YKL-40/CHI3L1, His, Human
YKL-40/CHI3L1, His, Human

Immobilized YKL-40/CHI3L1, His, Human, His Tag at 2 μg /ml (100 μl/well) on the plate. Dose response curve for Anti-YKL-40 Antibody , hFc Tag with the EC50 of 38.2ng/ml determined by ELISA.

YKL-40/CHI3L1, His, Human

The purity of YKL-40/CHI3L1, His, Human is greater than 95% as determined by SEC-HPLC.

YKL-40/CHI3L1, His, Human

YKL-40/CHI3L1, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

YKL-40/CHI3L1, His, Human

YKL-40 (also known as Chitinase 3-like 1) is a glycoprotein produced by inflammatory, cancer and stem cells. Its physiological role is not completely understood but YKL-40 is elevated in the brain and cerebrospinal fluid (CSF) in several neurological and neurodegenerative diseases associated with inflammatory processes. Yet the precise characterization of YKL-40 in dementia cases is missing. YKL-40 is a disease-specific marker of neuroinflammation showing its highest levels in prion diseases. Therefore, YKL-40 quantification might have a potential for application in the evaluation of therapeutic intervention in dementias with a neuroinflammatory component.
Z05965
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Product Introduction
Species Human
Protein Construction
YKL-40/CHI3L1 (Tyr22-Thr383)
Accession # P36222		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 41.6 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 42-50 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • YKL-40/CHI3L1, His, Human
    • YKL-40/CHI3L1, His, Human

    Immobilized YKL-40/CHI3L1, His, Human, His Tag at 2 μg /ml (100 μl/well) on the plate. Dose response curve for Anti-YKL-40 Antibody , hFc Tag with the EC50 of 38.2ng/ml determined by ELISA.

  • YKL-40/CHI3L1, His, Human
    • YKL-40/CHI3L1, His, Human

    The purity of YKL-40/CHI3L1, His, Human is greater than 95% as determined by SEC-HPLC.

  • YKL-40/CHI3L1, His, Human
    • YKL-40/CHI3L1, His, Human

    YKL-40/CHI3L1, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background YKL-40 (also known as Chitinase 3-like 1) is a glycoprotein produced by inflammatory, cancer and stem cells. Its physiological role is not completely understood but YKL-40 is elevated in the brain and cerebrospinal fluid (CSF) in several neurological and neurodegenerative diseases associated with inflammatory processes. Yet the precise characterization of YKL-40 in dementia cases is missing. YKL-40 is a disease-specific marker of neuroinflammation showing its highest levels in prion diseases. Therefore, YKL-40 quantification might have a potential for application in the evaluation of therapeutic intervention in dementias with a neuroinflammatory component.
Synonyms BRP39; CGP-39; GP-39; Chil1; ASRT7; FLJ38139; HC-gp39; YKL-40; YKL40; YYL-40; AW208766; CHI3L1; Chitinase 3 like 1

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.