Nectin-1/PVRL1/CD111 hFc Chimera, Human
Nectin-1/PVRL1/CD111 HFc Chimera, Human

Immobilized Human Nectin-3, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Nectin-1/PVRL1/CD111 hFc Chimera, Human, hFc Tag with the EC50 of 14.7ng/ml determined by ELISA.

Nectin-1/PVRL1/CD111 HFc Chimera, Human

Immobilized Human Nectin-4, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Nectin-1/PVRL1/CD111 hFc Chimera, Human, hFc Tag with the EC50 of 0.27 μg/ml determined by ELISA.

Nectin-1/PVRL1/CD111 HFc Chimera, Human

The purity of Nectin-1/PVRL1/CD111 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

Nectin-1/PVRL1/CD111 HFc Chimera, Human

Nectin-1/PVRL1/CD111 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Nectin-1/PVRL1/CD111 hFc Chimera, Human

Nectins are a small family of Ca -independent immunoglobulin (Ig)-like cell adhesion molecules (CAMs) that organize intercellular junctions. They are highly homologous to the human receptor for poliovirus, and as such have been alternately named poliovirus receptor-related proteins.Nectin-1 promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between Nectin-1 and Nectin-3 and between Nectin-1 and Nectin-4. Has some neurite outgrowth-promoting activity.
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Product Introduction
Species Human
Protein Construction
Nectin-1/PVRL1/CD11 (Gln31-Thr334)_x000D_
Accession # Q15223-1		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 59.89 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 70-80 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • Nectin-1/PVRL1/CD111 HFc Chimera, Human
    • Nectin-1/PVRL1/CD111 HFc Chimera, Human

    Immobilized Human Nectin-3, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Nectin-1/PVRL1/CD111 hFc Chimera, Human, hFc Tag with the EC50 of 14.7ng/ml determined by ELISA.

  • Nectin-1/PVRL1/CD111 HFc Chimera, Human
    • Nectin-1/PVRL1/CD111 HFc Chimera, Human

    Immobilized Human Nectin-4, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Nectin-1/PVRL1/CD111 hFc Chimera, Human, hFc Tag with the EC50 of 0.27 μg/ml determined by ELISA.

  • Nectin-1/PVRL1/CD111 HFc Chimera, Human
    • Nectin-1/PVRL1/CD111 HFc Chimera, Human

    The purity of Nectin-1/PVRL1/CD111 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

  • Nectin-1/PVRL1/CD111 HFc Chimera, Human
    • Nectin-1/PVRL1/CD111 HFc Chimera, Human

    Nectin-1/PVRL1/CD111 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Nectins are a small family of Ca -independent immunoglobulin (Ig)-like cell adhesion molecules (CAMs) that organize intercellular junctions. They are highly homologous to the human receptor for poliovirus, and as such have been alternately named poliovirus receptor-related proteins.Nectin-1 promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between Nectin-1 and Nectin-3 and between Nectin-1 and Nectin-4. Has some neurite outgrowth-promoting activity.
Synonyms CD111; ED4; HIgRPVRR; HVEC; MGC142031; Nectin1; PRR; PRR1; PRR1MGC16207; PVRL1; PVRR1; SK-12; PVRL1; CLPED1; HIgR; OFC7; PVRR

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.