M-CSF/CSF-1, Human
M-CSF/CSF-1, Human

Measured in a cell proliferation assay using RAW264.7 cells.The ED50 for this effect is 1-10 ng/mL.

M-CSF/CSF-1, Human

Immobilized M-CSF/CSF-1, Human, No Tag at 0.5 μg/ml (100 μI/well) on the plate. Dose response curve for Human M-CSF R, hFc Tag with the EC50 of 30.0ng/ml determined by ELISA.

M-CSF/CSF-1, Human

The purity of M-CSF/CSF-1, Human is greater than 95% as determined by SEC-HPLC.

M-CSF/CSF-1, Human

M-CSF/CSF-1, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

M-CSF/CSF-1, Human

M-CSF/CSF-1, Human, No Tag immobilized on CM5 Chip can bind Human M-CSF R, hFc Tag with an affinity constant of 2.06 nM as determined in SPR assay (Biacore T200).

M-CSF/CSF-1, Human

CSF-1, also known as M-CSF , is a four alpha -helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation. CSF-1 is also essential for the survival and proliferation of osteoclast progenitors.CSF-1 is cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand.
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Product Introduction
Species Human
Protein Construction
M-CSF/CSF-1 (Glu33-Asn190)
Accession # P09603-1
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 0.05EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 18.40 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 23-28 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • M-CSF/CSF-1, Human
    • M-CSF/CSF-1, Human

    Measured in a cell proliferation assay using RAW264.7 cells.The ED50 for this effect is 1-10 ng/mL.

  • M-CSF/CSF-1, Human
    • M-CSF/CSF-1, Human

    Immobilized M-CSF/CSF-1, Human, No Tag at 0.5 μg/ml (100 μI/well) on the plate. Dose response curve for Human M-CSF R, hFc Tag with the EC50 of 30.0ng/ml determined by ELISA.

  • M-CSF/CSF-1, Human
    • M-CSF/CSF-1, Human

    The purity of M-CSF/CSF-1, Human is greater than 95% as determined by SEC-HPLC.

  • M-CSF/CSF-1, Human
    • M-CSF/CSF-1, Human

    M-CSF/CSF-1, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • M-CSF/CSF-1, Human
    • M-CSF/CSF-1, Human

    M-CSF/CSF-1, Human, No Tag immobilized on CM5 Chip can bind Human M-CSF R, hFc Tag with an affinity constant of 2.06 nM as determined in SPR assay (Biacore T200).


Background
Target Background CSF-1, also known as M-CSF , is a four alpha -helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation. CSF-1 is also essential for the survival and proliferation of osteoclast progenitors.CSF-1 is cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand.
Synonyms CSF1; CSF-1; MCSF; M-CSF; MGC31930; Lanimostim

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.