HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer, His & Avi, Human
HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer, His & Avi, Human

The purity of HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer, His & Avi, Human is greater than 95% as determined by SEC-HPLC.

HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer, His & Avi, Human

HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer, His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer, His & Avi, Human

HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer, His & Avi, Human, His Tag captured on CM5 Chip via Anti-His Antibody can bind Anti-HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Antibody, hFc Tag with an affinity constant of 2.35 nM as determined in SPR assay (Biacore T200).

HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer, His & Avi, Human

p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein.p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.
Z06584
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Product Introduction
Species Human
Protein Construction
HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer[Gly25-Thr305 (HLA-A*02:01), Ile21-Met119 (B2M) and HMTEVVRHC peptide]
Accession # A0A140T913(HLA-A*02:01)&P61769(B2M)&HMTEVVRHC		 His Avi
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer, His & Avi, Human captured on CM5 Chip via Anti­His Antibody can bind Anti-HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Antibody, hFc Tag in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System E.coli
Theoretical Molecular Weight 35.6 kDa (HLA-A*02:01) and 11.9 kDa (B2M)
Apparent Molecular Weight The protein has a predicted MW of 35.6 kDa (HLA-A*02:01) and 11.9 kDa (B2M) same as Bis-Tris PAGE result.
Formulation Supplied as 0.22 μm filtered solution in 20 mM Tris, 200 mM NaCl (pH 8.0).
Concentration Verified by one or more methods from A280/Bioactivity/BCA/Bradford.
Storage & Stability Upon receiving, the product remains stable for 6 months at -80°C or below. Avoid repeated freeze-thaw cycles.

Examples
  • HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer, His & Avi, Human
    • HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer, His & Avi, Human

    The purity of HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer, His & Avi, Human is greater than 95% as determined by SEC-HPLC.

  • HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer, His & Avi, Human
    • HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer, His & Avi, Human

    HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer, His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer, His & Avi, Human
    • HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer, His & Avi, Human

    HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer, His & Avi, Human, His Tag captured on CM5 Chip via Anti-His Antibody can bind Anti-HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Antibody, hFc Tag with an affinity constant of 2.35 nM as determined in SPR assay (Biacore T200).


Background
Target Background p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein.p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.
Synonyms MHC; HLA-A; P53; TP53; Antigen NY-CO-13; BCC7; FLJ92943; LFS1; TRP53

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.