cxcl8b.3 cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	cxcl8b.3
Entrez Gene ID	100003859
Full Name	chemokine (C-X-C motif) ligand 8b, duplicate 3
Synonyms	cxcl-c13d
General protein information	Preferred Names chemokine (C-X-C motif) ligand 8b, duplicate 3 Names uncharacterized protein LOC100003859 CXCL8_L2_chr7 chemokine (C-X-C motif) ligand C13d chemokine CXCL-C13c cxcl8ba dr-scNA16716-CXCL8
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001115068.1	NP_001108540.1	uncharacterized protein LOC100003859 precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

CXCR1 remodels the vascular niche to promote hematopoietic stem and progenitor cell engraftment.
Blaser BW, Moore JL, Hagedorn EJ, Li B, Riquelme R, Lichtig A, Yang S, Zhou Y, Tamplin OJ, Binder V, Zon LI
The Journal of experimental medicine214(4)1011-1027(2017 Apr)

Cxcl8-l1 and Cxcl8-l2 are required in the zebrafish defense against Salmonella Typhimurium.
de Oliveira S, Lopez-Mu?oz A, Mart?nez-Navarro FJ, Galindo-Villegas J, Mulero V, Calado ?
Developmental and comparative immunology49(1)44-8(2015 Mar)

The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection.
Torraca V, Cui C, Boland R, Bebelman JP, van der Sar AM, Smit MJ, Siderius M, Spaink HP, Meijer AH
Disease models & mechanisms8(3)253-69(2015 Mar)

Deficiency in hematopoietic phosphatase ptpn6/Shp1 hyperactivates the innate immune system and impairs control of bacterial infections in zebrafish embryos.
Kanwal Z, Zakrzewska A, den Hertog J, Spaink HP, Schaaf MJ, Meijer AH
Journal of immunology (Baltimore, Md. : 1950)190(4)1631-45(2013 Feb)

Systematic classification of vertebrate chemokines based on conserved synteny and evolutionary history.
Nomiyama H, Osada N, Yoshie O
Genes to cells : devoted to molecular & cellular mechanisms18(1)1-16(2013 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that both Cxcl8-l1 and Cxcl8-l2 are required for larva survival upon Salmonella Typhimurium infection.
Title: Cxcl8-l1 and Cxcl8-l2 are required in the zebrafish defense against Salmonella Typhimurium.

The following cxcl8b.3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the cxcl8b.3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa01767	NM_001115068.1 Latest version!	Danio rerio chemokine (C-X-C motif) ligand 8b, duplicate 3 (cxcl8b.3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

cxcl8b.3 ( NM_001115068.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001108540.1 Danio rerio chemokine (C-X-C motif) ligand 8b, duplicate 3 (cxcl8b.3), mRNA.

Price & Availability↑

CloneID	ODa01767
Clone ID Related Accession (Same CDS sequence)	NM_001115068.1
Accession Version	NM_001115068.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 354bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-03-13
Organism	Danio rerio(zebrafish)
Product	uncharacterized protein LOC100003859 precursor
Comment	Comment: PREDICTED REFSEQ: This record has not been reviewed and the function is unknown. The reference sequence was derived from AB331765.1. On Mar 2, 2008 this sequence version replaced XM_001343272.1. ##Evidence-Data-START## Transcript exon combination :: AB331765.1, CO923720.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA4476759, SAMEA4476785 [ECO:0000350] ##Evidence-Data-END##

ATGAGGTGCT CAGTTTTCGT TTTTCTGGCA TGCATGACAC TGCTGTCCAC AACAGAAGTG 
TTTGCTGCTC GACTGCCCAT CCAGCAGTTA CGCTGTCAGT GTGTGAAGAC GTATACGGGA 
AAACCAATCA ATCCCAAACT AATACAGAGT TTACAGACCA TTCCTGCTGG AGCGCGGTGC 
AAAAACATGG AGGTCATTGC CACTGTGAAA AAAGGGAAGA CCTGCCTCAA TCCCAAGGAT 
GAATGGGTGA CAAAGATCAT CGAAGGCAGG AGTGTCAAAG TACCTACCAG AGGGCCATTT 
ACTACCCTCC CTCCAAATTC TACCTCCGCC CCTCAACTGA CGTCAAAAAT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001108540.1
CDS	42..395
Translation	MRCSVFVFLACMTLLSTTEVFAARLPIQQLRCQCVKTYTGKPINPKLIQSLQTIPAGARCKNMEVIATVKKGKTCLNPKDEWVTKIIEGRSVKVPTRGPFTTLPPNSTSAPQLTSKM

Target ORF information:

RefSeq Version	NM_001115068.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio chemokine (C-X-C motif) ligand 8b, duplicate 3 (cxcl8b.3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001115068.1

ORF Insert Sequence:

ATGAGGTGCT CAGTTTTCGT TTTTCTGGCA TGCATGACAC TGCTGTCCAC AACAGAAGTG 
TTTGCTGCTC GACTGCCCAT CCAGCAGTTA CGCTGTCAGT GTGTGAAGAC GTATACGGGA 
AAACCAATCA ATCCCAAACT AATACAGAGT TTACAGACCA TTCCTGCTGG AGCGCGGTGC 
AAAAACATGG AGGTCATTGC CACTGTGAAA AAAGGGAAGA CCTGCCTCAA TCCCAAGGAT 
GAATGGGTGA CAAAGATCAT CGAAGGCAGG AGTGTCAAAG TACCTACCAG AGGGCCATTT 
ACTACCCTCC CTCCAAATTC TACCTCCGCC CCTCAACTGA CGTCAAAAAT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CXCR1 remodels the vascular niche to promote hematopoietic stem and progenitor cell engraftment.
The Journal of experimental medicine214(4)1011-1027(2017 Apr)
Blaser BW,Moore JL,Hagedorn EJ,Li B,Riquelme R,Lichtig A,Yang S,Zhou Y,Tamplin OJ,Binder V,Zon LI

Cxcl8-l1 and Cxcl8-l2 are required in the zebrafish defense against Salmonella Typhimurium.
Developmental and comparative immunology49(1)44-8(2015 Mar)
de Oliveira S,Lopez-Mu?oz A,Mart?nez-Navarro FJ,Galindo-Villegas J,Mulero V,Calado ?

The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection.
Disease models & mechanisms8(3)253-69(2015 Mar)
Torraca V,Cui C,Boland R,Bebelman JP,van der Sar AM,Smit MJ,Siderius M,Spaink HP,Meijer AH

Deficiency in hematopoietic phosphatase ptpn6/Shp1 hyperactivates the innate immune system and impairs control of bacterial infections in zebrafish embryos.
Journal of immunology (Baltimore, Md. : 1950)190(4)1631-45(2013 Feb)
Kanwal Z,Zakrzewska A,den Hertog J,Spaink HP,Schaaf MJ,Meijer AH

Systematic classification of vertebrate chemokines based on conserved synteny and evolutionary history.
Genes to cells : devoted to molecular & cellular mechanisms18(1)1-16(2013 Jan)
Nomiyama H,Osada N,Yoshie O