCTAGAC ATGCTACGAC CTCTGGGCTT CAAGCTGAAG 
GGCCGCGCAG GCCTGGTTTC TCGGAAGAGC TCGGGATGGT CAGAGTCGGT GGACACTTCC 
CACACATCTG CTTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Pathogen response-like recruitment and activation of neutrophils by sterile immunogenic dying cells drives neutrophil-mediated residual cell killing.
Cell death and differentiation24(5)832-843(2017 May)
Garg AD,Vandenberk L,Fang S,Fasche T,Van Eygen S,Maes J,Van Woensel M,Koks C,Vanthillo N,Graf N,de Witte P,Van Gool S,Salven P,Agostinis P

CXCR1 remodels the vascular niche to promote hematopoietic stem and progenitor cell engraftment.
The Journal of experimental medicine214(4)1011-1027(2017 Apr)
Blaser BW,Moore JL,Hagedorn EJ,Li B,Riquelme R,Lichtig A,Yang S,Zhou Y,Tamplin OJ,Binder V,Zon LI

The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection.
Disease models & mechanisms8(3)253-69(2015 Mar)
Torraca V,Cui C,Boland R,Bebelman JP,van der Sar AM,Smit MJ,Siderius M,Spaink HP,Meijer AH

First Demonstration of Antigen Induced Cytokine Expression by CD4-1+ Lymphocytes in a Poikilotherm: Studies in Zebrafish (Danio rerio).
PloS one10(6)e0126378(2015)
Yoon S,Mitra S,Wyse C,Alnabulsi A,Zou J,Weerdenburg EM,van der Sar AM,Wang D,Secombes CJ,Bird S

Selection of reliable biomarkers from PCR array analyses using relative distance computational model: methodology and proof-of-concept study.
PloS one8(12)e83954(2013)
Liu C,Xu H,Lam SH,Gong Z