IL-7R alpha/CD127 hFc Chimera, Human
IL-7R Alpha/CD127 HFc Chimera, Human

Immobilized IL-7R alpha/CD127 hFc Chimera, Human, No Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Human IL-7R alpha, hFc Tag with the EC50 of 16.4ng/ml determined by ELISA.

IL-7R Alpha/CD127 HFc Chimera, Human

The purity of IL-7R alpha/CD127 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

IL-7R Alpha/CD127 HFc Chimera, Human

IL-7R alpha/CD127 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

IL-7R alpha/CD127 hFc Chimera, Human

Interleukin 7 (IL-7) and its receptor (IL-7R, a heterodimer of IL-7Rα and γc) are essential for normal lymphoid development. IL-7 and IL-7R activate three main pathways: STAT5, PI3K/Akt/mTOR and MEK/Erk, ultimately leading to the promotion of leukemia cell viability, cell cycle progression and growth.
Z05514
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Product Introduction
Species Human
Protein Construction
IL-7 R alpha/CD127 (Glu21-Gly236)
Accession # P16871-1		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 51.6 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 65-75 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • IL-7R Alpha/CD127 HFc Chimera, Human
    • IL-7R Alpha/CD127 HFc Chimera, Human

    Immobilized IL-7R alpha/CD127 hFc Chimera, Human, No Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Human IL-7R alpha, hFc Tag with the EC50 of 16.4ng/ml determined by ELISA.

  • IL-7R Alpha/CD127 HFc Chimera, Human
    • IL-7R Alpha/CD127 HFc Chimera, Human

    The purity of IL-7R alpha/CD127 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

  • IL-7R Alpha/CD127 HFc Chimera, Human
    • IL-7R Alpha/CD127 HFc Chimera, Human

    IL-7R alpha/CD127 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Interleukin 7 (IL-7) and its receptor (IL-7R, a heterodimer of IL-7Rα and γc) are essential for normal lymphoid development. IL-7 and IL-7R activate three main pathways: STAT5, PI3K/Akt/mTOR and MEK/Erk, ultimately leading to the promotion of leukemia cell viability, cell cycle progression and growth.
Synonyms IL-7R alpha; IL7Ra; CD127; CDW127; IL7Rα

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.