Fas/TNFRSF6/CD95 hFc Chimera, Mouse
Fas/TNFRSF6/CD95 HFc Chimera, Mouse

Immobilized Human Fas Ligand, His Tag at 1 μg /ml (100 μl/well) on the plate. Dose response curve for Fas/TNFRSF6/CD95 hFc Chimera, Mouse, hFc Tag with the EC50 of 0.28 μg /ml determined by ELISA.

Fas/TNFRSF6/CD95 HFc Chimera, Mouse

The purity of Fas/TNFRSF6/CD95 hFc Chimera, Mouse is greater than 95% as determined by SEC-HPLC.

Fas/TNFRSF6/CD95 HFc Chimera, Mouse

Fas/TNFRSF6/CD95 hFc Chimera, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Fas/TNFRSF6/CD95 hFc Chimera, Mouse

CD95 (also known as Fas) is a member of the tumor necrosis factor receptor (TNFR) superfamily. Its cognate ligand, CD95L, is implicated in immune homeostasis and immune surveillance. Mutations in this receptor are associated with a loss of apoptotic signaling and have been detected in an autoimmune disorder called autoimmune lymphoproliferative syndrome (ALPS) type Ia, which shares some clinical features with systemic lupus erythematosus (SLE).
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Product Introduction
Species Mouse
Protein Construction
Fas/TNFRSF6/CD95 (Gln22-Arg169)_x000D_
Accession # P25446		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 43.3 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 60-65 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • Fas/TNFRSF6/CD95 HFc Chimera, Mouse
    • Fas/TNFRSF6/CD95 HFc Chimera, Mouse

    Immobilized Human Fas Ligand, His Tag at 1 μg /ml (100 μl/well) on the plate. Dose response curve for Fas/TNFRSF6/CD95 hFc Chimera, Mouse, hFc Tag with the EC50 of 0.28 μg /ml determined by ELISA.

  • Fas/TNFRSF6/CD95 HFc Chimera, Mouse
    • Fas/TNFRSF6/CD95 HFc Chimera, Mouse

    The purity of Fas/TNFRSF6/CD95 hFc Chimera, Mouse is greater than 95% as determined by SEC-HPLC.

  • Fas/TNFRSF6/CD95 HFc Chimera, Mouse
    • Fas/TNFRSF6/CD95 HFc Chimera, Mouse

    Fas/TNFRSF6/CD95 hFc Chimera, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background CD95 (also known as Fas) is a member of the tumor necrosis factor receptor (TNFR) superfamily. Its cognate ligand, CD95L, is implicated in immune homeostasis and immune surveillance. Mutations in this receptor are associated with a loss of apoptotic signaling and have been detected in an autoimmune disorder called autoimmune lymphoproliferative syndrome (ALPS) type Ia, which shares some clinical features with systemic lupus erythematosus (SLE).
Synonyms FASLG receptor; CD95; APT1; FAS1; TNFRSF6; FAS; ALPS1A; APO1; FASTM; FasR

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.