HLA-A*11:01&B2M&KRAS WT (VVVGAGGVGK) Tetramer, His & Avi, Human
HLA-A*11:01&B2M&KRAS WT (VVVGAGGVGK) Tetramer, His & Avi, Human

The purity of HLA-A*11:01&B2M&KRAS WT (VVVGAGGVGK) Tetramer, His & Avi, Human is greater than 95% as determined by SEC-HPLC.

HLA-A*11:01&B2M&KRAS WT (VVVGAGGVGK) Tetramer, His & Avi, Human

HLA-A*11:01&B2M&KRAS WT (VVVGAGGVGK) Tetramer, His & Avi, Human on Bis-Tris PAGE under Non reduced (N) condition. The purity is greater than 95%.

HLA-A*11:01&B2M&KRAS WT (VVVGAGGVGK) Tetramer, His & Avi, Human

Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target.
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Product Introduction
Species Human
Protein Construction
HLA-A*11:01&B2M&KRAS WT (VVVGAGGVGK) Tetramer[Gly25-Thr305(HLA-A*11:01), Ile21-Met119(B2M) and VVVGAGGVGK peptide]
Accession # AAV53343.1(HLA-A*11:01)&P61769(B2M)&VVVGAGGVGK		 His Avi
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 258 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 260-265 kDa under Non reducing (N) condition based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • HLA-A*11:01&B2M&KRAS WT (VVVGAGGVGK) Tetramer, His & Avi, Human
    • HLA-A*11:01&B2M&KRAS WT (VVVGAGGVGK) Tetramer, His & Avi, Human

    The purity of HLA-A*11:01&B2M&KRAS WT (VVVGAGGVGK) Tetramer, His & Avi, Human is greater than 95% as determined by SEC-HPLC.

  • HLA-A*11:01&B2M&KRAS WT (VVVGAGGVGK) Tetramer, His & Avi, Human
    • HLA-A*11:01&B2M&KRAS WT (VVVGAGGVGK) Tetramer, His & Avi, Human

    HLA-A*11:01&B2M&KRAS WT (VVVGAGGVGK) Tetramer, His & Avi, Human on Bis-Tris PAGE under Non reduced (N) condition. The purity is greater than 95%.


Background
Target Background Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target.
Synonyms MHC; KRAS; K-Ras 2; KRAS2; C-K-RAS; CFC2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KRAS1; KRAS2; NS; NS3; RASK2; GTPase Kras; KI-RAS; RALD

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.