M-CSF R/CSF1R/CD115, Human
M-CSF R/CSF1R/CD115, Human

Immobilized M-CSF R/CSF1R/CD115, Human, No Tag at 0.5 μg/ml (100 μI/well) on the plate. Dose response curve for Anti-M-CSF R Antibody, hFc Tag with the EC50 of 8.0ng/ml determined by ELISA.

M-CSF R/CSF1R/CD115, Human

The purity of M-CSF R/CSF1R/CD115, Human is greater than 95% as determined by SEC-HPLC.

M-CSF R/CSF1R/CD115, Human

M-CSF R/CSF1R/CD115, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

M-CSF R/CSF1R/CD115, Human

CSF1R also known as M-CSF receptor, the product of the c-fms proto-oncogene, is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region.CSF1R is tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes.
Z05636
¥35,443.00

Ask us a question
Product Introduction
Species Human
Protein Construction
M-CSF R/CSF1R/CD115 (Ile20-Glu512)_x000D_
Accession # P07333-1
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized M-CSF R/CSF1R/CD115, Human at 0.5μg/ml (100μl/well) on the plate can bind Anti­M­CSF R Antibody, hFc Tag. Test result was comparable to standard batch
Expression System HEK293
Theoretical Molecular Weight 54.49 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 70-100 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • M-CSF R/CSF1R/CD115, Human
    • M-CSF R/CSF1R/CD115, Human

    Immobilized M-CSF R/CSF1R/CD115, Human, No Tag at 0.5 μg/ml (100 μI/well) on the plate. Dose response curve for Anti-M-CSF R Antibody, hFc Tag with the EC50 of 8.0ng/ml determined by ELISA.

  • M-CSF R/CSF1R/CD115, Human
    • M-CSF R/CSF1R/CD115, Human

    The purity of M-CSF R/CSF1R/CD115, Human is greater than 95% as determined by SEC-HPLC.

  • M-CSF R/CSF1R/CD115, Human
    • M-CSF R/CSF1R/CD115, Human

    M-CSF R/CSF1R/CD115, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background CSF1R also known as M-CSF receptor, the product of the c-fms proto-oncogene, is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region.CSF1R is tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes.
Synonyms CD115; CSF1R; CSF-1-R; CSFR; FMSFIM2; M-CSF R; MCSFR; M-CSFR; C-FMS; FIM2; FMS; HDLS

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.