c-MPL/Thrombopoietin R, His, Mouse
C-MPL/Thrombopoietin R, His, Mouse

The purity of c-MPL/Thrombopoietin R, His, Mouse is greater than 95% as determined by SEC-HPLC.

C-MPL/Thrombopoietin R, His, Mouse

c-MPL/Thrombopoietin R, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

c-MPL/Thrombopoietin R, His, Mouse

The c-mpl gene encodes a member of the hematopoietic cytokine receptor superfamily. This gene was discovered through the study of a murine retrovirus which induces an acute myeloproliferative syndrome in mice.MPLV (for myeloproliferative leukemia virus) has transduced a truncated and constitutively activated form of the c-mpl receptor chain. High levels of c-mpl expression were detected in 45% of acute myeloid leukemia (AML). No correlation was found between c-mpl expression and the French-American-British classification subtype of AML.
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Product Introduction
Species Mouse
Protein Construction
c-MPL/Thrombopoietin R (Gln26-Trp482)_x000D_
Accession # Q08351-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 52.3 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 65-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • C-MPL/Thrombopoietin R, His, Mouse
    • C-MPL/Thrombopoietin R, His, Mouse

    The purity of c-MPL/Thrombopoietin R, His, Mouse is greater than 95% as determined by SEC-HPLC.

  • C-MPL/Thrombopoietin R, His, Mouse
    • C-MPL/Thrombopoietin R, His, Mouse

    c-MPL/Thrombopoietin R, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background The c-mpl gene encodes a member of the hematopoietic cytokine receptor superfamily. This gene was discovered through the study of a murine retrovirus which induces an acute myeloproliferative syndrome in mice.MPLV (for myeloproliferative leukemia virus) has transduced a truncated and constitutively activated form of the c-mpl receptor chain. High levels of c-mpl expression were detected in 45% of acute myeloid leukemia (AML). No correlation was found between c-mpl expression and the French-American-British classification subtype of AML.
Synonyms TPO-R; CD110; MPL; c-Mpl; MPLV; K12

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.