HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Monomer[Biotin], His & Avi, Human
HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Monomer[Biotin], His & Avi, Human

The purity of HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Monomer[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Monomer[Biotin], His & Avi, Human

HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Monomer[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Monomer[Biotin], His & Avi, Human

HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Monomer[Biotin], His & Avi, Human, His Tag captured on CM5 Chip via Anti-His Antibody can bind HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) TCR with an affinity constant of 55.67 μM as determined in SPR assay (Biacore T200).

HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Monomer[Biotin], His & Avi, Human

Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.
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Product Introduction
Species Human
Protein Construction
HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Monomer [Gly25-Thr305(HLA-A*11:01), Ile21-Met119(B2M) and VVGAVGVGK peptide]
Accession # AAV53343.1(HLA-A*11:01)&P61769(B2M)&VVGAVGVGK		 His Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Monomer[Biotin], His & Avi, Human captured on CM5 Chip via AntiHis Antibody can bind HLA­A*11:01&B2M&KRAS G12V (VVGAVGVGK) TCR in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 50.2 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 56-65 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Monomer[Biotin], His & Avi, Human
    • HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Monomer[Biotin], His & Avi, Human

    The purity of HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Monomer[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

  • HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Monomer[Biotin], His & Avi, Human
    • HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Monomer[Biotin], His & Avi, Human

    HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Monomer[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Monomer[Biotin], His & Avi, Human
    • HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Monomer[Biotin], His & Avi, Human

    HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Monomer[Biotin], His & Avi, Human, His Tag captured on CM5 Chip via Anti-His Antibody can bind HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) TCR with an affinity constant of 55.67 μM as determined in SPR assay (Biacore T200).


Background
Target Background Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.
Synonyms MHC; KRAS; K-Ras 2; KRAS2; C-K-RAS; CFC2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KRAS1; KRAS2; NS; NS3; RASK2; GTPase Kras; KI-RAS; RALD

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.