| Gene Symbol | unc-104 |
| Entrez Gene ID | 174144 |
| Full Name | Kinesin-like protein unc-104 |
| Gene Type | protein-coding |
| Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » unc-104 cDNA ORF clone
| Gene Symbol | unc-104 |
| Entrez Gene ID | 174144 |
| Full Name | Kinesin-like protein unc-104 |
| Gene Type | protein-coding |
| Organism | Caenorhabditis elegans |
| mRNA | Protein | Name |
|---|---|---|
| NM_171017.9 | NP_741019.3 | Kinesin-like protein unc-104 |
| NM_001026870.5 | NP_001022041.2 | Kinesin-like protein unc-104 |
| NM_001026870.6 | NP_001022041.2 | Kinesin-like protein unc-104 |
| NM_171017.8 | NP_741019.3 | Kinesin-like protein unc-104 |
| KIF1A | XP_002799156.1 | |
| Gallus gallus (chicken) | KIF1A | XP_003641781.1 |
| Rattus norvegicus (Norway rat) | Kif1a | XP_006245623.1 |
| Drosophila melanogaster (fruit fly) | unc-104 | NP_001246373.1 |
| Anopheles gambiae (African malaria mosquito) | KIF1A_ANOGA | XP_314493.3 |
| Pan troglodytes (chimpanzee) | KIF1A | XP_003309612.1 |
| Bos taurus (cattle) | KIF1A | XP_005205116.1 |
| Mus musculus (house mouse) | Kif1a | NP_032466.2 |
| Caenorhabditis elegans (roundworm) | unc-104 | NP_001022041.1 |
| Homo sapiens (human) | KIF1A | NP_004312.2 |
| Canis lupus familiaris (dog) | KIF1A | NP_001161945.1 |
| Danio rerio (zebrafish) | kif1a | XP_005166002.1 |
| Danio rerio (zebrafish) | kif1ab | XP_005171271.1 |
| Xenopus tropicalis (tropical clawed frog) | kif1a | XP_002933380.2 |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Synaptic vesicle bound small GTPase ARL-8 activates UNC-104 by unlocking the autoinhibition. The results demonstrate that the autoinhibitory mechanism is utilized to regulate the distribution of transport cargoes and is important for synaptogenesis in vivo.
Title: Autoinhibition of a Neuronal Kinesin UNC-104/KIF1A Regulates the Size and Density of Synapses.
LIN-2 and SYD-2 both positively affect the velocity of UNC-104
Title: Identification and Characterization of LIN-2(CASK) as a Regulator of Kinesin-3 UNC-104(KIF1A) Motility and Clustering in Neurons.
findings indicate that autophagy is spatially regulated in neurons through the transport of ATG-9 by KIF1A/UNC-104 to regulate neurodevelopment
Title: KIF1A/UNC-104 Transports ATG-9 to Regulate Neurodevelopment and Autophagy at Synapses.
Reduced function of UNC-104 accelerates motor circuit dysfunction with age, whereas upregulation of UNC-104 significantly improves motor function at advanced ages and also mildly extends lifespan. In addition, UNC-104-overexpressing animals outperform wild-type controls in associative learning and memory tests.
Title: The Neuronal Kinesin UNC-104/KIF1A Is a Key Regulator of Synaptic Aging and Insulin Signaling-Regulated Memory.
This study establishes an essential role of the CC1-FHA dimer for KIF1A/unc-104-mediated neuronal transport.
Title: The CC1-FHA dimer is essential for KIF1A-mediated axonal transport of synaptic vesicles in C. elegans.
The following unc-104 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the unc-104 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OCa337483 | |
| Clone ID Related Accession (Same CDS sequence) | NM_171017.9 , NM_171017.8 | |
| Accession Version | NM_171017.9 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 4755bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-10-17 | |
| Organism | Caenorhabditis elegans | |
| Product | Kinesin-like protein unc-104 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003280). On Sep 4, 2019 this sequence version replaced NM_171017.8. | |
1 | ATGTCATCGG TTAAAGTAGC TGTACGTGTT CGCCCATTCA ACCAACGGGA AATCTCGAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_741019.3 |
| CDS | 201..4955 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_171017.9 |
1 | ATGTCATCGG TTAAAGTAGC TGTACGTGTT CGCCCATTCA ACCAACGGGA AATCTCGAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OCa337483 | |
| Clone ID Related Accession (Same CDS sequence) | NM_171017.9 , NM_171017.8 | |
| Accession Version | NM_171017.8 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 4755bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-04-08 | |
| Organism | Caenorhabditis elegans | |
| Product | Kinesin-like protein unc-104 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003280). On Feb 27, 2013 this sequence version replaced NM_171017.7. COMPLETENESS: incomplete on both ends. | |
1 | ATGTCATCGG TTAAAGTAGC TGTACGTGTT CGCCCATTCA ACCAACGGGA AATCTCGAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_741019.3 |
| CDS | 1..4755 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_171017.8 |
1 | ATGTCATCGG TTAAAGTAGC TGTACGTGTT CGCCCATTCA ACCAACGGGA AATCTCGAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OCa337484 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001026870.5 , NM_001026870.6 | |
| Accession Version | NM_001026870.5 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 4887bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-04-08 | |
| Organism | Caenorhabditis elegans | |
| Product | Kinesin-like protein unc-104 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003280). On Feb 27, 2013 this sequence version replaced NM_001026870.4. COMPLETENESS: incomplete on both ends. | |
1 | ATGTCATCGG TTAAAGTAGC TGTACGTGTT CGCCCATTCA ACCAACGGGA AATCTCGAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001022041.2 |
| CDS | 1..4887 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001026870.5 |
1 | ATGTCATCGG TTAAAGTAGC TGTACGTGTT CGCCCATTCA ACCAACGGGA AATCTCGAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OCa337484 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001026870.5 , NM_001026870.6 | |
| Accession Version | NM_001026870.6 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 4887bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-10-17 | |
| Organism | Caenorhabditis elegans | |
| Product | Kinesin-like protein unc-104 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003280). On Sep 4, 2019 this sequence version replaced NM_001026870.5. | |
1 | ATGTCATCGG TTAAAGTAGC TGTACGTGTT CGCCCATTCA ACCAACGGGA AATCTCGAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001022041.2 |
| CDS | 137..5023 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001026870.6 |
1 | ATGTCATCGG TTAAAGTAGC TGTACGTGTT CGCCCATTCA ACCAACGGGA AATCTCGAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |