PD-L1/B7-H1, His, Mouse
PD-L1/B7-H1, His, Mouse

The purity of PD-L1/B7-H1, His, Mouse is greater than 95% as determined by SEC-HPLC.

PD-L1/B7-H1, His, Mouse

PD-L1/B7-H1, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

PD-L1/B7-H1, His, Mouse

PD-L1/B7-H1, His, Mouse, His Tag captured on CM5 Chip via anti-his antibody can bind Mouse PD-1, hFc Tag with an affinity constant of 0.62 μM as determined in SPR assay (Biacore T200).

PD-L1/B7-H1, His, Mouse

B7-H1, also known as PD-L1 and CD274, is an approximately 65 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. PD-L1 has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance.
Z06302
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Product Introduction
Species Mouse
Protein Construction
PD-L1/B7-H1 (Phe19-Thr238)_x000D_
Accession # NP_068693		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Loaded PD-L1/B7-H1, His, Mouse on Anti-His-Biosensor can bind Mouse PD-1, hFc Tag in BLI assay (Gator® Prime). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 25.9 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 45-60 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • PD-L1/B7-H1, His, Mouse
    • PD-L1/B7-H1, His, Mouse

    The purity of PD-L1/B7-H1, His, Mouse is greater than 95% as determined by SEC-HPLC.

  • PD-L1/B7-H1, His, Mouse
    • PD-L1/B7-H1, His, Mouse

    PD-L1/B7-H1, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • PD-L1/B7-H1, His, Mouse
    • PD-L1/B7-H1, His, Mouse

    PD-L1/B7-H1, His, Mouse, His Tag captured on CM5 Chip via anti-his antibody can bind Mouse PD-1, hFc Tag with an affinity constant of 0.62 μM as determined in SPR assay (Biacore T200).


Background
Target Background B7-H1, also known as PD-L1 and CD274, is an approximately 65 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. PD-L1 has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance.
Synonyms CD274; PDL1; PD-L1; PD-L1B7 homolog 1;B7-H; B7H1; B7-H1; PDCD1L1; PDCD1LG1

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.