IL6 cDNA ORF clone, Capra hircus(goat)

Gene
Clones
gRNAs

Summary

Gene Symbol	IL6
Entrez Gene ID	100860785
Full Name	interleukin 6
Synonyms	IL-6
Gene Type	protein-coding
Organism	Capra hircus(goat)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001285640.1	NP_001272569.1	interleukin-6 precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Characterization of Liaoning cashmere goat transcriptome: sequencing, de novo assembly, functional annotation and comparative analysis.
Liu H, Wang T, Wang J, Quan F, Zhang Y
PloS one8(10)e77062(2013)

Unchanged interleukin 6 level of protein and energy restricted goats during late gestation: the role of elevated blood nitric oxide.
He Z, Tan Z, Sun Z, Beauchemin KA, Tang S, Zhou C, Han X, Wang M, Wu D
The Journal of endocrinology213(1)59-65(2012 Apr)

Molecular cloning of caprine IL-6 cDNA and its expression in insect cells.
Takakura H, Mori Y, Tatsumi M
International archives of allergy and immunology113(4)409-16(1997 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Plasma nitric oxide acts as a regulator of cytokine function exhibiting negative feedback to maintain steady plasma IL-6 concentration in protein- or energy-restricted goats during late gestation.
Title: Unchanged interleukin 6 level of protein and energy restricted goats during late gestation: the role of elevated blood nitric oxide.

The following IL6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCa157004	NM_001285640.1 Latest version!	Capra hircus interleukin 6 (IL6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$174.30 $249.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IL6 ( NM_001285640.1 ) cDNA ORF clone, Capra hircus(goat) -> NP_001272569.1 Capra hircus interleukin 6 (IL6), mRNA.

Price & Availability↑

CloneID	OCa157004
Clone ID Related Accession (Same CDS sequence)	NM_001285640.1
Accession Version	NM_001285640.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Capra hircus(goat)
Product	interleukin-6 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from HM565937.1. On Oct 22, 2013 this sequence version replaced XM_005679035.1. ##Evidence-Data-START## Transcript exon combination :: D86569.1, HM565937.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN02264637, SAMN02264643 [ECO:0000348] ##Evidence-Data-END##

ATGAACTCCC TCTTCACAAG CGCCTTCAGT CCACTCGCTG TCTCCCTGGG GCTGCTCCTG 
GTGATGACTT CTGCTTTCCC TACCCCGGGT CCCCTGGGAG AAGATTTCAA GAATGACACC 
ACCCCAAGCA GACTACTTCT GACCACTCCA GAAAAAACCG AAGCTCTCAT TAAGCACATC 
GTCGACAAAA TCTCTGCAAT AAGAAAGGAG ATATGTGAAA AGAATGACGA GTGTGAAAAC 
AGCAAGGAGA CACTGGCAGA AAATAAGCTG AAACTTCCAA AAATGGAGGA AAAAGATGGA 
TGCTTCCAAT CTGGGTTCAA TCAGGCGATT TGCTTGATCA AAACCACTGC TGGTCTTCTG 
GAGTATCAGA TATACCTGGA CTTCCTCCAG AACGAGTTTG AGGGAAATCA GGAAACTGTC 
ATGGAGTTGC AGAGCAGTAT CAGAACACTG ATCCAGATCC TGAAGGAAAA GATCGCAGGT 
CTAATAACCA CTCCAGCCAC AAACACTGAC ATGCTGGAGA AGATGCAGTC CTCAAACGAG 
TGGGTAAAGA ACGCAAAGGT TATCATCATC CTGAGAAGCC TTGAGAATTT CCTGCAGTTC 
AGCCTGAGAG CTATTCGGAT GAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001272569.1
CDS	1..627
Translation	MNSLFTSAFSPLAVSLGLLLVMTSAFPTPGPLGEDFKNDTTPSRLLLTTPEKTEALIKHIVDKISAIRKEICEKNDECENSKETLAENKLKLPKMEEKDGCFQSGFNQAICLIKTTAGLLEYQIYLDFLQNEFEGNQETVMELQSSIRTLIQILKEKIAGLITTPATNTDMLEKMQSSNEWVKNAKVIIILRSLENFLQFSLRAIRMK

Target ORF information:

RefSeq Version	NM_001285640.1
Organism	Capra hircus(goat)
Definition	Capra hircus interleukin 6 (IL6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001285640.1

ORF Insert Sequence:

ATGAACTCCC TCTTCACAAG CGCCTTCAGT CCACTCGCTG TCTCCCTGGG GCTGCTCCTG 
GTGATGACTT CTGCTTTCCC TACCCCGGGT CCCCTGGGAG AAGATTTCAA GAATGACACC 
ACCCCAAGCA GACTACTTCT GACCACTCCA GAAAAAACCG AAGCTCTCAT TAAGCACATC 
GTCGACAAAA TCTCTGCAAT AAGAAAGGAG ATATGTGAAA AGAATGACGA GTGTGAAAAC 
AGCAAGGAGA CACTGGCAGA AAATAAGCTG AAACTTCCAA AAATGGAGGA AAAAGATGGA 
TGCTTCCAAT CTGGGTTCAA TCAGGCGATT TGCTTGATCA AAACCACTGC TGGTCTTCTG 
GAGTATCAGA TATACCTGGA CTTCCTCCAG AACGAGTTTG AGGGAAATCA GGAAACTGTC 
ATGGAGTTGC AGAGCAGTAT CAGAACACTG ATCCAGATCC TGAAGGAAAA GATCGCAGGT 
CTAATAACCA CTCCAGCCAC AAACACTGAC ATGCTGGAGA AGATGCAGTC CTCAAACGAG 
TGGGTAAAGA ACGCAAAGGT TATCATCATC CTGAGAAGCC TTGAGAATTT CCTGCAGTTC 
AGCCTGAGAG CTATTCGGAT GAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Characterization of Liaoning cashmere goat transcriptome: sequencing, de novo assembly, functional annotation and comparative analysis.
PloS one8(10)e77062(2013)
Liu H,Wang T,Wang J,Quan F,Zhang Y

Unchanged interleukin 6 level of protein and energy restricted goats during late gestation: the role of elevated blood nitric oxide.
The Journal of endocrinology213(1)59-65(2012 Apr)
He Z,Tan Z,Sun Z,Beauchemin KA,Tang S,Zhou C,Han X,Wang M,Wu D

Molecular cloning of caprine IL-6 cDNA and its expression in insect cells.
International archives of allergy and immunology113(4)409-16(1997 Aug)
Takakura H,Mori Y,Tatsumi M